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2024-05-19 15:41:01

Gene list

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COG category: Signal transduction mechanisms
Organism: Dictyostelium discoideum AX4, AX4

Number of genes found: 428

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0267514 DDB_G0267514 DDB0232428 CDS259066 2751 - 0.28426
DDB_G0267566 DDB_G0267566 putative protein serinethreonine kinase contains an ankyrin repeat domain similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS343868 2535 - 0.244181
DDB_G0267686 DDB_G0267686 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains an RGS (Regulator of G protein Signaling) domainDDB0232428 CDS564277 6693 - 0.276109
DDB_G0267828 DDB_G0267828 DDB0232428 CDS926752 2484 + 0.271739
DDB_G0267992 DDB_G0267992 DDB0232428 CDS1244589 789 - 0.309252
DDB_G0268006 DDB_G0268006 DDB0232428 CDS1288689 435 - 0.287356
DDB_G0268012 DDB_G0268012 DDB0232428 CDS1302705 1149 - 0.191471
DDB_G0268078 DDB_G0268078 DDB0232428 CDS1417972 1524 + 0.281496
DDB_G0268486_ps DDB_G0268486 putative pseudogene contains protein kinase domainDDB0232428 CDS498516 2820 - 0.22305
DDB_G0268550 DDB_G0268550 kinase domain similar to those of mitogen-activated protein kinases similar to the STE20 familyDDB0232428 CDS1145507 1611 - 0.189323
DDB_G0268642 DDB_G0268642 related to the GCN2 family of protein kinases which phosphorylate the alpha subunit of eIF2 unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232428 CDS1801909 3237 - 0.255792
DDB_G0268656 DDB_G0268656 highly similar to human ULK (Unc51-like kinase) does not contain the full consensus sequence required for kinase functionDDB0232428 CDS1863917 954 - 0.220126
DDB_G0268876 DDB_G0268876 member of the TKL (tyrosine kinase-like) group of protein kinases contains filamin repeat similar to ABP120DDB0232428 CDS2297918 4158 - 0.279702
DDB_G0269096 DDB_G0269096 DDB0232428 CDS2393899 858 - 0.29021
DDB_G0269628 DDB_G0269628 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS3183487 2214 - 0.303975
DDB_G0270056 DDB_G0270056 DDB0232428 CDS4130694 4299 - 0.25378
DDB_G0270146 DDB_G0270146 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232428 CDS4304005 1908 - 0.287212
DDB_G0270176 DDB_G0270176 the amino terminus contains leucine-rich repeats and the carboxyl terminus a protein phosphatase 2C domain a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activityDDB0232428 CDS4369737 4080 + 0.239216
DDB_G0270690 DDB_G0270690 DDB0232428 CDS3883017 432 - 0.261574
DDB_G0271054 DDB_G0271054 contains one SMADFHA domain contains one coiled-coil domainDDB0232428 CDS4565256 1737 - 0.235463
DDB_G0271350 DDB_G0271350 DDB0232429 CDS54276 828 - 0.242754
DDB_G0271402 DDB_G0271402 DDB0232429 CDS241165 2298 + 0.309835
DDB_G0271538 DDB_G0271538 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family expressed in pstO cellsDDB0232429 CDS568653 1584 - 0.285985
DDB_G0271550 DDB_G0271550 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS634463 1179 + 0.267176
DDB_G0271664 DDB_G0271664 similar to mammalian XPR1 which may confer susceptibility to infection with murine leukaemia viruses also similar to yeast SYG1 a G-protein associated signal transduction protein and plant PHO1 that may be involved in phosphate transportDDB0232429 CDS442827 2772 + 0.297258
DDB_G0271682 DDB_G0271682 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains two kinase domains one of which is predicted to be inactiveDDB0232429 CDS792553 3075 + 0.247154
DDB_G0271860 DDB_G0271860 dual specificity phosphatases remove phosphate groups from tyrosine and serinethreonine residues DDB0232429 CDS939689 1683 + 0.263815
DDB_G0272092 DDB_G0272092 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains a C2 domain (Ca2-dependent membrane-targeting module) an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232429 CDS1251605 2961 - 0.296184
DDB_G0272254 DDB_G0272254 member of the TKL (tyrosine kinase-like) group contains a galactose oxidase central domain and three Kelch motifsDDB0232429 CDS1396081 3996 - 0.264765
DDB_G0272282 DDB_G0272282 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) and MAST (microtubule-associated serinethreonine kinase)DDB0232429 CDS1572926 6309 + 0.272468
DDB_G0272680 DDB_G0272680 protein phosphatase 2C is a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activityDDB0232429 CDS2003225 3447 + 0.286916
DDB_G0272690 DDB_G0272690 DDB0232429 CDS1968947 2271 + 0.265962
DDB_G0272797 DDB_G0272797 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS2368968 2043 - 0.313754
DDB_G0273361 DDB_G0273361 contains 5 transmembrane domains there is a second copy of this gene DDB0232429 CDS2727455 936 - 0.244658
DDB_G0273707 DDB_G0273707 contains 5 transmembrane domains there is a second copy of this gene DDB0232429 CDS3303396 936 + 0.244658
DDB_G0274007 DDB_G0274007 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS3660427 2043 + 0.313754
DDB_G0274153 DDB_G0274153 protein phosphatase 2C is a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activityDDB0232429 CDS4909656 1932 + 0.315217
DDB_G0274169 DDB_G0274169 DDB0232429 CDS4865070 345 + 0.228986
DDB_G0274439 DDB_G0274439 in E. coli bolA plays a role in general stress response and affects cellular morphogenesis this protein is about 50 amino acids shorter on the amino terminus compared to homologsDDB0232429 CDS4596108 159 + 0.27673
DDB_G0274481 DDB_G0274481 similar to mammalian XPR1 which may confer susceptibility to infection with murine leukaemia viruses also similar to yeast SYG1 a G-protein associated signal transduction protein and plant PHO1 that may be involved in phosphate transport DDB0232429 CDS4437706 3162 - 0.28463
DDB_G0274537 DDB_G0274537 contains a sac phosphatase domain similar to D. discoideum sac1 similar to D. purpureum proteinDDB0232429 CDS4257363 4317 - 0.281214
DDB_G0274613 DDB_G0274613 kinase domain similar to mitogen-activated protein kinases does not contain the consensus sequences known to be required for kinase function contains a RING zinc finger domainDDB0232429 CDS4893134 2496 - 0.260417
DDB_G0274757 DDB_G0274757 DDB0232429 CDS3781238 573 - 0.319372
DDB_G0274781 DDB_G0274781 contains three EF hands similar to mammalian neuron specific calcium-binding protein hippocalcin belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232429 CDS3825256 678 + 0.29646
DDB_G0274821 DDB_G0274821 DDB0232429 CDS3992986 2565 - 0.181287
DDB_G0274877 DDB_G0274877 DDB0232429 CDS4317924 2226 - 0.261905
DDB_G0275057 DDB_G0275057 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS5089988 1050 + 0.33619
DDB_G0275165 DDB_G0275165 DDB0232429 CDS5143836 2766 - 0.298988
DDB_G0275865 DDB_G0275865 DDB0232429 CDS5772751 1584 - 0.351641
DDB_G0276121 DDB_G0276121 DDB0232429 CDS6256669 2142 + 0.339869
DDB_G0276181 DDB_G0276181 member of the TKL (tyrosine kinase-like) group of protein kinases contains a PH (pleckstrin homology) domainDDB0232429 CDS6410071 4668 - 0.262853
DDB_G0276461 DDB_G0276461 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232429 CDS6904331 2397 - 0.267418
DDB_G0276567 DDB_G0276567 homolog of S. cerevisiae CDC50 (cell division control protein 50) which is required for polarized cell growth contains two putative transmembrane domainsDDB0232429 CDS6951075 939 - 0.292865
DDB_G0277129 DDB_G0277129 DDB0232429 CDS7609682 513 - 0.28655
DDB_G0277165 DDB_G0277165 CAMKL family protein kinase the protein kinase domain is similar to those of the CAMKLBRSK subfamily which are named based on brain-specific expression in human and neuronal expression in wormDDB0232429 CDS7893420 2502 - 0.271783
DDB_G0277449 DDB_G0277449 member of the AGC kinase group similar to kinase domains of SGK (serum and glucocorticoid responsive kinase) AktPKB and RSK (ribosomal S6 kinase) family membersDDB0232429 CDS8121319 1371 + 0.300511
DDB_G0277537 DDB_G0277537 subunit of PI4K responsible for the phosphorylation of phosphatidylinositol (PI) to PI4P (ATP 1-phosphatidyl-1D-myo-inositol ADP 1-phosphatidyl-1D-myo-inositol 4-phosphate) the first committed step in the generation of phosphatidylinositol 45-bisphosphate (PIP2) a precursor of the second messenger inositol 145-trisphosphate (InsP3)DDB0232429 CDS7989159 7383 + 0.301233
DDB_G0277539 DDB_G0277539 putative protein tyrosine kinase similar to human wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232429 CDS8010617 2997 - 0.248248
DDB_G0277989 DDB_G0277989 DDB0232430 CDS119614 4302 + 0.225477
DDB_G0278087_ps DDB_G0278087 putative pseudogene containing a partial protein kinase domain and a partial ankyrin repeatDDB0232430 CDS256195 1557 - 0.285806
DDB_G0278099_ps DDB_G0278099 putative pseudogene kinase motif-containing (KMC)DDB0232430 CDS270787 678 - 0.222714
DDB_G0278487 DDB_G0278487 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases belongs to the CMGC group of protein kinasesDDB0232430 CDS959760 1911 + 0.288854
DDB_G0278499 DDB_G0278499 protein phosphatase 2C is a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activity similar to P. pallidum proteinDDB0232430 CDS971318 2076 + 0.322254
DDB_G0278509 DDB_G0278509 DDB0232430 CDS984753 3747 + 0.238858
DDB_G0278521 DDB_G0278521 member of the TKL (tyrosine kinase-like) group the MLK (mixed lineage kinase) family and the HH498 subfamily contains an ankyrin repeatDDB0232430 CDS1000912 2727 - 0.226989
DDB_G0278535 DDB_G0278535 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232430 CDS1034770 2547 + 0.329407
DDB_G0278665 DDB_G0278665 DDB0232430 CDS753135 3273 - 0.31103
DDB_G0278845 DDB_G0278845 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) family membersDDB0232430 CDS1269374 4053 - 0.265976
DDB_G0278901 DDB_G0278901 DDB0232430 CDS1361340 4488 - 0.282308
DDB_G0278909 DDB_G0278909 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains an N-terminal LRR and a C-terminal armadillobeta-catenin repeat unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS1376167 5811 + 0.293581
DDB_G0278921 DDB_G0278921 DDB0232430 CDS1404420 2766 - 0.236081
DDB_G0279405 DDB_G0279405 CAMKL family protein kinase the protein kinase domain has similarity to those of calciumcalmodulin-dependent protein kinase kinases (CAMKK) that belong to a proposed calcium-triggered signaling cascade involved in a number of cellular processesDDB0232430 CDS1975813 2088 + 0.290709
DDB_G0279461 DDB_G0279461 protein phosphatase 2C is a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activityDDB0232430 CDS2082919 3021 + 0.28335
DDB_G0279513 DDB_G0279513 DDB0232430 CDS2186381 1854 + 0.28425
DDB_G0279655 DDB_G0279655 similar to Dictyostelium and H. sapiens ppp2r4 (PTPA) the phosphatase 2A regulatory subunit B'DDB0232430 CDS2376263 1407 - 0.257996
DDB_G0279719 DDB_G0279719 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232430 CDS2480611 2829 - 0.265111
DDB_G0279831 DDB_G0279831 putative protein serinethreonine kinase CAMK group the protein kinase domain is similar to those of mammalian CAM kinase IDDB0232430 CDS2602496 2787 + 0.267671
DDB_G0279995 DDB_G0279995 CAZy family GH9 catalyzes the hydrolysis of glucosidic linkagesDDB0232430 CDS2833406 2523 - 0.309948
DDB_G0280067 DDB_G0280067 similar to T-cell activation protein phosphatase 2C the protein phosphatase 2C-related domain occurs in protein phosphatase 2C (PPC2) as well as in other proteins such as pyruvate dehydrogenase (lipoamide)]-phosphatase and adenylate cyclaseDDB0232430 CDS2886853 1551 + 0.295938
DDB_G0280073 DDB_G0280073 DDB0232430 CDS2894240 1194 - 0.281407
DDB_G0280111 DDB_G0280111 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232430 CDS2948944 3381 - 0.280982
DDB_G0280131 DDB_G0280131 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains armadillobeta-catenin-like repeats unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS2985578 3579 - 0.308187
DDB_G0280133 DDB_G0280133 CAMK family protein kinase protein kinase domain similar to those of mammalian SNF1 like kinasesDDB0232430 CDS2991402 4518 + 0.285967
DDB_G0280193 DDB_G0280193 DDB0232430 CDS3084374 2466 - 0.227088
DDB_G0280377 DDB_G0280377 DDB0232430 CDS3071897 2355 + 0.265393
DDB_G0280461 DDB_G0280461 DDB0232430 CDS3391535 1257 - 0.24105
DDB_G0280557 DDB_G0280557 similar to erkA and erkB and other MAP kinases does not contain the consensus sequences required for kinase functionDDB0232430 CDS3496721 1383 + 0.237889
DDB_G0280559 DDB_G0280559 similar to many different classes of kinases including several MAPKs unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS3499719 642 + 0.252336
DDB_G0280643 DDB_G0280643 similar to many CMGC family members including several MAPKsDDB0232430 CDS3598294 1329 - 0.261851
DDB_G0280717 DDB_G0280717 member of the AGC kinase group similar to the kinase domains of PKC (protein kinase C) and MAST (microtubule-associated serinethreonine kinase)DDB0232430 CDS3670258 1236 - 0.258091
DDB_G0280855 DDB_G0280855 similar to erkA and erkB and other MAP kinases unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS3794487 1179 + 0.25106
DDB_G0281331 DDB_G0281331 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosis contains 7 predicted transmembrane domainsDDB0232430 CDS4278355 2115 + 0.259102
DDB_G0281427 DDB_G0281427 DDB0232430 CDS4470521 4176 - 0.256944
DDB_G0281745 DDB_G0281745 DDB0232430 CDS4910382 1794 + 0.337793
DDB_G0281953 DDB_G0281953 DDB0232430 CDS5193203 501 - 0.279441
DDB_G0281963 DDB_G0281963 DDB0232430 CDS5173395 1185 + 0.296203
DDB_G0282105 DDB_G0282105 protein phosphatase 2C is a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activityDDB0232430 CDS5377643 2877 + 0.269378
DDB_G0282193 DDB_G0282193 DDB0232430 CDS5505181 435 + 0.305747
DDB_G0282287 DDB_G0282287 DDB0232430 CDS5546265 1794 - 0.296544
DDB_G0282429 DDB_G0282429 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232430 CDS5758659 939 - 0.312034
DDB_G0282671_ps DDB_G0282671 putative pseudogene weakly similar to AGC protein kinases does not contain the consensus sequences required for kinase functionDDB0232430 CDS6098622 765 + 0.257516
DDB_G0282895 DDB_G0282895 member of the TKL (tyrosine kinase-like) group contains three N-terminal MORN (Membrane Occupation and Recognition Nexus) repeatsDDB0232430 CDS6249781 4905 + 0.262385
DDB_G0282963 DDB_G0282963 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS60445 5286 + 0.265796
DDB_G0283065 DDB_G0283065 putative eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase putative protein serinethreonine kinase related to the GCN2 (general control non-derepressible) family of protein kinases that phosphorylate the alpha subunit of eIF2DDB0232431 CDS122741 1914 - 0.242424
DDB_G0283187 DDB_G0283187 catalyzes the reaction: A phosphoprotein Hsub2subO a protein phosphate conserved serinethreonine protein phosphatase family proteinDDB0232431 CDS381819 939 + 0.308839
DDB_G0283301 DDB_G0283301 DDB0232431 CDS480042 1992 + 0.254016
DDB_G0283337 DDB_G0283337 DDB0232431 CDS491931 3387 - 0.219368
DDB_G0283397 DDB_G0283397 DDB0232431 CDS606939 2757 - 0.283642
DDB_G0283417 DDB_G0283417 dual specificity phosphatases remove phosphate groups from tyrosine and serinethreonine residues DDB0232431 CDS654013 693 - 0.215007
DDB_G0283821 DDB_G0283821 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232431 CDS1155677 2826 - 0.295824
DDB_G0283919 DDB_G0283919 the protein phosphatase 2C-related domain occurs in protein phosphatase 2C (PPC2) as well as in other proteins such as pyruvate dehydrogenase (lipoamide)]-phosphatase and adenylate cyclaseDDB0232431 CDS1275553 3243 + 0.30589
DDB_G0283927 DDB_G0283927 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232431 CDS1307685 1458 - 0.226337
DDB_G0284243 DDB_G0284243 similar to yeast PTC1 type 2C protein phosphatase (PP2C) which is involved in mitochondrial inheritance tRNA splicing sporulation and cell separationDDB0232431 CDS1735866 1212 - 0.329208
DDB_G0284251 DDB_G0284251 kinase domain similar to those of mitogen-activated protein kinases similar to the STE20 familyDDB0232431 CDS1754346 1491 - 0.273642
DDB_G0284491 DDB_G0284491 DDB0232431 CDS2041403 3639 - 0.233855
DDB_G0284587 DDB_G0284587 DDB0232431 CDS2187151 1236 + 0.231392
DDB_G0284661 DDB_G0284661 putative protein serinethreonine kinase CAMK group kinase domain similar to mammalian CAM kinase IDDB0232431 CDS2309177 1446 - 0.304288
DDB_G0285191 DDB_G0285191 DDB0232431 CDS2965339 1785 - 0.317647
DDB_G0285265 DDB_G0285265 contains one EF hand similar to calmodulinDDB0232431 CDS3032493 420 - 0.292857
DDB_G0285463 DDB_G0285463 member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) family contains 7 putative transmembrane domainsDDB0232431 CDS3259648 2076 - 0.308285
DDB_G0285909 DDB_G0285909 catalyzes the removal of a phosphate group attached to a tyrosine residue ortholog of S. cerevisiae SIW14 that plays a role in actin filament organization and endocytosisDDB0232431 CDS3812938 546 + 0.287546
DDB_G0285923 DDB_G0285923 DDB0232431 CDS3831998 2388 - 0.356784
DDB_G0285967 DDB_G0285967 tensin family protein (related to the tumor suppressor PTEN) contains a a lipid phosphatase domain and a C2-like domain and a C-terminal LIM domain (absent from PTEN)DDB0232431 CDS3881074 2997 - 0.265933
DDB_G0286115 DDB_G0286115 PIP5K catalyze the formation of phosphoinositol-45-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathwayDDB0232431 CDS4051045 3816 + 0.277778
DDB_G0286383 DDB_G0286383 DDB0232431 CDS4391636 708 + 0.237288
DDB_G0286479 DDB_G0286479 DDB0232431 CDS4506469 3504 - 0.257991
DDB_G0286481 DDB_G0286481 putative protein serinethreonine kinase similar to casein kinase II the alpha chain of a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS4514745 1818 - 0.264026
DDB_G0286613 DDB_G0286613 DDB0232431 CDS4708744 7692 - 0.303952
DDB_G0286627 DDB_G0286627 putative protein serinethreonine kinase belongs to the STE group the kinase domain is similar to yeast BCK1 a mitogen-activated protein (MAP) kinase kinase kinaseDDB0232431 CDS4756048 2016 - 0.251984
DDB_G0286841 DDB_G0286841 member of the AGC kinase group similar to the kinase domains of MAST kinases (Microtubule-Associated SerineThreonine kinase)DDB0232431 CDS4966020 1389 - 0.218143
DDB_G0286887 DDB_G0286887 DDB0232431 CDS5026472 372 - 0.271505
DDB_G0287001 DDB_G0287001 member of the TKL (tyrosine kinase-like) group contains zinc-binding LIM domainDDB0232431 CDS5188585 1953 - 0.28213
DDB_G0287725 DDB_G0287725 DDB0232432 CDS605033 1716 + 0.262238
DDB_G0287787_ps DDB_G0287787 putative pseudogene similar to many different classes of protein kinasesDDB0232432 CDS701445 2061 - 0.289665
DDB_G0288107 DDB_G0288107 the protein phosphatase 2C-related domain occurs in protein phosphatase 2C (PPC2) as well as in other proteins such as pyruvate dehydrogenase (lipoamide)]-phosphatase and adenylate cyclaseDDB0232432 CDS1124020 1182 + 0.267343
DDB_G0288147 DDB_G0288147 member of the tyrosine kinase-like (TKL) group similar to plant serinethreonine kinases contains a phorbol esterdiacylglycerol-binding domainDDB0232432 CDS1147360 4044 + 0.271513
DDB_G0288199_ps DDB_G0288199 putative pseudogene xpr1 family geneDDB0232432 CDS1217412 1167 + 0.172237
DDB_G0288795 DDB_G0288795 putative protein serinethreonine kinase AGC group similar to the kinase domains of mammalian AKTPKB similar to yeast protein kinases GAD8 and SCH9DDB0232432 CDS1975761 1926 - 0.317757
DDB_G0289409 DDB_G0289409 DDB0232432 CDS2755696 11793 + 0.287628
DDB_G0289423 DDB_G0289423 similar to mammalian XPR1 which may confer susceptibility to infection with murine leukaemia viruses also similar to yeast SYG1 a G-protein associated signal transduction protein and plant PHO1 that may be involved in phosphate transport DDB0232432 CDS2794822 3246 + 0.279421
DDB_G0289979 DDB_G0289979 has similarity to mammalian tensin a cytoplasmic phosphoprotein DDB0232432 CDS3435700 2715 - 0.299079
DDB_G0290027 DDB_G0290027 DDB0232432 CDS3557818 264 + 0.265152
DDB_G0290075 DDB_G0290075 protein phosphatase 2C is a serinethreonine specific protein phosphatase with broad substrate specificity and dependent on divalent cations (mainly manganese and magnesium) for its activityDDB0232432 CDS3618710 1620 - 0.297531
DDB_G0290319 DDB_G0290319 DDB0232432 CDS3952440 456 + 0.27193
DDB_G0290471 DDB_G0290471 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats does not contain the consensus sequences required for kinase functionDDB0232432 CDS4105828 1059 - 0.234183
DDB_G0290595 DDB_G0290595 DDB0232432 CDS4337348 687 + 0.257642
DDB_G0290621 DDB_G0290621 DDB0232432 CDS4383355 2904 - 0.22865
DDB_G0290647 DDB_G0290647 similar to mammalian XPR1 which may confer susceptibility to infection with murine leukaemia viruses also similar to yeast SYG1 a G-protein associated signal transduction protein and plant PHO1 that may be involved in phosphate transport DDB0232432 CDS4170905 2784 + 0.30819
DDB_G0290653 DDB_G0290653 DDB0232432 CDS4220163 5154 - 0.28832
DDB_G0290859 DDB_G0290859 member of the AGC kinase group similar to NDR (nuclear Dbf2-related) and RSK (ribosomal S6 kinase) family membersDDB0232432 CDS4688665 1260 + 0.307143
DDB_G0291133 DDB_G0291133 putative protein tyrosine kinase similar to S. pombe wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232432 CDS5030354 2337 + 0.26059
DDB_G0291350 DDB_G0291350 putative protein serinethreonine kinase similar to mammalian MPSK (myristoylated and palmitoylated serinethreonine kinase) a kinase involved in transcriptional regulation and protein phosphorylation may be an intermediary in the TGF-beta signaling pathwayDDB0232433 CDS162730 1110 - 0.245045
DDB_G0291424 DDB_G0291424 DDB0232433 CDS289088 2709 + 0.276486
DDB_G0291516 DDB_G0291516 highly similar to DDB0232433 CDS469339 2898 + 0.277433
DDB_G0291664 DDB_G0291664 highly similar to DDB0232433 CDS338918 2880 + 0.291319
DDB_G0291842 DDB_G0291842 putative protein tyrosine kinase similar to S. pombe WEE1 inhibitor of mitosis through phosphorylation of cdc2DDB0232433 CDS822502 1059 - 0.351275
DDB_G0291918 DDB_G0291918 putative protein serinethreonine kinase CAMK group kinase domain is similar to those of mammalian death-associated protein kinases (DAPK)DDB0232433 CDS943654 2010 + 0.287065
DDB_G0292024 DDB_G0292024 dual specificity phosphatases remove phosphate groups from tyrosine and serinethreonine residues DDB0232433 CDS1039810 501 + 0.339321
DDB_G0292190 DDB_G0292190 DDB0232433 CDS1259597 2835 - 0.257143
DDB_G0292194 DDB_G0292194 DDB0232433 CDS1279409 1680 + 0.250595
DDB_G0292350 DDB_G0292350 DDB0232433 CDS1496951 3675 + 0.270204
DDB_G0292354 DDB_G0292354 putative protein serinethreonine kinase TTBK family similar to casein kinase similar to mammalian tau-tubulin kinase (TTBK) which phosphorylates the microtubule-associated protein tau implicated in Alzheimer's diseaseDDB0232433 CDS1420214 1488 + 0.30578
DDB_G0292550 DDB_G0292550 DDB0232433 CDS1642791 4194 - 0.223891
DDB_G0292624 DDB_G0292624 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232433 CDS1864394 942 + 0.298301
DDB_G0292734 DDB_G0292734 putative eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase putative protein serinethreonine kinase related to the GCN2 (general control non-derepressible) family of protein kinases that phosphorylate the alpha subunit of eIF2DDB0232433 CDS2002272 888 + 0.324324
DDB_G0292880 DDB_G0292880 dual specificity phosphatases remove phosphate groups from tyrosine and serinethreonine residues DDB0232433 CDS2200299 1833 + 0.286961
DDB_G0292920 DDB_G0292920 tensin family protein (related to the tumor suppressor PTEN) contains a a lipid phosphatase domain and a C2-like domainDDB0232433 CDS2274050 1362 - 0.259912
DDB_G0292922 DDB_G0292922 DDB0232433 CDS2276495 447 + 0.232662
DDB_G0293156_ps DDB_G0293156 putative pseudogene related to the TKL (tyrosine kinase-like) group of protein kinases contains a partial kinase domainDDB0232433 CDS2336989 324 + 0.327161
DDB_G0293184 DDB_G0293184 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesis contains RhoGAP domain found in the Rho family of small G proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS2540484 3561 + 0.281382
DDB_G0293276 DDB_G0293276 member of the AGC kinase group similar to kinase domains of AktPKB and MAST (microtubule-associated serinethreonine kinase) family membersDDB0232433 CDS2701490 1551 - 0.246937
DDB_G0293292 DDB_G0293292 putative protein serinethreonine kinase N-terminal kinase domain similar to vertebrate Nek kinases which are involved in regulation of mitosis C-terminal kinase domain weakly similar to ULK (Unc-51-like kinase)DDB0232433 CDS2647324 4116 + 0.234208
DDB_G0293386 DDB_G0293386 DDB0232433 CDS2792033 2073 - 0.232996
DDB_G0293746 DDB_G0293746 low level of similarity to mammalian PLK (polo-like kinase) unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS3265690 1188 + 0.223906
DDB_G0293958 DDB_G0293958 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232433 CDS3460612 4779 + 0.208203
Dd5P1 DDB_G0279927 DDB0232430 CDS2713196 2823 + 0.295785
Dd5P2 DDB_G0284187 DDB0232431 CDS1813905 5403 - 0.294281
Dd5P3 DDB_G0292392 DDB0232433 CDS1583730 4140 - 0.320773
Dd5P4 DDB_G0267462 inositol 5-phosphatase similar to the human protein OCRL which when defect causes Lowe syndrome involved in Dictyostelium growth development and phagocytosisDDB0232428 CDS1752059 2364 + 0.26692
acaA DDB_G0281545 twelve transmembrane domain adenylyl cyclase expressed during aggregation essential for streaming in early developmentDDB0232430 CDS4958602 4224 + 0.264205
acgA DDB_G0274569 DDB0232429 CDS3977236 2577 + 0.261156
acp1 DDB_G0267484 conserved low molecular weight phosphotyrosine protein phosphatase acts on tyrosine phosphorylated proteins low-MW aryl phosphates and natural and synthetic acyl phosphatesDDB0232428 CDS208100 540 + 0.303704
acrA DDB_G0267376 contains a cyclase domain 7 transmembrane helices a histidine kinase domain and two receiver domainsDDB0232428 CDS1738891 6372 + 0.274796
arkA DDB_G0289555 suppressor of spalten (spnA) mutant member of the TKL (tyrosine kinase-like) group and ARK (ankyrin repeat-containing kinase) familyDDB0232432 CDS2941850 4383 + 0.300707
atg1 DDB_G0292390 Dictyostelium homolog of yeast atg1 belongs to the ULK (Unc-51-like kinase) family of kinases required for macroautophagyDDB0232433 CDS1694801 2007 + 0.255605
atr1 DDB_G0291380 atypical PIKK family protein kinase similar to protein kinase ATR which modulates cell cycle progression and DNA repair in other organisms ATR phosphorylates Rad17 histone H2AX p53 and Nbs1DDB0232433 CDS214264 9474 - 0.259552
aurK DDB_G0279343 putative protein serinethreonine kinase Aur family associates with the mitotic spindle and plays a key role in mitosis the single Dictyostelium aurora kinase has properties of both aurora A and B kinases in other organismsDDB0232430 CDS1959552 1155 - 0.30303
bud32 DDB_G0279977 belongs to the Bud32 family highly similar in sequence and length to yeast BUD32 and mammalian PRPK (p53-related protein kinase)DDB0232430 CDS2805237 759 + 0.264822
cak1-1 DDB_G0273059 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS2688821 1281 + 0.320062
cak1-2 DDB_G0273737 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS3341355 1281 - 0.320062
calA DDB_G0279407 calcium-dependent regulatory protein involved in cytokinesis regulated by cytosolic Ca2 fluxes allowing differential binding to target CaM binding proteins (CaMBPs) binds several proteins among them nuclear NumA and Cdk5DDB0232430 CDS2244074 459 - 0.35512
calB DDB_G0269104 DDB0232428 CDS2981116 450 + 0.275556
canA DDB_G0276883 catalytic subunit of the Casup2supcalmodulin-dependent serinethreonine protein phosphataseDDB0232429 CDS7189408 1872 + 0.320513
capA-1 DDB_G0272560 there is a second copy of this gene DDB0232429 CDS2353564 1893 - 0.43159
capA-2 DDB_G0274023 there is a second copy of this gene DDB0232429 CDS3677221 1893 + 0.43159
capB DDB_G0277501 bCommunity annotation:b I used an mRNAseq read fitter which is particular friendly to splice variants (in preparation) to determine the developmental time course of the two curated splice variants of capB using the raw data of Dicty Express (courteously provided by G. Shaulsky and A Parikh). Both variants increase in mid to late development splvarB shows in addition a strong peak in veg cells. The curves for the two variants should add up to the curve for the common sequences and this is approximately true during development suggesting that variants A and B account for most of the developmental transcription. In the growth phase however A and B add up to less than the total suggesting that an additional variant exists which is expressed largely or entirely in the growth phase. Harry MacWilliams October 2010br DDB0232429 CDS8096571 1626 + 0.389914
casK DDB_G0276885 CK2 family protein kinase a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232429 CDS7370887 1014 + 0.310651
cbpL DDB_G0288785 putative Ca2-binding protein with 4 putative EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232432 CDS1964055 576 + 0.258681
cbpM DDB_G0286371 putative Ca2-binding protein with 4 putative EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232431 CDS4370399 552 - 0.277174
cdc7 DDB_G0292152 similar to S. cerevisiae cell division control protein 7 (CDC7) a serinethreonine kinase required for mitosis and meiosisDDB0232433 CDS1294776 3186 + 0.23666
cdk1 DDB_G0272813 similar to CDK1 and CDK2 cell cycle CAK (CDK-activating kinase) kinases predicted to activate SG2 cyclins cyclin A B and DDDB0232429 CDS2216835 891 + 0.331089
cdk10 DDB_G0268480 putative cell division cycle 2 (CDC2)-like protein kinase has similarity to PITSLRE proteins and other cyclin-dependent kinase 2 kinasesDDB0232428 CDS294048 1101 - 0.256131
cdk11 DDB_G0283279 very similar to human CDL1 (PITSLRE serinethreonine-protein kinase CDC2L1) which appears to play multiple roles in cell cycle progression cytokinesis and apoptosis predicted to interact with DDB0232431 CDS446640 1077 - 0.338904
cdk5 DDB_G0288677 CMGC group protein kinase highly similar to mammalian cdk5 localizes to the nucleus and shuttles to the cytoplasm during late mitosis binds calmodulin PsaADDB0232432 CDS1885785 879 + 0.302617
cdk7 DDB_G0285417 putative ortholog of CDK7 and CTK1 which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit predicted to be activated by DDB0232431 CDS3627427 1083 + 0.307479
cdk8 DDB_G0267442 controls RNA polymerase II activity by phosphorylating the carboxy terminal domain (CTD) of the largest subunit predicted to interact with DDB0232428 CDS1582311 1143 - 0.314961
cdk9-1 DDB_G0273207 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS2708039 2085 + 0.282974
cdk9-2 DDB_G0273721 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS3321422 2085 - 0.282974
cenA DDB_G0288427 similar to human Centrin 2 EF-hand protein localizes to the centromer from which it dissociates during mitosisDDB0232432 CDS1525659 456 + 0.245614
cenB DDB_G0279151 centrin required for nuclear and centrosome stability localizes to the nucleus in interphase but not during mitosis and is involved in the centrosome cycleDDB0232430 CDS1697579 453 - 0.258278
clkA DDB_G0281179 similar to cyclin-like kinases (CLK) putative dual specifity kinaseDDB0232430 CDS4167312 2799 + 0.215077
cnbA DDB_G0267446 regulatory subunit of the Casup2supcalmodulin-dependent serinethreonine protein phosphatase contains an EF-hand calcium binding motifDDB0232428 CDS816934 1041 - 0.26513
cnbB DDB_G0285999 contains 3 EF-hands similar to calcineurin B (cnbA) the regulatory subunit of the Ca2calmodulin-dependent serinethreonine protein phosphataseDDB0232431 CDS3918232 552 + 0.269928
cnrN DDB_G0287969 identified as a suppressor of smlA null mutant cnr14 phosphatase involved in late-aggregation events including the regulation of fruiting body size as well as cAMP and PI3K signalingDDB0232432 CDS912043 1920 + 0.25625
csnk2b DDB_G0284601 ortholog of the CK2 beta chain the regulatory subunit of the ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS2209637 807 - 0.281289
dgcA DDB_G0283453 Dictyostelium diguanylate cyclase synthesizes cyclic-di-GMP from 2 molecules of GTP expressed at the slug and fruiting body tip responsible for stalk differentiationDDB0232431 CDS715640 1566 - 0.210089
dhkA DDB_G0280961 two-component histidine kinase which first autophosphorylates a histidine and then transfers the phosphate onto an aspartate before the signal is transduced also known as histidyl-aspartyl phosphorelayDDB0232430 CDS4220018 6453 + 0.284054
dhkB DDB_G0277845 DDB0232430 CDS525688 5910 - 0.298646
dhkC DDB_G0274191 DDB0232429 CDS4805683 3678 + 0.259652
dhkD DDB_G0282289 DDB0232430 CDS5632424 4641 - 0.280112
dhkE DDB_G0269204 DDB0232428 CDS2700289 5100 - 0.217451
dhkF DDB_G0276143 DDB0232429 CDS6523775 3330 - 0.25976
dhkH DDB_G0279913 DDB0232430 CDS2725463 4137 + 0.263718
dhkI-1 DDB_G0273475 there is a second copy of this gene DDB0232429 CDS2926565 5211 - 0.257148
dhkI-2 DDB_G0295835 there is a second copy of this gene DDB0232429 CDS3099906 5199 + 0.25755
dhkJ DDB_G0277883 DDB0232430 CDS102264 6189 + 0.320407
dhkK DDB_G0277887 DDB0232430 CDS942210 3642 - 0.280066
dhkL DDB_G0282927 DDB0232431 CDS127874 5130 + 0.280507
dhkM DDB_G0282377 DDB0232430 CDS5726442 7167 + 0.242919
dlrA DDB_G0290485 DDB0232432 CDS4410371 2457 - 0.299959
dnapkcs DDB_G0281167 atypical PIKK family protein kinase similar to human DNA-PKcs required for the repair of DNA double-strand breaks belongs to the PIKK family of protein kinasesDDB0232430 CDS4132807 12900 + 0.265504
dokA DDB_G0274101 DDB0232429 CDS4563185 5016 + 0.297648
drkA DDB_G0289791 DDB0232432 CDS3144874 1929 + 0.276827
drkB DDB_G0289709 DDB0232432 CDS3147575 2073 + 0.2904
drkC DDB_G0281899 tyrosine kinase member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily involved in phagocytosis and late phagosomelysosome fusion enriched in S cells in slugsDDB0232430 CDS5088116 2250 - 0.305778
drkD DDB_G0281557 member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily contains a leucine-rich repeat (LRR) regionDDB0232430 CDS4777368 3867 + 0.334885
dst1 DDB_G0274593 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS3862026 2214 + 0.289521
dst2 DDB_G0267730 putative protein serinethreonine kinase the kinase domain is similar to mitogen-activated protein kinases and other STE20-like kinases stress-responsive kinaseDDB0232428 CDS719427 3429 + 0.33275
dst3 DDB_G0291267 putative protein serinethreonine kinase the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS35064 1689 - 0.351095
dst4 DDB_G0288071 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232432 CDS1048762 1458 - 0.325789
dupA DDB_G0277071 contains both a kinase domain and a phosphatase domain similar to MAP kinase phosphatase in plants and dual-specificty phosphatase 19 in mammals regulates the MAP Kinase response to Legionella pneumophila infection in DictyosteliumDDB0232429 CDS7439874 7365 - 0.295995
dyrk1 DDB_G0277485 DDB0232429 CDS7981156 2511 + 0.249303
dyrk2 DDB_G0293750 DDB0232433 CDS3272270 2748 + 0.306405
erkA DDB_G0286353 DDB0232431 CDS4355028 1590 + 0.303774
erkB DDB_G0283903 DDB0232431 CDS1385123 1110 - 0.323423
fhkA DDB_G0293656 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsbrbr bCommunity annotation:b The five fhk-X genes differ substantially in their response to the disruption of the retinoblastoma-like gene rblA. FhkA is substantially and highly signficantly upregulated in the ko strain while none of the other genes show major changes. Consistent with its regulation the fhkA promoter contains a putative E2F-type binding site (TTTGCGCCTTTT). Virtually all genes associated with replication fork progression are upregulated in the rblA disruptant these include cdc45 all mcm genes all gins genes all rfc genes four polA subunits three polD subunits two putatitive polE subunits PCNA the single-strand binding protein rfa1 the flap endonuclease repG as well as DNA ligase-1 and topoisomerase-2. All these genes show overexpression factors ranging from 4 to 15DDB0232433 CDS3219230 1782 - 0.231201
fhkB DDB_G0280599 CAMK group RAD53 family protein kinase the protein kinase domain is similar to those of mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3548058 3429 - 0.26305
fhkC DDB_G0281567 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 and yeast RAD53 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS4871788 1788 + 0.291387
fhkD DDB_G0285963 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232431 CDS3876403 2250 - 0.286667
fhkE DDB_G0280321 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3257414 2139 + 0.257597
fnkA DDB_G0275561 protein kinase STE groupDDB0232429 CDS5624593 2382 + 0.283375
fnkB DDB_G0267934 DDB0232428 CDS1147906 1593 - 0.251726
fnkE DDB_G0275879 protein kinase domain similar to those of the mitogen-activated protein kinases which belong to the STE20 family contains two protein kinase domains one of which is predicted to be inactive contains several FNIP repeatsDDB0232429 CDS5838829 3966 + 0.2824
fnkF_ps DDB_G0275183 putative pseudogene STEFNIP protein kinase familyDDB0232429 CDS5290527 2628 - 0.270548
fnkG_ps-1 DDB_G0273353 putative pseudogene STEFNIP protein kinase family DDB0232429 CDS2671646 1275 + 0.247059
fnkG_ps-2 DDB_G0273751 putative pseudogene STEFNIP protein kinase family there is a second copy of this gene DDB0232429 CDS3358648 1275 - 0.247059
fray1 DDB_G0278863 kinase domain similar to OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232430 CDS1298188 1725 - 0.338551
fray2 DDB_G0276577 the kinase domain is similar to mammalian stress-induced STK and OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232429 CDS6994954 3087 - 0.339164
fttB DDB_G0269138 localizes to the cell cortex binds myosin II and regulates microtubule length the cortical cytoskeleton and cytokinesis functions in the same pathway as racE to regulate these processesDDB0232428 CDS3949672 759 + 0.361001
gafA DDB_G0271136 contains a GAF domain (cGMP-specific and stimulated PDEs Anabaena adenylate cyclases and E. coli FhlA)DDB0232429 CDS83383 477 + 0.291405
gapA DDB_G0269140 DDB0232428 CDS3059126 2583 - 0.297716
gbpC DDB_G0291079 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases belongs to the LRRK family of protein kinases contains LRR Roc COR RasGEF protein kinase DEP cyclic nucleotide-binding and GRAM domains involved in cGMP-mediated chemotaxis catalyzes GDP to GTP exchange on its own Roc domain translocates from cytoplasm to cell cortex after cAMP stimulation GRAM domain binds directly to plasma membraneDDB0232432 CDS4959991 7896 + 0.333967
gbpD DDB_G0282373 guanine nucleotide exchange factor for Rap1 involved in cell-substrate adhesionDDB0232430 CDS6118341 3939 + 0.289667
gcA DDB_G0275009 DDB0232429 CDS5230828 4452 + 0.277403
gdt1 DDB_G0278723 represses discoidin expression member of the TKL (tyrosine kinase-like) group and the GDT family unlikely to function as a kinase as it does not contain a catalytic aspartate putative transmembrane proteinDDB0232430 CDS1161694 4986 - 0.239872
gdt2 DDB_G0270666 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3713353 4914 - 0.252747
gdt3_ps DDB_G0285891 putative pseudogene member of the TKL (tyrosine kinase-like) group and the GDT family belongs to the MLK protein kinase familyDDB0232431 CDS3781232 5880 - 0.234014
gdt4 DDB_G0270550 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS2926042 4863 + 0.265474
gdt6 DDB_G0270544 member of the TKL (tyrosine kinase-like) group and the GDT family unlikely to function as a kinase as it does not contain a catalytic aspartate putative transmembrane proteinDDB0232428 CDS2913781 4359 + 0.274145
gdt8 DDB_G0270668 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3723386 3981 - 0.283848
gdt9 DDB_G0278879 DDB0232430 CDS1327589 4734 + 0.274398
gefX DDB_G0269298 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains RasGEF nucleotide exchange factor domainDDB0232428 CDS2476607 2883 - 0.312522
glkA DDB_G0270218 putative protein serinethreonine kinase GSK family member of the CMGC kinase group similar to Drosophila shaggy and other glycogen synthase kinasesDDB0232428 CDS4429657 1422 + 0.23699
gskA DDB_G0272110 protein serinethreonine kinase GSK family member of the CMGC kinase group essential for cell specification activated by CAR3 through ZAK1 (prespore-) and inhibited by CAR4 (prestalk-) signallingDDB0232429 CDS1334436 1404 - 0.324786
gxcD DDB_G0267854 DDB0232428 CDS970209 3192 + 0.294486
gxcFF DDB_G0284739 DDB0232431 CDS2399480 2226 - 0.260108
gxcG DDB_G0282073 DDB0232430 CDS5205115 1920 + 0.295312
gxcII DDB_G0278703 DDB0232430 CDS1052856 2625 + 0.258286
gxcKK DDB_G0293340 DDB0232433 CDS2757100 2004 - 0.25
gxcM DDB_G0272372 DDB0232429 CDS1367731 3438 - 0.299593
gxcV DDB_G0282271 DDB0232430 CDS5595367 1446 + 0.284924
iksA DDB_G0283109 similar to fungal kinases contains an IQ calmodulin-binding regionDDB0232431 CDS257953 2940 + 0.272449
iqgC DDB_G0288977 contains a rasGAP domain similar to mammalian IQGAP proteins but lacking the calponin domain and the IQ-calmodulin binding regionDDB0232432 CDS2198403 2454 + 0.347596
ireA DDB_G0267650 ortholog of the yeast IRE1 serinethreonine kinaseendoribonuclease a transmembrane protein involved in the unfolded protein response contains a ribonuclease 2-5A domain and 3 pyrrolo-quinoline quinone (PQQ) domainsDDB0232428 CDS495110 2955 + 0.237902
irlA DDB_G0272987 DDB0232429 CDS2020830 4296 + 0.26513
irlB-1 DDB_G0273333 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS2539802 4347 - 0.216931
irlB-2 DDB_G0273857 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS3487559 4347 + 0.216931
irlC DDB_G0270894 the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy contains a SWIM Zn-finger domainDDB0232428 CDS3195968 4335 + 0.231834
irlD DDB_G0269632 DDB0232428 CDS3190841 4518 + 0.261399
irlE DDB_G0288803 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophyDDB0232432 CDS1985593 4053 + 0.237602
kinX DDB_G0283391 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232431 CDS749416 3285 + 0.312329
kinY DDB_G0289661 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232432 CDS3255902 1740 + 0.251149
krsA DDB_G0284181 putative protein serinethreonine kinase belongs to the protein kinase MST subfamily similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase involved in signal transduction and hyperosmotic responseDDB0232431 CDS1697612 1386 - 0.313853
krsB DDB_G0267978 putative protein serinethreonine kinase N-terminus similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase C-terminal half belongs to the peptidase C2 family contains 4 calpain III domains and has similarity to calpain-like cysteine proteaseDDB0232428 CDS1220851 3318 + 0.331826
kxcA DDB_G0289859 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains calmodulin-binding RhoGEF and pleckstrin homology (PH) domainsDDB0232432 CDS3309104 3936 + 0.256352
kxcB DDB_G0293124 kinase domain similar to those of stress-induced STK kinases contains a DH (Dbl homology) domain followed by a PH (pleckstrin homology) domain found in proteins shown to encode a GEF activity specific for Rho family membersDDB0232433 CDS2557594 3378 - 0.301066
lkb1 DDB_G0279629 CAMK group CAMKL family kinase protein kinase involved in regulating both development and the stress responseDDB0232430 CDS2335074 1761 - 0.294719
mekA DDB_G0269152 STE SerThr protein kinase family mitogen-activated protein kinase kinase involved in chemotaxis and early development phosphorylates the MAP kinase Erk1 (erkA) is sumoyalated by sumo and ubiquinated by mip1DDB0232428 CDS4015409 1983 - 0.252143
mkcA DDB_G0285427 similar to MAP cascade kinases belonging to the PAK sub-family of the STE20 serinethreonine kinases partial suppressor of tagB mutationDDB0232431 CDS3440715 2583 - 0.275648
mkcB DDB_G0290723 similar to Dictyostelium mkcA and other mitogen-activated protein kinases (Ste20PAK family) REMI mutant forms aberrant fruiting bodies see DDB0232432 CDS4499748 2145 + 0.332867
mkcC DDB_G0287853 kinase domain very similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232432 CDS826726 2676 + 0.342302
mkcD DDB_G0277413 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232429 CDS7960057 1959 + 0.291986
mkcE DDB_G0281649 kinase domain similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232430 CDS4757942 2148 + 0.271881
mkcF DDB_G0270102 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family) contains one SH3 (src Homology-3) domainDDB0232428 CDS4222376 2034 - 0.319076
mkkA DDB_G0283265 developmentally regulated MEKKDDB0232431 CDS530684 3804 + 0.287066
mkpB-1 DDB_G0273199 similar to the cofilin phosphatase slingshot and to other dual-specificity phosphatasesbr there is a second copy of this gene DDB0232429 CDS2698234 1431 + 0.292802
mkpB-2 DDB_G0273729 similar to the cofilin phosphatase slingshot and to other dual-specificity phosphatasesbr there is a second copy of this gene DDB0232429 CDS3332122 1431 - 0.292802
mlcC DDB_G0289563 light chain that binds to the neck region of myoC contains two calcium-binding EF-hand motifs but does not bind calciumDDB0232432 CDS2954406 225 - 0.311111
mlcD DDB_G0277917 DDB0232430 CDS607477 444 + 0.304054
mlcE DDB_G0277859 component of actin-based molecular motor myosin II (conventional myosin) componentDDB0232430 CDS76885 453 + 0.364238
mlcR DDB_G0276077 component of actin-based molecular motor myosin II (conventional myosin) componentDDB0232429 CDS6426413 486 + 0.31893
mlkA DDB_G0279925 CAMK1 family protein kinase phosphorylates the myosin II regulatory light chain at S13 is not regulated by Ca2calmodulinDDB0232430 CDS2752719 888 - 0.317568
mpl3 DDB_G0278445 DDB0232430 CDS890638 2571 - 0.257098
mps1 DDB_G0280995 putative protein threoninetyrosine kinase similar to yeast and zebrafish mps1 (monopolar spindle) kinase a threoninetyrosine kinaseDDB0232430 CDS3923506 2952 + 0.289295
mrkA DDB_G0292304 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains 1 kinase-associated (KA1) domain and 1 UBA domainDDB0232433 CDS1433748 3183 - 0.286836
mrkB DDB_G0285643 CAMKL family protein kinase similar to SNF1 kinases MARK kinases and AMPK kinasesDDB0232431 CDS3523048 2148 - 0.284916
mrkC DDB_G0281895 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains C-terminal kinase associated domain 1DDB0232430 CDS5083659 2322 + 0.295866
ncsA DDB_G0275931 contains four EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232429 CDS6088223 561 - 0.279857
ndrA DDB_G0278457 member of the AGC kinases NDR group localizes to centrosomes and to the spindle during prometaphase and is involved in phagocytosisDDB0232430 CDS907158 1593 + 0.344633
ndrB DDB_G0288753 member of the AGC kinase group similar to NDR protein kinases including yeast morphogenesis proteins ORB6 and CBK1DDB0232432 CDS1909293 1629 - 0.324125
ndrC DDB_G0284839 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinases DDB0232431 CDS2493584 3939 + 0.307692
ndrD DDB_G0289543 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinasesDDB0232432 CDS2920470 6339 + 0.255088
nek2 DDB_G0270814 protein serinethreonine kinase homologous to human Nek2 kinase involved in formation of microtubule-organizing centers (MTOCs)DDB0232428 CDS4847143 1257 - 0.258552
nek3 DDB_G0275241 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosis not a human Nek3 homologDDB0232429 CDS4983790 3372 - 0.269276
nek4 DDB_G0289277 similar to vertebrate Nek kinases which are involved in regulation of mitosis most similar to Nek4DDB0232432 CDS2561379 1494 - 0.222222
pXi DDB_G0289119 CAMK group protein serinethreonine kinaseDDB0232432 CDS2420542 2076 - 0.25289
pakA DDB_G0269166 STE20PAKA protein kinase involved in the regulation of the cytoskeleton during chemotaxis and required for cytokinesis contains PAK-boxP21-Rho-binding (CRIB) domain found in the WASP C-terminalDDB0232428 CDS3436536 3594 + 0.33222
pakB DDB_G0276459 protein serinethreonine kinase that phosphorylates myoD (myosin ID) and myoK (myosin IK) heavy chains similar to p21-activated kinase belongs to the STE20 family PAKA subfamily of protein kinasesDDB0232429 CDS6847900 2559 - 0.339195
pakC DDB_G0267450 STE20PAK protein kinase required for normal chemotaxis contains PAK-boxP21-Rho-binding (CRIB) domain and pleckstrin homology (PH) domainDDB0232428 CDS229145 1434 - 0.33682
pakD DDB_G0269696 similar to Dictyostelium pakA and other mitogen-activated protein kinases (Ste20PAK family) putative p21-activated kinase contains a calponin-like actin-binding domain a p21-Rho-binding domain and a PKC conserved region 1 (C1) regulates the actin cytoskeleton response during chemotaxis to cAMPDDB0232428 CDS3345400 5037 + 0.25273
pakE DDB_G0293932 putative protein serinethreonine kinase belongs to the PAKL subfamily of protein kinases the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS3512665 2781 + 0.270766
pakF DDB_G0274409 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS4648326 3531 - 0.282073
pakG DDB_G0282891 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232430 CDS6346144 3540 + 0.284181
pakH-1 DDB_G0273121 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamily stress-responsive kinase there is a second copy of this gene DDB0232429 CDS2532742 1542 + 0.282101
pakH-2 DDB_G0273865 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamilystress-responsive kinase there is a second copy of this gene DDB0232429 CDS3497296 1542 - 0.282101
pats1 DDB_G0269250 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 and protein kinase domainsDDB0232428 CDS2657392 9555 - 0.289901
pde7 DDB_G0289145 DDB0232432 CDS2414259 1278 - 0.27856
pdeD DDB_G0274383 DDB0232429 CDS4904282 2604 + 0.323733
pdeE DDB_G0276027 DDB0232429 CDS6313321 3291 - 0.307809
pdkA DDB_G0281471 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232430 CDS4550105 2061 - 0.273654
pdkB DDB_G0284489 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232431 CDS2038480 2727 + 0.260726
pdsA DDB_G0285995 DDB0232431 CDS3929775 1359 - 0.339956
phg2 DDB_G0283699 serinethreonine kinase regulating cell substrate adhesion phagocytosis motility and actin organization member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS995559 4164 - 0.304275
pho2a DDB_G0290263 catalytic subunit of protein phosphatase 2A composed of a catalytic subunit (pho2A) a regulatory subunit (phr2AB) and a scaffold subunit (pppA) an additional regulatory B56 (psrA) subunit has been identified DDB0232432 CDS3933600 921 - 0.336591
phr2aB DDB_G0283905 regulatory subunit of protein phosphatase 2A composed of a catalytic subunit (pho2A) a regulatory subunit (phr2AB) and a scaffold subunit (pppA) an additional regulatory B56 (psrA) subunit has been identifiedDDB0232431 CDS1423354 1452 - 0.331267
pik6 DDB_G0275635 phosphatidylinositol phosphate kinase that binds diacylglycerol essential for normal early developmental gene expressionDDB0232429 CDS6045706 4770 + 0.275681
pikA DDB_G0278727 DDB0232430 CDS1154369 4716 + 0.261026
pikB DDB_G0283081 DDB0232431 CDS247398 5574 - 0.311805
pikC DDB_G0275011 DDB0232429 CDS5211773 5094 + 0.270907
pikD DDB_G0288485 subunit of PI4K responsible for the phosphorylation of phosphatidylinositol (PI) to PI4P (ATP 1-phosphatidyl-1D-myo-inositol ADP 1-phosphatidyl-1D-myo-inositol 4-phosphate) the first committed step in the generation of phosphatidylinositol 45-bisphosphate (PIP2) a precursor of the second messenger inositol 145-trisphosphate (InsP3)DDB0232432 CDS1616073 3543 + 0.269828
pikE DDB_G0289601 ortholog of yeast VPS34 a phosphatidylinositol 3-kinaseDDB0232432 CDS3005109 2451 - 0.299878
pikF DDB_G0268548 putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring has the capacity to bind and be activated by the GTP-bound small GTPase rasDDB0232428 CDS1099622 4149 + 0.291396
pikG DDB_G0282625 putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring has the capacity to bind and be activated by the GTP-bound small GTPase rasDDB0232430 CDS6013022 5016 - 0.234649
pikH DDB_G0291093 putative PI3k putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring unlike other PI3Ks does not contain a ras binding domain but a PH domain and does not localize to the cell cortex upon chemotactic stimulationDDB0232432 CDS4980832 5463 - 0.242541
pikI DDB_G0267588 DDB0232428 CDS376992 2160 - 0.32963
pip5k3 DDB_G0279149 ortholog of mammlian PIP5K3 and S. cerevisiae FAB1 contains in addition to the C-terminal PIP kinase domain an N-terminal FYVE-type zinc finger domain and a central chaperonin Cpn60TCP-1 domainDDB0232430 CDS1689106 7971 + 0.275624
pkaC DDB_G0283907 AGC group PKA family protein kinase protein serinethreonine kinase regulates spore cell differentiationDDB0232431 CDS1394958 1947 + 0.333847
pkaD DDB_G0277145 DDB0232429 CDS7643321 2145 - 0.253613
pkaR DDB_G0279413 DDB0232430 CDS2222668 984 - 0.319106
pkbA DDB_G0268620 AGC group AKT family protein serinethreonine kinase similar to other metazoan AktPKB including an N-terminal PH domain homologous kinase and C-terminal regulatory domains and phosphorylation sites required for AktPKB activationDDB0232428 CDS1977388 1335 + 0.357303
pkgA DDB_G0276157 serinethreonine protein kinase of the MAST (Microtubule Associated SerineThreonine kinase) familyDDB0232429 CDS6275918 4104 - 0.287037
pkgB DDB_G0290157 AGC group protein serinethreonine kinase cAMP-activated protein kinase involved in morphogenesis during multicellular developmentDDB0232432 CDS3717777 1440 - 0.324306
pkgC DDB_G0286125 serinethreonine protein kinase of the AGC group similar to mammalian ribosomal protein S6 kinaseDDB0232431 CDS4067973 2733 - 0.312843
pkgD DDB_G0284029 AGC group protein serinethreonine kinase similar to cAMP-activated protein kinase catalytic subunitsDDB0232431 CDS1459718 2979 - 0.28231
pkgE_ps DDB_G0280981 putative pseudogene similar to AGC protein kinases of the AKT familyDDB0232430 CDS3912677 1095 + 0.343379
plip DDB_G0272835 phosphoinositide phosphatase with low specific activity compared to other known phosphoinositide phosphatases can dephosphorylate several phosphoinositide substrates with a preference for PI(5)P constitutively expressed putative ortholog of H. sapiens EPM2A involved in myoclonic epilepsy of LaforaDDB0232429 CDS1986849 699 + 0.273248
plk DDB_G0274503 putative protein serinethreonine kinase similar to yeast CDC5 Drosophila polo and mammalian PLK which play a role in mitosis and localize to the centrosomesDDB0232429 CDS4379150 2937 - 0.280899
ppp2r4 DDB_G0270036 ortholog of the human PPP2R4 (PTPA) that stimulates the phosphotyrosyl phosphatase activity of PP2A in the presence of ATP and Mg(2) in vitroDDB0232428 CDS4068160 978 + 0.287321
ppp4c DDB_G0272116 protein serinethreonine phosphatase required for chemotaxis and development suppresses the DDB0232429 CDS1426809 918 - 0.331155
ppp5C DDB_G0283157 DDB0232431 CDS299093 1545 - 0.307443
ppp6c DDB_G0272118 DDB0232429 CDS1655025 918 + 0.332244
pppB DDB_G0275619 DDB0232429 CDS6106886 966 - 0.356108
prafA DDB_G0278887 belongs to a conserved family of multi-pass transmembrane proteins contains 3 predicted transmembrane domainsDDB0232430 CDS1342274 708 - 0.303672
prpf4B DDB_G0279703 protein serinethreonine kinase DYRK family member of the CMGC kinase group similar to mammalian pre-mRNA processing factor PRP4 kinase and DYRK kinasesDDB0232430 CDS2466144 2436 + 0.296388
pten DDB_G0286557 DDB0232431 CDS4733890 1602 - 0.315855
ptpA1-1 DDB_G0273097 there is a second copy of this gene DDB0232429 CDS2586710 1569 - 0.289994
ptpA1-2 DDB_G0273817 there is a second copy of this gene DDB0232429 CDS3443306 1569 + 0.289994
ptpB DDB_G0277865 DDB0232430 CDS381607 1134 + 0.277778
ptpC DDB_G0282145 DDB0232430 CDS5439955 2973 + 0.28927
pyk3 DDB_G0289001 member of the TKL (tyrosine kinase-like) group and the DPYK (Dictyostelium protein tyrosine kinase) family of protein kinases contains two kinase domains one of which is predicted to be inactive the C-terminal kinase domain has tyrosine kinase activitybr bCommunity annotation:b Pyk3 appears to be involved in differentiation pathway choice as the KO shows reduced pstO differentiation and compensatory expansion of the prespore region. Pyk3 has been proposed to act in a pathway involving ptpC and statC effectively potentiating the action of DIF-1. One of the factors that influences pathway choice is cell cycle position classic experiments show that cold-synchronized cells which enter development shortly after warming prefer the stalk pathway. This is due to an increased DIF sensitivity. New results (Strasser Tsang and MacWilliams in preparation) now show that the pyk3 transcript is upregulated roughly fivefold after cold synchronization at a time when cells show strong stalk preference (pDDB0232432 CDS2269413 4017 - 0.283047
qkgA-1 DDB_G0273259 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS2831844 4662 + 0.27885
qkgA-2 DDB_G0273635 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS3195191 4662 - 0.27885
rad18 DDB_G0278935 RAD18 ortholog a E3 ubiquitin ligase required for postreplicational DNA repair forms a heterodimer with RAD6DDB0232430 CDS1193824 2007 + 0.223717
rckA DDB_G0278737 member of the TKL (tyrosine kinase-like) group contains an RGS (Regulator of G protein Signaling) domainDDB0232430 CDS1218919 3378 + 0.261693
rdeA DDB_G0282923 DDB0232431 CDS67134 765 + 0.299346
regA DDB_G0284331 contains a 3'5'-cyclic nucleotide phosphodiesterase and an RR domain found in two-component signal transduction systemsDDB0232431 CDS1956975 2382 - 0.290932
rgaA DDB_G0287585 DDB0232432 CDS498740 2469 + 0.357635
rio1 DDB_G0280431 atypical RIO family protein kinase yeast serinethreonine kinase RIO1 plays a role in cell cycle progressionDDB0232430 CDS3344181 1725 - 0.302609
rio2 DDB_G0282099 atypical RIO family protein kinase contains winged helix DNA-binding domain in addition to RIO domain yeast serinethreonine kinase RIO1 plays a role in cell cycle progressionDDB0232430 CDS5366397 1569 + 0.291906
roco11 DDB_G0268636 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232428 CDS2199646 4464 + 0.267473
roco4 DDB_G0288251 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232432 CDS1284583 5181 + 0.332947
roco5 DDB_G0294533 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains RhoGEF PH LRR Roc COR and protein kinase domainsDDB0232432 CDS1439427 8403 - 0.309413
roco6 DDB_G0279417 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 PH and protein kinase domainsDDB0232430 CDS2094570 6444 + 0.293451
roco7 DDB_G0267472 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains Roc COR WD40 and protein kinase domains related to LRR-containing kinases but does not contain an LRR domainDDB0232428 CDS628403 7848 - 0.293833
roco8 DDB_G0286127 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains DEP LRR Roc COR and protein kinase domainsDDB0232431 CDS4112361 5604 - 0.267131
roco9 DDB_G0288183 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases contains RhoGAP LRR Roc Cor and protein kinase domainsDDB0232432 CDS1219231 10098 - 0.264706
rpkA DDB_G0283615 DDB0232431 CDS1020192 2487 - 0.291516
sac1 DDB_G0271630 conserved protein from yeast to human in yeast involved in protein trafficking and secretionDDB0232429 CDS575486 1746 + 0.344788
samkA DDB_G0269876 DDB0232428 CDS3775693 1923 + 0.228289
samkB DDB_G0284859 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232431 CDS2549067 1782 + 0.251403
samkB_ps1 DDB_G0270988 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232428 CDS3791042 1593 - 0.264909
samkC DDB_G0270678 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232428 CDS3778203 2628 + 0.251903
samkD DDB_G0270680 similar to SNF1-like kinases unlikely to function as a kinase as it lacks the catalytic aspartateDDB0232428 CDS3781297 1662 + 0.197954
samkE_ps1 DDB_G0283165 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232431 CDS352482 1272 - 0.26022
sepA DDB_G0276465 plays a role in the regulation of cleavage furrow formation similar to S. pombe cdc7DDB0232429 CDS6942806 3504 + 0.32363
sgcA DDB_G0276269 DDB0232429 CDS6582943 8532 - 0.290319
shkA DDB_G0283267 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domain negative regulator of phosphoinositol signalingDDB0232431 CDS438511 1584 + 0.318182
shkB DDB_G0288617 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS1745652 1962 - 0.331295
shkC DDB_G0278409 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS836437 1521 - 0.332676
shkD DDB_G0281343 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS4376038 2235 + 0.314541
shkE DDB_G0290451 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS4058161 2133 + 0.284107
sky1 DDB_G0275627 similar to SRPKs (Serinearginine-Rich Protein specific Kinases) serinethreonine kinases that specifically phosphoryate arginine-serine rich domains found in the SR family of splicing factorsDDB0232429 CDS5951942 1971 - 0.318113
smg1 DDB_G0275845 atypical PIKK family protein kinase similar to the PI-3-kinase-related kinase SMG1 which functions in nonsense-mediated mRNA decay belongs to the PIKK family of protein kinasesDDB0232429 CDS5665840 7035 + 0.267235
snfA DDB_G0277905 CAMKL family protein kinase catalytic subunit of the AMP-activated protein kinase (AMPK) complex similar to SNF1 kinases and AMPK experiments in Dictyostelium show that AMPK signaling plays an important role in mitochondrial disease.DDB0232430 CDS589784 2184 + 0.250458
spkA-1 DDB_G0273445 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS2969377 1917 - 0.310381
spkA-2 DDB_G0273531 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS3060166 1917 + 0.310381
splA DDB_G0283385 dual-specificity protein kinase involved in spore coat formation and morphogenesis member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) familyDDB0232431 CDS623097 7233 + 0.323655
splB DDB_G0285321 member of the TKL (tyrosine kinase-like) group activates the transcriptional regulator STATcDDB0232431 CDS3131349 3468 + 0.27797
spnA DDB_G0276155 gene essential for Dictyostelium development with an N-terminal Galpha regulatory domain and a C-terminal PP2C serinethreonine phosphatase domainDDB0232429 CDS6284187 2928 - 0.311134
spoT DDB_G0287233 DDB0232432 CDS32102 627 - 0.271132
svkA DDB_G0286359 very similar to mammalian ST25 kinase (SOK1) and other STE20-like kinases stress-responsive kinase phosphorylates severin essential for cell separation during cytokinesisDDB0232431 CDS4476218 1437 + 0.343076
tor DDB_G0281569 atypical PIKK family FRAP subfamily protein kinase ortholog of tor a protein kinase that plays a central role in response to nutrients stress and intracellular energy state called mTOR in mammals in dTOR in Drosophila DDB0232430 CDS4934791 7143 - 0.347893
tsuA DDB_G0267962 putative protein serinethreonine kinase similar to mammalian STK36 and fly fused kinase (fu) a ST kinase involved in the hedgehog signal transduction pathway belongs to the ULK (Unc-51-like kinase) family of kinasesDDB0232428 CDS1191800 6744 + 0.248517
vps15 DDB_G0282627 putative protein serinethreonine kinase similar to human PIK3R4 and yeast VPS15 which regulate the phosphatidylinositol 3 kinase VPS34 (hVps34) yeast VPS15VPS34 complex known to be involved in vacuolar protein sortingDDB0232430 CDS6019111 5901 + 0.306219
xpr1 DDB_G0285957 ortholog of XPR1 which in mammals confers susceptibility to infection with murine leukaemia viruses also similar to yeast SYG1 a G-protein associated signal transduction protein and plant PHO1 that may be involved in phosphate transportDDB0232431 CDS3794131 2760 - 0.294203
yakA DDB_G0283605 belongs to the CMGC group of protein kinases putative protein serinethreonine kinaseDDB0232431 CDS868454 4377 + 0.303404
zak2 DDB_G0276187 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL group highly similar to zakA and has overlapping function with zakA shown to be a tyrosine kinase and regulator of GSK3 also regulates pattern formation during development via dstC (STATc) signalingDDB0232429 CDS6396810 1908 - 0.253145
zakA DDB_G0276025 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL groupDDB0232429 CDS6393550 2346 - 0.239983