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2024-05-19 18:08:53

Gene list

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COG category: Replication, recombination and repair
Organism: Dictyostelium discoideum AX4, AX4

Number of genes found: 564

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0267178_RTE DDB_G0267178 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS1890 1398 + 0.395565
DDB_G0267182_RTE DDB_G0267182 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS5505 2265 + 0.39426
DDB_G0267188_RTE DDB_G0267188 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS10033 1971 + 0.392187
DDB_G0267210_RTE DDB_G0267210 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS29137 2907 + 0.396285
DDB_G0267236_RTE DDB_G0267236 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS46105 2265 - 0.394702
DDB_G0267244_RTE DDB_G0267244 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS57242 2172 - 0.39733
DDB_G0267248_RTE DDB_G0267248 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS61559 663 - 0.377074
DDB_G0267258_RTE DDB_G0267258 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS74542 2265 - 0.392053
DDB_G0267294_RTE DDB_G0267294 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS105880 2265 + 0.393377
DDB_G0267326_RTE DDB_G0267326 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS129934 2457 + 0.400488
DDB_G0267342_RTE DDB_G0267342 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232428 CDS145444 2778 + 0.397768
DDB_G0267514 DDB_G0267514 DDB0232428 CDS259066 2751 - 0.28426
DDB_G0267556 DDB_G0267556 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232428 CDS327145 3480 - 0.281034
DDB_G0267566 DDB_G0267566 putative protein serinethreonine kinase contains an ankyrin repeat domain similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS343868 2535 - 0.244181
DDB_G0267638 DDB_G0267638 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232428 CDS464992 9210 + 0.282953
DDB_G0267686 DDB_G0267686 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains an RGS (Regulator of G protein Signaling) domainDDB0232428 CDS564277 6693 - 0.276109
DDB_G0268052 DDB_G0268052 DDB0232428 CDS1359896 3105 - 0.298873
DDB_G0268078 DDB_G0268078 DDB0232428 CDS1417972 1524 + 0.281496
DDB_G0268212 DDB_G0268212 contains an N-terminal DEADDEAH box helicase a central helicase associated domain (HA2) and a C-terminal domain of unknown function DUF1605 common to DEAD box helicasesDDB0232428 CDS1695570 1368 - 0.234649
DDB_G0268218 DDB_G0268218 DDB0232428 CDS1708888 2547 + 0.217903
DDB_G0268236 DDB_G0268236 DDB0232428 CDS1733949 1590 - 0.367296
DDB_G0268430 DDB_G0268430 DDB0232428 CDS1423638 2802 + 0.246253
DDB_G0268486_ps DDB_G0268486 putative pseudogene contains protein kinase domainDDB0232428 CDS498516 2820 - 0.22305
DDB_G0268492 DDB_G0268492 DDB0232428 CDS520101 2007 - 0.247135
DDB_G0268656 DDB_G0268656 highly similar to human ULK (Unc51-like kinase) does not contain the full consensus sequence required for kinase functionDDB0232428 CDS1863917 954 - 0.220126
DDB_G0268660 DDB_G0268660 highly similar to neighboring gene DDB0232428 CDS1873355 6945 - 0.257307
DDB_G0268662 DDB_G0268662 highly similar to neighboring gene DDB0232428 CDS1881042 7572 - 0.267697
DDB_G0268876 DDB_G0268876 member of the TKL (tyrosine kinase-like) group of protein kinases contains filamin repeat similar to ABP120DDB0232428 CDS2297918 4158 - 0.279702
DDB_G0268914 DDB_G0268914 DDB0232428 CDS2371552 13623 - 0.261396
DDB_G0268922 DDB_G0268922 DDB0232428 CDS1846133 3798 - 0.269879
DDB_G0268924 DDB_G0268924 DDB0232428 CDS1866297 5295 - 0.259679
DDB_G0268926_ps DDB_G0268926 putative pseudogene fragment similar to a family of D. discoideum genes including DDB0232428 CDS1872318 456 - 0.27193
DDB_G0269370 DDB_G0269370 very similar to the human 25 kDa cleavage and polyadenylation specificity factor component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3' processingDDB0232428 CDS2630812 603 + 0.288557
DDB_G0269498 DDB_G0269498 DDB0232428 CDS2883107 1053 - 0.212726
DDB_G0269628 DDB_G0269628 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS3183487 2214 - 0.303975
DDB_G0269986 DDB_G0269986 DDB0232428 CDS3977474 2391 + 0.24634
DDB_G0270146 DDB_G0270146 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232428 CDS4304005 1908 - 0.287212
DDB_G0270444 DDB_G0270444 kinase domain similar to mitogen-activated protein kinases does not contain the consensus sequences required for kinase function N-terminus contains WD40 repeatsDDB0232428 CDS4890352 4083 + 0.281411
DDB_G0271376 DDB_G0271376 DDB0232429 CDS144988 762 + 0.295276
DDB_G0271402 DDB_G0271402 DDB0232429 CDS241165 2298 + 0.309835
DDB_G0271538 DDB_G0271538 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family expressed in pstO cellsDDB0232429 CDS568653 1584 - 0.285985
DDB_G0271550 DDB_G0271550 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS634463 1179 + 0.267176
DDB_G0271682 DDB_G0271682 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains two kinase domains one of which is predicted to be inactiveDDB0232429 CDS792553 3075 + 0.247154
DDB_G0271732 DDB_G0271732 highly similar to mammalian DNA-binding protein SMUBP-2 (IGHMBP2) involved in muscular atrophy and other diseases putative ortholog of S. cerevisiae HCS1 a DNA helicase associated with alpha DNA polymeraseDDB0232429 CDS872358 3075 - 0.267967
DDB_G0271962 DDB_G0271962 DDB0232429 CDS1080455 1401 - 0.271235
DDB_G0272082 DDB_G0272082 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232429 CDS1245702 5517 + 0.237992
DDB_G0272092 DDB_G0272092 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains a C2 domain (Ca2-dependent membrane-targeting module) an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232429 CDS1251605 2961 - 0.296184
DDB_G0272254 DDB_G0272254 member of the TKL (tyrosine kinase-like) group contains a galactose oxidase central domain and three Kelch motifsDDB0232429 CDS1396081 3996 - 0.264765
DDB_G0272282 DDB_G0272282 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) and MAST (microtubule-associated serinethreonine kinase)DDB0232429 CDS1572926 6309 + 0.272468
DDB_G0272384 DDB_G0272384 E.coli ATP-dependent DNA helicase RecQ is involved in genome maintenance similar to Bloom syndrome protein defects in BLM cause genetic instability including a high level of sister chromatid exchanges associated with a greatly increased predisposition to a wide range of cancersDDB0232429 CDS1405577 2922 + 0.255305
DDB_G0272388 DDB_G0272388 DDB0232429 CDS1417426 2022 - 0.250247
DDB_G0272472 DDB_G0272472 DDB0232429 CDS1736613 4527 + 0.299978
DDB_G0272554_RTE DDB_G0272554 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232429 CDS1837120 2265 + 0.393377
DDB_G0272797 DDB_G0272797 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS2368968 2043 - 0.313754
DDB_G0272877 DDB_G0272877 contains 4 coiled-coil domains there is a second copy of this gene DDB0232429 CDS2317791 1677 + 0.305903
DDB_G0272997 DDB_G0272997 DDB0232429 CDS2081848 3345 - 0.23707
DDB_G0273053 DDB_G0273053 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog there is a second copy of this gene DDB0232429 CDS2288541 4557 - 0.250384
DDB_G0273165 DDB_G0273165 catalyses the endonucleolytic cleavage of apurinic or apyrimidinic sites to generate products with a 5'-phosphate there is a second copy of this gene DDB0232429 CDS2484199 969 - 0.252838
DDB_G0273907 DDB_G0273907 catalyses the endonucleolytic cleavage of apurinic or apyrimidinic sites to generate products with a 5'-phosphate there is a second copy of this gene DDB0232429 CDS3546510 969 + 0.252838
DDB_G0274007 DDB_G0274007 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS3660427 2043 + 0.313754
DDB_G0274049 DDB_G0274049 contains 4 coiled-coil domains there is a second copy of this gene DDB0232429 CDS3712319 1677 - 0.305903
DDB_G0274075 DDB_G0274075 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog there is a second copy of this gene DDB0232429 CDS3738689 4557 + 0.250384
DDB_G0274399 DDB_G0274399 similar to ATP-dependent RNA helicase M NAM7and to putative helicases involved in RNA maturation SEN1 human senataxin imlicated in ataxia-ocular apraxia 2 (AOA2) and amyotrophic lateral sclerosis 4 (ALS4) also belongs to this familyDDB0232429 CDS4681340 2904 + 0.333333
DDB_G0274419 DDB_G0274419 bCommunity annotation:b DDB_G0274419 appears to encode a DNA polymerase with closest affinities to pol I of bacteria (the Kornberg polymerase). This is a low-processivity polymerase thought to function in DNA repair. DDB_G0274419 is only marginally (2x)overexpressed in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted (Doquang et al in preparation). DNA polymerases associated with replication show overexpression factors of 5- to 14-fold in this strain as as do several genes associated with replication-coupled repair while most genes associated with replication-independent repair pathways show overexpression factors of 2 or less. This suggests that DDB_G0274419 acts in replication-uncoupled DNA repair. Harry MacWilliams September 2009DDB0232429 CDS4627713 3354 - 0.230471
DDB_G0274483 DDB_G0274483 DDB0232429 CDS4423293 4917 - 0.273744
DDB_G0274613 DDB_G0274613 kinase domain similar to mitogen-activated protein kinases does not contain the consensus sequences known to be required for kinase function contains a RING zinc finger domainDDB0232429 CDS4893134 2496 - 0.260417
DDB_G0274777 DDB_G0274777 similar to Dna2 a DNA replication factor required for Okazaki fragment processing and involved in DNA repair pathwaysDDB0232429 CDS3809416 5517 + 0.240348
DDB_G0274821 DDB_G0274821 DDB0232429 CDS3992986 2565 - 0.181287
DDB_G0274835 DDB_G0274835 DDB0232429 CDS4088247 369 + 0.238482
DDB_G0274847 DDB_G0274847 DDB0232429 CDS4177568 5643 + 0.270069
DDB_G0274901 DDB_G0274901 DDB0232429 CDS4391451 1377 - 0.17284
DDB_G0274965 DDB_G0274965 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232429 CDS4676573 4203 - 0.281704
DDB_G0275057 DDB_G0275057 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS5089988 1050 + 0.33619
DDB_G0275165 DDB_G0275165 DDB0232429 CDS5143836 2766 - 0.298988
DDB_G0275469 DDB_G0275469 similar to endonuclease V which catalyses the endonucleolytic cleavage of apurinic or apyrimidinic sites to generate products with a 5'-phosphate DDB0232429 CDS6096697 1617 - 0.29128
DDB_G0275509 DDB_G0275509 DDB0232429 CDS6023716 2607 + 0.197929
DDB_G0275539 DDB_G0275539 DDB0232429 CDS5727073 3975 - 0.272453
DDB_G0275633 DDB_G0275633 ortholog of human SKIV2L2 (SuperKIller Viralicitic 2L2) protein and yeast MTR4 a helicase required for mRNA export from the nucleusDDB0232429 CDS5972320 3387 + 0.346324
DDB_G0276045 DDB_G0276045 DDB0232429 CDS6496624 900 + 0.3
DDB_G0276181 DDB_G0276181 member of the TKL (tyrosine kinase-like) group of protein kinases contains a PH (pleckstrin homology) domainDDB0232429 CDS6410071 4668 - 0.262853
DDB_G0276281 DDB_G0276281 DDB0232429 CDS6608304 1032 - 0.223837
DDB_G0276339_ps DDB_G0276339 putative pseudogene similar to DDB0232429 CDS6661296 507 - 0.353057
DDB_G0276461 DDB_G0276461 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232429 CDS6904331 2397 - 0.267418
DDB_G0277165 DDB_G0277165 CAMKL family protein kinase the protein kinase domain is similar to those of the CAMKLBRSK subfamily which are named based on brain-specific expression in human and neuronal expression in wormDDB0232429 CDS7893420 2502 - 0.271783
DDB_G0277211 DDB_G0277211 ortholog of human SKIV2L (SuperKIller Viralicitic 2L) protein and yeast SKI2 a helicase required for repressing propagation of dsRNA virusesDDB0232429 CDS7627913 4137 - 0.292966
DDB_G0277327 DDB_G0277327 DDB0232429 CDS7723793 3354 - 0.304114
DDB_G0277449 DDB_G0277449 member of the AGC kinase group similar to kinase domains of SGK (serum and glucocorticoid responsive kinase) AktPKB and RSK (ribosomal S6 kinase) family membersDDB0232429 CDS8121319 1371 + 0.300511
DDB_G0277537 DDB_G0277537 subunit of PI4K responsible for the phosphorylation of phosphatidylinositol (PI) to PI4P (ATP 1-phosphatidyl-1D-myo-inositol ADP 1-phosphatidyl-1D-myo-inositol 4-phosphate) the first committed step in the generation of phosphatidylinositol 45-bisphosphate (PIP2) a precursor of the second messenger inositol 145-trisphosphate (InsP3)DDB0232429 CDS7989159 7383 + 0.301233
DDB_G0277539 DDB_G0277539 putative protein tyrosine kinase similar to human wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232429 CDS8010617 2997 - 0.248248
DDB_G0277705 DDB_G0277705 DDB0232429 CDS8352571 1524 - 0.229659
DDB_G0277749 DDB_G0277749 DDB0232429 CDS8434187 5040 + 0.242262
DDB_G0278087_ps DDB_G0278087 putative pseudogene containing a partial protein kinase domain and a partial ankyrin repeatDDB0232430 CDS256195 1557 - 0.285806
DDB_G0278221_RTE DDB_G0278221 ORF2 protein fragment of DIRS1 retrotransposon refer to Genbank M11339 for full-length elementDDB0232430 CDS495104 504 + 0.367063
DDB_G0278363 DDB_G0278363 DDB0232430 CDS761869 702 + 0.32906
DDB_G0278425 DDB_G0278425 DDB0232430 CDS866714 3273 - 0.276199
DDB_G0278487 DDB_G0278487 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases belongs to the CMGC group of protein kinasesDDB0232430 CDS959760 1911 + 0.288854
DDB_G0278509 DDB_G0278509 DDB0232430 CDS984753 3747 + 0.238858
DDB_G0278521 DDB_G0278521 member of the TKL (tyrosine kinase-like) group the MLK (mixed lineage kinase) family and the HH498 subfamily contains an ankyrin repeatDDB0232430 CDS1000912 2727 - 0.226989
DDB_G0278535 DDB_G0278535 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232430 CDS1034770 2547 + 0.329407
DDB_G0278665 DDB_G0278665 DDB0232430 CDS753135 3273 - 0.31103
DDB_G0278761 DDB_G0278761 DDB0232430 CDS1131314 5382 + 0.281865
DDB_G0278825 DDB_G0278825 DDB0232430 CDS1248051 2718 + 0.316409
DDB_G0278827 DDB_G0278827 DDB0232430 CDS1252983 5451 - 0.259035
DDB_G0278845 DDB_G0278845 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) family membersDDB0232430 CDS1269374 4053 - 0.265976
DDB_G0278901 DDB_G0278901 DDB0232430 CDS1361340 4488 - 0.282308
DDB_G0278909 DDB_G0278909 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains an N-terminal LRR and a C-terminal armadillobeta-catenin repeat unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS1376167 5811 + 0.293581
DDB_G0278937 DDB_G0278937 DDB0232430 CDS1214678 2715 + 0.271455
DDB_G0279209 DDB_G0279209 DDB0232430 CDS1761272 399 - 0.265664
DDB_G0279223 DDB_G0279223 contains a nucleic acid binding domain the oligonucleotideoligosaccharide binding motif (OB fold)DDB0232430 CDS1790126 552 + 0.309783
DDB_G0279405 DDB_G0279405 CAMKL family protein kinase the protein kinase domain has similarity to those of calciumcalmodulin-dependent protein kinase kinases (CAMKK) that belong to a proposed calcium-triggered signaling cascade involved in a number of cellular processesDDB0232430 CDS1975813 2088 + 0.290709
DDB_G0279719 DDB_G0279719 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232430 CDS2480611 2829 - 0.265111
DDB_G0279831 DDB_G0279831 putative protein serinethreonine kinase CAMK group the protein kinase domain is similar to those of mammalian CAM kinase IDDB0232430 CDS2602496 2787 + 0.267671
DDB_G0280111 DDB_G0280111 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232430 CDS2948944 3381 - 0.280982
DDB_G0280131 DDB_G0280131 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains armadillobeta-catenin-like repeats unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS2985578 3579 - 0.308187
DDB_G0280133 DDB_G0280133 CAMK family protein kinase protein kinase domain similar to those of mammalian SNF1 like kinasesDDB0232430 CDS2991402 4518 + 0.285967
DDB_G0280257 DDB_G0280257 DDB0232430 CDS3173383 1245 + 0.324498
DDB_G0280281 DDB_G0280281 DDB0232430 CDS3200265 1836 + 0.270697
DDB_G0280413 DDB_G0280413 DDB0232430 CDS3319399 3333 + 0.229223
DDB_G0280461 DDB_G0280461 DDB0232430 CDS3391535 1257 - 0.24105
DDB_G0280557 DDB_G0280557 similar to erkA and erkB and other MAP kinases does not contain the consensus sequences required for kinase functionDDB0232430 CDS3496721 1383 + 0.237889
DDB_G0280643 DDB_G0280643 similar to many CMGC family members including several MAPKsDDB0232430 CDS3598294 1329 - 0.261851
DDB_G0280717 DDB_G0280717 member of the AGC kinase group similar to the kinase domains of PKC (protein kinase C) and MAST (microtubule-associated serinethreonine kinase)DDB0232430 CDS3670258 1236 - 0.258091
DDB_G0280765 DDB_G0280765 DDB0232430 CDS3715566 2334 + 0.321765
DDB_G0280855 DDB_G0280855 similar to erkA and erkB and other MAP kinases unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS3794487 1179 + 0.25106
DDB_G0280913 DDB_G0280913 DDB0232430 CDS3873660 1587 - 0.245117
DDB_G0281431 DDB_G0281431 DDB0232430 CDS4477171 2763 + 0.26131
DDB_G0281503 DDB_G0281503 DDB0232430 CDS4637514 3360 + 0.285417
DDB_G0281559 DDB_G0281559 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog REMI mutant forms large sori see DDB0232430 CDS4978870 3066 - 0.299739
DDB_G0281745 DDB_G0281745 DDB0232430 CDS4910382 1794 + 0.337793
DDB_G0281845 DDB_G0281845 DDB0232430 CDS5006578 4032 + 0.255208
DDB_G0281925 DDB_G0281925 DDB0232430 CDS5132437 1761 - 0.366269
DDB_G0282115 DDB_G0282115 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS5399711 4923 - 0.275848
DDB_G0282299 DDB_G0282299 DDB0232430 CDS5607244 2508 - 0.219298
DDB_G0282429 DDB_G0282429 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232430 CDS5758659 939 - 0.312034
DDB_G0282531 DDB_G0282531 ortholog of human Tat DNase 1 (TATDN1) belongs to a large superfamily of metalloenzymesDDB0232430 CDS5890637 975 - 0.259487
DDB_G0282603 DDB_G0282603 DDB0232430 CDS5993046 600 + 0.261667
DDB_G0282679 DDB_G0282679 DDB0232430 CDS6110131 4380 + 0.237671
DDB_G0282851 DDB_G0282851 DDB0232430 CDS6297857 4146 + 0.263869
DDB_G0282895 DDB_G0282895 member of the TKL (tyrosine kinase-like) group contains three N-terminal MORN (Membrane Occupation and Recognition Nexus) repeatsDDB0232430 CDS6249781 4905 + 0.262385
DDB_G0282963 DDB_G0282963 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS60445 5286 + 0.265796
DDB_G0283065 DDB_G0283065 putative eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase putative protein serinethreonine kinase related to the GCN2 (general control non-derepressible) family of protein kinases that phosphorylate the alpha subunit of eIF2DDB0232431 CDS122741 1914 - 0.242424
DDB_G0283189 DDB_G0283189 similar to DNA polymerase epsilon subunit A in yeast and vertebrates thought to be involved in DNA replication DNA repair and cell-cycle checkpoint control in eukaryotesDDB0232431 CDS385928 7143 - 0.297494
DDB_G0283301 DDB_G0283301 DDB0232431 CDS480042 1992 + 0.254016
DDB_G0283337 DDB_G0283337 DDB0232431 CDS491931 3387 - 0.219368
DDB_G0283397 DDB_G0283397 DDB0232431 CDS606939 2757 - 0.283642
DDB_G0283759 DDB_G0283759 DDB0232431 CDS1232305 3240 + 0.274383
DDB_G0283797 DDB_G0283797 DDB0232431 CDS1118346 1470 - 0.267347
DDB_G0283821 DDB_G0283821 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232431 CDS1155677 2826 - 0.295824
DDB_G0283927 DDB_G0283927 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232431 CDS1307685 1458 - 0.226337
DDB_G0284241 DDB_G0284241 DDB0232431 CDS1733961 1293 + 0.243619
DDB_G0284251 DDB_G0284251 kinase domain similar to those of mitogen-activated protein kinases similar to the STE20 familyDDB0232431 CDS1754346 1491 - 0.273642
DDB_G0284507 DDB_G0284507 putative ortholog of Rad51C which is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks interacts with XRCC3DDB0232431 CDS2070281 1146 - 0.233857
DDB_G0284649 DDB_G0284649 DDB0232431 CDS2287653 2103 - 0.258678
DDB_G0284661 DDB_G0284661 putative protein serinethreonine kinase CAMK group kinase domain similar to mammalian CAM kinase IDDB0232431 CDS2309177 1446 - 0.304288
DDB_G0284689 DDB_G0284689 DDB0232431 CDS2350414 5040 + 0.22996
DDB_G0284817 DDB_G0284817 DDB0232431 CDS2518687 1641 - 0.311395
DDB_G0284997 DDB_G0284997 DDB0232431 CDS2784039 1125 - 0.315556
DDB_G0285021 DDB_G0285021 belongs to the complex I LYR family similar to human NDUFB9 (NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9)DDB0232431 CDS2830332 321 - 0.323988
DDB_G0285243 DDB_G0285243 has partial similarity to the S. cerevisiae SEN1 a putative helicase required for RNA polymerase II transcription termination and processing of RNAsDDB0232431 CDS2998910 6210 + 0.295169
DDB_G0285285 DDB_G0285285 DDB0232431 CDS3060850 1323 - 0.253212
DDB_G0285287 DDB_G0285287 putative ortholog of Rad51D which is involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaksDDB0232431 CDS3062767 1065 - 0.23662
DDB_G0285437 DDB_G0285437 DDB0232431 CDS3223269 969 + 0.27451
DDB_G0285463 DDB_G0285463 member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) family contains 7 putative transmembrane domainsDDB0232431 CDS3259648 2076 - 0.308285
DDB_G0285767 DDB_G0285767 DDB0232431 CDS3448354 4086 + 0.254772
DDB_G0285911 DDB_G0285911 DDB0232431 CDS3814964 3186 + 0.27307
DDB_G0286065 DDB_G0286065 DDB0232431 CDS4016707 1554 + 0.276062
DDB_G0286071 DDB_G0286071 DDB0232431 CDS4026106 339 - 0.233038
DDB_G0286219 DDB_G0286219 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog highly similar to mammalian TBP-associated factor 172 (TAF-172BTAF1) and yeast MOT1DDB0232431 CDS4198019 6018 + 0.302758
DDB_G0286479 DDB_G0286479 DDB0232431 CDS4506469 3504 - 0.257991
DDB_G0286481 DDB_G0286481 putative protein serinethreonine kinase similar to casein kinase II the alpha chain of a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS4514745 1818 - 0.264026
DDB_G0286627 DDB_G0286627 putative protein serinethreonine kinase belongs to the STE group the kinase domain is similar to yeast BCK1 a mitogen-activated protein (MAP) kinase kinase kinaseDDB0232431 CDS4756048 2016 - 0.251984
DDB_G0286841 DDB_G0286841 member of the AGC kinase group similar to the kinase domains of MAST kinases (Microtubule-Associated SerineThreonine kinase)DDB0232431 CDS4966020 1389 - 0.218143
DDB_G0286883 DDB_G0286883 DDB0232431 CDS5022922 573 - 0.277487
DDB_G0287001 DDB_G0287001 member of the TKL (tyrosine kinase-like) group contains zinc-binding LIM domainDDB0232431 CDS5188585 1953 - 0.28213
DDB_G0287069 DDB_G0287069 DDB0232431 CDS5289970 1167 + 0.264782
DDB_G0287149 DDB_G0287149 similar to mammalian DNA polymerase kappa (POLK) and E. coli dinB a translesion DNA repair polymeraseDDB0232431 CDS5382189 1554 - 0.240026
DDB_G0287171 DDB_G0287171 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS5429343 5619 + 0.2399
DDB_G0287397 DDB_G0287397 DDB0232432 CDS251848 2013 - 0.273224
DDB_G0287447 DDB_G0287447 ortholog of the bacterial epsilon subunit of DNA polymerase III a multisubunit enzyme responsible for most of the replicative synthesis in bacteria the contain the editing function and is a proofreading 3'-5' exonuclease the Dictyostelium gene is missing approximately 100 amino acids at the carboxyl terminusDDB0232432 CDS185922 1452 + 0.232782
DDB_G0287533 DDB_G0287533 DDB0232432 CDS373625 1149 + 0.260226
DDB_G0288039 DDB_G0288039 DDB0232432 CDS1009340 771 + 0.268482
DDB_G0288073 DDB_G0288073 DDB0232432 CDS1051212 6114 - 0.292607
DDB_G0288147 DDB_G0288147 member of the tyrosine kinase-like (TKL) group similar to plant serinethreonine kinases contains a phorbol esterdiacylglycerol-binding domainDDB0232432 CDS1147360 4044 + 0.271513
DDB_G0288209 DDB_G0288209 ortholog of mitochondrial twinkle protein involved in mitochondrial DNA (mtDNA) metabolism defects in this gene cause progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 3DDB0232432 CDS1246731 2319 + 0.269082
DDB_G0288573 DDB_G0288573 DDB0232432 CDS1700402 684 + 0.276316
DDB_G0288795 DDB_G0288795 putative protein serinethreonine kinase AGC group similar to the kinase domains of mammalian AKTPKB similar to yeast protein kinases GAD8 and SCH9DDB0232432 CDS1975761 1926 - 0.317757
DDB_G0288947 DDB_G0288947 DDB0232432 CDS2162285 4416 + 0.279212
DDB_G0289033 DDB_G0289033 DDB0232432 CDS2277325 4770 - 0.292243
DDB_G0289503_ps DDB_G0289503 putative pseudogene almost identical to neighboring gene DDB0232432 CDS2868325 5166 - 0.258227
DDB_G0289529 DDB_G0289529 DDB0232432 CDS2862639 5034 - 0.265395
DDB_G0289705 DDB_G0289705 DDB0232432 CDS3136742 6009 + 0.305542
DDB_G0289719 DDB_G0289719 DDB0232432 CDS3159163 4260 + 0.28662
DDB_G0289921 DDB_G0289921 DDB0232432 CDS3426110 3708 + 0.263484
DDB_G0290311 DDB_G0290311 DDB0232432 CDS3942085 1086 - 0.300184
DDB_G0290471 DDB_G0290471 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats does not contain the consensus sequences required for kinase functionDDB0232432 CDS4105828 1059 - 0.234183
DDB_G0290539 DDB_G0290539 DDB0232432 CDS4236850 714 - 0.219888
DDB_G0290621 DDB_G0290621 DDB0232432 CDS4383355 2904 - 0.22865
DDB_G0290689 DDB_G0290689 homolog of E. coli rppH very similar to DDB0232432 CDS4419333 552 - 0.278986
DDB_G0290859 DDB_G0290859 member of the AGC kinase group similar to NDR (nuclear Dbf2-related) and RSK (ribosomal S6 kinase) family membersDDB0232432 CDS4688665 1260 + 0.307143
DDB_G0290969 DDB_G0290969 DDB0232432 CDS4808227 1179 - 0.189992
DDB_G0291131 DDB_G0291131 DDB0232432 CDS5027479 2148 + 0.363128
DDB_G0291133 DDB_G0291133 putative protein tyrosine kinase similar to S. pombe wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232432 CDS5030354 2337 + 0.26059
DDB_G0291350 DDB_G0291350 putative protein serinethreonine kinase similar to mammalian MPSK (myristoylated and palmitoylated serinethreonine kinase) a kinase involved in transcriptional regulation and protein phosphorylation may be an intermediary in the TGF-beta signaling pathwayDDB0232433 CDS162730 1110 - 0.245045
DDB_G0291464 DDB_G0291464 DDB0232433 CDS369674 3414 - 0.289104
DDB_G0291534 DDB_G0291534 DDB0232433 CDS487852 1113 + 0.261456
DDB_G0291664 DDB_G0291664 highly similar to DDB0232433 CDS338918 2880 + 0.291319
DDB_G0291842 DDB_G0291842 putative protein tyrosine kinase similar to S. pombe WEE1 inhibitor of mitosis through phosphorylation of cdc2DDB0232433 CDS822502 1059 - 0.351275
DDB_G0291872 DDB_G0291872 DDB0232433 CDS855161 2688 + 0.273438
DDB_G0291918 DDB_G0291918 putative protein serinethreonine kinase CAMK group kinase domain is similar to those of mammalian death-associated protein kinases (DAPK)DDB0232433 CDS943654 2010 + 0.287065
DDB_G0292010 DDB_G0292010 DDB0232433 CDS1014321 2334 + 0.288346
DDB_G0292108 DDB_G0292108 DDB0232433 CDS1192584 2490 - 0.278715
DDB_G0292350 DDB_G0292350 DDB0232433 CDS1496951 3675 + 0.270204
DDB_G0292354 DDB_G0292354 putative protein serinethreonine kinase TTBK family similar to casein kinase similar to mammalian tau-tubulin kinase (TTBK) which phosphorylates the microtubule-associated protein tau implicated in Alzheimer's diseaseDDB0232433 CDS1420214 1488 + 0.30578
DDB_G0292416 DDB_G0292416 DDB0232433 CDS1569201 2793 - 0.257787
DDB_G0292550 DDB_G0292550 DDB0232433 CDS1642791 4194 - 0.223891
DDB_G0292624 DDB_G0292624 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232433 CDS1864394 942 + 0.298301
DDB_G0292914 DDB_G0292914 DDB0232433 CDS2269065 723 + 0.262794
DDB_G0293064 DDB_G0293064 DDB0232433 CDS2418202 1722 - 0.334495
DDB_G0293120 DDB_G0293120 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2546935 6618 - 0.294349
DDB_G0293184 DDB_G0293184 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesis contains RhoGAP domain found in the Rho family of small G proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS2540484 3561 + 0.281382
DDB_G0293212 DDB_G0293212 DDB0232433 CDS2696303 2541 + 0.275482
DDB_G0293276 DDB_G0293276 member of the AGC kinase group similar to kinase domains of AktPKB and MAST (microtubule-associated serinethreonine kinase) family membersDDB0232433 CDS2701490 1551 - 0.246937
DDB_G0293292 DDB_G0293292 putative protein serinethreonine kinase N-terminal kinase domain similar to vertebrate Nek kinases which are involved in regulation of mitosis C-terminal kinase domain weakly similar to ULK (Unc-51-like kinase)DDB0232433 CDS2647324 4116 + 0.234208
DDB_G0293380 DDB_G0293380 bCommunity annotation:b DDB G0293380 contains a conserved domain which is best matched by COG0116 N6 adenine-specific DNA methylase (E-value 5e-14). The similarity to PRK11783 rRNA methyltransferase is lower (9e-11). The blast matches list both putative RNA methylases and putative N6 adenine-specific DNA methylases. Thus although it does not now appear to be possible to assign DDB_G0293380 conclusively to either category the case for a DNA methylase currently looks a bit stronger.br DDB_G0293380 is overexpressed fivefold (p0.008) in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted. Most genes with functions necessary for cell cycle progression are overexpressed in this strain and most of the overexpressed genes have identifiable cell cycle functions. A tempting interpretation is that the product of DDB_G0293380 is involved in a DNA methylation pathway which is coupled with DNA replication. Harry MacWilliams December 2009br DDB0232433 CDS2824551 1686 + 0.242586
DDB_G0293582 DDB_G0293582 DDB0232433 CDS3074914 744 + 0.264785
DDB_G0293586 DDB_G0293586 contains one LisH domain contains 3 predicted coiled-coil domainsDDB0232433 CDS3081583 6045 - 0.305045
DDB_G0293958 DDB_G0293958 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232433 CDS3460612 4779 + 0.208203
DDB_G0295683 DDB_G0295683 DDB0232433 CDS1769740 4770 + 0.291614
DDB_G0295737 DDB_G0295737 DDB0232432 CDS3359151 2817 - 0.29535
DDB_G0302588 DDB_G0302588 DDB0232428 CDS1056562 10701 - 0.305766
H2Bv3 DDB_G0286509 DDB0232431 CDS4575107 465 + 0.393548
abcH3 DDB_G0275697 DDB0232429 CDS5590467 3357 - 0.233244
alkB DDB_G0285575 DDB0232431 CDS3395637 1182 + 0.307953
apeA DDB_G0277701 AP-endonuclease catalyses the exonucleolytic cleavage of damaged double stranded DNA in the 3'- to 5'-direction to yield nucleoside 5'-phosphatesDDB0232429 CDS8367690 1086 + 0.323204
apnA DDB_G0279923 breaks the C-O-P bond 5' to an apurinic or apyrimidinic site in DNA brbr bCommunity annotation:b ApnA has a canonical PCNA-interacting domain also known as a PIP sequence in this case QtsItdFF. For a discussion of PIP domains (see Supplementary table 1 in DDB0232430 CDS2784977 1629 - 0.259055
apnB DDB_G0277247 breaks the C-O-P bond 3' to an apurinic or apyrimidinic site in DNADDB0232429 CDS7816486 1050 + 0.281905
aqr DDB_G0274797 ortholog of the mammalian aquarius (AQR) protein an intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesisDDB0232429 CDS3881369 4464 - 0.225134
arkA DDB_G0289555 suppressor of spalten (spnA) mutant member of the TKL (tyrosine kinase-like) group and ARK (ankyrin repeat-containing kinase) familyDDB0232432 CDS2941850 4383 + 0.300707
atg1 DDB_G0292390 Dictyostelium homolog of yeast atg1 belongs to the ULK (Unc-51-like kinase) family of kinases required for macroautophagyDDB0232433 CDS1694801 2007 + 0.255605
atr1 DDB_G0291380 atypical PIKK family protein kinase similar to protein kinase ATR which modulates cell cycle progression and DNA repair in other organisms ATR phosphorylates Rad17 histone H2AX p53 and Nbs1DDB0232433 CDS214264 9474 - 0.259552
aurK DDB_G0279343 putative protein serinethreonine kinase Aur family associates with the mitotic spindle and plays a key role in mitosis the single Dictyostelium aurora kinase has properties of both aurora A and B kinases in other organismsDDB0232430 CDS1959552 1155 - 0.30303
blm DDB_G0292130 E. coli ATP-dependent DNA helicase RecQ is involved in genome maintenance this is the ortholog of the H. sapiens Bloom syndrome protein defects in BLM cause genetic instability including a high level of sister chromatid exchanges associated with a greatly increased predisposition to a wide range of cancersDDB0232433 CDS1240457 3780 + 0.286243
bzpJ DDB_G0274993 DDB0232429 CDS4824947 2364 + 0.258883
cak1-1 DDB_G0273059 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS2688821 1281 + 0.320062
cak1-2 DDB_G0273737 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS3341355 1281 - 0.320062
casK DDB_G0276885 CK2 family protein kinase a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232429 CDS7370887 1014 + 0.310651
cdc6 DDB_G0275983 bCommunity annotation:b ortholog of cdc6 long known to be a critical member of the DNA pre-replication complex and more recently implicated in control of mitosis (see DDB0232429 CDS6146641 1317 + 0.247532
cdc7 DDB_G0292152 similar to S. cerevisiae cell division control protein 7 (CDC7) a serinethreonine kinase required for mitosis and meiosisDDB0232433 CDS1294776 3186 + 0.23666
cdk1 DDB_G0272813 similar to CDK1 and CDK2 cell cycle CAK (CDK-activating kinase) kinases predicted to activate SG2 cyclins cyclin A B and DDDB0232429 CDS2216835 891 + 0.331089
cdk10 DDB_G0268480 putative cell division cycle 2 (CDC2)-like protein kinase has similarity to PITSLRE proteins and other cyclin-dependent kinase 2 kinasesDDB0232428 CDS294048 1101 - 0.256131
cdk11 DDB_G0283279 very similar to human CDL1 (PITSLRE serinethreonine-protein kinase CDC2L1) which appears to play multiple roles in cell cycle progression cytokinesis and apoptosis predicted to interact with DDB0232431 CDS446640 1077 - 0.338904
cdk5 DDB_G0288677 CMGC group protein kinase highly similar to mammalian cdk5 localizes to the nucleus and shuttles to the cytoplasm during late mitosis binds calmodulin PsaADDB0232432 CDS1885785 879 + 0.302617
cdk7 DDB_G0285417 putative ortholog of CDK7 and CTK1 which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit predicted to be activated by DDB0232431 CDS3627427 1083 + 0.307479
cdk8 DDB_G0267442 controls RNA polymerase II activity by phosphorylating the carboxy terminal domain (CTD) of the largest subunit predicted to interact with DDB0232428 CDS1582311 1143 - 0.314961
cdk9-1 DDB_G0273207 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS2708039 2085 + 0.282974
cdk9-2 DDB_G0273721 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS3321422 2085 - 0.282974
cepK DDB_G0293544 localizes to the corona of the centrosome and to centromeres affects cell growth and chemotactic motility and is involved in the interaction with the nuclear envelopeDDB0232433 CDS2990987 6333 - 0.225959
chdA DDB_G0284171 CHD gene family protein containing a chromodomain a helicase domain and a DNA-binding domain similar to H. sapiens chromodomain-helicase-DNA-binding protein 2 (CHD-2) (SwissProt: O14647) chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS1645755 5754 - 0.310219
chdB DDB_G0280705 CHD gene family protein containing a chromodomain a C terminal helicase domain and a DNA-binding domain chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS3648861 7122 - 0.267762
chdC DDB_G0293012 CHD gene family protein containing a chromodomain a helicase domain and a DNA-binding domain chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2321154 9216 + 0.312174
chtf18 DDB_G0272758 in S. cerevisiae essential for the fidelity of chromosome transmission and component of the RFC complexbrbr bCommunity annotation:b CTF18 (DDB0232429 CDS2108163 2814 + 0.264748
clkA DDB_G0281179 similar to cyclin-like kinases (CLK) putative dual specifity kinaseDDB0232430 CDS4167312 2799 + 0.215077
cog4 DDB_G0267960 highly similar to COG4 component of the conserved oligomeric Golgi complex which is composed of eight different subunitsDDB0232428 CDS1187972 2736 - 0.240863
commd1 DDB_G0292074 belongs to a family of conserved mammalian HCaRG (hypertension-related calcium-regulated gene) proteinsDDB0232433 CDS1155156 564 - 0.210993
cycC DDB_G0274139 similar to metazoan cyclin C predicted to interact with cyclin-dependent kinase DDB0232429 CDS4921649 768 + 0.247396
cycH DDB_G0268668 similar to metazoan cyclin H predicted to interact with cyclin-dependent kinase DDB0232428 CDS1891354 861 - 0.190476
cycK DDB_G0286617 similar to metazoan cyclin K predicted to interact with the cyclin-dependent kinase DDB0232431 CDS4722525 1218 - 0.297209
cycL DDB_G0285553 similar to metazoan and higher plants cyclin Lania-6 predicted to interact with DDB0232431 CDS3372094 822 - 0.284672
dcp2 DDB_G0283315 ortholog of the conserved mRNA-decapping enzyme 2 necessary for the degradation of mRNAsDDB0232431 CDS515744 1863 + 0.31723
dcp2_ps DDB_G0283809 putative pseudogene similar to DDB0232431 CDS1130346 258 - 0.325581
ddx1 DDB_G0269966 ortholog of ATP-dependent RNA helicase DDX1 contains an SPRY domain which is of unknown functionDDB0232428 CDS3941617 2298 + 0.302002
ddx10 DDB_G0284017 DDB0232431 CDS1436851 2637 + 0.277209
ddx17 DDB_G0293168 conserved RNA helicase very similar to mammalian DDX17 (p72) and DDX5 (p68) and yeast DBP2DDB0232433 CDS2360817 2358 - 0.370229
ddx18 DDB_G0282741 DDB0232430 CDS6230156 1809 - 0.334439
ddx20 DDB_G0277527 ortholog of H. sapiens DDX20Gemin 3 a component of Cajal bodies (CBs) and Gems nuclear organelles responsible for spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesisDDB0232429 CDS8128317 2550 - 0.22902
ddx24 DDB_G0281841 DDB0232430 CDS5000989 2823 + 0.30039
ddx27 DDB_G0281711 DDB0232430 CDS4866495 2352 + 0.305697
ddx3 DDB_G0283661 conserved RNA helicase very similar to mammalian DDX3X and DDX3Y and yeast DBP1DDB0232431 CDS939305 2139 - 0.370266
ddx31 DDB_G0271708 DDB0232429 CDS830367 2727 + 0.26696
ddx41 DDB_G0287361 conserved RNA helicase ortholog of D. melanogaster DEAD box protein abstrakt which is required during post-transcriptional gene expressionDDB0232432 CDS183547 2016 - 0.315476
ddx42 DDB_G0288501 conserved putative RNA helicase very similar to mammalian DDX42DDB0232432 CDS1607944 2961 + 0.274232
ddx47 DDB_G0280147 DDB0232430 CDS3015956 1641 - 0.312614
ddx49 DDB_G0270396 DDB0232428 CDS4752654 1527 + 0.27112
ddx5 DDB_G0293036 DDB0232433 CDS2373448 2094 + 0.258835
ddx51 DDB_G0293740 DDB0232433 CDS3249527 1692 - 0.229905
ddx52 DDB_G0274325 ortholog of H. sapiens DDX52 and S. cerevisiae ROK1 (Rescuer Of Kem1) ROK1 required for 18S rRNA synthesisDDB0232429 CDS3957548 2007 + 0.271051
ddx55 DDB_G0291588 ortholog of H. sapiens DDX55 and S. cerevisiae SBP4 (Suppressor of PAB1) SBP4 required for synthesis of 60S ribosomal subunitsDDB0232433 CDS577637 1992 - 0.270582
ddx56 DDB_G0280407 ortholog of H. sapiens DDX56 and S. cerevisiae DBP9 (Dead Box Protein 9) involved in biogenesis of the 60S ribosomal subunitDDB0232430 CDS3312082 2058 + 0.266764
ddx6 DDB_G0291804 ortholog of H. sapiens DDX6 and S. cerevisiae DHH1 (DExDH-box Helicase)DDB0232433 CDS773358 1272 + 0.367925
dhx15 DDB_G0285213 DDB0232431 CDS2984261 2184 + 0.330128
dhx16 DDB_G0285937 DEADDEAH box helicases are involved in various aspects of RNA metabolism including nuclear pre-mRNA splicingDDB0232431 CDS3866187 3321 + 0.311352
dhx33 DDB_G0270110 DEADDEAH box helicases are involved in various aspects of RNA metabolismDDB0232428 CDS4244035 2193 + 0.272686
dhx35 DDB_G0269306 DEADDEAH box helicases are involved in various aspects of RNA metabolismDDB0232428 CDS2485989 2151 - 0.272431
dhx37 DDB_G0287351 ortholog of H. sapiens DHX37 and S. cerevisiae ECM16 an RNA helicase involved in ribosomal biosynthesisDDB0232432 CDS165026 4386 - 0.287278
dhx57 DDB_G0267516 putative RNA helicase contains an RWD domain (RING finger and WD repeat)DDB0232428 CDS263217 4356 - 0.278007
dhx8 DDB_G0291183 conserved RNA helicase S. cerevisiae ortholog PRP22 mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexesDDB0232432 CDS5107365 3483 - 0.335343
dhx9 DDB_G0275313 ortholog of the human DHX9 that unwinds double-stranded DNA and RNA in a 3' to 5' directionDDB0232429 CDS5331812 4419 - 0.27857
dnapkcs DDB_G0281167 atypical PIKK family protein kinase similar to human DNA-PKcs required for the repair of DNA double-strand breaks belongs to the PIKK family of protein kinasesDDB0232430 CDS4132807 12900 + 0.265504
dnmA DDB_G0288047 methylates cytosines in DNA belongs to the dnmt2 subfamily which has weak methylase activityDDB0232432 CDS1026957 1140 - 0.240351
drkA DDB_G0289791 DDB0232432 CDS3144874 1929 + 0.276827
drkB DDB_G0289709 DDB0232432 CDS3147575 2073 + 0.2904
drkC DDB_G0281899 tyrosine kinase member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily involved in phagocytosis and late phagosomelysosome fusion enriched in S cells in slugsDDB0232430 CDS5088116 2250 - 0.305778
drkD DDB_G0281557 member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily contains a leucine-rich repeat (LRR) regionDDB0232430 CDS4777368 3867 + 0.334885
dst1 DDB_G0274593 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS3862026 2214 + 0.289521
dst2 DDB_G0267730 putative protein serinethreonine kinase the kinase domain is similar to mitogen-activated protein kinases and other STE20-like kinases stress-responsive kinaseDDB0232428 CDS719427 3429 + 0.33275
dst3 DDB_G0291267 putative protein serinethreonine kinase the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS35064 1689 - 0.351095
dst4 DDB_G0288071 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232432 CDS1048762 1458 - 0.325789
dupA DDB_G0277071 contains both a kinase domain and a phosphatase domain similar to MAP kinase phosphatase in plants and dual-specificty phosphatase 19 in mammals regulates the MAP Kinase response to Legionella pneumophila infection in DictyosteliumDDB0232429 CDS7439874 7365 - 0.295995
dynB DDB_G0285503 DDB0232431 CDS3322100 1293 + 0.269142
dynC DDB_G0277561 DDB0232429 CDS8131744 714 - 0.246499
dyrk1 DDB_G0277485 DDB0232429 CDS7981156 2511 + 0.249303
dyrk2 DDB_G0293750 DDB0232433 CDS3272270 2748 + 0.306405
enlA DDB_G0276103 N-terminal similarity to talin C-terminal similarity to fimbrins actin binding protein plays a role in cytokinesis and substrate adhesionbr bNomenclature conflict:b This gene has been erroneously referred to as DDB0232429 CDS6301145 4512 + 0.341534
ercc1 DDB_G0267682 ortholog of H. sapiens ERCC1 and S. cerevisiae RAD10 nucleotide excision repair genes defects in ERCC1 cause cerebro-oculo-facio-skeletal syndrome type 4 (COFS4)DDB0232428 CDS559492 1545 + 0.291909
ercc6 DDB_G0281441 ortholog of S. cerevisiae RAD26 and H. sapiens ERCC6 (CSB) involved in Cockayne syndrome chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS4502255 4968 - 0.273752
erkA DDB_G0286353 DDB0232431 CDS4355028 1590 + 0.303774
erkB DDB_G0283903 DDB0232431 CDS1385123 1110 - 0.323423
exo1 DDB_G0291570 highly similar to S. pombe exonuclease I a 5'-3' exonuclease involved in DNA repair recombination replication and telomere integrityDDB0232433 CDS561048 3141 + 0.266794
exoc7 DDB_G0272991 subunit of the exocyst complex which targets secretory vesicles to active sites of exocytosisDDB0232429 CDS2034015 2523 - 0.328973
fhkA DDB_G0293656 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsbrbr bCommunity annotation:b The five fhk-X genes differ substantially in their response to the disruption of the retinoblastoma-like gene rblA. FhkA is substantially and highly signficantly upregulated in the ko strain while none of the other genes show major changes. Consistent with its regulation the fhkA promoter contains a putative E2F-type binding site (TTTGCGCCTTTT). Virtually all genes associated with replication fork progression are upregulated in the rblA disruptant these include cdc45 all mcm genes all gins genes all rfc genes four polA subunits three polD subunits two putatitive polE subunits PCNA the single-strand binding protein rfa1 the flap endonuclease repG as well as DNA ligase-1 and topoisomerase-2. All these genes show overexpression factors ranging from 4 to 15DDB0232433 CDS3219230 1782 - 0.231201
fhkB DDB_G0280599 CAMK group RAD53 family protein kinase the protein kinase domain is similar to those of mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3548058 3429 - 0.26305
fhkC DDB_G0281567 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 and yeast RAD53 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS4871788 1788 + 0.291387
fhkD DDB_G0285963 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232431 CDS3876403 2250 - 0.286667
fhkE DDB_G0280321 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3257414 2139 + 0.257597
fncJ DDB_G0286621 ortholog of Fanconi anaemia complementation group protein involved DNA cross-link repair also known as BRIP1 (BRCA1 Interacting Protein 1) however the Dicty gene appears to be missing the region that interacts with BRCA1 in the human protein unlike other members of the complex null mutant is not sensitive to DNA damaging agents brbr mammalian ortholog is part of the Fanconi anaemia nuclear complex that includes FANC A B C E F G L and M the FA complex interacts with ube2t a E2 ubiquitin-conjugating enzyme to monoubiquitinate FANCD2 and FANCI. Ubiquinated FANCD2 and FANCI form a complex that colocalizes at sites of DNA damage with the FANCJ helicase as well as FANCN and FANCD1 in human mutations in this gene cause Fanconi anaemia an autosomal recessive disorder affecting all bone marrow elements Dictyostelium has orthologs for DDB0232431 CDS4729555 3237 + 0.296262
fncM DDB_G0274841 ortholog of Fanconi anaemia complementation group M protein involved DNA cross-link repair null mutant is sensitive to DNA damaging agents brbr mammalian ortholog is part of the Fanconi anaemia nuclear complex that includes FANC A B C E F G L and M the FA complex interacts with ube2t a E2 ubiquitin-conjugating enzyme to monoubiquitinate FANCD2 and FANCI. Ubiquinated FANCD2 and FANCI form a complex that colocalizes at sites of DNA damage with the FANCJ helicase as well as FANCN and FANCD1 in human mutations in this gene cause Fanconi anaemia an autosomal recessive disorder affecting all bone marrow elements Dictyostelium has orthologs for DDB0232429 CDS4112099 5370 + 0.280447
fnkA DDB_G0275561 protein kinase STE groupDDB0232429 CDS5624593 2382 + 0.283375
fnkB DDB_G0267934 DDB0232428 CDS1147906 1593 - 0.251726
fnkE DDB_G0275879 protein kinase domain similar to those of the mitogen-activated protein kinases which belong to the STE20 family contains two protein kinase domains one of which is predicted to be inactive contains several FNIP repeatsDDB0232429 CDS5838829 3966 + 0.2824
fnkF_ps DDB_G0275183 putative pseudogene STEFNIP protein kinase familyDDB0232429 CDS5290527 2628 - 0.270548
fray1 DDB_G0278863 kinase domain similar to OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232430 CDS1298188 1725 - 0.338551
fray2 DDB_G0276577 the kinase domain is similar to mammalian stress-induced STK and OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232429 CDS6994954 3087 - 0.339164
gacJJ DDB_G0290873 DDB0232432 CDS4700102 2622 + 0.300153
gacP DDB_G0279009 DDB0232430 CDS1510645 1731 + 0.317158
gbpC DDB_G0291079 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases belongs to the LRRK family of protein kinases contains LRR Roc COR RasGEF protein kinase DEP cyclic nucleotide-binding and GRAM domains involved in cGMP-mediated chemotaxis catalyzes GDP to GTP exchange on its own Roc domain translocates from cytoplasm to cell cortex after cAMP stimulation GRAM domain binds directly to plasma membraneDDB0232432 CDS4959991 7896 + 0.333967
gdt2 DDB_G0270666 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3713353 4914 - 0.252747
gdt3_ps DDB_G0285891 putative pseudogene member of the TKL (tyrosine kinase-like) group and the GDT family belongs to the MLK protein kinase familyDDB0232431 CDS3781232 5880 - 0.234014
gdt4 DDB_G0270550 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS2926042 4863 + 0.265474
gdt6 DDB_G0270544 member of the TKL (tyrosine kinase-like) group and the GDT family unlikely to function as a kinase as it does not contain a catalytic aspartate putative transmembrane proteinDDB0232428 CDS2913781 4359 + 0.274145
gdt8 DDB_G0270668 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3723386 3981 - 0.283848
gdt9 DDB_G0278879 DDB0232430 CDS1327589 4734 + 0.274398
gefX DDB_G0269298 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains RasGEF nucleotide exchange factor domainDDB0232428 CDS2476607 2883 - 0.312522
glkA DDB_G0270218 putative protein serinethreonine kinase GSK family member of the CMGC kinase group similar to Drosophila shaggy and other glycogen synthase kinasesDDB0232428 CDS4429657 1422 + 0.23699
gskA DDB_G0272110 protein serinethreonine kinase GSK family member of the CMGC kinase group essential for cell specification activated by CAR3 through ZAK1 (prespore-) and inhibited by CAR4 (prestalk-) signallingDDB0232429 CDS1334436 1404 - 0.324786
gtf2h2 DDB_G0272362 DDB0232429 CDS1296713 1386 - 0.309524
gtf2h3 DDB_G0275517 DDB0232429 CDS6059895 1119 + 0.268097
gtf2h4 DDB_G0293228 ortholog of S. cerevisiae TFB2 subunit of TFIIH and nucleotide excision repair factor 3 complexes involved in transcription initiation required for nucleotide excision repairDDB0232433 CDS2676500 1452 - 0.303719
helA DDB_G0292992 DDB0232433 CDS2367392 3276 + 0.291209
helB1 DDB_G0275443 conserved RNA helicase S. cerevisiae ortholog PRP5 is necessary for pre-spliceosome formationDDB0232429 CDS5780689 3456 - 0.335938
helB2 DDB_G0277857 conserved RNA helicase S. cerevisiae ortholog PRP28 is involved in RNA isomerization at the 5' splice siteDDB0232430 CDS776296 2505 + 0.335729
helC DDB_G0281553 DDB0232430 CDS4949807 1398 + 0.286838
helE DDB_G0281949 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS5309986 4623 - 0.237508
helF DDB_G0294407 DDB0232429 CDS2123898 2514 - 0.28043
ifdA DDB_G0269146 similar to eukaryotic translation initiation factor 4A isoform 2 DDB0232428 CDS2640023 1188 + 0.393939
iksA DDB_G0283109 similar to fungal kinases contains an IQ calmodulin-binding regionDDB0232431 CDS257953 2940 + 0.272449
iliI DDB_G0269630 belongs to a superfamily of metalloenzymes induced by Legionella pneumophila infectionDDB0232428 CDS3187028 1047 - 0.299904
iliK DDB_G0278649 belongs to a superfamily of metalloenzymes induced by Legionella pneumophila infectionDDB0232430 CDS636762 1002 + 0.336327
ino80 DDB_G0292358 similar to S. cerevisiae INO80 an ATPase that forms a large complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS1406177 6390 + 0.308607
ireA DDB_G0267650 ortholog of the yeast IRE1 serinethreonine kinaseendoribonuclease a transmembrane protein involved in the unfolded protein response contains a ribonuclease 2-5A domain and 3 pyrrolo-quinoline quinone (PQQ) domainsDDB0232428 CDS495110 2955 + 0.237902
irlA DDB_G0272987 DDB0232429 CDS2020830 4296 + 0.26513
irlB-1 DDB_G0273333 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS2539802 4347 - 0.216931
irlB-2 DDB_G0273857 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS3487559 4347 + 0.216931
irlC DDB_G0270894 the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy contains a SWIM Zn-finger domainDDB0232428 CDS3195968 4335 + 0.231834
irlD DDB_G0269632 DDB0232428 CDS3190841 4518 + 0.261399
irlE DDB_G0288803 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophyDDB0232432 CDS1985593 4053 + 0.237602
isw DDB_G0292948 similar to ISWI and mammalian SMARCA ATPases involved in nucleosome remodeling chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2254360 3666 + 0.336061
kinX DDB_G0283391 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232431 CDS749416 3285 + 0.312329
kinY DDB_G0289661 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232432 CDS3255902 1740 + 0.251149
krsA DDB_G0284181 putative protein serinethreonine kinase belongs to the protein kinase MST subfamily similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase involved in signal transduction and hyperosmotic responseDDB0232431 CDS1697612 1386 - 0.313853
krsB DDB_G0267978 putative protein serinethreonine kinase N-terminus similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase C-terminal half belongs to the peptidase C2 family contains 4 calpain III domains and has similarity to calpain-like cysteine proteaseDDB0232428 CDS1220851 3318 + 0.331826
kxcA DDB_G0289859 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains calmodulin-binding RhoGEF and pleckstrin homology (PH) domainsDDB0232432 CDS3309104 3936 + 0.256352
kxcB DDB_G0293124 kinase domain similar to those of stress-induced STK kinases contains a DH (Dbl homology) domain followed by a PH (pleckstrin homology) domain found in proteins shown to encode a GEF activity specific for Rho family membersDDB0232433 CDS2557594 3378 - 0.301066
lig1 DDB_G0274493 ATP-dependent DNA ligase required for the ligation of Okazaki fragments during lagging-strand DNA synthesisDDB0232429 CDS4400712 3579 - 0.299246
lig3 DDB_G0283857 ATP-dependent DNA ligase contains the BRCT domain which is also found in BRCA1 interacts with XRCC1DDB0232431 CDS1062604 3528 + 0.289399
lig4 DDB_G0292760 ATP-dependent DNA ligase contains the BRCT domain which is also found in BRCA1 forms a complex with XRCC4DDB0232433 CDS2052081 3267 + 0.270279
lkb1 DDB_G0279629 CAMK group CAMKL family kinase protein kinase involved in regulating both development and the stress responseDDB0232430 CDS2335074 1761 - 0.294719
lysA DDB_G0276797 contains lysin motifLysM domain may be involved in bacterial cell wall degradationDDB0232429 CDS7337818 4218 - 0.276671
lzic DDB_G0288823 DDB0232432 CDS2035104 579 + 0.26943
magA DDB_G0271050 hydrolyses alkylated adenine residues on DNA releasing 3-methyladenineDDB0232428 CDS4479608 873 - 0.279496
mcm2 DDB_G0286623 similar to MCM2 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232431 CDS4745862 3027 + 0.320449
mcm3 DDB_G0280309 similar to MCM3 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232430 CDS3235987 2604 - 0.305684
mcm4 DDB_G0275623 similar to MCM4 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232429 CDS5936245 2661 - 0.287862
mcm5 DDB_G0292958 similar to MCM5 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232433 CDS2121500 2274 - 0.329815
mcm6 DDB_G0272760 similar to MCM6 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232429 CDS2111171 2604 - 0.300307
mcm7 DDB_G0282933 similar to MCM7 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232431 CDS12867 2370 + 0.319409
mcm8 DDB_G0283009 DDB0232431 CDS149067 2439 - 0.304633
mcm9 DDB_G0286035 DDB0232431 CDS3976133 3828 + 0.299373
mekA DDB_G0269152 STE SerThr protein kinase family mitogen-activated protein kinase kinase involved in chemotaxis and early development phosphorylates the MAP kinase Erk1 (erkA) is sumoyalated by sumo and ubiquinated by mip1DDB0232428 CDS4015409 1983 - 0.252143
mf12 DDB_G0288067 DDB0232432 CDS1125741 4554 + 0.284365
mgmt DDB_G0275095 transfers methyl groups from DNA containing sup6supO-methylguanine to a cysteine residueDDB0232429 CDS5058865 618 - 0.237864
mkcA DDB_G0285427 similar to MAP cascade kinases belonging to the PAK sub-family of the STE20 serinethreonine kinases partial suppressor of tagB mutationDDB0232431 CDS3440715 2583 - 0.275648
mkcB DDB_G0290723 similar to Dictyostelium mkcA and other mitogen-activated protein kinases (Ste20PAK family) REMI mutant forms aberrant fruiting bodies see DDB0232432 CDS4499748 2145 + 0.332867
mkcC DDB_G0287853 kinase domain very similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232432 CDS826726 2676 + 0.342302
mkcD DDB_G0277413 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232429 CDS7960057 1959 + 0.291986
mkcE DDB_G0281649 kinase domain similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232430 CDS4757942 2148 + 0.271881
mkcF DDB_G0270102 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family) contains one SH3 (src Homology-3) domainDDB0232428 CDS4222376 2034 - 0.319076
mkkA DDB_G0283265 developmentally regulated MEKKDDB0232431 CDS530684 3804 + 0.287066
mlh1 DDB_G0287393 MLH1 ortholog required for DNA mismatch repairDDB0232432 CDS247623 2655 - 0.282109
mlh3 DDB_G0283883 MLH3 ortholog required for DNA mismatch repairDDB0232431 CDS1160700 4977 + 0.279687
mlkA DDB_G0279925 CAMK1 family protein kinase phosphorylates the myosin II regulatory light chain at S13 is not regulated by Ca2calmodulinDDB0232430 CDS2752719 888 - 0.317568
mnat1 DDB_G0289079 DDB0232432 CDS2330339 978 + 0.293456
mps1 DDB_G0280995 putative protein threoninetyrosine kinase similar to yeast and zebrafish mps1 (monopolar spindle) kinase a threoninetyrosine kinaseDDB0232430 CDS3923506 2952 + 0.289295
mre11 DDB_G0293546 similar to S. cerevisiae MRE11 involved in processing double-strand DNA breaks with Rad50 in other organisms Mre11 is part of a complex with Rad50 and Nbs1 no Nbs1 ortholog has been found in Dictyostelium DDB0232433 CDS3016431 2070 + 0.304348
mrkA DDB_G0292304 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains 1 kinase-associated (KA1) domain and 1 UBA domainDDB0232433 CDS1433748 3183 - 0.286836
mrkB DDB_G0285643 CAMKL family protein kinase similar to SNF1 kinases MARK kinases and AMPK kinasesDDB0232431 CDS3523048 2148 - 0.284916
mrkC DDB_G0281895 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains C-terminal kinase associated domain 1DDB0232430 CDS5083659 2322 + 0.295866
msh1 DDB_G0275999 similar to bacterial mismatch repair protein MutS putative mitochondrial mismatch repair proteinDDB0232429 CDS6158412 2697 - 0.251761
msh2 DDB_G0275809 DDB0232429 CDS5513128 2814 - 0.297797
msh3 DDB_G0281683 DDB0232430 CDS4806161 4287 + 0.292279
msh4 DDB_G0283957 DDB0232431 CDS1370478 3126 - 0.240883
msh5 DDB_G0284747 DDB0232431 CDS2423376 2643 - 0.239879
msh6 DDB_G0268614 DDB0232428 CDS238722 3783 + 0.335977
mus81 DDB_G0276519 similar to endonuclease Mus81 conserved from yeast to human involved in DNA repair and replication fork stabilityDDB0232429 CDS7009387 2763 - 0.239595
myh DDB_G0270764 ortholog of MYH which removes misincorporated adenine residues opposite template 8-oxoguanine during DNA replicationDDB0232428 CDS4483000 1725 + 0.262029
ndrA DDB_G0278457 member of the AGC kinases NDR group localizes to centrosomes and to the spindle during prometaphase and is involved in phagocytosisDDB0232430 CDS907158 1593 + 0.344633
ndrB DDB_G0288753 member of the AGC kinase group similar to NDR protein kinases including yeast morphogenesis proteins ORB6 and CBK1DDB0232432 CDS1909293 1629 - 0.324125
ndrC DDB_G0284839 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinases DDB0232431 CDS2493584 3939 + 0.307692
ndrD DDB_G0289543 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinasesDDB0232432 CDS2920470 6339 + 0.255088
nek2 DDB_G0270814 protein serinethreonine kinase homologous to human Nek2 kinase involved in formation of microtubule-organizing centers (MTOCs)DDB0232428 CDS4847143 1257 - 0.258552
nek3 DDB_G0275241 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosis not a human Nek3 homologDDB0232429 CDS4983790 3372 - 0.269276
nek4 DDB_G0289277 similar to vertebrate Nek kinases which are involved in regulation of mitosis most similar to Nek4DDB0232432 CDS2561379 1494 - 0.222222
ogg1 DDB_G0292618 similar to E. coli MutM and OGG1 a bifunctional DNA glycosylase that contains an activity that excises 8-oxoguanine and other derivatives of guanine from DNA and a beta-lyase activity that nicks DNA 3' of the lesionDDB0232433 CDS1847428 1320 - 0.258333
orcA DDB_G0283073 DNA replication initiation is driven by a conserved six protein complex the origin recognition complex (ORC) has a role in both chromosomal replication and mating type transcriptional silencingDDB0232431 CDS182130 1896 - 0.2827
orcB DDB_G0269894 DNA replication initiation is driven by a conserved six protein complex the origin recognition complex (ORC) has a role in both chromosomal replication and mating type transcriptional silencingDDB0232428 CDS3810811 1176 + 0.256803
orcD DDB_G0271562 DNA replication initiation is driven by a conserved six protein complex the origin recognition complex (ORC) has a role in both chromosomal replication and mating type transcriptional silencingDDB0232429 CDS681736 1323 + 0.226757
pXi DDB_G0289119 CAMK group protein serinethreonine kinaseDDB0232432 CDS2420542 2076 - 0.25289
pakA DDB_G0269166 STE20PAKA protein kinase involved in the regulation of the cytoskeleton during chemotaxis and required for cytokinesis contains PAK-boxP21-Rho-binding (CRIB) domain found in the WASP C-terminalDDB0232428 CDS3436536 3594 + 0.33222
pakB DDB_G0276459 protein serinethreonine kinase that phosphorylates myoD (myosin ID) and myoK (myosin IK) heavy chains similar to p21-activated kinase belongs to the STE20 family PAKA subfamily of protein kinasesDDB0232429 CDS6847900 2559 - 0.339195
pakC DDB_G0267450 STE20PAK protein kinase required for normal chemotaxis contains PAK-boxP21-Rho-binding (CRIB) domain and pleckstrin homology (PH) domainDDB0232428 CDS229145 1434 - 0.33682
pakD DDB_G0269696 similar to Dictyostelium pakA and other mitogen-activated protein kinases (Ste20PAK family) putative p21-activated kinase contains a calponin-like actin-binding domain a p21-Rho-binding domain and a PKC conserved region 1 (C1) regulates the actin cytoskeleton response during chemotaxis to cAMPDDB0232428 CDS3345400 5037 + 0.25273
pakE DDB_G0293932 putative protein serinethreonine kinase belongs to the PAKL subfamily of protein kinases the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS3512665 2781 + 0.270766
pakF DDB_G0274409 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS4648326 3531 - 0.282073
pakG DDB_G0282891 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232430 CDS6346144 3540 + 0.284181
pakH-1 DDB_G0273121 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamily stress-responsive kinase there is a second copy of this gene DDB0232429 CDS2532742 1542 + 0.282101
pakH-2 DDB_G0273865 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamilystress-responsive kinase there is a second copy of this gene DDB0232429 CDS3497296 1542 - 0.282101
pats1 DDB_G0269250 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 and protein kinase domainsDDB0232428 CDS2657392 9555 - 0.289901
pcna DDB_G0287607 DDB0232432 CDS463300 777 - 0.352638
pdkA DDB_G0281471 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232430 CDS4550105 2061 - 0.273654
pdkB DDB_G0284489 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232431 CDS2038480 2727 + 0.260726
pfdn3 DDB_G0286473 DDB0232431 CDS4502996 588 - 0.268707
phg2 DDB_G0283699 serinethreonine kinase regulating cell substrate adhesion phagocytosis motility and actin organization member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS995559 4164 - 0.304275
pich DDB_G0288873 ortholog of human DNA excision repair protein ERCC-6-like (ERCC6L)br bCommunity annotation:b DDB_G0288873 but not ercc6 is strongly overexpressed (6x) in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted. Most cells involved in S-phase or mitosis are overexpressed in this strain. Ercc6-like is an essential component of the spindle checkpoint which localizes to the kinetochore in prometaphase it is found on thin threads that stretch between sister kinetochores. It is thought to function as part of the tension sensor the functional core of the spindle checkpoint [see Baumann et al Cell 128 101-114 (2007)]. Other spindle checkpoint components are strongly overexpressed in the rblA null. This suggests that DDB_G0288873 may actually code for the spindle tension sensor in Dicty. Harry MacWilliams May 2010br DDB0232432 CDS2065550 3999 - 0.295074
pif1 DDB_G0277925 very similar to the conserved DNA helicase PIF1 in S. cerevisiae involved in telomere formation and elongationDDB0232430 CDS12156 2010 - 0.283582
pikA DDB_G0278727 DDB0232430 CDS1154369 4716 + 0.261026
pikB DDB_G0283081 DDB0232431 CDS247398 5574 - 0.311805
pikC DDB_G0275011 DDB0232429 CDS5211773 5094 + 0.270907
pikD DDB_G0288485 subunit of PI4K responsible for the phosphorylation of phosphatidylinositol (PI) to PI4P (ATP 1-phosphatidyl-1D-myo-inositol ADP 1-phosphatidyl-1D-myo-inositol 4-phosphate) the first committed step in the generation of phosphatidylinositol 45-bisphosphate (PIP2) a precursor of the second messenger inositol 145-trisphosphate (InsP3)DDB0232432 CDS1616073 3543 + 0.269828
pikE DDB_G0289601 ortholog of yeast VPS34 a phosphatidylinositol 3-kinaseDDB0232432 CDS3005109 2451 - 0.299878
pikF DDB_G0268548 putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring has the capacity to bind and be activated by the GTP-bound small GTPase rasDDB0232428 CDS1099622 4149 + 0.291396
pikG DDB_G0282625 putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring has the capacity to bind and be activated by the GTP-bound small GTPase rasDDB0232430 CDS6013022 5016 - 0.234649
pikH DDB_G0291093 putative PI3k putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring unlike other PI3Ks does not contain a ras binding domain but a PH domain and does not localize to the cell cortex upon chemotactic stimulationDDB0232432 CDS4980832 5463 - 0.242541
pkaC DDB_G0283907 AGC group PKA family protein kinase protein serinethreonine kinase regulates spore cell differentiationDDB0232431 CDS1394958 1947 + 0.333847
pkaD DDB_G0277145 DDB0232429 CDS7643321 2145 - 0.253613
pkbA DDB_G0268620 AGC group AKT family protein serinethreonine kinase similar to other metazoan AktPKB including an N-terminal PH domain homologous kinase and C-terminal regulatory domains and phosphorylation sites required for AktPKB activationDDB0232428 CDS1977388 1335 + 0.357303
pkgA DDB_G0276157 serinethreonine protein kinase of the MAST (Microtubule Associated SerineThreonine kinase) familyDDB0232429 CDS6275918 4104 - 0.287037
pkgB DDB_G0290157 AGC group protein serinethreonine kinase cAMP-activated protein kinase involved in morphogenesis during multicellular developmentDDB0232432 CDS3717777 1440 - 0.324306
pkgC DDB_G0286125 serinethreonine protein kinase of the AGC group similar to mammalian ribosomal protein S6 kinaseDDB0232431 CDS4067973 2733 - 0.312843
pkgD DDB_G0284029 AGC group protein serinethreonine kinase similar to cAMP-activated protein kinase catalytic subunitsDDB0232431 CDS1459718 2979 - 0.28231
pkgE_ps DDB_G0280981 putative pseudogene similar to AGC protein kinases of the AKT familyDDB0232430 CDS3912677 1095 + 0.343379
plk DDB_G0274503 putative protein serinethreonine kinase similar to yeast CDC5 Drosophila polo and mammalian PLK which play a role in mitosis and localize to the centrosomesDDB0232429 CDS4379150 2937 - 0.280899
pms1 DDB_G0283981 ortholog of H. sapiens PMS2 and S. cerevisiae PMS1 required for DNA mismatch repairDDB0232431 CDS1418066 3069 - 0.273053
polA DDB_G0267464 contains one 5'-3' exonuclease domain and one 3'-5' exonuclease domainDDB0232428 CDS1469084 4110 - 0.29708
polA1 DDB_G0282191 ortholog of the catalytic subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replicationDDB0232430 CDS5500018 4530 + 0.305519
polA2 DDB_G0282731 ortholog of the B subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replicationDDB0232430 CDS6220731 1872 + 0.280983
polA3 DDB_G0270442 ortholog of the DNA primase large subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replicationDDB0232428 CDS4882826 1413 - 0.279547
polA4 DDB_G0285853 ortholog of the DNA primase small subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replicationDDB0232431 CDS3724070 1230 - 0.281301
polB DDB_G0284713 similar to yeast Pol4 and mammalian DNA polymerase beta involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ)DDB0232431 CDS2376164 1530 - 0.261438
polD1 DDB_G0285381 required for chromomsomal DNA replication contains a polymerase and a 3'-5' exonuclease domainDDB0232431 CDS3206066 3315 - 0.332428
polD2 DDB_G0281641 DDB0232430 CDS4748825 1566 - 0.288633
prpf4B DDB_G0279703 protein serinethreonine kinase DYRK family member of the CMGC kinase group similar to mammalian pre-mRNA processing factor PRP4 kinase and DYRK kinasesDDB0232430 CDS2466144 2436 + 0.296388
pyk3 DDB_G0289001 member of the TKL (tyrosine kinase-like) group and the DPYK (Dictyostelium protein tyrosine kinase) family of protein kinases contains two kinase domains one of which is predicted to be inactive the C-terminal kinase domain has tyrosine kinase activitybr bCommunity annotation:b Pyk3 appears to be involved in differentiation pathway choice as the KO shows reduced pstO differentiation and compensatory expansion of the prespore region. Pyk3 has been proposed to act in a pathway involving ptpC and statC effectively potentiating the action of DIF-1. One of the factors that influences pathway choice is cell cycle position classic experiments show that cold-synchronized cells which enter development shortly after warming prefer the stalk pathway. This is due to an increased DIF sensitivity. New results (Strasser Tsang and MacWilliams in preparation) now show that the pyk3 transcript is upregulated roughly fivefold after cold synchronization at a time when cells show strong stalk preference (pDDB0232432 CDS2269413 4017 - 0.283047
qkgA-1 DDB_G0273259 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS2831844 4662 + 0.27885
qkgA-2 DDB_G0273635 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS3195191 4662 - 0.27885
rad17 DDB_G0292504 similar to S. pombe and H. sapiens RAD17 and S. cerevisiae RAD24 component of Rad17-RFC complex which loads the 9-1-1 (Rad9-Rad1-Hus1) complex onto damaged DNADDB0232433 CDS1748396 3576 + 0.245526
rad50 DDB_G0292786 similar to S. cerevisiae RAD50 involved in processing double-strand DNA breaks with Mre11 in other organisms Rad50 is part of a complex with Mre11 and Nbs1 no Nbs1 ortholog has been found in Dictyostelium DDB0232433 CDS2029933 4056 + 0.272189
rad51-1 DDB_G0273139 ortholog of Rad51 which is involved in activation of homologous recombination and double-strand break repair and interacts with XRCC3 there is a second copy of this gene DDB0232429 CDS2861364 1056 - 0.344697
rad51-2 DDB_G0273611 ortholog of Rad51 which is involved in activation of homologous recombination and double-strand break repair and interacts with XRCC3 there is a second copy of this gene DDB0232429 CDS3169189 1056 + 0.344697
rad52 DDB_G0269406 DDB0232428 CDS2715190 906 - 0.364238
rad54 DDB_G0282997 similar to RAD54 DNA repair protein chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS118731 2796 + 0.33226
rad54b DDB_G0285117 similar to RAD54b DNA repair protein chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS2873116 2970 - 0.278788
rcdII DDB_G0284041 DDB0232431 CDS1500251 1395 - 0.26595
rckA DDB_G0278737 member of the TKL (tyrosine kinase-like) group contains an RGS (Regulator of G protein Signaling) domainDDB0232430 CDS1218919 3378 + 0.261693
recA DDB_G0276073 similar to recombinase A proteins found in bacteria and in A. thaliana plays a role in DNA repairDDB0232429 CDS6430683 1359 - 0.288447
repB DDB_G0278729 ortholog of H. sapiens xeroderma pigmentosum group B (XPB) M. musculus ERCC3 and S. cerevisiae RAD25 upregulated in the presence of DNA damaging agentsDDB0232430 CDS1389108 2403 + 0.33042
repD DDB_G0267414 ortholog of H. sapiens xeroderma pigmentosum group D (XPD) M. musculus ERCC2 and S. cerevisiae RAD3DDB0232428 CDS833130 2331 - 0.33891
repG DDB_G0284987 similar to H. sapiens xeroderma pigmentosum group G (XPG) M. musculus ERCC5 and S. pombe RAD2 cleaves 5' overhang flap structure generated when DNA polymerase encounters the 5'end of a downstream Okazaki fragment DDB0232431 CDS2762877 1155 - 0.309091
rev3 DDB_G0271608 ortholog of DNA polymerase zeta catalytic subunit involed in DNA repairDDB0232429 CDS480277 8106 + 0.253886
rexo4 DDB_G0281327 DDB0232430 CDS4193116 897 + 0.235229
rfa1 DDB_G0289513 DDB0232432 CDS2891660 2040 + 0.320098
rfc1 DDB_G0285961 ortholog of H. sapiens RFC 140 kDa subunitDDB0232431 CDS3845828 4206 + 0.3136
rfc2 DDB_G0291868 ortholog of H. sapiens RFC2 (40 kDa subunit) and S. cerevisiae RFC2DDB0232433 CDS850606 1017 + 0.328417
rfc3 DDB_G0293702 ortholog of H. sapiens RFC3 (38 kDa subunit) and S. cerevisiae RFC5DDB0232433 CDS3014705 1044 - 0.331418
rfc4 DDB_G0286027 ortholog of H. sapiens RFC4 (37 kDa subunit) and S. cerevisiae RFC2DDB0232431 CDS3966261 1044 + 0.314176
rfc5 DDB_G0282235 ortholog of H. sapiens RFC5 (36 kDa subunit) and S. cerevisiae RFC3DDB0232430 CDS5553806 1044 + 0.267241
rnaseh2A DDB_G0292584 catalytic subunit of RNase HII an endonuclease that specifically degrades the RNA of RNA:DNA hybrids defects in H. sapiens RNASEH2A cause Aicardi-Goutieres syndrome type 4 a genetically heterogeneous autosomal recessive encephalopathyDDB0232433 CDS1802425 870 - 0.287356
roco11 DDB_G0268636 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232428 CDS2199646 4464 + 0.267473
roco4 DDB_G0288251 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232432 CDS1284583 5181 + 0.332947
roco5 DDB_G0294533 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains RhoGEF PH LRR Roc COR and protein kinase domainsDDB0232432 CDS1439427 8403 - 0.309413
roco6 DDB_G0279417 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 PH and protein kinase domainsDDB0232430 CDS2094570 6444 + 0.293451
roco7 DDB_G0267472 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains Roc COR WD40 and protein kinase domains related to LRR-containing kinases but does not contain an LRR domainDDB0232428 CDS628403 7848 - 0.293833
roco8 DDB_G0286127 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains DEP LRR Roc COR and protein kinase domainsDDB0232431 CDS4112361 5604 - 0.267131
roco9 DDB_G0288183 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases contains RhoGAP LRR Roc Cor and protein kinase domainsDDB0232432 CDS1219231 10098 - 0.264706
rpa49 DDB_G0290909 component of the RNA polymerase I complex weakly similar to S. cerevisiae RPA49 and M. musculus RNA polymerase I associated factor 53DDB0232432 CDS4737794 1128 + 0.265957
rrpA DDB_G0289659 DDB0232432 CDS3196021 7254 + 0.263441
rrpB DDB_G0291249 one of the three D. discoideum RNA-directed RNA polymerases for which a distinct function has not yet been identifiedDDB0232433 CDS442657 7212 - 0.266916
rrpC DDB_G0280963 RNA-directed RNA polymerase involved in RNA interference and the production of siRNA also involved in the metabolism of other miRNAsDDB0232430 CDS3986737 6858 + 0.247302
samkA DDB_G0269876 DDB0232428 CDS3775693 1923 + 0.228289
samkB DDB_G0284859 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232431 CDS2549067 1782 + 0.251403
samkB_ps1 DDB_G0270988 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232428 CDS3791042 1593 - 0.264909
samkC DDB_G0270678 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232428 CDS3778203 2628 + 0.251903
samkD DDB_G0270680 similar to SNF1-like kinases unlikely to function as a kinase as it lacks the catalytic aspartateDDB0232428 CDS3781297 1662 + 0.197954
samkE_ps1 DDB_G0283165 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232431 CDS352482 1272 - 0.26022
sepA DDB_G0276465 plays a role in the regulation of cleavage furrow formation similar to S. pombe cdc7DDB0232429 CDS6942806 3504 + 0.32363
shkA DDB_G0283267 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domain negative regulator of phosphoinositol signalingDDB0232431 CDS438511 1584 + 0.318182
shkB DDB_G0288617 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS1745652 1962 - 0.331295
shkC DDB_G0278409 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS836437 1521 - 0.332676
shkD DDB_G0281343 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS4376038 2235 + 0.314541
shkE DDB_G0290451 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS4058161 2133 + 0.284107
sky1 DDB_G0275627 similar to SRPKs (Serinearginine-Rich Protein specific Kinases) serinethreonine kinases that specifically phosphoryate arginine-serine rich domains found in the SR family of splicing factorsDDB0232429 CDS5951942 1971 - 0.318113
smg1 DDB_G0275845 atypical PIKK family protein kinase similar to the PI-3-kinase-related kinase SMG1 which functions in nonsense-mediated mRNA decay belongs to the PIKK family of protein kinasesDDB0232429 CDS5665840 7035 + 0.267235
snf2a DDB_G0285205 SNF2 family protein similar to human SMARCA4 putative regulator of chromatinDDB0232431 CDS2921996 4815 + 0.304673
snf2b DDB_G0271052 SNF2 family protein similar to human SMARCA4 putative regulator of chromatinDDB0232428 CDS4502537 9744 - 0.313218
snfA DDB_G0277905 CAMKL family protein kinase catalytic subunit of the AMP-activated protein kinase (AMPK) complex similar to SNF1 kinases and AMPK experiments in Dictyostelium show that AMPK signaling plays an important role in mitochondrial disease.DDB0232430 CDS589784 2184 + 0.250458
spkA-1 DDB_G0273445 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS2969377 1917 - 0.310381
spkA-2 DDB_G0273531 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS3060166 1917 + 0.310381
splA DDB_G0283385 dual-specificity protein kinase involved in spore coat formation and morphogenesis member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) familyDDB0232431 CDS623097 7233 + 0.323655
splB DDB_G0285321 member of the TKL (tyrosine kinase-like) group activates the transcriptional regulator STATcDDB0232431 CDS3131349 3468 + 0.27797
spt16 DDB_G0282677 similar to SPT16 of the FACT complex a heterodimer of ssrp1 and spt16 the FACT complex is a general chromatin factor that acts to reorganize nucleosomes involved in multiple processes that require DNA as a template such as mRNA elongation DNA replication and DNA repairDDB0232430 CDS6105920 3219 - 0.339546
spt16_ps DDB_G0282775 putative pseudogene similar to D. discoideum gene DDB0232430 CDS5907328 582 + 0.359107
sqpA DDB_G0277873 DDB0232430 CDS467909 2169 + 0.244813
ssrp1 DDB_G0290331 ortholog of the SSRP1 component of the FACT complex a heterodimer of ssrp1 and spt16 the FACT complex is a general chromatin factor that acts to reorganize nucleosomes involved in multiple processes that require DNA as a template such as mRNA elongation DNA replication and DNA repairDDB0232432 CDS3969916 1584 - 0.342172
sun1 DDB_G0272869 localizes to the inner and outer nuclear membrane mediates the attachment between centrosome and nucleus associates the centromere cluster with the centrosome and stabilizes the genome during mitosis contains one transmembrane domainDDB0232429 CDS2057584 2718 - 0.270419
svkA DDB_G0286359 very similar to mammalian ST25 kinase (SOK1) and other STE20-like kinases stress-responsive kinase phosphorylates severin essential for cell separation during cytokinesisDDB0232431 CDS4476218 1437 + 0.343076
thoc7 DDB_G0275979 ortholog of THOC7 which exists in the THO complex required for transcriptional elongationDDB0232429 CDS6151550 648 + 0.225309
tifA DDB_G0269192 similar to eukaryotic initiation factor 4A isoform 3DDB0232428 CDS3537960 1218 + 0.316092
tmem120 DDB_G0288699 conserved transmembrane protein contains 4 putative transmembrane domainsDDB0232432 CDS1842289 1107 - 0.311653
top1 DDB_G0283205 ortholog of TOP1 a nuclear topoisomerase responsible for relaxing single-stranded supercoiled DNADDB0232431 CDS416900 2682 + 0.35123
top2 DDB_G0270418 controls the topological state of DNA by transient double-strand breakage and subsequent rejoining of DNA strands this is predicted to be a nuclear topoisomerase IIDDB0232428 CDS4831688 4566 - 0.329172
top2mt DDB_G0279737 controls the topological state of DNA by transient double-strand breakage and subsequent rejoining of DNA strands Top2mt has been shown to be localized to the mitochondriaDDB0232430 CDS2512313 3855 - 0.284566
top3 DDB_G0275257 ortholog of TOP3 a nuclear topoisomerase responsible for relaxing single-stranded negatively-supercoiled DNADDB0232429 CDS5038466 2487 - 0.300362
tor DDB_G0281569 atypical PIKK family FRAP subfamily protein kinase ortholog of tor a protein kinase that plays a central role in response to nutrients stress and intracellular energy state called mTOR in mammals in dTOR in Drosophila DDB0232430 CDS4934791 7143 - 0.347893
trmt11 DDB_G0283969 DDB0232431 CDS1400103 1524 + 0.270341
tsuA DDB_G0267962 putative protein serinethreonine kinase similar to mammalian STK36 and fly fused kinase (fu) a ST kinase involved in the hedgehog signal transduction pathway belongs to the ULK (Unc-51-like kinase) family of kinasesDDB0232428 CDS1191800 6744 + 0.248517
u2af1 DDB_G0285077 small subunit of the U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) which is a splicing factor that forms a heterodimer with DDB0232431 CDS2799520 1416 + 0.366525
uap56 DDB_G0269932 conserved splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint the human ortholog (BAT1) forms a homodimer and interacts directly with DDB0232428 CDS3893359 1287 - 0.359751
uglA DDB_G0277877 DDB0232430 CDS330250 1041 + 0.332373
uglB DDB_G0273013 DDB0232429 CDS2160250 1794 - 0.230769
upf1 DDB_G0288923 ortholog of yeast NAM7 and the mammalian UPF1 (up-frameshift suppressor 1) or RENT1 protein part of a post-splicing multiprotein complex and involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codonsDDB0232432 CDS2130048 3996 + 0.318068
vilC DDB_G0271058 belongs to the villingelsolin family contains 5 gelsolin-like repeats and one villin headpiece domainDDB0232428 CDS4570908 4587 - 0.297362
vinB DDB_G0281499 DDB0232430 CDS4621318 5355 + 0.320635
vps15 DDB_G0282627 putative protein serinethreonine kinase similar to human PIK3R4 and yeast VPS15 which regulate the phosphatidylinositol 3 kinase VPS34 (hVps34) yeast VPS15VPS34 complex known to be involved in vacuolar protein sortingDDB0232430 CDS6019111 5901 + 0.306219
vti1A DDB_G0292974 DDB0232433 CDS2202494 654 - 0.281346
wrn DDB_G0268512 E. coli ATP-dependent DNA helicase RecQ is involved in genome maintenance this is the ortholog of the H. sapiens Werner syndrome protein defects in WRN cause the premature onset of multiple age-related disordersDDB0232428 CDS769229 3411 - 0.230431
wrnip1 DDB_G0272158 ortholog of Werner helicase-interacting protein 1 a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesisDDB0232429 CDS1585133 2631 + 0.302547
xpc DDB_G0292296 DDB0232433 CDS1414792 2904 + 0.266529
xpf DDB_G0284419 DDB0232431 CDS1971161 2895 + 0.245596
xrcc2 DDB_G0290297 putative ortholog of XRCC2 which is involved in double-strand break repair interacts with RAD51DDB0232432 CDS3921390 1167 + 0.251928
xrcc3 DDB_G0283637 putative ortholog of XRCC3 which is involved in double-strand break repair interacts with RAD51DDB0232431 CDS893273 1695 + 0.220059
xrn1 DDB_G0276137 DDB0232429 CDS6232603 5250 - 0.333333
xrn2 DDB_G0269922 DDB0232428 CDS3871046 3573 - 0.285195
yakA DDB_G0283605 belongs to the CMGC group of protein kinases putative protein serinethreonine kinaseDDB0232431 CDS868454 4377 + 0.303404
ybl1 DDB_G0272222 member of the histone H2A-H2B sub-family related to the NF-YB subunit of the CCAAT-binding activator NF-YDDB0232429 CDS1710917 417 - 0.297362
zak2 DDB_G0276187 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL group highly similar to zakA and has overlapping function with zakA shown to be a tyrosine kinase and regulator of GSK3 also regulates pattern formation during development via dstC (STATc) signalingDDB0232429 CDS6396810 1908 - 0.253145
zakA DDB_G0276025 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL groupDDB0232429 CDS6393550 2346 - 0.239983