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2024-05-19 16:48:15

Gene list

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COG category: Transcription
Organism: Dictyostelium discoideum AX4, AX4

Number of genes found: 473

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0267514 DDB_G0267514 DDB0232428 CDS259066 2751 - 0.28426
DDB_G0267556 DDB_G0267556 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232428 CDS327145 3480 - 0.281034
DDB_G0267566 DDB_G0267566 putative protein serinethreonine kinase contains an ankyrin repeat domain similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS343868 2535 - 0.244181
DDB_G0267638 DDB_G0267638 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232428 CDS464992 9210 + 0.282953
DDB_G0267686 DDB_G0267686 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains an RGS (Regulator of G protein Signaling) domainDDB0232428 CDS564277 6693 - 0.276109
DDB_G0267772 DDB_G0267772 DDB0232428 CDS824718 237 + 0.198312
DDB_G0268078 DDB_G0268078 DDB0232428 CDS1417972 1524 + 0.281496
DDB_G0268186 DDB_G0268186 DDB0232428 CDS1622398 4515 - 0.242968
DDB_G0268266 DDB_G0268266 DDB0232428 CDS233800 2070 + 0.257005
DDB_G0268486_ps DDB_G0268486 putative pseudogene contains protein kinase domainDDB0232428 CDS498516 2820 - 0.22305
DDB_G0268506 DDB_G0268506 DDB0232428 CDS663020 3363 - 0.237288
DDB_G0268656 DDB_G0268656 highly similar to human ULK (Unc51-like kinase) does not contain the full consensus sequence required for kinase functionDDB0232428 CDS1863917 954 - 0.220126
DDB_G0268876 DDB_G0268876 member of the TKL (tyrosine kinase-like) group of protein kinases contains filamin repeat similar to ABP120DDB0232428 CDS2297918 4158 - 0.279702
DDB_G0269286 DDB_G0269286 DDB0232428 CDS2451692 3708 - 0.242988
DDB_G0269628 DDB_G0269628 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS3183487 2214 - 0.303975
DDB_G0269986 DDB_G0269986 DDB0232428 CDS3977474 2391 + 0.24634
DDB_G0270146 DDB_G0270146 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232428 CDS4304005 1908 - 0.287212
DDB_G0270156 DDB_G0270156 DDB0232428 CDS4329080 2703 - 0.27488
DDB_G0271402 DDB_G0271402 DDB0232429 CDS241165 2298 + 0.309835
DDB_G0271538 DDB_G0271538 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family expressed in pstO cellsDDB0232429 CDS568653 1584 - 0.285985
DDB_G0271550 DDB_G0271550 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS634463 1179 + 0.267176
DDB_G0271682 DDB_G0271682 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains two kinase domains one of which is predicted to be inactiveDDB0232429 CDS792553 3075 + 0.247154
DDB_G0271690 DDB_G0271690 DDB0232429 CDS763571 2349 + 0.286505
DDB_G0271948 DDB_G0271948 DDB0232429 CDS1006829 2154 + 0.221913
DDB_G0272014 DDB_G0272014 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family similar to human AADAT (kynureninealpha-aminoadipate aminotransferase) and S. cerevisiae ARO8 (aromatic amino acid aminotransferase)DDB0232429 CDS1172213 1446 - 0.278008
DDB_G0272056 DDB_G0272056 putative ortholog of H. sapiens CNOT3 and S. cerevisiae NOT3 component of the CCR4-NOT transcription complexDDB0232429 CDS1115108 2601 + 0.329489
DDB_G0272082 DDB_G0272082 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232429 CDS1245702 5517 + 0.237992
DDB_G0272092 DDB_G0272092 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains a C2 domain (Ca2-dependent membrane-targeting module) an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232429 CDS1251605 2961 - 0.296184
DDB_G0272108 DDB_G0272108 shares a short region of similarity with the splicing regulator TIA-1 REMI mutant forms aberrant fruiting bodies see DDB0232429 CDS1281320 1410 - 0.274468
DDB_G0272254 DDB_G0272254 member of the TKL (tyrosine kinase-like) group contains a galactose oxidase central domain and three Kelch motifsDDB0232429 CDS1396081 3996 - 0.264765
DDB_G0272282 DDB_G0272282 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) and MAST (microtubule-associated serinethreonine kinase)DDB0232429 CDS1572926 6309 + 0.272468
DDB_G0272740 DDB_G0272740 bCommunity annotation:b DDB_G0272740 is similar to histone2a-related transcription factors of the Hap5CBFNF-Y family which bind to the subsequence CCAAT and is threefold upregulated (p3E-7) in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted (Doquang et al in preparation). Most genes associated with S-phase or mitosis are upregulated in this strain. This is is consistent with the idea that factors of the the Hap5CBFNF-Y factors are involved in cell cycle progression in Dictyostelium as they are in animal cells. Harry MacWilliams September 2009br Closer examination of the blast results suggests that this gene does NOT code for an NF-Y subunit. Real orthologs to DDB_G0272740 do seem to occur in some fungi for instance Aspergillis and Ajellomyces although there are none in budding yeast. Insects also have a protein that is much more closely related to DDB_G0272740 than it is to nfyC it is called chrac-16 and is a component of the chromatin accessibility complexDDB0232429 CDS2228582 477 + 0.283019
DDB_G0272797 DDB_G0272797 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS2368968 2043 - 0.313754
DDB_G0273053 DDB_G0273053 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog there is a second copy of this gene DDB0232429 CDS2288541 4557 - 0.250384
DDB_G0274007 DDB_G0274007 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS3660427 2043 + 0.313754
DDB_G0274075 DDB_G0274075 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog there is a second copy of this gene DDB0232429 CDS3738689 4557 + 0.250384
DDB_G0274523 DDB_G0274523 DDB0232429 CDS4286028 2715 - 0.239779
DDB_G0274613 DDB_G0274613 kinase domain similar to mitogen-activated protein kinases does not contain the consensus sequences known to be required for kinase function contains a RING zinc finger domainDDB0232429 CDS4893134 2496 - 0.260417
DDB_G0274821 DDB_G0274821 DDB0232429 CDS3992986 2565 - 0.181287
DDB_G0274965 DDB_G0274965 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232429 CDS4676573 4203 - 0.281704
DDB_G0275005 DDB_G0275005 putative ortholog of H. sapiens CNOT4 and S. cerevisiae MOT2 component of the CCR4-NOT transcription complexDDB0232429 CDS4898014 4461 + 0.30195
DDB_G0275057 DDB_G0275057 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS5089988 1050 + 0.33619
DDB_G0275165 DDB_G0275165 DDB0232429 CDS5143836 2766 - 0.298988
DDB_G0275375 DDB_G0275375 DDB0232429 CDS5469261 5103 - 0.22477
DDB_G0275409 DDB_G0275409 DDB0232429 CDS5421845 2214 + 0.247967
DDB_G0275509 DDB_G0275509 DDB0232429 CDS6023716 2607 + 0.197929
DDB_G0275993 DDB_G0275993 DDB0232429 CDS6150629 687 - 0.227074
DDB_G0276029 DDB_G0276029 putative ortholog of H. sapiens CNOT1 and S. cerevisiae CDC39 REMI mutant forms aberrant fruiting bodies (see DDB0232429 CDS6435703 7581 - 0.303654
DDB_G0276117 DDB_G0276117 DDB0232429 CDS6262508 615 - 0.21626
DDB_G0276181 DDB_G0276181 member of the TKL (tyrosine kinase-like) group of protein kinases contains a PH (pleckstrin homology) domainDDB0232429 CDS6410071 4668 - 0.262853
DDB_G0276461 DDB_G0276461 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232429 CDS6904331 2397 - 0.267418
DDB_G0276567 DDB_G0276567 homolog of S. cerevisiae CDC50 (cell division control protein 50) which is required for polarized cell growth contains two putative transmembrane domainsDDB0232429 CDS6951075 939 - 0.292865
DDB_G0277165 DDB_G0277165 CAMKL family protein kinase the protein kinase domain is similar to those of the CAMKLBRSK subfamily which are named based on brain-specific expression in human and neuronal expression in wormDDB0232429 CDS7893420 2502 - 0.271783
DDB_G0277353 DDB_G0277353 DDB0232429 CDS7808700 1902 - 0.325973
DDB_G0277449 DDB_G0277449 member of the AGC kinase group similar to kinase domains of SGK (serum and glucocorticoid responsive kinase) AktPKB and RSK (ribosomal S6 kinase) family membersDDB0232429 CDS8121319 1371 + 0.300511
DDB_G0277539 DDB_G0277539 putative protein tyrosine kinase similar to human wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232429 CDS8010617 2997 - 0.248248
DDB_G0278087_ps DDB_G0278087 putative pseudogene containing a partial protein kinase domain and a partial ankyrin repeatDDB0232430 CDS256195 1557 - 0.285806
DDB_G0278487 DDB_G0278487 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases belongs to the CMGC group of protein kinasesDDB0232430 CDS959760 1911 + 0.288854
DDB_G0278509 DDB_G0278509 DDB0232430 CDS984753 3747 + 0.238858
DDB_G0278521 DDB_G0278521 member of the TKL (tyrosine kinase-like) group the MLK (mixed lineage kinase) family and the HH498 subfamily contains an ankyrin repeatDDB0232430 CDS1000912 2727 - 0.226989
DDB_G0278535 DDB_G0278535 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232430 CDS1034770 2547 + 0.329407
DDB_G0278665 DDB_G0278665 DDB0232430 CDS753135 3273 - 0.31103
DDB_G0278757 DDB_G0278757 DDB0232430 CDS1123519 4032 - 0.308532
DDB_G0278845 DDB_G0278845 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) family membersDDB0232430 CDS1269374 4053 - 0.265976
DDB_G0278901 DDB_G0278901 DDB0232430 CDS1361340 4488 - 0.282308
DDB_G0278909 DDB_G0278909 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains an N-terminal LRR and a C-terminal armadillobeta-catenin repeat unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS1376167 5811 + 0.293581
DDB_G0278937 DDB_G0278937 DDB0232430 CDS1214678 2715 + 0.271455
DDB_G0279405 DDB_G0279405 CAMKL family protein kinase the protein kinase domain has similarity to those of calciumcalmodulin-dependent protein kinase kinases (CAMKK) that belong to a proposed calcium-triggered signaling cascade involved in a number of cellular processesDDB0232430 CDS1975813 2088 + 0.290709
DDB_G0279539 DDB_G0279539 DDB0232430 CDS2228944 1122 + 0.344029
DDB_G0279563 DDB_G0279563 DDB0232430 CDS2264498 864 + 0.274306
DDB_G0279719 DDB_G0279719 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232430 CDS2480611 2829 - 0.265111
DDB_G0279749 DDB_G0279749 DDB0232430 CDS2499904 324 - 0.262346
DDB_G0279831 DDB_G0279831 putative protein serinethreonine kinase CAMK group the protein kinase domain is similar to those of mammalian CAM kinase IDDB0232430 CDS2602496 2787 + 0.267671
DDB_G0279851 DDB_G0279851 putative histone acetyltransferase highly similar to bacterial GCN5-related N-acetyltransferase (GNAT)DDB0232430 CDS2640159 516 - 0.284884
DDB_G0280111 DDB_G0280111 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232430 CDS2948944 3381 - 0.280982
DDB_G0280131 DDB_G0280131 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains armadillobeta-catenin-like repeats unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS2985578 3579 - 0.308187
DDB_G0280133 DDB_G0280133 CAMK family protein kinase protein kinase domain similar to those of mammalian SNF1 like kinasesDDB0232430 CDS2991402 4518 + 0.285967
DDB_G0280257 DDB_G0280257 DDB0232430 CDS3173383 1245 + 0.324498
DDB_G0280393 DDB_G0280393 DDB0232430 CDS3254509 1239 + 0.338983
DDB_G0280461 DDB_G0280461 DDB0232430 CDS3391535 1257 - 0.24105
DDB_G0280557 DDB_G0280557 similar to erkA and erkB and other MAP kinases does not contain the consensus sequences required for kinase functionDDB0232430 CDS3496721 1383 + 0.237889
DDB_G0280643 DDB_G0280643 similar to many CMGC family members including several MAPKsDDB0232430 CDS3598294 1329 - 0.261851
DDB_G0280717 DDB_G0280717 member of the AGC kinase group similar to the kinase domains of PKC (protein kinase C) and MAST (microtubule-associated serinethreonine kinase)DDB0232430 CDS3670258 1236 - 0.258091
DDB_G0280855 DDB_G0280855 similar to erkA and erkB and other MAP kinases unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS3794487 1179 + 0.25106
DDB_G0280913 DDB_G0280913 DDB0232430 CDS3873660 1587 - 0.245117
DDB_G0281165 DDB_G0281165 DDB0232430 CDS4129870 2256 + 0.290337
DDB_G0281283 DDB_G0281283 DDB0232430 CDS4337681 660 + 0.283333
DDB_G0281559 DDB_G0281559 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog REMI mutant forms large sori see DDB0232430 CDS4978870 3066 - 0.299739
DDB_G0281687 DDB_G0281687 DDB0232430 CDS4813506 2856 + 0.279412
DDB_G0281705 DDB_G0281705 DDB0232430 CDS4853137 936 - 0.314103
DDB_G0281745 DDB_G0281745 DDB0232430 CDS4910382 1794 + 0.337793
DDB_G0281925 DDB_G0281925 DDB0232430 CDS5132437 1761 - 0.366269
DDB_G0282115 DDB_G0282115 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS5399711 4923 - 0.275848
DDB_G0282429 DDB_G0282429 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232430 CDS5758659 939 - 0.312034
DDB_G0282873 DDB_G0282873 DDB0232430 CDS6325570 2859 - 0.359566
DDB_G0282895 DDB_G0282895 member of the TKL (tyrosine kinase-like) group contains three N-terminal MORN (Membrane Occupation and Recognition Nexus) repeatsDDB0232430 CDS6249781 4905 + 0.262385
DDB_G0282963 DDB_G0282963 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS60445 5286 + 0.265796
DDB_G0283065 DDB_G0283065 putative eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase putative protein serinethreonine kinase related to the GCN2 (general control non-derepressible) family of protein kinases that phosphorylate the alpha subunit of eIF2DDB0232431 CDS122741 1914 - 0.242424
DDB_G0283301 DDB_G0283301 DDB0232431 CDS480042 1992 + 0.254016
DDB_G0283337 DDB_G0283337 DDB0232431 CDS491931 3387 - 0.219368
DDB_G0283397 DDB_G0283397 DDB0232431 CDS606939 2757 - 0.283642
DDB_G0283821 DDB_G0283821 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232431 CDS1155677 2826 - 0.295824
DDB_G0283927 DDB_G0283927 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232431 CDS1307685 1458 - 0.226337
DDB_G0284245 DDB_G0284245 contains a single N-terminal RRM domain which is similar to those in human splicing factors arginineserine-rich such as SFRS4 and SFRS6 however these proteins contain two N-terminal RRM domainsDDB0232431 CDS1747466 1098 - 0.301457
DDB_G0284251 DDB_G0284251 kinase domain similar to those of mitogen-activated protein kinases similar to the STE20 familyDDB0232431 CDS1754346 1491 - 0.273642
DDB_G0284577 DDB_G0284577 putative ortholog of H. sapiens CNOT2 and S. cerevisiae CDC36 component of the CCR4-NOT transcription complexDDB0232431 CDS2176004 1740 - 0.281034
DDB_G0284661 DDB_G0284661 putative protein serinethreonine kinase CAMK group kinase domain similar to mammalian CAM kinase IDDB0232431 CDS2309177 1446 - 0.304288
DDB_G0285361 DDB_G0285361 DDB0232431 CDS3169327 984 - 0.322154
DDB_G0285403 DDB_G0285403 DDB0232431 CDS3157812 3108 - 0.320463
DDB_G0285435 DDB_G0285435 DDB0232431 CDS3216790 4929 - 0.313857
DDB_G0285463 DDB_G0285463 member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) family contains 7 putative transmembrane domainsDDB0232431 CDS3259648 2076 - 0.308285
DDB_G0286143 DDB_G0286143 DDB0232431 CDS4126891 1035 + 0.28599
DDB_G0286145 DDB_G0286145 DDB0232431 CDS4130109 1128 + 0.25266
DDB_G0286219 DDB_G0286219 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homolog highly similar to mammalian TBP-associated factor 172 (TAF-172BTAF1) and yeast MOT1DDB0232431 CDS4198019 6018 + 0.302758
DDB_G0286481 DDB_G0286481 putative protein serinethreonine kinase similar to casein kinase II the alpha chain of a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS4514745 1818 - 0.264026
DDB_G0286523 DDB_G0286523 DDB0232431 CDS4588407 1884 + 0.306794
DDB_G0286627 DDB_G0286627 putative protein serinethreonine kinase belongs to the STE group the kinase domain is similar to yeast BCK1 a mitogen-activated protein (MAP) kinase kinase kinaseDDB0232431 CDS4756048 2016 - 0.251984
DDB_G0286697 DDB_G0286697 DDB0232431 CDS4858448 3414 - 0.227006
DDB_G0286841 DDB_G0286841 member of the AGC kinase group similar to the kinase domains of MAST kinases (Microtubule-Associated SerineThreonine kinase)DDB0232431 CDS4966020 1389 - 0.218143
DDB_G0287001 DDB_G0287001 member of the TKL (tyrosine kinase-like) group contains zinc-binding LIM domainDDB0232431 CDS5188585 1953 - 0.28213
DDB_G0287171 DDB_G0287171 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS5429343 5619 + 0.2399
DDB_G0287305 DDB_G0287305 DDB0232432 CDS110292 543 - 0.246777
DDB_G0287309 DDB_G0287309 DDB0232432 CDS112586 600 + 0.26
DDB_G0287711 DDB_G0287711 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family homolog of human AADAT (kynureninealpha-aminoadipate aminotransferase) and S. cerevisiae ARO8 (aromatic amino acid aminotransferase)DDB0232432 CDS588099 1323 - 0.281179
DDB_G0287979 DDB_G0287979 DDB0232432 CDS922041 3255 - 0.242704
DDB_G0288147 DDB_G0288147 member of the tyrosine kinase-like (TKL) group similar to plant serinethreonine kinases contains a phorbol esterdiacylglycerol-binding domainDDB0232432 CDS1147360 4044 + 0.271513
DDB_G0288469 DDB_G0288469 DDB0232432 CDS1563184 2883 + 0.226153
DDB_G0288669 DDB_G0288669 DDB0232432 CDS1797088 930 - 0.230108
DDB_G0288795 DDB_G0288795 putative protein serinethreonine kinase AGC group similar to the kinase domains of mammalian AKTPKB similar to yeast protein kinases GAD8 and SCH9DDB0232432 CDS1975761 1926 - 0.317757
DDB_G0288865 DDB_G0288865 DDB0232432 CDS1959111 486 - 0.257202
DDB_G0288981 DDB_G0288981 DDB0232432 CDS2203346 441 - 0.206349
DDB_G0289053 DDB_G0289053 similar to mammalian RNPS1 (RNA-binding protein with serine-rich domain 1) part of pre- and post-splicing multiprotein mRNP complexesDDB0232432 CDS2302813 1539 - 0.322287
DDB_G0289215 DDB_G0289215 DDB0232432 CDS2489574 1527 - 0.206287
DDB_G0289217 DDB_G0289217 DDB0232432 CDS2491401 1482 + 0.274629
DDB_G0289453 DDB_G0289453 possible homolog of human LSM11 a U7 snRNA-associated Sm-like proteinDDB0232432 CDS2807299 774 - 0.277778
DDB_G0289583 DDB_G0289583 ortholog of human SDCCAG1 (serologically defined colon cancer antigen 1) a conserved eukaryotic protein of unknown functionDDB0232432 CDS2992157 3807 - 0.276333
DDB_G0289933 DDB_G0289933 DDB0232432 CDS3455388 1629 - 0.274401
DDB_G0289941 DDB_G0289941 DDB0232432 CDS3478416 1446 + 0.296681
DDB_G0290199 DDB_G0290199 DDB0232432 CDS3783788 651 - 0.241167
DDB_G0290471 DDB_G0290471 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats does not contain the consensus sequences required for kinase functionDDB0232432 CDS4105828 1059 - 0.234183
DDB_G0290621 DDB_G0290621 DDB0232432 CDS4383355 2904 - 0.22865
DDB_G0290859 DDB_G0290859 member of the AGC kinase group similar to NDR (nuclear Dbf2-related) and RSK (ribosomal S6 kinase) family membersDDB0232432 CDS4688665 1260 + 0.307143
DDB_G0291015 DDB_G0291015 possible homolog of human LSM10 a U7 snRNA-associated Sm-like proteinDDB0232432 CDS4891178 414 - 0.23913
DDB_G0291083 DDB_G0291083 DDB0232432 CDS4954952 606 - 0.20132
DDB_G0291133 DDB_G0291133 putative protein tyrosine kinase similar to S. pombe wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232432 CDS5030354 2337 + 0.26059
DDB_G0291350 DDB_G0291350 putative protein serinethreonine kinase similar to mammalian MPSK (myristoylated and palmitoylated serinethreonine kinase) a kinase involved in transcriptional regulation and protein phosphorylation may be an intermediary in the TGF-beta signaling pathwayDDB0232433 CDS162730 1110 - 0.245045
DDB_G0291386 DDB_G0291386 DDB0232433 CDS229175 1392 + 0.297414
DDB_G0291664 DDB_G0291664 highly similar to DDB0232433 CDS338918 2880 + 0.291319
DDB_G0291842 DDB_G0291842 putative protein tyrosine kinase similar to S. pombe WEE1 inhibitor of mitosis through phosphorylation of cdc2DDB0232433 CDS822502 1059 - 0.351275
DDB_G0291918 DDB_G0291918 putative protein serinethreonine kinase CAMK group kinase domain is similar to those of mammalian death-associated protein kinases (DAPK)DDB0232433 CDS943654 2010 + 0.287065
DDB_G0291966 DDB_G0291966 DDB0232433 CDS948054 939 - 0.345048
DDB_G0292010 DDB_G0292010 DDB0232433 CDS1014321 2334 + 0.288346
DDB_G0292108 DDB_G0292108 DDB0232433 CDS1192584 2490 - 0.278715
DDB_G0292350 DDB_G0292350 DDB0232433 CDS1496951 3675 + 0.270204
DDB_G0292354 DDB_G0292354 putative protein serinethreonine kinase TTBK family similar to casein kinase similar to mammalian tau-tubulin kinase (TTBK) which phosphorylates the microtubule-associated protein tau implicated in Alzheimer's diseaseDDB0232433 CDS1420214 1488 + 0.30578
DDB_G0292422 DDB_G0292422 contains two RNA recognition motifs (RRMs) which are putative RNA binding domainsDDB0232433 CDS1580488 2064 - 0.265988
DDB_G0292472 DDB_G0292472 DDB0232433 CDS1689735 1653 + 0.238355
DDB_G0292550 DDB_G0292550 DDB0232433 CDS1642791 4194 - 0.223891
DDB_G0292624 DDB_G0292624 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232433 CDS1864394 942 + 0.298301
DDB_G0292914 DDB_G0292914 DDB0232433 CDS2269065 723 + 0.262794
DDB_G0293064 DDB_G0293064 DDB0232433 CDS2418202 1722 - 0.334495
DDB_G0293120 DDB_G0293120 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2546935 6618 - 0.294349
DDB_G0293128 DDB_G0293128 DDB0232433 CDS2567187 6678 + 0.28227
DDB_G0293184 DDB_G0293184 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesis contains RhoGAP domain found in the Rho family of small G proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS2540484 3561 + 0.281382
DDB_G0293276 DDB_G0293276 member of the AGC kinase group similar to kinase domains of AktPKB and MAST (microtubule-associated serinethreonine kinase) family membersDDB0232433 CDS2701490 1551 - 0.246937
DDB_G0293292 DDB_G0293292 putative protein serinethreonine kinase N-terminal kinase domain similar to vertebrate Nek kinases which are involved in regulation of mitosis C-terminal kinase domain weakly similar to ULK (Unc-51-like kinase)DDB0232433 CDS2647324 4116 + 0.234208
DDB_G0293514 DDB_G0293514 DDB0232433 CDS2984590 492 + 0.292683
DDB_G0293614 DDB_G0293614 ortholog of S. cerevisiae DIS3 and H. sapiens KIAA1008 component of the nucleolar exosome involved in RNA processingDDB0232433 CDS3144728 3021 - 0.300232
DDB_G0293800 DDB_G0293800 atypical protein kinase GTE group contains ankyrin repeats a bromodomain and a BTPPOZ domainDDB0232433 CDS3334534 2421 + 0.297811
DDB_G0293924 DDB_G0293924 DDB0232433 CDS3490466 2661 + 0.282601
DDB_G0293958 DDB_G0293958 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232433 CDS3460612 4779 + 0.208203
DDB_G0294559 DDB_G0294559 DDB0232431 CDS1421546 1047 - 0.281757
DDB_G0347687 DDB_G0347687 DDB0232428 CDS2752444 537 - 0.299814
H3v1 DDB_G0291185 DDB0232432 CDS5034573 1860 - 0.374731
arkA DDB_G0289555 suppressor of spalten (spnA) mutant member of the TKL (tyrosine kinase-like) group and ARK (ankyrin repeat-containing kinase) familyDDB0232432 CDS2941850 4383 + 0.300707
asf1 DDB_G0285513 DDB0232431 CDS3334165 465 - 0.301075
atg1 DDB_G0292390 Dictyostelium homolog of yeast atg1 belongs to the ULK (Unc-51-like kinase) family of kinases required for macroautophagyDDB0232433 CDS1694801 2007 + 0.255605
aurK DDB_G0279343 putative protein serinethreonine kinase Aur family associates with the mitotic spindle and plays a key role in mitosis the single Dictyostelium aurora kinase has properties of both aurora A and B kinases in other organismsDDB0232430 CDS1959552 1155 - 0.30303
brf1 DDB_G0281215 general transcription factor required for the initiation of transcription by RNA polymerase III TFIIIB subunit interacts with the non LTR retrotransposon TRE5-ADDB0232430 CDS4228761 2121 - 0.309288
bud31 DDB_G0270360 a very conserved protein known as G10 protein or BUD31 which in human is suggested to be a nuclear transcription factor and in S. pombe and S. cerevisiae has been shown to be a splicing factorDDB0232428 CDS4710295 666 - 0.27027
cak1-1 DDB_G0273059 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS2688821 1281 + 0.320062
cak1-2 DDB_G0273737 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS3341355 1281 - 0.320062
casK DDB_G0276885 CK2 family protein kinase a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232429 CDS7370887 1014 + 0.310651
ccdc25 DDB_G0269786 DDB0232428 CDS3556678 621 + 0.278583
cdc5l DDB_G0279311 contains two Myb DNA-binding domains ortholog of human CDC5L and yeast CEF1 may play a role in transcriptional activation and in mRNA splicingDDB0232430 CDS1918418 2403 - 0.28506
cdc7 DDB_G0292152 similar to S. cerevisiae cell division control protein 7 (CDC7) a serinethreonine kinase required for mitosis and meiosisDDB0232433 CDS1294776 3186 + 0.23666
cdc73 DDB_G0274885 component of the conserved Paf1 complex a multifunctional complex involved in histone methylation and plays a role in RNA elongation and processing defects in human CDC73 cause hyperparathyroidism-jaw tumor syndrome (HPT-JT) parathyroid carcinoma and hyperparathyroidism (FIHP)DDB0232429 CDS4342175 1599 - 0.290807
cdk1 DDB_G0272813 similar to CDK1 and CDK2 cell cycle CAK (CDK-activating kinase) kinases predicted to activate SG2 cyclins cyclin A B and DDDB0232429 CDS2216835 891 + 0.331089
cdk10 DDB_G0268480 putative cell division cycle 2 (CDC2)-like protein kinase has similarity to PITSLRE proteins and other cyclin-dependent kinase 2 kinasesDDB0232428 CDS294048 1101 - 0.256131
cdk11 DDB_G0283279 very similar to human CDL1 (PITSLRE serinethreonine-protein kinase CDC2L1) which appears to play multiple roles in cell cycle progression cytokinesis and apoptosis predicted to interact with DDB0232431 CDS446640 1077 - 0.338904
cdk5 DDB_G0288677 CMGC group protein kinase highly similar to mammalian cdk5 localizes to the nucleus and shuttles to the cytoplasm during late mitosis binds calmodulin PsaADDB0232432 CDS1885785 879 + 0.302617
cdk7 DDB_G0285417 putative ortholog of CDK7 and CTK1 which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit predicted to be activated by DDB0232431 CDS3627427 1083 + 0.307479
cdk8 DDB_G0267442 controls RNA polymerase II activity by phosphorylating the carboxy terminal domain (CTD) of the largest subunit predicted to interact with DDB0232428 CDS1582311 1143 - 0.314961
cdk9-1 DDB_G0273207 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS2708039 2085 + 0.282974
cdk9-2 DDB_G0273721 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS3321422 2085 - 0.282974
chdA DDB_G0284171 CHD gene family protein containing a chromodomain a helicase domain and a DNA-binding domain similar to H. sapiens chromodomain-helicase-DNA-binding protein 2 (CHD-2) (SwissProt: O14647) chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS1645755 5754 - 0.310219
chdB DDB_G0280705 CHD gene family protein containing a chromodomain a C terminal helicase domain and a DNA-binding domain chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS3648861 7122 - 0.267762
chdC DDB_G0293012 CHD gene family protein containing a chromodomain a helicase domain and a DNA-binding domain chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2321154 9216 + 0.312174
cinD-1 DDB_G0273061 ortholog of Saccharomyces cerevisiae Mbf1 protein expressed at high level in vegetative celly and decreases sharply in early development induced by cycloheximide there is a second copy of this gene DDB0232429 CDS2640075 315 + 0.336508
cinD-2 DDB_G0273775 ortholog of Saccharomyces cerevisiae Mbf1 protein expressed at high level in vegetative celly and decreases sharply in early development induced by cycloheximide there is a second copy of this gene DDB0232429 CDS3390843 315 - 0.336508
clkA DDB_G0281179 similar to cyclin-like kinases (CLK) putative dual specifity kinaseDDB0232430 CDS4167312 2799 + 0.215077
csnk2b DDB_G0284601 ortholog of the CK2 beta chain the regulatory subunit of the ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS2209637 807 - 0.281289
ctdspl2 DDB_G0290365 DDB0232432 CDS3881786 1704 + 0.297535
cxeA DDB_G0269118 DDB0232428 CDS3937103 363 + 0.336088
cycC DDB_G0274139 similar to metazoan cyclin C predicted to interact with cyclin-dependent kinase DDB0232429 CDS4921649 768 + 0.247396
cycH DDB_G0268668 similar to metazoan cyclin H predicted to interact with cyclin-dependent kinase DDB0232428 CDS1891354 861 - 0.190476
cycK DDB_G0286617 similar to metazoan cyclin K predicted to interact with the cyclin-dependent kinase DDB0232431 CDS4722525 1218 - 0.297209
cycL DDB_G0285553 similar to metazoan and higher plants cyclin Lania-6 predicted to interact with DDB0232431 CDS3372094 822 - 0.284672
ddx1 DDB_G0269966 ortholog of ATP-dependent RNA helicase DDX1 contains an SPRY domain which is of unknown functionDDB0232428 CDS3941617 2298 + 0.302002
ddx10 DDB_G0284017 DDB0232431 CDS1436851 2637 + 0.277209
ddx17 DDB_G0293168 conserved RNA helicase very similar to mammalian DDX17 (p72) and DDX5 (p68) and yeast DBP2DDB0232433 CDS2360817 2358 - 0.370229
ddx18 DDB_G0282741 DDB0232430 CDS6230156 1809 - 0.334439
ddx20 DDB_G0277527 ortholog of H. sapiens DDX20Gemin 3 a component of Cajal bodies (CBs) and Gems nuclear organelles responsible for spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesisDDB0232429 CDS8128317 2550 - 0.22902
ddx24 DDB_G0281841 DDB0232430 CDS5000989 2823 + 0.30039
ddx27 DDB_G0281711 DDB0232430 CDS4866495 2352 + 0.305697
ddx3 DDB_G0283661 conserved RNA helicase very similar to mammalian DDX3X and DDX3Y and yeast DBP1DDB0232431 CDS939305 2139 - 0.370266
ddx31 DDB_G0271708 DDB0232429 CDS830367 2727 + 0.26696
ddx41 DDB_G0287361 conserved RNA helicase ortholog of D. melanogaster DEAD box protein abstrakt which is required during post-transcriptional gene expressionDDB0232432 CDS183547 2016 - 0.315476
ddx42 DDB_G0288501 conserved putative RNA helicase very similar to mammalian DDX42DDB0232432 CDS1607944 2961 + 0.274232
ddx47 DDB_G0280147 DDB0232430 CDS3015956 1641 - 0.312614
ddx49 DDB_G0270396 DDB0232428 CDS4752654 1527 + 0.27112
ddx5 DDB_G0293036 DDB0232433 CDS2373448 2094 + 0.258835
ddx51 DDB_G0293740 DDB0232433 CDS3249527 1692 - 0.229905
ddx52 DDB_G0274325 ortholog of H. sapiens DDX52 and S. cerevisiae ROK1 (Rescuer Of Kem1) ROK1 required for 18S rRNA synthesisDDB0232429 CDS3957548 2007 + 0.271051
ddx55 DDB_G0291588 ortholog of H. sapiens DDX55 and S. cerevisiae SBP4 (Suppressor of PAB1) SBP4 required for synthesis of 60S ribosomal subunitsDDB0232433 CDS577637 1992 - 0.270582
ddx56 DDB_G0280407 ortholog of H. sapiens DDX56 and S. cerevisiae DBP9 (Dead Box Protein 9) involved in biogenesis of the 60S ribosomal subunitDDB0232430 CDS3312082 2058 + 0.266764
ddx6 DDB_G0291804 ortholog of H. sapiens DDX6 and S. cerevisiae DHH1 (DExDH-box Helicase)DDB0232433 CDS773358 1272 + 0.367925
dr1 DDB_G0269638 DDB0232428 CDS3204015 537 - 0.312849
drap1 DDB_G0292510 DDB0232433 CDS1574061 1653 - 0.255898
drkA DDB_G0289791 DDB0232432 CDS3144874 1929 + 0.276827
drkB DDB_G0289709 DDB0232432 CDS3147575 2073 + 0.2904
drkC DDB_G0281899 tyrosine kinase member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily involved in phagocytosis and late phagosomelysosome fusion enriched in S cells in slugsDDB0232430 CDS5088116 2250 - 0.305778
drkD DDB_G0281557 member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily contains a leucine-rich repeat (LRR) regionDDB0232430 CDS4777368 3867 + 0.334885
drnA-1 DDB_G0273051 similar to the mammalian Dicer protein an RNase III protein that converts long dsRNA (double-stranded RNA) into siRNA (small interfering RNA) there is a second copy of this gene DDB0232429 CDS2284317 3612 - 0.251661
drnA-2 DDB_G0274077 similar to the mammalian Dicer protein an RNase III protein that converts long dsRNA (double-stranded RNA) into siRNA (small interfering RNA) there is a second copy of this gene DDB0232429 CDS3743727 3612 + 0.251661
drnB DDB_G0268410 similar to the mammalian Dicer protein an RNase III protein that converts long dsRNA (double-stranded RNA) into siRNA (small interfering RNA) in Dictyostelium involved in RNA interference and microRNA processingDDB0232428 CDS1225333 4158 + 0.28836
dst1 DDB_G0274593 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS3862026 2214 + 0.289521
dst2 DDB_G0267730 putative protein serinethreonine kinase the kinase domain is similar to mitogen-activated protein kinases and other STE20-like kinases stress-responsive kinaseDDB0232428 CDS719427 3429 + 0.33275
dst3 DDB_G0291267 putative protein serinethreonine kinase the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS35064 1689 - 0.351095
dst4 DDB_G0288071 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232432 CDS1048762 1458 - 0.325789
dupA DDB_G0277071 contains both a kinase domain and a phosphatase domain similar to MAP kinase phosphatase in plants and dual-specificty phosphatase 19 in mammals regulates the MAP Kinase response to Legionella pneumophila infection in DictyosteliumDDB0232429 CDS7439874 7365 - 0.295995
dyrk1 DDB_G0277485 DDB0232429 CDS7981156 2511 + 0.249303
dyrk2 DDB_G0293750 DDB0232433 CDS3272270 2748 + 0.306405
eif3G DDB_G0279549 EIF3G ortholog the eukaryotic initiation factor delta subunit In human binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA is composed of at least 12 different subunitsDDB0232430 CDS2241015 702 - 0.331909
elp1 DDB_G0284075 similar to S. cerevisiae IKI3 subunit of the RNA polymerase II elongator complex and mammalian IKAP proteinsDDB0232431 CDS1525708 4173 + 0.306255
elp3 DDB_G0290103 similar to ELP3 the histone acetyltransferase subunit of the subunit of the RNA polymerase II elongator complexDDB0232432 CDS3656306 1680 + 0.335119
ercc6 DDB_G0281441 ortholog of S. cerevisiae RAD26 and H. sapiens ERCC6 (CSB) involved in Cockayne syndrome chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS4502255 4968 - 0.273752
erkA DDB_G0286353 DDB0232431 CDS4355028 1590 + 0.303774
erkB DDB_G0283903 DDB0232431 CDS1385123 1110 - 0.323423
fhkA DDB_G0293656 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsbrbr bCommunity annotation:b The five fhk-X genes differ substantially in their response to the disruption of the retinoblastoma-like gene rblA. FhkA is substantially and highly signficantly upregulated in the ko strain while none of the other genes show major changes. Consistent with its regulation the fhkA promoter contains a putative E2F-type binding site (TTTGCGCCTTTT). Virtually all genes associated with replication fork progression are upregulated in the rblA disruptant these include cdc45 all mcm genes all gins genes all rfc genes four polA subunits three polD subunits two putatitive polE subunits PCNA the single-strand binding protein rfa1 the flap endonuclease repG as well as DNA ligase-1 and topoisomerase-2. All these genes show overexpression factors ranging from 4 to 15DDB0232433 CDS3219230 1782 - 0.231201
fhkB DDB_G0280599 CAMK group RAD53 family protein kinase the protein kinase domain is similar to those of mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3548058 3429 - 0.26305
fhkC DDB_G0281567 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 and yeast RAD53 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS4871788 1788 + 0.291387
fhkD DDB_G0285963 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232431 CDS3876403 2250 - 0.286667
fhkE DDB_G0280321 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3257414 2139 + 0.257597
fncJ DDB_G0286621 ortholog of Fanconi anaemia complementation group protein involved DNA cross-link repair also known as BRIP1 (BRCA1 Interacting Protein 1) however the Dicty gene appears to be missing the region that interacts with BRCA1 in the human protein unlike other members of the complex null mutant is not sensitive to DNA damaging agents brbr mammalian ortholog is part of the Fanconi anaemia nuclear complex that includes FANC A B C E F G L and M the FA complex interacts with ube2t a E2 ubiquitin-conjugating enzyme to monoubiquitinate FANCD2 and FANCI. Ubiquinated FANCD2 and FANCI form a complex that colocalizes at sites of DNA damage with the FANCJ helicase as well as FANCN and FANCD1 in human mutations in this gene cause Fanconi anaemia an autosomal recessive disorder affecting all bone marrow elements Dictyostelium has orthologs for DDB0232431 CDS4729555 3237 + 0.296262
fnkA DDB_G0275561 protein kinase STE groupDDB0232429 CDS5624593 2382 + 0.283375
fnkB DDB_G0267934 DDB0232428 CDS1147906 1593 - 0.251726
fnkE DDB_G0275879 protein kinase domain similar to those of the mitogen-activated protein kinases which belong to the STE20 family contains two protein kinase domains one of which is predicted to be inactive contains several FNIP repeatsDDB0232429 CDS5838829 3966 + 0.2824
fnkF_ps DDB_G0275183 putative pseudogene STEFNIP protein kinase familyDDB0232429 CDS5290527 2628 - 0.270548
fray1 DDB_G0278863 kinase domain similar to OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232430 CDS1298188 1725 - 0.338551
fray2 DDB_G0276577 the kinase domain is similar to mammalian stress-induced STK and OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232429 CDS6994954 3087 - 0.339164
gbpC DDB_G0291079 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases belongs to the LRRK family of protein kinases contains LRR Roc COR RasGEF protein kinase DEP cyclic nucleotide-binding and GRAM domains involved in cGMP-mediated chemotaxis catalyzes GDP to GTP exchange on its own Roc domain translocates from cytoplasm to cell cortex after cAMP stimulation GRAM domain binds directly to plasma membraneDDB0232432 CDS4959991 7896 + 0.333967
gcn5 DDB_G0283459 DDB0232431 CDS727119 1239 - 0.284907
gdt2 DDB_G0270666 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3713353 4914 - 0.252747
gdt3_ps DDB_G0285891 putative pseudogene member of the TKL (tyrosine kinase-like) group and the GDT family belongs to the MLK protein kinase familyDDB0232431 CDS3781232 5880 - 0.234014
gdt4 DDB_G0270550 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS2926042 4863 + 0.265474
gdt6 DDB_G0270544 member of the TKL (tyrosine kinase-like) group and the GDT family unlikely to function as a kinase as it does not contain a catalytic aspartate putative transmembrane proteinDDB0232428 CDS2913781 4359 + 0.274145
gdt8 DDB_G0270668 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3723386 3981 - 0.283848
gdt9 DDB_G0278879 DDB0232430 CDS1327589 4734 + 0.274398
gefX DDB_G0269298 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains RasGEF nucleotide exchange factor domainDDB0232428 CDS2476607 2883 - 0.312522
glkA DDB_G0270218 putative protein serinethreonine kinase GSK family member of the CMGC kinase group similar to Drosophila shaggy and other glycogen synthase kinasesDDB0232428 CDS4429657 1422 + 0.23699
gna1 DDB_G0279475 gna bGblucosamibNbe-6-phosphate bAbcetyltransferaseDDB0232430 CDS2113626 474 - 0.242616
gskA DDB_G0272110 protein serinethreonine kinase GSK family member of the CMGC kinase group essential for cell specification activated by CAR3 through ZAK1 (prespore-) and inhibited by CAR4 (prestalk-) signallingDDB0232429 CDS1334436 1404 - 0.324786
gtf2a1 DDB_G0290327 encodes the two largest subunits of TFIIA important but not essential for transcriptional activation functioning as either an antirepressor or a coactivatorDDB0232432 CDS3966621 933 - 0.289389
gtf2a2 DDB_G0285343 important but not essential for transcriptional activation functioning as either an antirepressor or a coactivatorDDB0232431 CDS3114831 348 + 0.284483
gtf2b DDB_G0290929 DDB0232432 CDS4767056 978 + 0.373211
gtf2e1-1 DDB_G0273525 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening there is a second copy of this gene DDB0232429 CDS2978253 1371 + 0.296864
gtf2e1-2 DDB_G0273583 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening there is a second copy of this gene DDB0232429 CDS3051445 1371 - 0.296864
gtf2e2 DDB_G0287307 DDB0232432 CDS111192 831 - 0.315283
gtf2f2 DDB_G0287131 DDB0232431 CDS5353824 726 - 0.287879
gtf2h2 DDB_G0272362 DDB0232429 CDS1296713 1386 - 0.309524
gtf2h3 DDB_G0275517 DDB0232429 CDS6059895 1119 + 0.268097
gtf2h4 DDB_G0293228 ortholog of S. cerevisiae TFB2 subunit of TFIIH and nucleotide excision repair factor 3 complexes involved in transcription initiation required for nucleotide excision repairDDB0232433 CDS2676500 1452 - 0.303719
hbx10 DDB_G0284293 DDB0232431 CDS1841189 1917 + 0.27856
helA DDB_G0292992 DDB0232433 CDS2367392 3276 + 0.291209
helB1 DDB_G0275443 conserved RNA helicase S. cerevisiae ortholog PRP5 is necessary for pre-spliceosome formationDDB0232429 CDS5780689 3456 - 0.335938
helB2 DDB_G0277857 conserved RNA helicase S. cerevisiae ortholog PRP28 is involved in RNA isomerization at the 5' splice siteDDB0232430 CDS776296 2505 + 0.335729
helC DDB_G0281553 DDB0232430 CDS4949807 1398 + 0.286838
helE DDB_G0281949 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232430 CDS5309986 4623 - 0.237508
ifdA DDB_G0269146 similar to eukaryotic translation initiation factor 4A isoform 2 DDB0232428 CDS2640023 1188 + 0.393939
iksA DDB_G0283109 similar to fungal kinases contains an IQ calmodulin-binding regionDDB0232431 CDS257953 2940 + 0.272449
ino80 DDB_G0292358 similar to S. cerevisiae INO80 an ATPase that forms a large complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS1406177 6390 + 0.308607
ireA DDB_G0267650 ortholog of the yeast IRE1 serinethreonine kinaseendoribonuclease a transmembrane protein involved in the unfolded protein response contains a ribonuclease 2-5A domain and 3 pyrrolo-quinoline quinone (PQQ) domainsDDB0232428 CDS495110 2955 + 0.237902
irlA DDB_G0272987 DDB0232429 CDS2020830 4296 + 0.26513
irlB-1 DDB_G0273333 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS2539802 4347 - 0.216931
irlB-2 DDB_G0273857 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS3487559 4347 + 0.216931
irlC DDB_G0270894 the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy contains a SWIM Zn-finger domainDDB0232428 CDS3195968 4335 + 0.231834
irlD DDB_G0269632 DDB0232428 CDS3190841 4518 + 0.261399
irlE DDB_G0288803 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophyDDB0232432 CDS1985593 4053 + 0.237602
isw DDB_G0292948 similar to ISWI and mammalian SMARCA ATPases involved in nucleosome remodeling chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2254360 3666 + 0.336061
kinX DDB_G0283391 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232431 CDS749416 3285 + 0.312329
kinY DDB_G0289661 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232432 CDS3255902 1740 + 0.251149
krsA DDB_G0284181 putative protein serinethreonine kinase belongs to the protein kinase MST subfamily similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase involved in signal transduction and hyperosmotic responseDDB0232431 CDS1697612 1386 - 0.313853
krsB DDB_G0267978 putative protein serinethreonine kinase N-terminus similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase C-terminal half belongs to the peptidase C2 family contains 4 calpain III domains and has similarity to calpain-like cysteine proteaseDDB0232428 CDS1220851 3318 + 0.331826
kxcA DDB_G0289859 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains calmodulin-binding RhoGEF and pleckstrin homology (PH) domainsDDB0232432 CDS3309104 3936 + 0.256352
kxcB DDB_G0293124 kinase domain similar to those of stress-induced STK kinases contains a DH (Dbl homology) domain followed by a PH (pleckstrin homology) domain found in proteins shown to encode a GEF activity specific for Rho family membersDDB0232433 CDS2557594 3378 - 0.301066
lkb1 DDB_G0279629 CAMK group CAMKL family kinase protein kinase involved in regulating both development and the stress responseDDB0232430 CDS2335074 1761 - 0.294719
lsm1 DDB_G0279837 DDB0232430 CDS2608266 390 - 0.282051
lsm2 DDB_G0281779 DDB0232430 CDS4953475 354 + 0.254237
lsm3 DDB_G0277107 DDB0232429 CDS7535075 294 + 0.272109
lsm4 DDB_G0287053 DDB0232431 CDS5235945 534 - 0.35206
lsm5 DDB_G0268716 DDB0232428 CDS1990918 294 + 0.265306
lsm6 DDB_G0275719 DDB0232429 CDS5998936 267 + 0.29588
lsm7 DDB_G0289499 DDB0232432 CDS2859869 294 - 0.292517
lsm8 DDB_G0288479 DDB0232432 CDS1585841 285 - 0.322807
lsmd1 DDB_G0269552 snRNP Sm family protein similar to H. sapiens LSMD1 and to S. pombe U6 snRNP-associated protein Lsm7DDB0232428 CDS2982129 345 - 0.281159
med6 DDB_G0284421 ortholog of the mediator of RNA polymerase II transcription subunit 6 the mediator complex functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machineryDDB0232431 CDS1975693 804 - 0.257463
mekA DDB_G0269152 STE SerThr protein kinase family mitogen-activated protein kinase kinase involved in chemotaxis and early development phosphorylates the MAP kinase Erk1 (erkA) is sumoyalated by sumo and ubiquinated by mip1DDB0232428 CDS4015409 1983 - 0.252143
mkcA DDB_G0285427 similar to MAP cascade kinases belonging to the PAK sub-family of the STE20 serinethreonine kinases partial suppressor of tagB mutationDDB0232431 CDS3440715 2583 - 0.275648
mkcB DDB_G0290723 similar to Dictyostelium mkcA and other mitogen-activated protein kinases (Ste20PAK family) REMI mutant forms aberrant fruiting bodies see DDB0232432 CDS4499748 2145 + 0.332867
mkcC DDB_G0287853 kinase domain very similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232432 CDS826726 2676 + 0.342302
mkcD DDB_G0277413 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232429 CDS7960057 1959 + 0.291986
mkcE DDB_G0281649 kinase domain similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232430 CDS4757942 2148 + 0.271881
mkcF DDB_G0270102 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family) contains one SH3 (src Homology-3) domainDDB0232428 CDS4222376 2034 - 0.319076
mkkA DDB_G0283265 developmentally regulated MEKKDDB0232431 CDS530684 3804 + 0.287066
mlkA DDB_G0279925 CAMK1 family protein kinase phosphorylates the myosin II regulatory light chain at S13 is not regulated by Ca2calmodulinDDB0232430 CDS2752719 888 - 0.317568
mnat1 DDB_G0289079 DDB0232432 CDS2330339 978 + 0.293456
mps1 DDB_G0280995 putative protein threoninetyrosine kinase similar to yeast and zebrafish mps1 (monopolar spindle) kinase a threoninetyrosine kinaseDDB0232430 CDS3923506 2952 + 0.289295
mrkA DDB_G0292304 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains 1 kinase-associated (KA1) domain and 1 UBA domainDDB0232433 CDS1433748 3183 - 0.286836
mrkB DDB_G0285643 CAMKL family protein kinase similar to SNF1 kinases MARK kinases and AMPK kinasesDDB0232431 CDS3523048 2148 - 0.284916
mrkC DDB_G0281895 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains C-terminal kinase associated domain 1DDB0232430 CDS5083659 2322 + 0.295866
mybA DDB_G0293900 DDB0232433 CDS3493719 3693 - 0.25589
mybAA DDB_G0268368 DDB0232428 CDS1003245 2916 + 0.284979
mybQ DDB_G0289319 DDB0232432 CDS2641022 2730 - 0.334066
mybX DDB_G0288285 DDB0232432 CDS1347341 4863 - 0.282747
nacA DDB_G0281403 highly similar to the alpha subunit of the nascent polypeptide-associated complex (NAC) which binds the nascent polypeptide after peptide bond formationDDB0232430 CDS4433625 483 + 0.42029
nat9 DDB_G0272710 DDB0232429 CDS1909663 639 - 0.256651
ndrA DDB_G0278457 member of the AGC kinases NDR group localizes to centrosomes and to the spindle during prometaphase and is involved in phagocytosisDDB0232430 CDS907158 1593 + 0.344633
ndrB DDB_G0288753 member of the AGC kinase group similar to NDR protein kinases including yeast morphogenesis proteins ORB6 and CBK1DDB0232432 CDS1909293 1629 - 0.324125
ndrC DDB_G0284839 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinases DDB0232431 CDS2493584 3939 + 0.307692
ndrD DDB_G0289543 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinasesDDB0232432 CDS2920470 6339 + 0.255088
nek2 DDB_G0270814 protein serinethreonine kinase homologous to human Nek2 kinase involved in formation of microtubule-organizing centers (MTOCs)DDB0232428 CDS4847143 1257 - 0.258552
nek3 DDB_G0275241 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosis not a human Nek3 homologDDB0232429 CDS4983790 3372 - 0.269276
nek4 DDB_G0289277 similar to vertebrate Nek kinases which are involved in regulation of mitosis most similar to Nek4DDB0232432 CDS2561379 1494 - 0.222222
nfyC-1 DDB_G0273479 there is a second copy of this gene DDB0232429 CDS2945279 2055 - 0.249148
nfyC-2 DDB_G0273545 there is a second copy of this gene DDB0232429 CDS3084342 2055 + 0.249148
pXi DDB_G0289119 CAMK group protein serinethreonine kinaseDDB0232432 CDS2420542 2076 - 0.25289
pakA DDB_G0269166 STE20PAKA protein kinase involved in the regulation of the cytoskeleton during chemotaxis and required for cytokinesis contains PAK-boxP21-Rho-binding (CRIB) domain found in the WASP C-terminalDDB0232428 CDS3436536 3594 + 0.33222
pakB DDB_G0276459 protein serinethreonine kinase that phosphorylates myoD (myosin ID) and myoK (myosin IK) heavy chains similar to p21-activated kinase belongs to the STE20 family PAKA subfamily of protein kinasesDDB0232429 CDS6847900 2559 - 0.339195
pakC DDB_G0267450 STE20PAK protein kinase required for normal chemotaxis contains PAK-boxP21-Rho-binding (CRIB) domain and pleckstrin homology (PH) domainDDB0232428 CDS229145 1434 - 0.33682
pakD DDB_G0269696 similar to Dictyostelium pakA and other mitogen-activated protein kinases (Ste20PAK family) putative p21-activated kinase contains a calponin-like actin-binding domain a p21-Rho-binding domain and a PKC conserved region 1 (C1) regulates the actin cytoskeleton response during chemotaxis to cAMPDDB0232428 CDS3345400 5037 + 0.25273
pakE DDB_G0293932 putative protein serinethreonine kinase belongs to the PAKL subfamily of protein kinases the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS3512665 2781 + 0.270766
pakF DDB_G0274409 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS4648326 3531 - 0.282073
pakG DDB_G0282891 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232430 CDS6346144 3540 + 0.284181
pakH-1 DDB_G0273121 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamily stress-responsive kinase there is a second copy of this gene DDB0232429 CDS2532742 1542 + 0.282101
pakH-2 DDB_G0273865 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamilystress-responsive kinase there is a second copy of this gene DDB0232429 CDS3497296 1542 - 0.282101
pats1 DDB_G0269250 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 and protein kinase domainsDDB0232428 CDS2657392 9555 - 0.289901
pdkA DDB_G0281471 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232430 CDS4550105 2061 - 0.273654
pdkB DDB_G0284489 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232431 CDS2038480 2727 + 0.260726
phg2 DDB_G0283699 serinethreonine kinase regulating cell substrate adhesion phagocytosis motility and actin organization member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS995559 4164 - 0.304275
pich DDB_G0288873 ortholog of human DNA excision repair protein ERCC-6-like (ERCC6L)br bCommunity annotation:b DDB_G0288873 but not ercc6 is strongly overexpressed (6x) in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted. Most cells involved in S-phase or mitosis are overexpressed in this strain. Ercc6-like is an essential component of the spindle checkpoint which localizes to the kinetochore in prometaphase it is found on thin threads that stretch between sister kinetochores. It is thought to function as part of the tension sensor the functional core of the spindle checkpoint [see Baumann et al Cell 128 101-114 (2007)]. Other spindle checkpoint components are strongly overexpressed in the rblA null. This suggests that DDB_G0288873 may actually code for the spindle tension sensor in Dicty. Harry MacWilliams May 2010br DDB0232432 CDS2065550 3999 - 0.295074
pkaC DDB_G0283907 AGC group PKA family protein kinase protein serinethreonine kinase regulates spore cell differentiationDDB0232431 CDS1394958 1947 + 0.333847
pkaD DDB_G0277145 DDB0232429 CDS7643321 2145 - 0.253613
pkbA DDB_G0268620 AGC group AKT family protein serinethreonine kinase similar to other metazoan AktPKB including an N-terminal PH domain homologous kinase and C-terminal regulatory domains and phosphorylation sites required for AktPKB activationDDB0232428 CDS1977388 1335 + 0.357303
pkgA DDB_G0276157 serinethreonine protein kinase of the MAST (Microtubule Associated SerineThreonine kinase) familyDDB0232429 CDS6275918 4104 - 0.287037
pkgB DDB_G0290157 AGC group protein serinethreonine kinase cAMP-activated protein kinase involved in morphogenesis during multicellular developmentDDB0232432 CDS3717777 1440 - 0.324306
pkgC DDB_G0286125 serinethreonine protein kinase of the AGC group similar to mammalian ribosomal protein S6 kinaseDDB0232431 CDS4067973 2733 - 0.312843
pkgD DDB_G0284029 AGC group protein serinethreonine kinase similar to cAMP-activated protein kinase catalytic subunitsDDB0232431 CDS1459718 2979 - 0.28231
pkgE_ps DDB_G0280981 putative pseudogene similar to AGC protein kinases of the AKT familyDDB0232430 CDS3912677 1095 + 0.343379
plk DDB_G0274503 putative protein serinethreonine kinase similar to yeast CDC5 Drosophila polo and mammalian PLK which play a role in mitosis and localize to the centrosomesDDB0232429 CDS4379150 2937 - 0.280899
prpf4B DDB_G0279703 protein serinethreonine kinase DYRK family member of the CMGC kinase group similar to mammalian pre-mRNA processing factor PRP4 kinase and DYRK kinasesDDB0232430 CDS2466144 2436 + 0.296388
pyk3 DDB_G0289001 member of the TKL (tyrosine kinase-like) group and the DPYK (Dictyostelium protein tyrosine kinase) family of protein kinases contains two kinase domains one of which is predicted to be inactive the C-terminal kinase domain has tyrosine kinase activitybr bCommunity annotation:b Pyk3 appears to be involved in differentiation pathway choice as the KO shows reduced pstO differentiation and compensatory expansion of the prespore region. Pyk3 has been proposed to act in a pathway involving ptpC and statC effectively potentiating the action of DIF-1. One of the factors that influences pathway choice is cell cycle position classic experiments show that cold-synchronized cells which enter development shortly after warming prefer the stalk pathway. This is due to an increased DIF sensitivity. New results (Strasser Tsang and MacWilliams in preparation) now show that the pyk3 transcript is upregulated roughly fivefold after cold synchronization at a time when cells show strong stalk preference (pDDB0232432 CDS2269413 4017 - 0.283047
qkgA-1 DDB_G0273259 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS2831844 4662 + 0.27885
qkgA-2 DDB_G0273635 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS3195191 4662 - 0.27885
rad54 DDB_G0282997 similar to RAD54 DNA repair protein chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS118731 2796 + 0.33226
rad54b DDB_G0285117 similar to RAD54b DNA repair protein chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232431 CDS2873116 2970 - 0.278788
rckA DDB_G0278737 member of the TKL (tyrosine kinase-like) group contains an RGS (Regulator of G protein Signaling) domainDDB0232430 CDS1218919 3378 + 0.261693
repB DDB_G0278729 ortholog of H. sapiens xeroderma pigmentosum group B (XPB) M. musculus ERCC3 and S. cerevisiae RAD25 upregulated in the presence of DNA damaging agentsDDB0232430 CDS1389108 2403 + 0.33042
repD DDB_G0267414 ortholog of H. sapiens xeroderma pigmentosum group D (XPD) M. musculus ERCC2 and S. cerevisiae RAD3DDB0232428 CDS833130 2331 - 0.33891
rnpA DDB_G0282293 DDB0232430 CDS5604394 1656 - 0.226449
roco11 DDB_G0268636 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232428 CDS2199646 4464 + 0.267473
roco4 DDB_G0288251 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232432 CDS1284583 5181 + 0.332947
roco5 DDB_G0294533 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains RhoGEF PH LRR Roc COR and protein kinase domainsDDB0232432 CDS1439427 8403 - 0.309413
roco6 DDB_G0279417 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 PH and protein kinase domainsDDB0232430 CDS2094570 6444 + 0.293451
roco7 DDB_G0267472 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains Roc COR WD40 and protein kinase domains related to LRR-containing kinases but does not contain an LRR domainDDB0232428 CDS628403 7848 - 0.293833
roco8 DDB_G0286127 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains DEP LRR Roc COR and protein kinase domainsDDB0232431 CDS4112361 5604 - 0.267131
roco9 DDB_G0288183 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases contains RhoGAP LRR Roc Cor and protein kinase domainsDDB0232432 CDS1219231 10098 - 0.264706
rpa1 DDB_G0275759 component of the RNA polymerase I complex ortholog of S. cerevisiae RPA190DDB0232429 CDS5808489 4848 + 0.323432
rpa12 DDB_G0278263 component of the RNA polymerase I complex ortholog of S. cerevisiae RPA12DDB0232430 CDS579706 975 - 0.254359
rpa2 DDB_G0293560 component of the RNA polymerase I complex ortholog of S. cerevisiae RPA135DDB0232433 CDS3044865 3393 - 0.328912
rpa5 DDB_G0282339 subunit common to RNA polymerases I and III ortholog of H. sapiens RPA5 S. cerevisiae RPC40DDB0232430 CDS5656917 1038 + 0.293834
rpb1 DDB_G0279193 component of the RNA polymerase II complex ortholog of S. cerevisiae RPO21DDB0232430 CDS1783778 5184 + 0.368248
rpb10 DDB_G0272036 subunit common to RNA polymerases I II and III ortholog of S. cerevisiae RPB10DDB0232429 CDS1094076 213 + 0.300469
rpb11 DDB_G0277677 component of the RNA polymerase II complex ortholog of S. cerevisiae RPB11DDB0232429 CDS8346240 363 - 0.294766
rpb2 DDB_G0288257 component of the RNA polymerase II complex ortholog of S. cerevisiae RPB2DDB0232432 CDS1296275 3513 - 0.366354
rpb3 DDB_G0292244 component of the RNA polymerase II complex ortholog of S. cerevisiae RPB3DDB0232433 CDS1368967 909 + 0.29703
rpb4 DDB_G0282739 component of the RNA polymerase II complex ortholog of S. cerevisiae RPB4DDB0232430 CDS6226742 468 - 0.25
rpb5 DDB_G0291636 subunit common to RNA polymerases I II and III ortholog of S. cerevisiae RPB5DDB0232433 CDS457932 546 - 0.302198
rpb6 DDB_G0291037 subunit common to RNA polymerases I II and III ortholog of S. cerevisiae RPO26DDB0232432 CDS4838044 402 - 0.348259
rpb7 DDB_G0284891 component of the RNA polymerase II complex ortholog of S. cerevisiae RPB7DDB0232431 CDS2602996 519 + 0.306358
rpb9 DDB_G0268306 component of the RNA polymerase II complex ortholog of S. cerevisiae RPB9DDB0232428 CDS558538 339 - 0.330383
rpc1 DDB_G0277199 component of the RNA polymerase III complex ortholog of S. cerevisiae RPO31DDB0232429 CDS7733653 4353 + 0.336779
rpc11 DDB_G0287707 component of the RNA polymerase III complex ortholog of H. sapiens RPC10 and S. cerevisiae RPC11DDB0232432 CDS584047 336 + 0.285714
rpc19 DDB_G0291362 subunit common to RNA polymerases I and III ortholog of S. cerevisiae RPC19DDB0232433 CDS182518 351 + 0.290598
rpc2 DDB_G0288449 component of the RNA polymerase III complex ortholog of S. cerevisiae RPC2DDB0232432 CDS1494028 4827 + 0.310131
rpc25-1 DDB_G0273425 component of the RNA polymerase III complex ortholog of S. cerevisiae RPC25 and H. sapiens RPC8 there is a second copy of this gene DDB0232429 CDS2980579 759 - 0.31357
rpc25-2 DDB_G0273523 component of the RNA polymerase III complex ortholog of S. cerevisiae RPC25 and H. sapiens RPC8 there is a second copy of this gene DDB0232429 CDS3050335 759 + 0.31357
rpc34 DDB_G0272022 component of the RNA polymerase III complex has similarity to H. sapiens RPC6RPC39 and S. cerevisiae RPC34DDB0232429 CDS1182004 882 - 0.302721
rpmA DDB_G0267416 DDB0232428 CDS950030 2853 - 0.343148
rvb1 DDB_G0293226 similar to S. cerevisiae RVB1 a component of chromatin remodeling complexesDDB0232433 CDS2678243 1572 - 0.357506
rvb2 DDB_G0280775 similar to S. cerevisiae RVB2 a component of chromatin remodeling complexesDDB0232430 CDS3727138 1410 - 0.355319
samkA DDB_G0269876 DDB0232428 CDS3775693 1923 + 0.228289
samkB DDB_G0284859 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232431 CDS2549067 1782 + 0.251403
samkB_ps1 DDB_G0270988 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232428 CDS3791042 1593 - 0.264909
samkC DDB_G0270678 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232428 CDS3778203 2628 + 0.251903
samkD DDB_G0270680 similar to SNF1-like kinases unlikely to function as a kinase as it lacks the catalytic aspartateDDB0232428 CDS3781297 1662 + 0.197954
samkE_ps1 DDB_G0283165 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232431 CDS352482 1272 - 0.26022
sepA DDB_G0276465 plays a role in the regulation of cleavage furrow formation similar to S. pombe cdc7DDB0232429 CDS6942806 3504 + 0.32363
shkA DDB_G0283267 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domain negative regulator of phosphoinositol signalingDDB0232431 CDS438511 1584 + 0.318182
shkB DDB_G0288617 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS1745652 1962 - 0.331295
shkC DDB_G0278409 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS836437 1521 - 0.332676
shkD DDB_G0281343 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS4376038 2235 + 0.314541
shkE DDB_G0290451 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS4058161 2133 + 0.284107
sir2A DDB_G0283917 NAD-dependent deacetylase Sirutin 2 family protein that regulates various biological processes by deacetylating histones and other target proteins expressed more highly during vegetative growth DDB0232431 CDS1272110 1539 + 0.293047
sir2B DDB_G0286671 N-terminus has several ankyrin repeats C-terminus has a Sirutin (Sir2) domain a NAD-dependent deacetylase that regulates various biological processes by deacetylating histones and other target proteins expressed more highly during development localized to prestalk and rearguard region of the slug and to the apical disc and upper and lower cups in the culminant (similar expression pattern as sir2E) DDB0232431 CDS4818681 2337 + 0.267009
sir2C DDB_G0284795 NAD-dependent deacetylase Sirutin 2 family protein that regulates various biological processes by deacetylating histones and other target proteins expressed more highly during vegetative growth DDB0232431 CDS2489743 1371 - 0.231947
sir2D DDB_G0289967 NAD-dependent deacetylase Sirutin 2 family protein that regulates various biological processes by deacetylating histones and other target proteins expressed more highly during vegetative growth DDB0232432 CDS3383269 1629 - 0.281768
sir2E DDB_G0270928 NAD-dependent deacetylase Sirutin 2 family protein that regulate various biological processes by deacetylating histones and other target proteins nuclear protein expressed in pstA and pstO cells in the slug and to the apical disc upper and lower cups in the culminant (similar expression pattern as sir2B) DDB0232428 CDS3398987 1032 + 0.281008
sky1 DDB_G0275627 similar to SRPKs (Serinearginine-Rich Protein specific Kinases) serinethreonine kinases that specifically phosphoryate arginine-serine rich domains found in the SR family of splicing factorsDDB0232429 CDS5951942 1971 - 0.318113
snf2a DDB_G0285205 SNF2 family protein similar to human SMARCA4 putative regulator of chromatinDDB0232431 CDS2921996 4815 + 0.304673
snf2b DDB_G0271052 SNF2 family protein similar to human SMARCA4 putative regulator of chromatinDDB0232428 CDS4502537 9744 - 0.313218
snfA DDB_G0277905 CAMKL family protein kinase catalytic subunit of the AMP-activated protein kinase (AMPK) complex similar to SNF1 kinases and AMPK experiments in Dictyostelium show that AMPK signaling plays an important role in mitochondrial disease.DDB0232430 CDS589784 2184 + 0.250458
snrp70 DDB_G0268004 ortholog of human SNRP70 a component of the U1 snRNP involved in mRNA splicingDDB0232428 CDS1286207 1380 + 0.334783
snrpD1 DDB_G0278027 DDB0232430 CDS175913 396 + 0.335859
snrpD2 DDB_G0285395 DDB0232431 CDS3142648 339 - 0.294985
snrpD3 DDB_G0273003 DDB0232429 CDS2118091 441 + 0.378685
snrpE DDB_G0302414 conserved SMLSM core protein also known as SME1 associates with U1 U2 U4U6 and U5 snRNP DDB0232432 CDS1315343 279 - 0.25448
snrpF DDB_G0278821 DDB0232430 CDS1243062 276 + 0.315217
snrpG DDB_G0282863 DDB0232430 CDS6319736 258 - 0.282946
snrpb DDB_G0272320 DDB0232429 CDS1283864 825 - 0.453333
spkA-1 DDB_G0273445 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS2969377 1917 - 0.310381
spkA-2 DDB_G0273531 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS3060166 1917 + 0.310381
splA DDB_G0283385 dual-specificity protein kinase involved in spore coat formation and morphogenesis member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) familyDDB0232431 CDS623097 7233 + 0.323655
splB DDB_G0285321 member of the TKL (tyrosine kinase-like) group activates the transcriptional regulator STATcDDB0232431 CDS3131349 3468 + 0.27797
spoT DDB_G0287233 DDB0232432 CDS32102 627 - 0.271132
spt16 DDB_G0282677 similar to SPT16 of the FACT complex a heterodimer of ssrp1 and spt16 the FACT complex is a general chromatin factor that acts to reorganize nucleosomes involved in multiple processes that require DNA as a template such as mRNA elongation DNA replication and DNA repairDDB0232430 CDS6105920 3219 - 0.339546
spt16_ps DDB_G0282775 putative pseudogene similar to D. discoideum gene DDB0232430 CDS5907328 582 + 0.359107
spt4 DDB_G0285293 ortholog of the human SUPT4H1 and S. cerevisiae SPT4 (suppressor of Ty 4) a transcription-elongation factor that is tightly associated in a complex with SPT5DDB0232431 CDS3068070 276 + 0.344203
spt5 DDB_G0287661 ortholog of the human SUPT5H and S. cerevisiae SPT5 (suppressor of Ty 5) a transcription-elongation factor that is tightly associated in a complex with SPT4DDB0232432 CDS473577 3396 - 0.325383
spt6 DDB_G0272354 DDB0232429 CDS1271354 5265 - 0.350807
ssrp1 DDB_G0290331 ortholog of the SSRP1 component of the FACT complex a heterodimer of ssrp1 and spt16 the FACT complex is a general chromatin factor that acts to reorganize nucleosomes involved in multiple processes that require DNA as a template such as mRNA elongation DNA replication and DNA repairDDB0232432 CDS3969916 1584 - 0.342172
ssu72 DDB_G0272871 ortholog of human and S. cerevisiae SSU72 (suppressor of SUA7 protein 2) S. cerevisiae SSU72 is involved in several roles including 3' end formation of pre-mRNA and snoRNAs and dephosphorylation of RNA polymerase II the D. discoideum homolog of yeast SUA7 is DDB0232429 CDS2056744 645 + 0.297674
svkA DDB_G0286359 very similar to mammalian ST25 kinase (SOK1) and other STE20-like kinases stress-responsive kinase phosphorylates severin essential for cell separation during cytokinesisDDB0232431 CDS4476218 1437 + 0.343076
swi3 DDB_G0277033 similar to H. sapiens SWISNF subunit SMARCC1 and the yeast subunit SWI3 of the chromatin remodeling complexDDB0232429 CDS7295274 3672 - 0.301471
taf1 DDB_G0292242 ortholog of H. sapiens and S. cerevisiae TAF1 an atypical TAF1 family protein kinase and contains a bromodomain putative HAF group protein (histone acetyltransferase)DDB0232433 CDS1360709 6933 - 0.301457
taf11 DDB_G0278843 DDB0232430 CDS1267448 1353 - 0.321508
taf12 DDB_G0274697 subunit of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modificationDDB0232429 CDS4205325 1884 + 0.321125
taf13 DDB_G0292838 DDB0232433 CDS2136060 321 - 0.267913
taf6 DDB_G0288471 similar to S. cerevisiae TAF6 subunit of TFIID and SAGA complexes involved in transcription initiation of RNA polymerase II and in chromatin modificationDDB0232432 CDS1566143 1629 - 0.279926
taf9 DDB_G0272360 subunit of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modificationDDB0232429 CDS1294745 1860 + 0.306452
tbpA DDB_G0275617 general transcription factor that binds to the TATA-box promoter element component of the transcription factor TFIIIB shown to bind to subunits brf1 and weakly to bdp1 interacts with the non LTR retrotransposons TRE5-A and TRE5-BDDB0232429 CDS6092208 618 - 0.326861
tcea1 DDB_G0278241 general transcription elongation factor TFIIS enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sitesDDB0232430 CDS539874 960 + 0.301042
tifA DDB_G0269192 similar to eukaryotic initiation factor 4A isoform 3DDB0232428 CDS3537960 1218 + 0.316092
tsuA DDB_G0267962 putative protein serinethreonine kinase similar to mammalian STK36 and fly fused kinase (fu) a ST kinase involved in the hedgehog signal transduction pathway belongs to the ULK (Unc-51-like kinase) family of kinasesDDB0232428 CDS1191800 6744 + 0.248517
uap56 DDB_G0269932 conserved splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint the human ortholog (BAT1) forms a homodimer and interacts directly with DDB0232428 CDS3893359 1287 - 0.359751
uduA1 DDB_G0268332 upregulated in the uninfected DDB0232428 CDS708045 525 + 0.350476
uduA2 DDB_G0267726 upregulated in the uninfected DDB0232428 CDS711088 525 + 0.348571
uduA3 DDB_G0267728 upregulated in the uninfected DDB0232428 CDS713027 528 + 0.350379
vps15 DDB_G0282627 putative protein serinethreonine kinase similar to human PIK3R4 and yeast VPS15 which regulate the phosphatidylinositol 3 kinase VPS34 (hVps34) yeast VPS15VPS34 complex known to be involved in vacuolar protein sortingDDB0232430 CDS6019111 5901 + 0.306219
warA DDB_G0291075 DDB0232432 CDS5009348 2412 - 0.283167
yakA DDB_G0283605 belongs to the CMGC group of protein kinases putative protein serinethreonine kinaseDDB0232431 CDS868454 4377 + 0.303404
zak2 DDB_G0276187 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL group highly similar to zakA and has overlapping function with zakA shown to be a tyrosine kinase and regulator of GSK3 also regulates pattern formation during development via dstC (STATc) signalingDDB0232429 CDS6396810 1908 - 0.253145
zakA DDB_G0276025 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL groupDDB0232429 CDS6393550 2346 - 0.239983