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2024-05-19 17:20:50

Gene list

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COG category: General function prediction only
Organism: Dictyostelium discoideum AX4, AX4

Number of genes found: 1370

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0267514 DDB_G0267514 DDB0232428 CDS259066 2751 - 0.28426
DDB_G0267566 DDB_G0267566 putative protein serinethreonine kinase contains an ankyrin repeat domain similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS343868 2535 - 0.244181
DDB_G0267592 DDB_G0267592 DDB0232428 CDS383616 1596 + 0.309524
DDB_G0267632 DDB_G0267632 DDB0232428 CDS445092 1230 - 0.202439
DDB_G0267686 DDB_G0267686 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains an RGS (Regulator of G protein Signaling) domainDDB0232428 CDS564277 6693 - 0.276109
DDB_G0267732 DDB_G0267732 DDB0232428 CDS723287 6147 - 0.252969
DDB_G0267880 DDB_G0267880 similar to bacterial and fungal acetyltransferases member of the GNAT familyDDB0232428 CDS1028328 570 + 0.233333
DDB_G0267904 DDB_G0267904 putative ortholog of Xenopus AND-1 (Acidic Nucleoplasmic DNA-binding protein 1) that participates in loading the MCM2-7 helicase complex at the initiation of DNA replication brbr bCommunity annotation:b DDB G0267904 is a wd-repeat protein with moderate similarity to AND-1 also known as CTF4 a wd40 and HMG-box containing protein originally discovered in Xenopus. (see Franke et al AND-1 a natural chimeric DNA-binding protein combines an HMG-box with regulatory WD-repeats.Journal of Cell Science 110 1051-1062) AND-1CTF4 participates in loading the MCM2-7 helicase complex at the initiation of DNA replication (see Zhu et al Genes and Development 21 2288-2299 (2007) also Tanaka et al Genes to Cells 14 807-20 (2009). Recent work suggests that AND-1CTF4 links sister chromatid cohesion with DNA replication(see Tanaka et al Genes to Cells 14 991-1001 (2009).br DDB G0267904 is overexpressed 12-fold [1299 hits to 99 p1e-210] in a Dicty strain lacking the retinoblastoma-like gene rblA. Most genes aDDB0232428 CDS1077141 3267 - 0.285277
DDB_G0267954 DDB_G0267954 contains a C-terminal Bicoid-interacting 3 domain which occurs in methyltransferases that modify RNA-binding proteins has similarity to mammalian 7SK snRNA methylphosphate capping enzyme DDB0232428 CDS1175758 1302 + 0.195853
DDB_G0268018 DDB_G0268018 DDB0232428 CDS1314808 1596 + 0.280702
DDB_G0268064 DDB_G0268064 DDB0232428 CDS1393387 669 - 0.281016
DDB_G0268078 DDB_G0268078 DDB0232428 CDS1417972 1524 + 0.281496
DDB_G0268116 DDB_G0268116 similarity to Xenopus F8A1 protein human Factor VIII intron 22 proteinDDB0232428 CDS1479679 1113 - 0.238095
DDB_G0268132 DDB_G0268132 contains a SET domain involved in histone methylation an AWS (Associated With SET) domain and a post-SET zinc-binding domainDDB0232428 CDS1516724 2697 + 0.269559
DDB_G0268222 DDB_G0268222 belongs to the metallophosphoesterase superfamily similar to human PAPL (Ironzinc purple acid phosphatase-like protein) contains a predicted signal peptideDDB0232428 CDS1715767 1479 - 0.323191
DDB_G0268230 DDB_G0268230 DDB0232428 CDS1727069 1764 + 0.265306
DDB_G0268288 DDB_G0268288 DDB0232428 CDS386296 3792 - 0.238397
DDB_G0268322 DDB_G0268322 DDB0232428 CDS659396 1008 - 0.340278
DDB_G0268336 DDB_G0268336 DDB0232428 CDS731136 792 - 0.268939
DDB_G0268346 DDB_G0268346 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232428 CDS866636 1269 + 0.266351
DDB_G0268384 DDB_G0268384 DDB0232428 CDS1085918 2886 + 0.30492
DDB_G0268386 DDB_G0268386 similar to D. purpureum protein contains one SET domain and one tetratricopeptide repeat (TPR) regionDDB0232428 CDS1104198 2031 - 0.232398
DDB_G0268462 DDB_G0268462 DDB0232428 CDS1630091 1890 + 0.292064
DDB_G0268486_ps DDB_G0268486 putative pseudogene contains protein kinase domainDDB0232428 CDS498516 2820 - 0.22305
DDB_G0268492 DDB_G0268492 DDB0232428 CDS520101 2007 - 0.247135
DDB_G0268504 DDB_G0268504 contains two putative coiled-coil domains conserved in Dictyostelium and PolysphondyliumDDB0232428 CDS642853 15879 + 0.239688
DDB_G0268566 DDB_G0268566 DDB0232428 CDS1378934 1701 + 0.188713
DDB_G0268656 DDB_G0268656 highly similar to human ULK (Unc51-like kinase) does not contain the full consensus sequence required for kinase functionDDB0232428 CDS1863917 954 - 0.220126
DDB_G0268786 DDB_G0268786 DDB0232428 CDS2108112 1965 - 0.243766
DDB_G0268824 DDB_G0268824 DDB0232428 CDS2182743 1299 - 0.254811
DDB_G0268826 DDB_G0268826 DDB0232428 CDS2184410 3060 - 0.203595
DDB_G0268876 DDB_G0268876 member of the TKL (tyrosine kinase-like) group of protein kinases contains filamin repeat similar to ABP120DDB0232428 CDS2297918 4158 - 0.279702
DDB_G0268980_ps DDB_G0268980 putative pseudogene fragment very similar to parts of DDB_G0268948 a putative SAM dependent methyltransferaseDDB0232428 CDS2065538 243 - 0.288066
DDB_G0268990 DDB_G0268990 DDB0232428 CDS2079025 1308 + 0.249235
DDB_G0269052 DDB_G0269052 DDB0232428 CDS1898794 1815 - 0.230854
DDB_G0269272 DDB_G0269272 DDB0232428 CDS2434615 3645 + 0.257064
DDB_G0269294 DDB_G0269294 DDB0232428 CDS2471481 2553 - 0.224442
DDB_G0269340 DDB_G0269340 DDB0232428 CDS2565964 834 + 0.29976
DDB_G0269344 DDB_G0269344 DDB0232428 CDS2568156 1203 - 0.307564
DDB_G0269348 DDB_G0269348 DDB0232428 CDS2570683 1911 - 0.244898
DDB_G0269356 DDB_G0269356 DDB0232428 CDS2583576 819 + 0.246642
DDB_G0269358 DDB_G0269358 DDB0232428 CDS2584566 969 - 0.281734
DDB_G0269370 DDB_G0269370 very similar to the human 25 kDa cleavage and polyadenylation specificity factor component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3' processingDDB0232428 CDS2630812 603 + 0.288557
DDB_G0269430 DDB_G0269430 Sel1-like repeats are tetratricopeptide repeat sequences originally identified in a C. elegans receptor molecule which is a key negative regulator of the Notch pathway Dictyostelium like mammals has two sel1-like proteins which are located next to each otherDDB0232428 CDS2753471 2895 + 0.308463
DDB_G0269432 DDB_G0269432 Sel1-like repeats are tetratricopeptide repeat sequences originally identified in a C. elegans receptor molecule which is a key negative regulator of the Notch pathway Dictyostelium like mammals has two sel1-like proteins which are located next to each otherDDB0232428 CDS2756997 3183 + 0.270814
DDB_G0269442 DDB_G0269442 DDB0232428 CDS2784673 2772 - 0.240981
DDB_G0269448 DDB_G0269448 DDB0232428 CDS2791078 3879 - 0.267079
DDB_G0269452 DDB_G0269452 DDB0232428 CDS2799520 2991 - 0.248412
DDB_G0269460 DDB_G0269460 DDB0232428 CDS2818161 6666 - 0.271377
DDB_G0269462 DDB_G0269462 large protein containing two ubiquitin domains has no ortholog in other organismsDDB0232428 CDS2825931 7014 + 0.286142
DDB_G0269514 DDB_G0269514 DDB0232428 CDS2909436 1113 - 0.221024
DDB_G0269546 DDB_G0269546 DDB0232428 CDS2969017 4641 + 0.290239
DDB_G0269560 DDB_G0269560 DDB0232428 CDS2996712 1728 - 0.219329
DDB_G0269614 DDB_G0269614 DDB0232428 CDS3146250 1311 + 0.357742
DDB_G0269628 DDB_G0269628 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232428 CDS3183487 2214 - 0.303975
DDB_G0269644 DDB_G0269644 DDB0232428 CDS3214845 1650 + 0.258182
DDB_G0269658 DDB_G0269658 DDB0232428 CDS3247871 813 + 0.268143
DDB_G0269686 DDB_G0269686 DDB0232428 CDS3319946 2688 - 0.289062
DDB_G0269722 DDB_G0269722 belongs to the methyltransferase superfamily ortholog of human WBSCR22 an uncharacterized methyltransferase associated with Williams-Beuren syndromeDDB0232428 CDS3414230 864 + 0.340278
DDB_G0269732 DDB_G0269732 DDB0232428 CDS3443410 2439 + 0.357524
DDB_G0269754 DDB_G0269754 DDB0232428 CDS3484288 1062 + 0.211864
DDB_G0269778 DDB_G0269778 DDB0232428 CDS3547267 1083 + 0.290859
DDB_G0269800 DDB_G0269800 putative ortholog of the conserved chromatin assembly factor 1 (CAF1) subunit Bbr bNote:b Do not confuse this gene with DDB0232428 CDS3628624 2115 - 0.274704
DDB_G0269836 DDB_G0269836 DDB0232428 CDS3688411 786 - 0.229008
DDB_G0269888 DDB_G0269888 DDB0232428 CDS3802780 810 + 0.188889
DDB_G0269898 DDB_G0269898 DDB0232428 CDS3820454 2829 + 0.298339
DDB_G0269936 DDB_G0269936 DDB0232428 CDS3903678 1053 + 0.235518
DDB_G0269952 DDB_G0269952 DDB0232428 CDS3922020 795 - 0.208805
DDB_G0269964 DDB_G0269964 DDB0232428 CDS3938864 1998 + 0.285285
DDB_G0269982 DDB_G0269982 similar to human TBC1D22B S. pombe gyp1DDB0232428 CDS3972852 1635 - 0.292966
DDB_G0270016 DDB_G0270016 DDB0232428 CDS4029381 909 - 0.225523
DDB_G0270018 DDB_G0270018 DDB0232428 CDS4030543 942 - 0.291932
DDB_G0270096 DDB_G0270096 DDB0232428 CDS4205387 2373 - 0.292035
DDB_G0270146 DDB_G0270146 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232428 CDS4304005 1908 - 0.287212
DDB_G0270206 DDB_G0270206 DDB0232428 CDS4404424 3465 + 0.223954
DDB_G0270220 DDB_G0270220 DDB0232428 CDS4432689 2520 + 0.314683
DDB_G0270262 DDB_G0270262 DDB0232428 CDS4528758 627 + 0.23764
DDB_G0270284 DDB_G0270284 contains an N-terminal DOMON domain as it occurs in dopamine beta-monooxygenases the Dictyostelium protein is followed by a cytochrome b561 domain which contains 5 putative transmembrane regions in addition the protein contains a putative signal peptideDDB0232428 CDS4579488 1173 + 0.277067
DDB_G0270304 DDB_G0270304 DDB0232428 CDS4607306 630 - 0.284127
DDB_G0270324 DDB_G0270324 similar to N-myc downstream regulated gene 1 (NDRG1) defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D) also known as hereditary motor and sensory neuropathy Lom type (HMSNL)DDB0232428 CDS4644690 981 + 0.275229
DDB_G0270378 DDB_G0270378 similar to human TTC39C matches PFAM outer membrane protein IML2 mitochondrialtetratricopeptide repeat protein 39DDB0232428 CDS4727960 1596 + 0.311404
DDB_G0270436 DDB_G0270436 DDB0232428 CDS4873137 1566 - 0.297573
DDB_G0270552 DDB_G0270552 contains one C2H2-type zinc finger motif and 2 ankyrin repeats contains 2 predicted coiled-coil domainsDDB0232428 CDS2951187 2364 + 0.301184
DDB_G0270618 DDB_G0270618 DDB0232428 CDS3364045 1233 + 0.281427
DDB_G0270634 DDB_G0270634 similar to TNRC4 (TriNucleotide Repeat Containing 4 protein) and Bruno-like proteins contains 3 RRM domainsDDB0232428 CDS3530459 1107 + 0.317073
DDB_G0270652 DDB_G0270652 sulfurates the molybdenum cofactor which is essential for xanthine dehydrogenase and aldehyde oxidaseDDB0232428 CDS3647265 1122 + 0.266488
DDB_G0270692 DDB_G0270692 contains 6 ankyrin repeats contains one VPS9 (vacuolar sorting protein 9) domain similar to D. purpureum proteinDDB0232428 CDS3887599 3024 - 0.276786
DDB_G0270720 DDB_G0270720 DDB0232428 CDS4125800 1560 + 0.239744
DDB_G0270746 DDB_G0270746 putative ortholog of H. sapiens transducin beta-like 2 (TBL2) deleted in patients with Williams-Beuren syndrome (WBS)DDB0232428 CDS4336075 1377 - 0.257807
DDB_G0270766 DDB_G0270766 DDB0232428 CDS4499254 2994 + 0.257515
DDB_G0270856 DDB_G0270856 DDB0232428 CDS2591243 2496 + 0.271635
DDB_G0270878 DDB_G0270878 DDB0232428 CDS2931465 987 - 0.256332
DDB_G0270920 DDB_G0270920 DDB0232428 CDS3375140 3339 - 0.262953
DDB_G0270932 DDB_G0270932 DDB0232428 CDS3418520 3039 + 0.29253
DDB_G0271270 DDB_G0271270 DDB0232429 CDS179519 1080 - 0.287963
DDB_G0271316 DDB_G0271316 DDB0232429 CDS120793 657 - 0.231355
DDB_G0271376 DDB_G0271376 DDB0232429 CDS144988 762 + 0.295276
DDB_G0271402 DDB_G0271402 DDB0232429 CDS241165 2298 + 0.309835
DDB_G0271484 DDB_G0271484 DDB0232429 CDS427690 1485 + 0.256566
DDB_G0271538 DDB_G0271538 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family expressed in pstO cellsDDB0232429 CDS568653 1584 - 0.285985
DDB_G0271550 DDB_G0271550 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS634463 1179 + 0.267176
DDB_G0271680 DDB_G0271680 DDB0232429 CDS796698 1008 + 0.324405
DDB_G0271682 DDB_G0271682 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats contains two kinase domains one of which is predicted to be inactiveDDB0232429 CDS792553 3075 + 0.247154
DDB_G0271720 DDB_G0271720 almost identical to DDB0232429 CDS843067 1029 - 0.290573
DDB_G0271730 DDB_G0271730 DDB0232429 CDS868232 3978 + 0.311714
DDB_G0271740 DDB_G0271740 DDB0232429 CDS897538 1008 + 0.329365
DDB_G0271748_ps DDB_G0271748 putative pseudogene similar to a family of D. discoideum genes including DDB0232429 CDS711253 876 + 0.261416
DDB_G0271780 DDB_G0271780 DDB0232429 CDS899784 1026 + 0.312865
DDB_G0271802 DDB_G0271802 DDB0232429 CDS783832 954 + 0.267296
DDB_G0271820 DDB_G0271820 almost identical to DDB0232429 CDS837872 1035 - 0.284058
DDB_G0271884 DDB_G0271884 conserved putative quinone oxidoreductase belongs to the broader superfamily of zinc-dependent alcohol dehydrogenasesDDB0232429 CDS973836 996 - 0.358434
DDB_G0272020 DDB_G0272020 contains an N-terminal F-box domain a central SH2 domain and C-terminal ankyrin repeatsDDB0232429 CDS1179282 2412 + 0.246269
DDB_G0272064 DDB_G0272064 DDB0232429 CDS1150556 8169 + 0.281307
DDB_G0272092 DDB_G0272092 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains a C2 domain (Ca2-dependent membrane-targeting module) an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232429 CDS1251605 2961 - 0.296184
DDB_G0272128 DDB_G0272128 belongs to the short chain dehydrogenasesreductases family ortholog of human HSD17B10 which is involved in mitochondrial tRNA maturation and by interacting with intracellular amyloid-beta may contribute to the neuronal dysfunction associated with Alzheimer disease DDB0232429 CDS1375029 795 + 0.328302
DDB_G0272154 DDB_G0272154 DDB0232429 CDS1594214 906 - 0.378587
DDB_G0272180 DDB_G0272180 DDB0232429 CDS1518514 1008 + 0.240079
DDB_G0272184 DDB_G0272184 very conserved protein among bacteria and fungi zinc-binding ADH's are dimeric or tetrameric enzymes that bind two atoms of zinc per subunitDDB0232429 CDS1513508 966 - 0.385093
DDB_G0272186 DDB_G0272186 DDB0232429 CDS1509530 3153 - 0.292103
DDB_G0272192 DDB_G0272192 DDB0232429 CDS1412468 1497 + 0.329993
DDB_G0272206 DDB_G0272206 DDB0232429 CDS1658418 5340 + 0.265169
DDB_G0272254 DDB_G0272254 member of the TKL (tyrosine kinase-like) group contains a galactose oxidase central domain and three Kelch motifsDDB0232429 CDS1396081 3996 - 0.264765
DDB_G0272282 DDB_G0272282 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) and MAST (microtubule-associated serinethreonine kinase)DDB0232429 CDS1572926 6309 + 0.272468
DDB_G0272356 DDB_G0272356 DDB0232429 CDS1290469 1914 - 0.372518
DDB_G0272440 DDB_G0272440 very similar to the H. sapiens tumor protein p53-inducible protein 3 (TP53I3) belongs to the broader superfamily of zinc-dependent alcohol dehydrogenasesDDB0232429 CDS1596579 1008 - 0.340278
DDB_G0272466 DDB_G0272466 DDB0232429 CDS1706359 867 - 0.304498
DDB_G0272484 DDB_G0272484 contains the metal-dependent phosphohydrolase HD region similar to the H. sapiens SAM domain and HD domain-containing protein 1 (SAMHD1) but lacking the N-terminal SAM domainDDB0232429 CDS1760557 1545 - 0.297735
DDB_G0272628 DDB_G0272628 underexpressed in DDB0232429 CDS2278778 1023 - 0.333333
DDB_G0272666 DDB_G0272666 DDB0232429 CDS1858373 3930 + 0.265903
DDB_G0272797 DDB_G0272797 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS2368968 2043 - 0.313754
DDB_G0272839 DDB_G0272839 has a short region of similarity to aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxiaDDB0232429 CDS2148504 1173 + 0.224211
DDB_G0272913 DDB_G0272913 DDB0232429 CDS1908716 762 + 0.26378
DDB_G0272953 DDB_G0272953 DDB0232429 CDS1904183 1545 + 0.212945
DDB_G0273101 DDB_G0273101 there is a second copy of this gene DDB0232429 CDS2569065 6147 + 0.284041
DDB_G0273155 DDB_G0273155 there is a second copy of this gene DDB0232429 CDS2472439 1011 - 0.346192
DDB_G0273195 DDB_G0273195 member of the major facilitator superfamily (MFS) expressed in upper cup during culmination there is a second copy of this gene DDB0232429 CDS2690707 1764 - 0.294218
DDB_G0273301 DDB_G0273301 there is a second copy of this gene DDB0232429 CDS2668726 1926 - 0.323988
DDB_G0273413 DDB_G0273413 there is a second copy of this gene DDB0232429 CDS2940321 1371 + 0.243618
DDB_G0273417 DDB_G0273417 similar to bacterial S-adenosyl-L-methionine (SAM) methyltransferases similar to D. purpureum protein there is a second copy of this gene DDB0232429 CDS2943449 1407 + 0.25231
DDB_G0273477 DDB_G0273477 there is a second copy of this gene DDB0232429 CDS2933551 1509 - 0.204109
DDB_G0273547 DDB_G0273547 similar to bacterial S-adenosyl-L-methionine (SAM) methyltransferases similar to D. purpureum protein there is a second copy of this gene DDB0232429 CDS3086765 1407 - 0.25231
DDB_G0273551 DDB_G0273551 there is a second copy of this gene DDB0232429 CDS3090095 1371 - 0.243618
DDB_G0273557 DDB_G0273557 there is a second copy of this gene DDB0232429 CDS3096406 1509 + 0.204109
DDB_G0273735 DDB_G0273735 member of the major facilitator superfamily (MFS) expressed in upper cup during culmination there is a second copy of this gene DDB0232429 CDS3339316 1764 + 0.294218
DDB_G0273753 DDB_G0273753 there is a second copy of this gene DDB0232429 CDS3360515 1926 + 0.323988
DDB_G0273831 DDB_G0273831 there is a second copy of this gene DDB0232429 CDS3456169 6147 - 0.284041
DDB_G0273855 DDB_G0273855 there is a second copy of this gene DDB0232429 CDS3486160 915 + 0.243716
DDB_G0273921 DDB_G0273921 there is a second copy of this gene DDB0232429 CDS3558114 1011 + 0.346192
DDB_G0274007 DDB_G0274007 similar to cyclin dependent protein kinases there is a second copy of this gene DDB0232429 CDS3660427 2043 + 0.313754
DDB_G0274085 DDB_G0274085 underexpressed in DDB0232429 CDS3751889 1023 + 0.333333
DDB_G0274185 DDB_G0274185 contains an N-terminal oxidoreductase domain and a partial C-terminal oxidoreductase domain the GfoIdhMocA family proteins utilize NADP or NADDDB0232429 CDS4815159 1293 - 0.336427
DDB_G0274199 DDB_G0274199 DDB0232429 CDS4796097 1281 + 0.291179
DDB_G0274201 DDB_G0274201 DDB0232429 CDS4797968 951 + 0.268139
DDB_G0274251 DDB_G0274251 DDB0232429 CDS4152834 1077 + 0.226555
DDB_G0274265 DDB_G0274265 DDB0232429 CDS4139227 1803 - 0.291736
DDB_G0274273 DDB_G0274273 DDB0232429 CDS4010059 963 - 0.36864
DDB_G0274283 DDB_G0274283 DDB0232429 CDS4044553 1179 - 0.310433
DDB_G0274293 DDB_G0274293 DDB0232429 CDS4065363 1497 + 0.281229
DDB_G0274433 DDB_G0274433 bCommunity annotation:b DDB G0274433 is weakly similar to SDS23 and SDS24 of budding yeast which are themselves homologues of sds23 from fission yeast. The fission yeast gene interacts with the anaphase promoting complex in a manner which is not understood molecularly. The APC must be dephosphoryated by PPI for normal mitosis and sds23 overexpressers bypass the requirement for PPI (Ishii et al EMBO Journal 15 6629-6640 (1996). Deletion of sds23 gives very slowly growing cells with multiple nuclei and extremely prolonged anaphase. In budding yeast however the double deletion is viable with changes mainly in the size of the vacuole. In Dicty a role of DDB_G0274433 in cell cycle control is suggested by the gene's fivefold overexpression in a Dicty strain deficient in the Dictyostelium DDB0232429 CDS4606302 1062 + 0.29661
DDB_G0274499 DDB_G0274499 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity contains a predicted signal peptideDDB0232429 CDS4386087 942 + 0.316348
DDB_G0274505 DDB_G0274505 DDB0232429 CDS4376727 1509 - 0.297548
DDB_G0274527 DDB_G0274527 DDB0232429 CDS4275808 1428 - 0.298319
DDB_G0274613 DDB_G0274613 kinase domain similar to mitogen-activated protein kinases does not contain the consensus sequences known to be required for kinase function contains a RING zinc finger domainDDB0232429 CDS4893134 2496 - 0.260417
DDB_G0274663 DDB_G0274663 similar to human PRSS16 (thymus-specific serine protease) contains a putative signal peptideDDB0232429 CDS4408799 1464 - 0.347678
DDB_G0274739 DDB_G0274739 DDB0232429 CDS3941346 1341 + 0.226696
DDB_G0274781 DDB_G0274781 contains three EF hands similar to mammalian neuron specific calcium-binding protein hippocalcin belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232429 CDS3825256 678 + 0.29646
DDB_G0274801 DDB_G0274801 DDB0232429 CDS3911402 2562 - 0.369243
DDB_G0274807 DDB_G0274807 DDB0232429 CDS3946871 1851 - 0.222582
DDB_G0274821 DDB_G0274821 DDB0232429 CDS3992986 2565 - 0.181287
DDB_G0274911_ps DDB_G0274911 putative pseudogene fragment similar to D. discoideum gene DDB0232429 CDS4421760 1470 - 0.182993
DDB_G0274975 DDB_G0274975 DDB0232429 CDS4730779 4398 - 0.31105
DDB_G0275027 DDB_G0275027 DDB0232429 CDS5323069 276 - 0.297101
DDB_G0275041 DDB_G0275041 DDB0232429 CDS5273798 1026 + 0.220273
DDB_G0275049 DDB_G0275049 DDB0232429 CDS5249449 924 + 0.313853
DDB_G0275057 DDB_G0275057 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232429 CDS5089988 1050 + 0.33619
DDB_G0275075 DDB_G0275075 ortholog of mammalian NARG1 and yeast NAT1 part of a complex that displays alpha (N-terminal) acetyltransferase activity DDB0232429 CDS5130987 2445 + 0.285072
DDB_G0275097 DDB_G0275097 DDB0232429 CDS5060014 2256 + 0.321809
DDB_G0275149 DDB_G0275149 similar to S. cerevisiae AKR1 (palmitoyltransferase AKR1) contains 5 ankyrin repeats and 1 zinc finger DHHC domain contains 6 putative transmembrane domainsDDB0232429 CDS4965140 2097 + 0.299475
DDB_G0275165 DDB_G0275165 DDB0232429 CDS5143836 2766 - 0.298988
DDB_G0275195 DDB_G0275195 DDB0232429 CDS5206472 3642 - 0.31933
DDB_G0275203 DDB_G0275203 DDB0232429 CDS5105558 1707 + 0.176333
DDB_G0275205 DDB_G0275205 DDB0232429 CDS5081463 1533 - 0.270711
DDB_G0275215 DDB_G0275215 DDB0232429 CDS5007231 2076 - 0.244701
DDB_G0275289 DDB_G0275289 DDB0232429 CDS5225979 2826 - 0.209837
DDB_G0275345 DDB_G0275345 DDB0232429 CDS5397156 2109 + 0.266477
DDB_G0275351 DDB_G0275351 contains 1 C2H2-type zinc finger homolog of human ZNF593 and S. cerevisiae BUD20 (bud site selection protein 20) DDB0232429 CDS5402357 426 + 0.293427
DDB_G0275389 DDB_G0275389 DDB0232429 CDS5493095 1608 + 0.298507
DDB_G0275421 DDB_G0275421 contains 2 GRAM domains one RabGAPTBC domain and one EF hand domainDDB0232429 CDS5459788 3672 + 0.232026
DDB_G0275457 DDB_G0275457 DDB0232429 CDS6112474 780 + 0.284615
DDB_G0275459 DDB_G0275459 DDB0232429 CDS6113524 900 + 0.428889
DDB_G0275507 DDB_G0275507 similar to bacterial acetyltransferases homolog of E. coli maa (maltose O-acetyltransferase)DDB0232429 CDS6022499 591 - 0.314721
DDB_G0275529 DDB_G0275529 DDB0232429 CDS5892491 4269 - 0.223003
DDB_G0275559 DDB_G0275559 underexpressed in DDB0232429 CDS5618738 873 + 0.316151
DDB_G0275581 DDB_G0275581 DDB0232429 CDS5550573 2736 - 0.299708
DDB_G0275591 DDB_G0275591 DDB0232429 CDS5562777 2082 + 0.304995
DDB_G0275593 DDB_G0275593 DDB0232429 CDS5568361 1221 - 0.232596
DDB_G0275605_ps DDB_G0275605 putative pseudogene similar to gene DDB0232429 CDS5585797 1407 - 0.329069
DDB_G0275671 DDB_G0275671 putative serine esterase similar to hypothetical proteins in plants and yeastDDB0232429 CDS5687040 1239 + 0.268765
DDB_G0275793 DDB_G0275793 DDB0232429 CDS5611769 1593 - 0.2285
DDB_G0275913 DDB_G0275913 similar to bacterial acetyltransferases homolog of E. coli maa (maltose O-acetyltransferase) similar to D. purpureum proteinDDB0232429 CDS6029488 573 - 0.340314
DDB_G0275951 DDB_G0275951 DDB0232429 CDS5814130 711 + 0.341772
DDB_G0275953 DDB_G0275953 sulfurates the molybdenum cofactor which is essential for xanthine dehydrogenase and aldehyde oxidaseDDB0232429 CDS6210610 1044 - 0.272031
DDB_G0275971 DDB_G0275971 DDB0232429 CDS6175233 2100 + 0.335714
DDB_G0275993 DDB_G0275993 DDB0232429 CDS6150629 687 - 0.227074
DDB_G0276007 DDB_G0276007 DDB0232429 CDS6178436 639 + 0.27543
DDB_G0276013 DDB_G0276013 DDB0232429 CDS6191275 2247 - 0.304406
DDB_G0276017 DDB_G0276017 DDB0232429 CDS6201276 1317 + 0.23918
DDB_G0276031 DDB_G0276031 similar human THO complex subunit 3 (THOC3) although D. discoideum seems to be lacking THOC4 and THOC5DDB0232429 CDS6461770 1437 + 0.302714
DDB_G0276037 DDB_G0276037 DDB0232429 CDS6539160 1020 + 0.269608
DDB_G0276117 DDB_G0276117 DDB0232429 CDS6262508 615 - 0.21626
DDB_G0276181 DDB_G0276181 member of the TKL (tyrosine kinase-like) group of protein kinases contains a PH (pleckstrin homology) domainDDB0232429 CDS6410071 4668 - 0.262853
DDB_G0276227 DDB_G0276227 DDB0232429 CDS6222654 2514 + 0.239061
DDB_G0276237 DDB_G0276237 DDB0232429 CDS6306373 1077 + 0.275766
DDB_G0276251 DDB_G0276251 similar to H. sapiens GP17 involved in modification of glycosylphosphatidylinositol contains 16 transmembrane domainsDDB0232429 CDS6500338 4329 + 0.260799
DDB_G0276271 DDB_G0276271 DDB0232429 CDS6637140 1641 - 0.203534
DDB_G0276281 DDB_G0276281 DDB0232429 CDS6608304 1032 - 0.223837
DDB_G0276293 DDB_G0276293 DDB0232429 CDS6559102 1473 - 0.304141
DDB_G0276297 DDB_G0276297 DDB0232429 CDS6556293 1056 + 0.294508
DDB_G0276429 DDB_G0276429 DDB0232429 CDS6932540 1422 - 0.270042
DDB_G0276461 DDB_G0276461 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232429 CDS6904331 2397 - 0.267418
DDB_G0276531 DDB_G0276531 similar to elaC and TRZ a zinc phosphodiesterase with tRNA 3'-processing endonuclease activity and probably involved in tRNA maturation by removing a 3'-trailer from precursor tRNAbrbr bCommunity annotation:b similar to elaC an endoribonuclease conserved from bacteria to humans sequence variants of which are associated with aggressive prostate cancer. Nothing seems to be known about the connection between elaC and cell proliferation. The possible involvement of the Dicty gene in cell cycle control is suggested by its 34-fold overexpression in a Dicty strain lacking the retinoblastoma like gene DDB0232429 CDS6795915 2871 - 0.27621
DDB_G0276545 DDB_G0276545 DDB0232429 CDS6829983 1032 - 0.293605
DDB_G0276623 DDB_G0276623 DDB0232429 CDS7051390 537 - 0.320298
DDB_G0276633 DDB_G0276633 DDB0232429 CDS7061709 2496 + 0.262019
DDB_G0276725 DDB_G0276725 DDB0232429 CDS7175956 237 + 0.265823
DDB_G0276811 DDB_G0276811 DDB0232429 CDS7386858 2736 + 0.26462
DDB_G0276815 DDB_G0276815 contains 7 WD repeats belongs to the WD repeat WDSOF1 family homolog of human WDSOF1 S. cerevisiae SOF1 S. cerevisiae SOF1 is required for ribosomal RNA processingDDB0232429 CDS7390722 1338 - 0.309417
DDB_G0276855 DDB_G0276855 DDB0232429 CDS7489987 2193 + 0.300958
DDB_G0276897 DDB_G0276897 conserved hyphothetical protein similar to AprA an autocrine repressor of proliferationDDB0232429 CDS7267534 1494 + 0.299197
DDB_G0276961 DDB_G0276961 C-terminus similar to Arabidopsis thaliana plant adhesion molecule 1 Drosophila melanogaster extracellular matrix adhesion protein Pollux and human rab6 GTPase activating protein GAPCENADDB0232429 CDS7212385 1536 - 0.266927
DDB_G0276997 DDB_G0276997 DDB0232429 CDS7293362 1305 + 0.276628
DDB_G0277007 DDB_G0277007 homolog of human SLC35C1 (GDP-fucose transporter 1) defects in human SLC35C1 are the cause of leukocyte adhesion deficiency type II contains 10 putative transmembrane domainsDDB0232429 CDS7200459 1107 + 0.272809
DDB_G0277025 DDB_G0277025 DDB0232429 CDS7262534 714 + 0.257703
DDB_G0277031 DDB_G0277031 conserved hyphothetical protein similar to AprA an autocrine repressor of proliferationDDB0232429 CDS7281651 1533 - 0.297456
DDB_G0277043 DDB_G0277043 structural similarity to Zn-dependent peptidases contains a a predicted signal anchor sequence and 4 putative transmembrane domainsDDB0232429 CDS7322606 2187 - 0.288523
DDB_G0277149 DDB_G0277149 contains 3 TPR domains homolog of human TTC35 (tetratricopeptide repeat protein 35) DDB0232429 CDS7777377 969 + 0.26935
DDB_G0277151 DDB_G0277151 DDB0232429 CDS7889956 1455 - 0.22543
DDB_G0277165 DDB_G0277165 CAMKL family protein kinase the protein kinase domain is similar to those of the CAMKLBRSK subfamily which are named based on brain-specific expression in human and neuronal expression in wormDDB0232429 CDS7893420 2502 - 0.271783
DDB_G0277167 DDB_G0277167 DDB0232429 CDS7668593 1392 + 0.257902
DDB_G0277249 DDB_G0277249 DDB0232429 CDS7817927 849 - 0.34629
DDB_G0277257 DDB_G0277257 DDB0232429 CDS7833225 1404 - 0.340456
DDB_G0277337 DDB_G0277337 DDB0232429 CDS7774136 2658 - 0.307374
DDB_G0277427 DDB_G0277427 DDB0232429 CDS8043662 1911 + 0.299843
DDB_G0277449 DDB_G0277449 member of the AGC kinase group similar to kinase domains of SGK (serum and glucocorticoid responsive kinase) AktPKB and RSK (ribosomal S6 kinase) family membersDDB0232429 CDS8121319 1371 + 0.300511
DDB_G0277471 DDB_G0277471 homolog of human PAAF1 (proteasomal ATPase-associated factor 1) which inhibits proteasome 26S assembly and activity contains 3 WD repeats DDB0232429 CDS8143567 1278 - 0.305164
DDB_G0277533 DDB_G0277533 similar to human WDR48 a WD repeat endosomal proteinDDB0232429 CDS7976869 3519 - 0.24524
DDB_G0277539 DDB_G0277539 putative protein tyrosine kinase similar to human wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232429 CDS8010617 2997 - 0.248248
DDB_G0277573 DDB_G0277573 DDB0232429 CDS8170344 1017 + 0.277286
DDB_G0277575 DDB_G0277575 DDB0232429 CDS8169746 387 - 0.271318
DDB_G0277655_ps DDB_G0277655 putative pseudogene very similar to neighboring genes that belong to a large D. discoideum protein family of unknown function many clustered on chr 2DDB0232429 CDS8243854 3055 + 0.235025
DDB_G0277679 DDB_G0277679 DDB0232429 CDS8347286 1101 + 0.257039
DDB_G0277685 DDB_G0277685 DDB0232429 CDS8335817 6561 + 0.299192
DDB_G0277745 DDB_G0277745 DDB0232429 CDS8419128 882 - 0.290249
DDB_G0277941 DDB_G0277941 similar to HIRA histone cell cycle regulation defective homolog ADDB0232430 CDS39336 1431 + 0.288609
DDB_G0277967 DDB_G0277967 DDB0232430 CDS72018 3144 + 0.26145
DDB_G0277999 DDB_G0277999 sulfurates the molybdenum cofactor which is essential for xanthine dehydrogenase and aldehyde oxidaseDDB0232430 CDS144948 1182 - 0.265651
DDB_G0278059 DDB_G0278059 similar to the human acetyl-coenzyme A transporter 1 contains 10 putative transmembrane domainsDDB0232430 CDS207407 1857 - 0.234787
DDB_G0278087_ps DDB_G0278087 putative pseudogene containing a partial protein kinase domain and a partial ankyrin repeatDDB0232430 CDS256195 1557 - 0.285806
DDB_G0278111 DDB_G0278111 DDB0232430 CDS294308 354 - 0.327684
DDB_G0278113 DDB_G0278113 similar to protein-tyrosine phosphatases but probably not catalytically active due to lack of conservation of active site residues similar to human PTPLA (protein-tyrosine phosphatase-like member A) contains 4 putative transmembrane domainsDDB0232430 CDS295249 678 - 0.297935
DDB_G0278151 DDB_G0278151 DDB0232430 CDS372488 1455 - 0.294845
DDB_G0278181 DDB_G0278181 DDB0232430 CDS405756 2802 + 0.283726
DDB_G0278229 DDB_G0278229 DDB0232430 CDS512537 2673 - 0.263749
DDB_G0278239 DDB_G0278239 DDB0232430 CDS533251 1263 - 0.231987
DDB_G0278253 DDB_G0278253 DDB0232430 CDS566464 1710 - 0.27076
DDB_G0278281 DDB_G0278281 DDB0232430 CDS614554 1194 - 0.247069
DDB_G0278297 DDB_G0278297 DDB0232430 CDS639451 1203 - 0.270989
DDB_G0278303_ps DDB_G0278303 putative pseudogene beta-ketoacyl synthase family proteinDDB0232430 CDS652045 2175 - 0.243678
DDB_G0278327 DDB_G0278327 DDB0232430 CDS707798 1677 + 0.268933
DDB_G0278373 DDB_G0278373 at the N-terminus very similar to human ATPBD4 (ATP binding domain 4) also similar to plant and fungal endoribonuclease L-PSP family proteinsDDB0232430 CDS771365 2259 - 0.232846
DDB_G0278415 DDB_G0278415 DDB0232430 CDS857716 945 + 0.295238
DDB_G0278427 DDB_G0278427 DDB0232430 CDS870597 666 + 0.268769
DDB_G0278453 DDB_G0278453 contains 5 coiled-coil domains highly repetitive glutamine and glutamic acid-rich proteinDDB0232430 CDS901380 2472 + 0.330097
DDB_G0278473 DDB_G0278473 DDB0232430 CDS929409 1995 - 0.277694
DDB_G0278487 DDB_G0278487 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases belongs to the CMGC group of protein kinasesDDB0232430 CDS959760 1911 + 0.288854
DDB_G0278509 DDB_G0278509 DDB0232430 CDS984753 3747 + 0.238858
DDB_G0278521 DDB_G0278521 member of the TKL (tyrosine kinase-like) group the MLK (mixed lineage kinase) family and the HH498 subfamily contains an ankyrin repeatDDB0232430 CDS1000912 2727 - 0.226989
DDB_G0278535 DDB_G0278535 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family contains an ankyrin repeat region and a SAM (Sterile alpha motif) domainDDB0232430 CDS1034770 2547 + 0.329407
DDB_G0278597 DDB_G0278597 DDB0232430 CDS287423 831 - 0.305656
DDB_G0278655 DDB_G0278655 DDB0232430 CDS672611 867 + 0.302191
DDB_G0278661 DDB_G0278661 DDB0232430 CDS695788 4023 - 0.316182
DDB_G0278665 DDB_G0278665 DDB0232430 CDS753135 3273 - 0.31103
DDB_G0278675 DDB_G0278675 DDB0232430 CDS789665 1752 - 0.261986
DDB_G0278683 DDB_G0278683 DDB0232430 CDS839543 570 + 0.280702
DDB_G0278759 DDB_G0278759 DDB0232430 CDS1128110 2484 + 0.231079
DDB_G0278793 DDB_G0278793 DDB0232430 CDS1186077 690 + 0.350725
DDB_G0278819 DDB_G0278819 ortholog of human CRNKL1 (crooked neck-like) involved in pre-mRNA splicing contains 11 HAT (Half A TPR) repeatsDDB0232430 CDS1238183 2118 + 0.283758
DDB_G0278845 DDB_G0278845 member of the AGC kinase group similar to kinase domains of NDR (nuclear Dbf2-related) family membersDDB0232430 CDS1269374 4053 - 0.265976
DDB_G0278851 DDB_G0278851 bCommunity annotation:b DDB G0278851 is similar to the rik1-associated factor raf1 of S. pombe. Raf1 (as well as rik1) participates in the Clr4 methyltransferase complex (see Horn et al Genes and Development 19 1705-1714) which methylates H3K9 important in silencing centromeric and telomeric repeats. It has recently been shown that these repeats are transcribed for a limited period during S-phase (Chen et al Nature 451 734-737 (2008) that this transcription is essential for RNA-interference mediated heterochromatin assembly and that the repeats are transcriptionally repressed outside of S-phase.br DDB_G0278851 and a second member of the Clr4 complex the methyl transferase clr4suvA are both overexpressed about threefold (p2e-63) in a Dicty strain in which the retinoblastoma-like protein rblA has been disrupted. Most genes associated with S-phase or mitosis are overexpressed in this strain. The activity of the clr4 complex is thus likely to be S-phase associated. All these observations aDDB0232430 CDS1278474 2757 - 0.318099
DDB_G0278901 DDB_G0278901 DDB0232430 CDS1361340 4488 - 0.282308
DDB_G0278909 DDB_G0278909 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains an N-terminal LRR and a C-terminal armadillobeta-catenin repeat unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS1376167 5811 + 0.293581
DDB_G0278945 DDB_G0278945 DDB0232430 CDS1251221 960 + 0.292708
DDB_G0278953 DDB_G0278953 contains four CBS domains similar to protein kinase 5'AMP activated gamma subunit expressed in prespore cellsDDB0232430 CDS1335145 1080 - 0.312963
DDB_G0279003 DDB_G0279003 DDB0232430 CDS1503809 2328 + 0.334192
DDB_G0279019 DDB_G0279019 DDB0232430 CDS1519155 885 + 0.250847
DDB_G0279043 DDB_G0279043 DDB0232430 CDS1548959 603 + 0.310116
DDB_G0279107 DDB_G0279107 DDB0232430 CDS1638888 3717 - 0.283562
DDB_G0279139 DDB_G0279139 homolog of human ANKRD29 contains 8 ankyrin repeatsDDB0232430 CDS1678974 1143 + 0.297463
DDB_G0279179 DDB_G0279179 DDB0232430 CDS1715076 2779 + 0.348687
DDB_G0279241 DDB_G0279241 DDB0232430 CDS1814829 2760 - 0.236594
DDB_G0279259 DDB_G0279259 DDB0232430 CDS1848643 2526 + 0.266825
DDB_G0279261 DDB_G0279261 DDB0232430 CDS1855053 1911 + 0.22449
DDB_G0279275 DDB_G0279275 DDB0232430 CDS1874332 1704 + 0.286385
DDB_G0279355 DDB_G0279355 DDB0232430 CDS1981638 1146 + 0.283595
DDB_G0279363 DDB_G0279363 DDB0232430 CDS1987447 516 - 0.244186
DDB_G0279395 DDB_G0279395 DDB0232430 CDS1853231 1341 - 0.247576
DDB_G0279405 DDB_G0279405 CAMKL family protein kinase the protein kinase domain has similarity to those of calciumcalmodulin-dependent protein kinase kinases (CAMKK) that belong to a proposed calcium-triggered signaling cascade involved in a number of cellular processesDDB0232430 CDS1975813 2088 + 0.290709
DDB_G0279431 DDB_G0279431 DDB0232430 CDS2040372 1581 - 0.251107
DDB_G0279459 DDB_G0279459 bCommunity Annotationb DDB G0279459 contains a forkhead-associated domain which is similar to the corresponding domain in the KI-67 antigen a very widely used clinical proliferation marker and is the only hit when the KI-67 sequence is blasted against Dicty proteins. Direct comparison of the Dd sequence with KI-67 by Blast2Sequences identifies two regions of homology and gives an expected value of 4e-08 suggesting that the similarity may be real. The KI-67 antigen in humans is nuclear and present throughout the cell cycle in proliferating cells but undetectable in cells in G0. Recent work suggests that the protein is involved in ribosomal RNA synthesis ((Bullwinkel et al J Cell Physiology 206 624-635 (2005) Rahmanzadeh et al Cell and Molecular Biology 40 422-430 (2007). A role in chromatin compaction has also been ascribed to KI-67 (Kametaka et al Genes Cells 7 1231-42 (2002) but this appears to involve the C-terminus. The Dicty protein is significantly shorter than the human protein aDDB0232430 CDS2077799 3099 - 0.310745
DDB_G0279511 DDB_G0279511 DDB0232430 CDS2181977 3690 + 0.263957
DDB_G0279545 DDB_G0279545 similar to bacterial short-chain dehydrogenasereductase family proteinsDDB0232430 CDS2237325 879 - 0.290102
DDB_G0279589 DDB_G0279589 DDB0232430 CDS2089639 453 + 0.280353
DDB_G0279675 DDB_G0279675 belongs to the carbon-nitrogen hydrolase family similar to human VNN1 (pantetheine hydrolase) contains a predicted signal anchor sequenceDDB0232430 CDS2426331 1623 - 0.262477
DDB_G0279679 DDB_G0279679 DDB0232430 CDS2429651 855 - 0.226901
DDB_G0279695 DDB_G0279695 similar D. melanogaster ORF CG8021 and the RRM domain is similar to that of human RBM3DDB0232430 CDS2457402 255 + 0.298039
DDB_G0279719 DDB_G0279719 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232430 CDS2480611 2829 - 0.265111
DDB_G0279783 DDB_G0279783 similar to bacterial short-chain dehydrogenasereductase family proteinsDDB0232430 CDS2546062 888 - 0.240991
DDB_G0279807 DDB_G0279807 DDB0232430 CDS2563367 1908 - 0.321803
DDB_G0279821 DDB_G0279821 DDB0232430 CDS2586560 1749 - 0.263579
DDB_G0279823 DDB_G0279823 DDB0232430 CDS2588778 2685 - 0.299814
DDB_G0279831 DDB_G0279831 putative protein serinethreonine kinase CAMK group the protein kinase domain is similar to those of mammalian CAM kinase IDDB0232430 CDS2602496 2787 + 0.267671
DDB_G0279851 DDB_G0279851 putative histone acetyltransferase highly similar to bacterial GCN5-related N-acetyltransferase (GNAT)DDB0232430 CDS2640159 516 - 0.284884
DDB_G0279943 DDB_G0279943 belongs to the major facilitator superefamily contains 12 putative transmembrane domainsDDB0232430 CDS2721717 1488 - 0.309812
DDB_G0279965 DDB_G0279965 members of the NAD-dependent epimerasedehydratase family use nucleotide-sugar substrates for a variety of chemical reactions contains a putative signal peptideDDB0232430 CDS2775437 1203 - 0.305902
DDB_G0279987 DDB_G0279987 DDB0232430 CDS2820923 675 + 0.216296
DDB_G0280019 DDB_G0280019 conserved in bacteria and fungi similar to S. cerevisiae HSP31 (heat shock protein 31) a putative proteaseDDB0232430 CDS2796272 702 + 0.339031
DDB_G0280111 DDB_G0280111 putative protein serinethreonine kinase similar to the kinase domains of AAK1 (AP2 associated kinase) and BMP-inducible protein kinase (BIKe)DDB0232430 CDS2948944 3381 - 0.280982
DDB_G0280123 DDB_G0280123 DDB0232430 CDS2978017 708 + 0.262712
DDB_G0280131 DDB_G0280131 member of the TKL (tyrosine kinase-like) group and the ARMK (armadillo repeat-containing kinase) family contains armadillobeta-catenin-like repeats unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS2985578 3579 - 0.308187
DDB_G0280133 DDB_G0280133 CAMK family protein kinase protein kinase domain similar to those of mammalian SNF1 like kinasesDDB0232430 CDS2991402 4518 + 0.285967
DDB_G0280181 DDB_G0280181 contains three ankyrin repeats and an RA domain which plays a role in RasGTP activation in mammals and mating in yeast highly similar to DDB0232430 CDS3067276 1002 - 0.278443
DDB_G0280191 DDB_G0280191 DDB0232430 CDS3082696 1323 - 0.230537
DDB_G0280203_ps DDB_G0280203 putative pseudogene similar to pirin family proteins especially to DDB_G0281115 and DDB_G0280725DDB0232430 CDS3101331 654 + 0.314985
DDB_G0280221 DDB_G0280221 DDB0232430 CDS3129179 6531 - 0.27469
DDB_G0280261 DDB_G0280261 contains one LisH domain and 7 WD40 domains similar to human TBL1X (F-box-likeWD repeat-containing protein) which plays a role in transcription activation mediated by nuclear receptorsDDB0232430 CDS3178567 1743 - 0.324154
DDB_G0280289 DDB_G0280289 DDB0232430 CDS3208817 2961 - 0.333671
DDB_G0280329 DDB_G0280329 DDB0232430 CDS3262966 1128 + 0.221631
DDB_G0280367 DDB_G0280367 DDB0232430 CDS2917996 909 + 0.190319
DDB_G0280369 DDB_G0280369 DDB0232430 CDS2942956 4443 - 0.244655
DDB_G0280385 DDB_G0280385 DDB0232430 CDS3156312 1332 + 0.294294
DDB_G0280437 DDB_G0280437 DDB0232430 CDS3353124 897 - 0.222965
DDB_G0280461 DDB_G0280461 DDB0232430 CDS3391535 1257 - 0.24105
DDB_G0280549 DDB_G0280549 DDB0232430 CDS3481319 1116 + 0.269713
DDB_G0280557 DDB_G0280557 similar to erkA and erkB and other MAP kinases does not contain the consensus sequences required for kinase functionDDB0232430 CDS3496721 1383 + 0.237889
DDB_G0280581 DDB_G0280581 DDB0232430 CDS3524824 2070 - 0.20628
DDB_G0280643 DDB_G0280643 similar to many CMGC family members including several MAPKsDDB0232430 CDS3598294 1329 - 0.261851
DDB_G0280717 DDB_G0280717 member of the AGC kinase group similar to the kinase domains of PKC (protein kinase C) and MAST (microtubule-associated serinethreonine kinase)DDB0232430 CDS3670258 1236 - 0.258091
DDB_G0280725 DDB_G0280725 almost identical to DDB0232430 CDS3688197 888 - 0.335586
DDB_G0280729_ps DDB_G0280729 putative pseudogene belongs to the pirin familyDDB0232430 CDS3691400 840 - 0.333333
DDB_G0280735_ps DDB_G0280735 putative pseudogene predicted translation contains the C-terminal domain of pirin a nuclear protein of unknown functionDDB0232430 CDS3696501 207 + 0.357488
DDB_G0280767 DDB_G0280767 DDB0232430 CDS3718300 1269 + 0.312057
DDB_G0280801 DDB_G0280801 DDB0232430 CDS3766917 3807 + 0.328343
DDB_G0280805 DDB_G0280805 homolog of human and S. cerevisiae KRR1 (KRR-R motif-containing protein) contains one RNA-binding KH domain S. cerevisiae KRR1 is required for 40S ribosome biogenesisDDB0232430 CDS3779782 1125 - 0.277333
DDB_G0280825 DDB_G0280825 similar to bacterial acetyltransferases homolog of E. coli maa (maltose O-acetyltransferase) similar to D. purpureum proteinDDB0232430 CDS1441074 576 + 0.326389
DDB_G0280845 DDB_G0280845 DDB0232430 CDS1421922 2185 + 0.279634
DDB_G0280855 DDB_G0280855 similar to erkA and erkB and other MAP kinases unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232430 CDS3794487 1179 + 0.25106
DDB_G0280895 DDB_G0280895 has the same domain composition as fbxA and DDB0232430 CDS3841507 4506 - 0.264536
DDB_G0280923 DDB_G0280923 DDB0232430 CDS3886092 282 + 0.326241
DDB_G0280955 DDB_G0280955 GTPase activator for rab8A involved in the regulation of contractile vacuole function during hypoosmotic stressDDB0232430 CDS3904017 2202 - 0.262489
DDB_G0280997 DDB_G0280997 DDB0232430 CDS3926681 1029 - 0.295432
DDB_G0281059 DDB_G0281059 DDB0232430 CDS3994227 1068 + 0.256554
DDB_G0281083 DDB_G0281083 DDB0232430 CDS4029591 1737 - 0.312608
DDB_G0281115 DDB_G0281115 almost identical to DDB0232430 CDS4078245 888 + 0.323198
DDB_G0281119_ps DDB_G0281119 putative pseudogene similar to pirin family proteins especially to parts of DDB_G0281115 and DDB_G0280725DDB0232430 CDS4081406 591 + 0.329949
DDB_G0281123_ps DDB_G0281123 putative pseudogene similar to Dictyostelium genes DDB0232430 CDS4083976 387 + 0.307494
DDB_G0281137 DDB_G0281137 DDB0232430 CDS4091325 1794 + 0.240245
DDB_G0281155 DDB_G0281155 putative sugar transporter contains 12 putative transmembrane domainsDDB0232430 CDS4113808 1614 + 0.29368
DDB_G0281259 DDB_G0281259 similar to the DREV (DORA reverse strand) protein found in other eukaryotes believed to be a methyltransferase but is of unknown functionDDB0232430 CDS4305745 1230 + 0.243089
DDB_G0281283 DDB_G0281283 DDB0232430 CDS4337681 660 + 0.283333
DDB_G0281309 DDB_G0281309 DDB0232430 CDS4120970 603 - 0.296849
DDB_G0281333 DDB_G0281333 DDB0232430 CDS4318553 2700 - 0.266667
DDB_G0281359 DDB_G0281359 DDB0232430 CDS4401226 1032 + 0.251938
DDB_G0281505 DDB_G0281505 DDB0232430 CDS4641293 1014 - 0.287968
DDB_G0281589 DDB_G0281589 very similar to mammalian CBWD1 and CBWD2 ubiquitiously expressed COBW domain-containing proteins prokaryotic CobW involved in cobalamin (vitamin B12) biosynthesisDDB0232430 CDS4676319 1191 - 0.246012
DDB_G0281603 DDB_G0281603 DDB0232430 CDS4698687 1926 + 0.246106
DDB_G0281633_ps DDB_G0281633 putative pseudogene fragment similar to pirin family proteins especially to the C-terminal half of DDB_G0281115 and DDB_G0280725DDB0232430 CDS4738827 327 + 0.299694
DDB_G0281671 DDB_G0281671 DDB0232430 CDS4794386 4170 - 0.243885
DDB_G0281673 DDB_G0281673 DDB0232430 CDS4799865 822 + 0.290754
DDB_G0281745 DDB_G0281745 DDB0232430 CDS4910382 1794 + 0.337793
DDB_G0281751 DDB_G0281751 DDB0232430 CDS4916395 822 - 0.287105
DDB_G0281807_ps DDB_G0281807 putative pseudogene fragment similar to pirin family proteinDDB0232430 CDS4741312 333 + 0.321321
DDB_G0281831 DDB_G0281831 conserved in bacteria a member of the NK (nucleosidenucleotide kinase) superfamily also belongs to the zeta toxin family which in bacteria is a component of a postregulational killing systemDDB0232430 CDS4993575 507 - 0.262327
DDB_G0281839 DDB_G0281839 DDB0232430 CDS4997894 2502 + 0.328937
DDB_G0281903 DDB_G0281903 DDB0232430 CDS5094433 1218 + 0.254516
DDB_G0281909 DDB_G0281909 DDB0232430 CDS5103620 1836 - 0.289216
DDB_G0281917 DDB_G0281917 DDB0232430 CDS5121103 954 + 0.29979
DDB_G0281927 DDB_G0281927 DDB0232430 CDS5152552 942 + 0.272824
DDB_G0282005 DDB_G0282005 DDB0232430 CDS5234911 681 + 0.30837
DDB_G0282127 DDB_G0282127 DDB0232430 CDS5429045 1038 + 0.220617
DDB_G0282135 DDB_G0282135 conserved hyphothetical protein similar to AprA an autocrine repressor of proliferationDDB0232430 CDS5405787 1551 + 0.283688
DDB_G0282157 DDB_G0282157 DDB0232430 CDS5467686 1668 + 0.209832
DDB_G0282213 DDB_G0282213 DDB0232430 CDS5526720 1464 - 0.239071
DDB_G0282233 DDB_G0282233 DDB0232430 CDS5550968 1707 + 0.322203
DDB_G0282303 DDB_G0282303 DDB0232430 CDS5610805 2364 - 0.249154
DDB_G0282311 DDB_G0282311 DDB0232430 CDS5621318 1992 + 0.314759
DDB_G0282393 DDB_G0282393 DDB0232430 CDS5695519 699 + 0.276109
DDB_G0282407 DDB_G0282407 DDB0232430 CDS5710802 2262 - 0.376658
DDB_G0282429 DDB_G0282429 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232430 CDS5758659 939 - 0.312034
DDB_G0282477 DDB_G0282477 DDB0232430 CDS5822316 267 + 0.318352
DDB_G0282487 DDB_G0282487 DDB0232430 CDS5834821 936 + 0.185897
DDB_G0282573 DDB_G0282573 DDB0232430 CDS5953713 1227 + 0.294214
DDB_G0282575 DDB_G0282575 DDB0232430 CDS5957238 3585 + 0.278661
DDB_G0282603 DDB_G0282603 DDB0232430 CDS5993046 600 + 0.261667
DDB_G0282673 DDB_G0282673 DDB0232430 CDS6100946 1533 + 0.300065
DDB_G0282711 DDB_G0282711 contains a plant homeodomain (PHD) finger a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulationDDB0232430 CDS6179495 4086 - 0.263338
DDB_G0282765 DDB_G0282765 DDB0232430 CDS5832783 915 + 0.254645
DDB_G0282779_ps DDB_G0282779 putative pseudogene similar to D. discoideum genes DDB0232430 CDS5911017 2427 - 0.261228
DDB_G0282823 DDB_G0282823 DDB0232430 CDS6262357 2712 - 0.272493
DDB_G0282875 DDB_G0282875 DDB0232430 CDS6329217 729 + 0.242798
DDB_G0282885 DDB_G0282885 DDB0232430 CDS6339466 1203 + 0.23192
DDB_G0282895 DDB_G0282895 member of the TKL (tyrosine kinase-like) group contains three N-terminal MORN (Membrane Occupation and Recognition Nexus) repeatsDDB0232430 CDS6249781 4905 + 0.262385
DDB_G0282945 DDB_G0282945 DDB0232431 CDS31559 2010 - 0.280597
DDB_G0282963 DDB_G0282963 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS60445 5286 + 0.265796
DDB_G0283017 DDB_G0283017 DDB0232431 CDS164286 2676 + 0.246637
DDB_G0283039 DDB_G0283039 DDB0232431 CDS196663 1341 - 0.222968
DDB_G0283065 DDB_G0283065 putative eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase putative protein serinethreonine kinase related to the GCN2 (general control non-derepressible) family of protein kinases that phosphorylate the alpha subunit of eIF2DDB0232431 CDS122741 1914 - 0.242424
DDB_G0283191 DDB_G0283191 DDB0232431 CDS394762 1695 + 0.277286
DDB_G0283211_ps DDB_G0283211 putative pseudogene belongs to the large D. discoideum zinc-containing alcohol dehydrogenase (ADH) familyDDB0232431 CDS368141 768 - 0.272135
DDB_G0283291 DDB_G0283291 DDB0232431 CDS467526 1092 - 0.271978
DDB_G0283301 DDB_G0283301 DDB0232431 CDS480042 1992 + 0.254016
DDB_G0283337 DDB_G0283337 DDB0232431 CDS491931 3387 - 0.219368
DDB_G0283397 DDB_G0283397 DDB0232431 CDS606939 2757 - 0.283642
DDB_G0283399 DDB_G0283399 DDB0232431 CDS609993 504 - 0.18254
DDB_G0283451 DDB_G0283451 DDB0232431 CDS712043 1215 - 0.33251
DDB_G0283495 DDB_G0283495 DDB0232431 CDS611003 2319 + 0.337214
DDB_G0283535 DDB_G0283535 similar to H. sapiens DMXL1 and DMXL2 and D. melanogaster DmX REMI mutant fails to aggregate see DDB0232431 CDS837650 8379 - 0.297291
DDB_G0283551 DDB_G0283551 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity highly similar to neighboring gene DDB0232431 CDS810010 3975 - 0.255597
DDB_G0283553 DDB_G0283553 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity highly similar to neighboring gene DDB0232431 CDS815506 4545 - 0.252805
DDB_G0283565 DDB_G0283565 DDB0232431 CDS833347 3024 - 0.305886
DDB_G0283595 DDB_G0283595 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232431 CDS805455 3873 - 0.251743
DDB_G0283649 DDB_G0283649 similar to the S. cerevisiae LOT6 a FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxificationDDB0232431 CDS910617 600 - 0.301667
DDB_G0283677 DDB_G0283677 DDB0232431 CDS963963 882 + 0.217687
DDB_G0283687 DDB_G0283687 similar to CC1-like splicing factors characterized by an N-terminal arginine-rich low complexity domain followed by three RNA recognition domains similar to human RBM23 and RBM39DDB0232431 CDS982205 2184 + 0.330586
DDB_G0283697 DDB_G0283697 DDB0232431 CDS992255 2562 + 0.276347
DDB_G0283727 DDB_G0283727 DDB0232431 CDS1038776 756 + 0.376984
DDB_G0283793 DDB_G0283793 DDB0232431 CDS1114386 2136 - 0.305243
DDB_G0283799 DDB_G0283799 DDB0232431 CDS1120333 1098 - 0.211293
DDB_G0283803 DDB_G0283803 DDB0232431 CDS1122911 582 + 0.298969
DDB_G0283817 DDB_G0283817 DDB0232431 CDS1149949 882 + 0.314059
DDB_G0283821 DDB_G0283821 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesisDDB0232431 CDS1155677 2826 - 0.295824
DDB_G0283859 DDB_G0283859 DDB0232431 CDS1066871 5037 + 0.289458
DDB_G0283915 DDB_G0283915 DDB0232431 CDS1270973 702 + 0.337607
DDB_G0283927 DDB_G0283927 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232431 CDS1307685 1458 - 0.226337
DDB_G0283935 DDB_G0283935 similar to bacterial short-chain dehydrogenasereductase family proteinsDDB0232431 CDS1333704 942 + 0.284501
DDB_G0283949 DDB_G0283949 DDB0232431 CDS1350512 1398 - 0.268956
DDB_G0283977 DDB_G0283977 DDB0232431 CDS1409294 2622 - 0.217391
DDB_G0283985 DDB_G0283985 DDB0232431 CDS1263489 1608 + 0.250622
DDB_G0283991 DDB_G0283991 DDB0232431 CDS1287653 1092 + 0.308608
DDB_G0284055 DDB_G0284055 DDB0232431 CDS1474815 1335 - 0.270412
DDB_G0284079 DDB_G0284079 contains two ankyrin repeats and an RA domain which plays a role in RasGTP activation in mammals and mating in yeast highly similar to DDB0232431 CDS1538387 912 + 0.291667
DDB_G0284083 DDB_G0284083 DDB0232431 CDS1548205 999 + 0.209209
DDB_G0284085 DDB_G0284085 DDB0232431 CDS1549462 1098 + 0.175774
DDB_G0284091 DDB_G0284091 DDB0232431 CDS1556685 723 - 0.337483
DDB_G0284157 DDB_G0284157 DDB0232431 CDS1583322 3426 + 0.28955
DDB_G0284167 DDB_G0284167 DDB0232431 CDS1610129 882 - 0.422902
DDB_G0284207 DDB_G0284207 DDB0232431 CDS1688943 858 + 0.284382
DDB_G0284209 DDB_G0284209 DDB0232431 CDS1690478 876 - 0.280822
DDB_G0284211_ps DDB_G0284211 putative pseudogene belonging to the short-chain dehydrogenasereductase (SDR) familybrbr bCommunity annotation:b probably a recent pseudogene of the short-chain dehydrogenase family including DDB0185894. The coding sequence share high level of homology with DDB0185894 before and after the stop codon resulting in a truncated and probably non functional protein if that gene is still transcribed. Christophe Anjard May 2007DDB0232431 CDS1692886 738 + 0.298103
DDB_G0284223 DDB_G0284223 DDB0232431 CDS1712491 1641 - 0.322364
DDB_G0284239 DDB_G0284239 CAZy family GH9 catalyzes the hydrolysis of glucosidic linkagesDDB0232431 CDS1731488 2031 + 0.356475
DDB_G0284251 DDB_G0284251 kinase domain similar to those of mitogen-activated protein kinases similar to the STE20 familyDDB0232431 CDS1754346 1491 - 0.273642
DDB_G0284277 DDB_G0284277 similar to bacterial short-chain dehydrogenasereductase family proteinsDDB0232431 CDS1821556 870 - 0.314943
DDB_G0284289 DDB_G0284289 DDB0232431 CDS1835474 2166 - 0.262696
DDB_G0284351 DDB_G0284351 DDB0232431 CDS1869385 735 + 0.287075
DDB_G0284365 DDB_G0284365 DDB0232431 CDS1895020 681 + 0.287812
DDB_G0284429 DDB_G0284429 DDB0232431 CDS1981059 864 - 0.261574
DDB_G0284485 DDB_G0284485 DDB0232431 CDS2034779 846 - 0.321513
DDB_G0284539 DDB_G0284539 DDB0232431 CDS2152696 2997 - 0.242576
DDB_G0284565 DDB_G0284565 DDB0232431 CDS2142583 4788 - 0.267126
DDB_G0284603 DDB_G0284603 DDB0232431 CDS2211789 1413 + 0.208068
DDB_G0284661 DDB_G0284661 putative protein serinethreonine kinase CAMK group kinase domain similar to mammalian CAM kinase IDDB0232431 CDS2309177 1446 - 0.304288
DDB_G0284701 DDB_G0284701 DDB0232431 CDS2371416 1314 - 0.269406
DDB_G0284727 DDB_G0284727 DDB0232431 CDS2313169 2424 + 0.288779
DDB_G0284741 DDB_G0284741 DDB0232431 CDS2402392 4188 - 0.298472
DDB_G0284919 DDB_G0284919 similar to human DHRSX (dehydrogenasereductase SDR family member on chromosome X) and retinol dehydrogenaseDDB0232431 CDS2646442 990 - 0.233333
DDB_G0284937 DDB_G0284937 DDB0232431 CDS2665360 1026 + 0.287524
DDB_G0284969 DDB_G0284969 DDB0232431 CDS2719814 1764 + 0.272676
DDB_G0284995 DDB_G0284995 DDB0232431 CDS2782622 873 + 0.252005
DDB_G0285011 DDB_G0285011 similar to the fungi mitochondrial transferase caf17 a mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteinsDDB0232431 CDS2814046 1227 - 0.295029
DDB_G0285033 DDB_G0285033 belongs to the short-chain dehydrogenasereductase familyDDB0232431 CDS2839925 786 + 0.307888
DDB_G0285095 DDB_G0285095 DDB0232431 CDS2804851 792 - 0.306818
DDB_G0285127 DDB_G0285127 DDB0232431 CDS2886739 1101 - 0.217984
DDB_G0285209 DDB_G0285209 DDB0232431 CDS2951533 810 + 0.261728
DDB_G0285265 DDB_G0285265 contains one EF hand similar to calmodulinDDB0232431 CDS3032493 420 - 0.292857
DDB_G0285351 DDB_G0285351 DDB0232431 CDS3146811 1365 - 0.267399
DDB_G0285411 DDB_G0285411 DDB0232431 CDS3189133 4317 + 0.217049
DDB_G0285445 DDB_G0285445 has the same domain composition as fbxA and DDB0232431 CDS3230059 3537 - 0.271699
DDB_G0285463 DDB_G0285463 member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) family contains 7 putative transmembrane domainsDDB0232431 CDS3259648 2076 - 0.308285
DDB_G0285467 DDB_G0285467 DDB0232431 CDS3266519 1398 + 0.326896
DDB_G0285511 DDB_G0285511 DDB0232431 CDS3331170 1683 - 0.322638
DDB_G0285529 DDB_G0285529 DDB0232431 CDS3346712 1149 + 0.252393
DDB_G0285531 DDB_G0285531 DDB0232431 CDS3348010 1200 + 0.245833
DDB_G0285587 DDB_G0285587 DDB0232431 CDS3413814 1170 - 0.275214
DDB_G0285645 DDB_G0285645 DDB0232431 CDS3531932 957 - 0.256008
DDB_G0285663 DDB_G0285663 conserved protozoa protein that are putative permeases involved in the transport of lipids contains 10 putative transmembrane domainsDDB0232431 CDS3554545 3456 - 0.308738
DDB_G0285753_ps DDB_G0285753 putative pseudogene similar to a family of D. discoideum genes including DDB0232431 CDS3388026 975 + 0.29641
DDB_G0285755_ps DDB_G0285755 putative pseudogene similar to cyclin-like F-box containing proteinsDDB0232431 CDS3393941 645 - 0.317829
DDB_G0285803 DDB_G0285803 belongs to the GNAT family homolog of S. cerevisiae MAK3 (maintenance of killer protein 3)DDB0232431 CDS3673056 558 + 0.250896
DDB_G0285823 DDB_G0285823 DDB0232431 CDS3703536 1521 + 0.331361
DDB_G0285827 DDB_G0285827 DDB0232431 CDS3706474 1002 + 0.251497
DDB_G0285831 DDB_G0285831 DDB0232431 CDS3709396 522 + 0.260536
DDB_G0285837 DDB_G0285837 DDB0232431 CDS3674059 6603 - 0.283356
DDB_G0285897 DDB_G0285897 DDB0232431 CDS3798877 1701 + 0.280423
DDB_G0285903 DDB_G0285903 DDB0232431 CDS3808445 792 - 0.27399
DDB_G0285905 DDB_G0285905 DDB0232431 CDS3809647 843 - 0.204033
DDB_G0285969 DDB_G0285969 putative cysteine protease member of the DJ-1ThiJPfpI family which includes human PARK7 associated with Parkinson's diseaseDDB0232431 CDS3885433 618 - 0.305825
DDB_G0285973 DDB_G0285973 DDB0232431 CDS3894503 1404 + 0.289174
DDB_G0285989 DDB_G0285989 DDB0232431 CDS3911476 3705 + 0.239676
DDB_G0285991 DDB_G0285991 DDB0232431 CDS3915272 882 - 0.25737
DDB_G0286067 DDB_G0286067 DDB0232431 CDS4019113 3573 + 0.240974
DDB_G0286073 DDB_G0286073 DDB0232431 CDS4028900 1638 + 0.281441
DDB_G0286129 DDB_G0286129 similar to mammalian F-boxWD repeat-containing protein 7 which is part to the E3 ubiquitin-protein ligase complexDDB0232431 CDS4060377 2220 + 0.263514
DDB_G0286167 DDB_G0286167 DDB0232431 CDS4119612 1410 - 0.312057
DDB_G0286201_ps DDB_G0286201 putative pseudogene similar to a Dictyostelid family of oxidoreductases including DDB0232431 CDS4168246 846 + 0.239953
DDB_G0286203 DDB_G0286203 DDB0232431 CDS4169821 1026 + 0.24269
DDB_G0286223 DDB_G0286223 contains up to 13 WD40 repeats very similar to D. purpureum proteinDDB0232431 CDS4210540 2304 + 0.291667
DDB_G0286239 DDB_G0286239 DDB0232431 CDS4234344 1080 + 0.316667
DDB_G0286243 DDB_G0286243 DDB0232431 CDS4239634 3012 + 0.285193
DDB_G0286283 DDB_G0286283 DDB0232431 CDS4297454 924 + 0.199134
DDB_G0286297 DDB_G0286297 DDB0232431 CDS4322636 354 - 0.251412
DDB_G0286305 DDB_G0286305 DDB0232431 CDS4332234 1017 - 0.360865
DDB_G0286309 DDB_G0286309 DDB0232431 CDS4335795 1026 + 0.337232
DDB_G0286311 DDB_G0286311 DDB0232431 CDS4337464 4422 + 0.313433
DDB_G0286325_ps DDB_G0286325 putative pseudogene similar to D. discoideum gene DDB0232431 CDS4171531 354 + 0.262712
DDB_G0286397 DDB_G0286397 DDB0232431 CDS4407676 1281 - 0.225605
DDB_G0286443 DDB_G0286443 DDB0232431 CDS4513273 675 - 0.244444
DDB_G0286481 DDB_G0286481 putative protein serinethreonine kinase similar to casein kinase II the alpha chain of a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS4514745 1818 - 0.264026
DDB_G0286513 DDB_G0286513 DDB0232431 CDS4577203 1683 + 0.236482
DDB_G0286527_ps DDB_G0286527 putative pseudogene similar to a Dictyostelid family of putative SAM-dependent methyltransferases including DDB0232431 CDS4594246 561 - 0.247772
DDB_G0286575 DDB_G0286575 similar to retinol dehydrogenase and eukaryotic proteins of the short chain dehydrogenasesreductases familyDDB0232431 CDS4647468 873 + 0.218786
DDB_G0286581 DDB_G0286581 DDB0232431 CDS4651768 915 + 0.285246
DDB_G0286625 DDB_G0286625 conserved hyphothetical protein similar to AprA an autocrine repressor of proliferationDDB0232431 CDS4749168 1566 - 0.308429
DDB_G0286627 DDB_G0286627 putative protein serinethreonine kinase belongs to the STE group the kinase domain is similar to yeast BCK1 a mitogen-activated protein (MAP) kinase kinase kinaseDDB0232431 CDS4756048 2016 - 0.251984
DDB_G0286641 DDB_G0286641 putative GTPase that has high similarity to NOG1GTPBP4 GTPases which in S. cerevisiae associates with free 60S ribosomal subunits in the nucleolus this D. discoideumprotein is only about half the length and lacks the NOG1 C-terminal domainDDB0232431 CDS4774707 1044 + 0.198276
DDB_G0286691 DDB_G0286691 DDB0232431 CDS4852997 408 + 0.25
DDB_G0286713 DDB_G0286713 DDB0232431 CDS4882439 693 - 0.277056
DDB_G0286735 DDB_G0286735 DDB0232431 CDS4909097 2085 + 0.317026
DDB_G0286841 DDB_G0286841 member of the AGC kinase group similar to the kinase domains of MAST kinases (Microtubule-Associated SerineThreonine kinase)DDB0232431 CDS4966020 1389 - 0.218143
DDB_G0286845 DDB_G0286845 DDB0232431 CDS4972112 885 + 0.277966
DDB_G0286849 DDB_G0286849 similar to bacterial short-chain dehydrogenasereductase family proteins and human RDH8 (retinol dehydrogenase 8)DDB0232431 CDS4977120 870 - 0.28046
DDB_G0286861 DDB_G0286861 DDB0232431 CDS4978558 885 + 0.275706
DDB_G0286883 DDB_G0286883 DDB0232431 CDS5022922 573 - 0.277487
DDB_G0286947 DDB_G0286947 DDB0232431 CDS5126978 5022 + 0.258662
DDB_G0286979 DDB_G0286979 DDB0232431 CDS5150412 1884 - 0.277601
DDB_G0287001 DDB_G0287001 member of the TKL (tyrosine kinase-like) group contains zinc-binding LIM domainDDB0232431 CDS5188585 1953 - 0.28213
DDB_G0287003 DDB_G0287003 DDB0232431 CDS5191304 1254 - 0.334928
DDB_G0287013 DDB_G0287013 DDB0232431 CDS5205106 1026 - 0.346979
DDB_G0287017 DDB_G0287017 belongs to the HAD-like hydrolase superfamily similar to human HDHD3 (haloacid dehalogenase-like hydrolase domain-containing protein 3)DDB0232431 CDS5207898 858 - 0.221445
DDB_G0287037 DDB_G0287037 DDB0232431 CDS5215181 978 + 0.274029
DDB_G0287067 DDB_G0287067 DDB0232431 CDS5289082 393 - 0.29771
DDB_G0287081 DDB_G0287081 DDB0232431 CDS5304055 840 - 0.24881
DDB_G0287151 DDB_G0287151 similar to retinol dehydrogenase and eukaryotic short chain dehydrogenasesreductases family proteinsDDB0232431 CDS5393798 930 - 0.224731
DDB_G0287193 DDB_G0287193 DDB0232431 CDS5388100 3177 + 0.251495
DDB_G0287305 DDB_G0287305 DDB0232432 CDS110292 543 - 0.246777
DDB_G0287309 DDB_G0287309 DDB0232432 CDS112586 600 + 0.26
DDB_G0287319 DDB_G0287319 similar to human SLC35E2 (solute carrier family 35 member E2) contains 10 putative transmembrane domainsDDB0232432 CDS129877 1047 + 0.30468
DDB_G0287323 DDB_G0287323 contains an N-terminal oxidoreductase domain and a partial C-terminal oxidoreductase domain the GfoIdhMocA family proteins utilize NADP or NADDDB0232432 CDS133013 1293 + 0.28925
DDB_G0287331 DDB_G0287331 DDB0232432 CDS144715 2136 + 0.267322
DDB_G0287335 DDB_G0287335 has similarity to human cold inducible RNA binding protein (CIRBP) however it is considreably shorterDDB0232432 CDS148219 276 + 0.344203
DDB_G0287379 DDB_G0287379 DDB0232432 CDS233763 3231 + 0.320644
DDB_G0287407 DDB_G0287407 similar to nephrocystin 3 Grp94 neighboring nucleotidase and other TPR repeat-containing proteinsDDB0232432 CDS263392 4992 + 0.313902
DDB_G0287541 DDB_G0287541 DDB0232432 CDS397759 2010 + 0.21592
DDB_G0287617 DDB_G0287617 similar to Bax inhibitor 1 that may have a role in inhibition of apoptosis contains 7 transmembrane domainsDDB0232432 CDS479630 765 + 0.284967
DDB_G0287679 DDB_G0287679 DDB0232432 CDS545368 3369 - 0.290591
DDB_G0287729 DDB_G0287729 DDB0232432 CDS613467 2121 + 0.296558
DDB_G0287843 DDB_G0287843 DDB0232432 CDS806278 1923 - 0.333853
DDB_G0287909 DDB_G0287909 DDB0232432 CDS833953 3585 - 0.271409
DDB_G0287929 DDB_G0287929 DDB0232432 CDS861720 1377 + 0.302832
DDB_G0287961 DDB_G0287961 DDB0232432 CDS894476 5595 - 0.27328
DDB_G0288005 DDB_G0288005 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232432 CDS962125 960 - 0.314583
DDB_G0288011 DDB_G0288011 DDB0232432 CDS974125 780 + 0.305128
DDB_G0288029 DDB_G0288029 member of the aspartateglutamateuridylate kinase family similar to glutamate 5-kinaseDDB0232432 CDS994876 891 - 0.243547
DDB_G0288039 DDB_G0288039 DDB0232432 CDS1009340 771 + 0.268482
DDB_G0288069 DDB_G0288069 DDB0232432 CDS1045172 3249 + 0.271776
DDB_G0288147 DDB_G0288147 member of the tyrosine kinase-like (TKL) group similar to plant serinethreonine kinases contains a phorbol esterdiacylglycerol-binding domainDDB0232432 CDS1147360 4044 + 0.271513
DDB_G0288155 DDB_G0288155 DDB0232432 CDS1159975 741 - 0.333333
DDB_G0288165 DDB_G0288165 sulfurates the molybdenum cofactor which is essential for xanthine dehydrogenase and aldehyde oxidaseDDB0232432 CDS1172053 1116 - 0.292115
DDB_G0288201 DDB_G0288201 DDB0232432 CDS1230521 942 - 0.266454
DDB_G0288255 DDB_G0288255 very similar to bacterial ribosomal RNA large subunit methyltransferase Nalso known as radical SAM protein or Cfr family proteinDDB0232432 CDS1294679 1224 - 0.287582
DDB_G0288263 DDB_G0288263 DDB0232432 CDS1310716 1266 - 0.226698
DDB_G0288279 DDB_G0288279 DDB0232432 CDS1332303 747 + 0.253012
DDB_G0288291 DDB_G0288291 contains 1 RRM (RNA recognition motif) domain similar to the RRM domain of eukaryotic peptidyl-prolyl cis-trans isomerase E DDB0232432 CDS1356313 372 + 0.266129
DDB_G0288395 DDB_G0288395 DDB0232432 CDS1489692 339 - 0.247788
DDB_G0288405 DDB_G0288405 DDB0232432 CDS1502693 2202 + 0.265668
DDB_G0288429 DDB_G0288429 belongs to the short-chain dehydrogenasesreductases (SDR) familyDDB0232432 CDS1527197 993 + 0.281974
DDB_G0288441 DDB_G0288441 DDB0232432 CDS1540991 804 + 0.263682
DDB_G0288453 DDB_G0288453 DDB0232432 CDS1521809 2913 - 0.270855
DDB_G0288465 DDB_G0288465 converts pantetheine 4'-phosphate to 3'-dephospho-CoA in other organisms this activity is part of a bifunctional enzyme that also has dephospho-CoA kinase activity in Dictyostelium the latter activity is encoded by DDB0232432 CDS1558211 1230 - 0.233333
DDB_G0288525 DDB_G0288525 DDB0232432 CDS1644947 1674 - 0.247909
DDB_G0288529 DDB_G0288529 DDB0232432 CDS1628807 1587 + 0.267171
DDB_G0288531 DDB_G0288531 DDB0232432 CDS1649759 2196 + 0.255009
DDB_G0288535 DDB_G0288535 DDB0232432 CDS1660756 1395 - 0.235842
DDB_G0288547 DDB_G0288547 DDB0232432 CDS1676407 1038 - 0.259152
DDB_G0288559 DDB_G0288559 DDB0232432 CDS1685010 1650 + 0.303636
DDB_G0288591 DDB_G0288591 DDB0232432 CDS1726934 861 + 0.293844
DDB_G0288597 DDB_G0288597 DDB0232432 CDS1732418 1926 - 0.226895
DDB_G0288625 DDB_G0288625 DDB0232432 CDS1759888 2316 - 0.295337
DDB_G0288651 DDB_G0288651 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232432 CDS1782938 1353 - 0.317812
DDB_G0288669 DDB_G0288669 DDB0232432 CDS1797088 930 - 0.230108
DDB_G0288729 DDB_G0288729 ortholog of the mammalian reticulon-4-interacting protein 1 a zinc-containing alcohol dehydrogenaseDDB0232432 CDS1887042 1059 - 0.249292
DDB_G0288779 DDB_G0288779 DDB0232432 CDS1950277 1482 + 0.212551
DDB_G0288795 DDB_G0288795 putative protein serinethreonine kinase AGC group similar to the kinase domains of mammalian AKTPKB similar to yeast protein kinases GAD8 and SCH9DDB0232432 CDS1975761 1926 - 0.317757
DDB_G0288811 DDB_G0288811 very similar to TBC1 domain family member 15 proteins and yeast GYP7 TBC domain-containing proteins in yeast are GTPase activator proteinsDDB0232432 CDS2006806 2490 + 0.284739
DDB_G0288865 DDB_G0288865 DDB0232432 CDS1959111 486 - 0.257202
DDB_G0288917 DDB_G0288917 similar to retinol dehydrogenase and eukaryotic proteins of the short chain dehydrogenasesreductases familyDDB0232432 CDS2119308 954 + 0.240042
DDB_G0288949 DDB_G0288949 DDB0232432 CDS2101452 1392 - 0.236351
DDB_G0288981 DDB_G0288981 DDB0232432 CDS2203346 441 - 0.206349
DDB_G0289031 DDB_G0289031 ortholog of the conserved spastic paraplegia 21 (SPG21) also known as Maspardin defects in human SPG21 are the cause of the neurodegenerative disorder spastic paraplegia also known as Mast syndromeDDB0232432 CDS2258354 1155 - 0.256277
DDB_G0289057 DDB_G0289057 DDB0232432 CDS2307545 936 + 0.238248
DDB_G0289059 DDB_G0289059 DDB0232432 CDS2308883 996 + 0.252008
DDB_G0289061 DDB_G0289061 DDB0232432 CDS2310384 1002 + 0.257485
DDB_G0289111 DDB_G0289111 DDB0232432 CDS2353928 942 + 0.335456
DDB_G0289127 DDB_G0289127 DDB0232432 CDS2385358 861 - 0.304297
DDB_G0289129 DDB_G0289129 DDB0232432 CDS2386701 885 - 0.310734
DDB_G0289167 DDB_G0289167 similar to bacterial short-chain dehydrogenasereductase family proteins and human RDH8 (retinol dehydrogenase 8)DDB0232432 CDS2441551 972 - 0.244856
DDB_G0289235 DDB_G0289235 DDB0232432 CDS2524160 2523 + 0.266746
DDB_G0289259 DDB_G0289259 similar to bacterial fungal and plant proteins from the short-chain dehydrogenasereductase familyDDB0232432 CDS2556391 879 - 0.265074
DDB_G0289335 DDB_G0289335 DDB0232432 CDS2652694 2064 - 0.28876
DDB_G0289349 DDB_G0289349 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity also contains an N-terminal transmembrane domainDDB0232432 CDS2670443 1479 + 0.279919
DDB_G0289355 DDB_G0289355 DDB0232432 CDS2681578 1893 + 0.216587
DDB_G0289403 DDB_G0289403 DDB0232432 CDS2749137 966 - 0.315735
DDB_G0289439 DDB_G0289439 DDB0232432 CDS2778983 405 + 0.367901
DDB_G0289581 DDB_G0289581 DDB0232432 CDS2997750 741 - 0.237517
DDB_G0289609 DDB_G0289609 contains two CBS domains expressed in pstAO cells and in upper cup during culminationDDB0232432 CDS3019826 438 - 0.296804
DDB_G0289669 DDB_G0289669 DDB0232432 CDS3069414 1626 - 0.264453
DDB_G0289671 DDB_G0289671 similar to human ABHD13 (Abhydrolase domain-containing protein 13) and S. pombe bem46 contains one putative transmembrane domainDDB0232432 CDS3072697 864 + 0.280093
DDB_G0289703 DDB_G0289703 DDB0232432 CDS3127157 2931 + 0.247015
DDB_G0289735 DDB_G0289735 DDB0232432 CDS3179530 1626 + 0.245387
DDB_G0290127 DDB_G0290127 DDB0232432 CDS3689897 1950 + 0.212308
DDB_G0290139 DDB_G0290139 DDB0232432 CDS3695903 1431 + 0.331936
DDB_G0290181 DDB_G0290181 similar to S.cerevisiae RRP5 and animal PDCD11 (Programmed cell death protein 11)DDB0232432 CDS3746723 2730 - 0.25641
DDB_G0290199 DDB_G0290199 DDB0232432 CDS3783788 651 - 0.241167
DDB_G0290225 DDB_G0290225 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity enriched in gametesDDB0232432 CDS3824091 1212 - 0.287954
DDB_G0290307 DDB_G0290307 contains three RRM domains homolog of ELAVL1 (embryonic lethal abnormal vision-like 1)DDB0232432 CDS3938585 1380 + 0.300725
DDB_G0290311 DDB_G0290311 DDB0232432 CDS3942085 1086 - 0.300184
DDB_G0290329 DDB_G0290329 DDB0232432 CDS3968559 906 - 0.335541
DDB_G0290369 DDB_G0290369 DDB0232432 CDS3976953 5661 + 0.242183
DDB_G0290415 DDB_G0290415 DDB0232432 CDS4053731 3303 + 0.277929
DDB_G0290423 DDB_G0290423 DDB0232432 CDS4067949 1743 + 0.242111
DDB_G0290427 DDB_G0290427 DDB0232432 CDS4113138 963 - 0.311526
DDB_G0290449 DDB_G0290449 DDB0232432 CDS4015567 924 - 0.238095
DDB_G0290471 DDB_G0290471 member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeats does not contain the consensus sequences required for kinase functionDDB0232432 CDS4105828 1059 - 0.234183
DDB_G0290521 DDB_G0290521 DDB0232432 CDS4200324 1293 - 0.354988
DDB_G0290605 DDB_G0290605 DDB0232432 CDS4356438 1155 + 0.27619
DDB_G0290621 DDB_G0290621 DDB0232432 CDS4383355 2904 - 0.22865
DDB_G0290623 DDB_G0290623 DDB0232432 CDS4387215 2436 + 0.2578
DDB_G0290689 DDB_G0290689 homolog of E. coli rppH very similar to DDB0232432 CDS4419333 552 - 0.278986
DDB_G0290771 DDB_G0290771 DDB0232432 CDS4578736 5247 - 0.27673
DDB_G0290827 DDB_G0290827 DDB0232432 CDS4603659 753 - 0.200531
DDB_G0290859 DDB_G0290859 member of the AGC kinase group similar to NDR (nuclear Dbf2-related) and RSK (ribosomal S6 kinase) family membersDDB0232432 CDS4688665 1260 + 0.307143
DDB_G0290877 DDB_G0290877 DDB0232432 CDS4704549 2475 - 0.288081
DDB_G0290983 DDB_G0290983 DDB0232432 CDS4844885 4008 - 0.221307
DDB_G0291003 DDB_G0291003 DDB0232432 CDS4876763 2598 - 0.299461
DDB_G0291013 DDB_G0291013 DDB0232432 CDS4889905 1149 + 0.302872
DDB_G0291059 DDB_G0291059 contains two ankyrin repeats and two K homology (KH) domains similar to high density lipoprotein-binding protein (vigilin)DDB0232432 CDS4839561 1155 + 0.303896
DDB_G0291133 DDB_G0291133 putative protein tyrosine kinase similar to S. pombe wee1 inhibitor of mitosis through phosphorylation of cdc2DDB0232432 CDS5030354 2337 + 0.26059
DDB_G0291149 DDB_G0291149 DDB0232432 CDS5052148 1569 - 0.251115
DDB_G0291167 DDB_G0291167 DDB0232432 CDS5083393 681 - 0.251101
DDB_G0291195 DDB_G0291195 DDB0232432 CDS5092325 792 + 0.294192
DDB_G0291205 DDB_G0291205 DDB0232432 CDS5120775 2727 + 0.268794
DDB_G0291336 DDB_G0291336 DDB0232433 CDS134282 834 - 0.2494
DDB_G0291338 DDB_G0291338 DDB0232433 CDS135540 657 + 0.219178
DDB_G0291350 DDB_G0291350 putative protein serinethreonine kinase similar to mammalian MPSK (myristoylated and palmitoylated serinethreonine kinase) a kinase involved in transcriptional regulation and protein phosphorylation may be an intermediary in the TGF-beta signaling pathwayDDB0232433 CDS162730 1110 - 0.245045
DDB_G0291402 DDB_G0291402 DDB0232433 CDS257921 447 - 0.306488
DDB_G0291444 DDB_G0291444 DDB0232433 CDS320738 1344 + 0.287946
DDB_G0291468 DDB_G0291468 DDB0232433 CDS378403 1608 + 0.264303
DDB_G0291472 DDB_G0291472 DDB0232433 CDS381635 1221 - 0.290745
DDB_G0291476 DDB_G0291476 DDB0232433 CDS396540 726 + 0.316804
DDB_G0291486 DDB_G0291486 similar to CUGBP proteins and Bruno-like proteins human CUGBP1 regulates splicing and translation of various RNAs contains 3 RRM domainsDDB0232433 CDS413873 1470 + 0.348299
DDB_G0291538 DDB_G0291538 similar to bacterial acetyltransferases homolog of E. coli maa (maltose O-acetyltransferase) contains a predicted peroxisomal targeting signalDDB0232433 CDS533329 546 + 0.322344
DDB_G0291578 DDB_G0291578 member of a small Dictyostelium gene family missing the carboxyl half compared to related proteinsDDB0232433 CDS571007 486 + 0.195473
DDB_G0291664 DDB_G0291664 highly similar to DDB0232433 CDS338918 2880 + 0.291319
DDB_G0291674 DDB_G0291674 similar to bacterial short-chain dehydrogenasereductase family proteins and human RDH8 (retinol dehydrogenase 8)DDB0232433 CDS431044 951 - 0.281809
DDB_G0291676 DDB_G0291676 similar to bacterial short-chain dehydrogenasereductase family proteinsDDB0232433 CDS432569 903 - 0.282392
DDB_G0291716 DDB_G0291716 DDB0232433 CDS726193 2322 - 0.251938
DDB_G0291720 DDB_G0291720 DDB0232433 CDS721305 1278 - 0.311424
DDB_G0291722 DDB_G0291722 DDB0232433 CDS719367 1344 - 0.233631
DDB_G0291726 DDB_G0291726 DDB0232433 CDS716979 690 - 0.356522
DDB_G0291758 DDB_G0291758 DDB0232433 CDS697440 1194 + 0.273869
DDB_G0291796 DDB_G0291796 DDB0232433 CDS757607 2541 + 0.284534
DDB_G0291824 DDB_G0291824 DDB0232433 CDS827281 1878 - 0.300319
DDB_G0291842 DDB_G0291842 putative protein tyrosine kinase similar to S. pombe WEE1 inhibitor of mitosis through phosphorylation of cdc2DDB0232433 CDS822502 1059 - 0.351275
DDB_G0291886_ps DDB_G0291886 similar to DDB0232433 CDS881755 2151 + 0.248257
DDB_G0291888 DDB_G0291888 DDB0232433 CDS886219 1416 + 0.214689
DDB_G0291896 DDB_G0291896 weakly similar to mammalian NASP (Nuclear Autoantigenic Sperm Protein) a histone chaperone required for DNA replication normal cell cycle progression and cell proliferationbrbr bCommunity annotation:b DDB G0291896 is similar (first blast hit both ways) to the N1N2 protein of Xenopus in humans known as NASP (nuclear autoantigenic sperm protein) a histone chaperone found in all dividing cells and implicated in chromatin assembly (see Wang et al NAR 36 5763-5772 (2008). NASP is required for cell cycle progression and is upregulated in a variety of cancers (see Alekseev et al Reproductive Biology and Endocrinology 7 45 2009).br DDB_G0291896 is overexpressed threefold (p2e-72) in a Dicty strain in which the retinoblastoma-like protein rblA has been disrupted. Most genes with functions in cell cycle progression are overexpressed in this strain and most overexpressed genes have identifiable cell cycle functions (Doquang et al. in preparation) these include other genes involved in chromatin asDDB0232433 CDS904350 1503 + 0.314039
DDB_G0291918 DDB_G0291918 putative protein serinethreonine kinase CAMK group kinase domain is similar to those of mammalian death-associated protein kinases (DAPK)DDB0232433 CDS943654 2010 + 0.287065
DDB_G0291926 DDB_G0291926 weakly similar ro S. cerevisiae Arc1 a protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasmDDB0232433 CDS959253 1092 - 0.282967
DDB_G0292006 DDB_G0292006 DDB0232433 CDS1004992 966 + 0.247412
DDB_G0292056 DDB_G0292056 DDB0232433 CDS1115547 5472 + 0.272844
DDB_G0292110 DDB_G0292110 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232433 CDS1201167 1053 + 0.253561
DDB_G0292116 DDB_G0292116 belongs to the short-chain dehydrogenasesreductases family similar to human HSDL2 (Hydroxysteroid dehydrogenase-like protein 2)DDB0232433 CDS1219275 849 - 0.328622
DDB_G0292298 DDB_G0292298 DDB0232433 CDS1424473 501 - 0.307385
DDB_G0292312 DDB_G0292312 DDB0232433 CDS1454104 1593 - 0.287508
DDB_G0292332 DDB_G0292332 DDB0232433 CDS1500852 561 + 0.210339
DDB_G0292350 DDB_G0292350 DDB0232433 CDS1496951 3675 + 0.270204
DDB_G0292354 DDB_G0292354 putative protein serinethreonine kinase TTBK family similar to casein kinase similar to mammalian tau-tubulin kinase (TTBK) which phosphorylates the microtubule-associated protein tau implicated in Alzheimer's diseaseDDB0232433 CDS1420214 1488 + 0.30578
DDB_G0292410 DDB_G0292410 similar to H. sapiens zinc finger CCCH-type containing 15 and M. musculus immediate early response erythropoietin 4DDB0232433 CDS1561008 1122 - 0.336898
DDB_G0292424 DDB_G0292424 DDB0232433 CDS1593747 1017 + 0.285152
DDB_G0292430 DDB_G0292430 DDB0232433 CDS1609068 1323 - 0.249433
DDB_G0292432 DDB_G0292432 DDB0232433 CDS1610862 1815 - 0.293113
DDB_G0292494 DDB_G0292494 similar to human TTC39A and TTC39B matches PFAM outer membrane protein IML2 mitochondrialtetratricopeptide repeat protein 39DDB0232433 CDS1739944 2388 - 0.220268
DDB_G0292528 DDB_G0292528 DDB0232433 CDS1616689 897 - 0.331104
DDB_G0292530 DDB_G0292530 DDB0232433 CDS1625548 2967 + 0.276373
DDB_G0292550 DDB_G0292550 DDB0232433 CDS1642791 4194 - 0.223891
DDB_G0292570 DDB_G0292570 DDB0232433 CDS1784981 522 - 0.254789
DDB_G0292574 DDB_G0292574 DDB0232433 CDS1791327 870 + 0.270115
DDB_G0292602 DDB_G0292602 DDB0232433 CDS1827272 879 - 0.31058
DDB_G0292624 DDB_G0292624 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232433 CDS1864394 942 + 0.298301
DDB_G0292698 DDB_G0292698 DDB0232433 CDS1997307 921 - 0.365907
DDB_G0292700 DDB_G0292700 DDB0232433 CDS1999329 894 - 0.241611
DDB_G0292714 DDB_G0292714 DDB0232433 CDS1780390 4446 + 0.234818
DDB_G0292746 DDB_G0292746 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity also contains a PH domain involved in intracellular signalingDDB0232433 CDS2069434 2898 + 0.327467
DDB_G0292774 DDB_G0292774 DDB0232433 CDS2013605 1098 + 0.270492
DDB_G0292834 DDB_G0292834 DDB0232433 CDS2130562 1710 - 0.29883
DDB_G0292852 DDB_G0292852 ortholog of human LACE1 an AFG1-like ATPase and similar to yeast AFG1 family of proteins contains a P-loop motif and are predicted to be ATPasesDDB0232433 CDS2099022 1584 + 0.279672
DDB_G0292960 DDB_G0292960 DDB0232433 CDS2129207 1173 + 0.225916
DDB_G0293032 DDB_G0293032 DDB0232433 CDS2351624 4698 - 0.270115
DDB_G0293034 DDB_G0293034 DDB0232433 CDS2371825 942 - 0.33121
DDB_G0293062 DDB_G0293062 conserved in plants and bacteria predicted to have a structural domain found in several acyl-CoA acyltransferase enzymesDDB0232433 CDS2415200 246 + 0.313008
DDB_G0293070 DDB_G0293070 putative ortholog of H. sapiens TEP1 a component of the telomerase ribonucleoprotein complex involved in replication of chromosome terminiDDB0232433 CDS2426564 7293 - 0.319896
DDB_G0293072 DDB_G0293072 DDB0232433 CDS2434758 1701 - 0.258083
DDB_G0293170 DDB_G0293170 DDB0232433 CDS2392178 3165 + 0.222749
DDB_G0293174 DDB_G0293174 DDB0232433 CDS2473465 3810 + 0.246194
DDB_G0293184 DDB_G0293184 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesis contains RhoGAP domain found in the Rho family of small G proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS2540484 3561 + 0.281382
DDB_G0293234 DDB_G0293234 ortholog of the conserved non-catalytic N-acetyltransferase that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein that contains a Met-Glu Met-Asp Met-Asn or Met-Met N-terminus ortholog of S. cerevisiae MDM20 the N-terminal acetyltransferase B (NatB) complex subunitDDB0232433 CDS2661843 2814 - 0.27221
DDB_G0293276 DDB_G0293276 member of the AGC kinase group similar to kinase domains of AktPKB and MAST (microtubule-associated serinethreonine kinase) family membersDDB0232433 CDS2701490 1551 - 0.246937
DDB_G0293292 DDB_G0293292 putative protein serinethreonine kinase N-terminal kinase domain similar to vertebrate Nek kinases which are involved in regulation of mitosis C-terminal kinase domain weakly similar to ULK (Unc-51-like kinase)DDB0232433 CDS2647324 4116 + 0.234208
DDB_G0293392 DDB_G0293392 conserved protein mammalian orthologs are predicted Zn-dependent hydrolases of the beta-lactamase foldDDB0232433 CDS2830538 1110 + 0.282883
DDB_G0293412 DDB_G0293412 DDB0232433 CDS2844115 2010 + 0.30199
DDB_G0293460 DDB_G0293460 DDB0232433 CDS2919081 1275 + 0.287843
DDB_G0293514 DDB_G0293514 DDB0232433 CDS2984590 492 + 0.292683
DDB_G0293562 DDB_G0293562 DDB0232433 CDS3048907 1584 + 0.289141
DDB_G0293592 DDB_G0293592 DDB0232433 CDS3100713 483 + 0.277433
DDB_G0293594 DDB_G0293594 DDB0232433 CDS3101875 492 + 0.264228
DDB_G0293604 DDB_G0293604 DDB0232433 CDS3126896 897 - 0.248606
DDB_G0293658 DDB_G0293658 DDB0232433 CDS3221806 1245 - 0.258635
DDB_G0293668 DDB_G0293668 DDB0232433 CDS3238981 909 + 0.20242
DDB_G0293670 DDB_G0293670 DDB0232433 CDS3241196 792 + 0.224747
DDB_G0293714 DDB_G0293714 DDB0232433 CDS3102749 504 + 0.281746
DDB_G0293718 DDB_G0293718 DDB0232433 CDS3104858 483 + 0.318841
DDB_G0293862 DDB_G0293862 DDB0232433 CDS3396260 750 - 0.309333
DDB_G0293864 DDB_G0293864 DDB0232433 CDS3398572 1527 + 0.251473
DDB_G0293868 DDB_G0293868 DDB0232433 CDS3402442 1638 - 0.230159
DDB_G0293930 DDB_G0293930 similar to human ZDHHC16 (zinc finger DHHC domain-containing protein 16) contains 4 putative transmembrane domainsDDB0232433 CDS3510935 960 - 0.258333
DDB_G0293956 DDB_G0293956 DDB0232433 CDS3572844 354 - 0.30226
DDB_G0293958 DDB_G0293958 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232433 CDS3460612 4779 + 0.208203
DDB_G0293976 DDB_G0293976 DDB0232433 CDS3485736 1347 - 0.200445
DDB_G0294292 DDB_G0294292 similar to S. cerevisiae Lgs1 a putative GTPase involved in 60S ribosomal subunit biogenesisDDB0232429 CDS8123 2025 + 0.304198
DDB_G0294571 DDB_G0294571 DDB0232432 CDS4610784 612 - 0.28268
DDB_G0294583 DDB_G0294583 DDB0232429 CDS1122814 705 + 0.229787
DDB_G0294585 DDB_G0294585 contains a domain found in the family of Major Royal Jelly Proteins constituting 82-90DDB0232430 CDS3552325 4941 - 0.277069
DDB_G0294589 DDB_G0294589 DDB0232431 CDS4603487 882 + 0.276644
DDB_G0294595 DDB_G0294595 multi-domain protein the TPR superhelical structures present a surface that is well suited to binding large substrates such as proteins and nucleic acidsDDB0232431 CDS1785353 1542 + 0.217899
DDB_G0294621 DDB_G0294621 contains three Sel1-like repeats which are related to tetratricopeptide (TPR) repeats DDB0232431 CDS86151 1854 + 0.304207
DDB_G0294629 DDB_G0294629 DDB0232433 CDS1603469 1785 - 0.285154
DDB_G0295481_ps DDB_G0295481 putative pseudogene fragment very similar to Dictyostelium ppiDDDB0232431 CDS944514 243 + 0.283951
DDB_G0295691 DDB_G0295691 shares a region of similarity with proteins of unknown functions contains eight predicted transmembrane domainsDDB0232433 CDS883760 1164 + 0.256873
DDB_G0295717 DDB_G0295717 DDB0232431 CDS2373104 2466 - 0.242092
DDB_G0295731 DDB_G0295731 DDB0232430 CDS2424448 1680 + 0.192857
DDB_G0295739 DDB_G0295739 DDB0232432 CDS3772467 999 - 0.309309
DDB_G0295781 DDB_G0295781 weakly similar to S. cerevisiae DUG3 involved in degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidaseDDB0232431 CDS4542261 1125 - 0.330667
DDB_G0295793 DDB_G0295793 DDB0232433 CDS2856788 1974 + 0.340426
DDB_G0295807 DDB_G0295807 DDB0232429 CDS986307 912 - 0.302632
DDB_G0295833 DDB_G0295833 there is a second copy of this gene DDB0232429 CDS2544712 915 - 0.243716
DDB_G0295847 DDB_G0295847 DDB0232428 CDS585586 4029 - 0.275503
DDB_G0295849 DDB_G0295849 DDB0232430 CDS5349087 1470 + 0.353061
DDB_G0304561 DDB_G0304561 similar to solute carrier family 35 member E4 (SLC35E4) proteins contains 10 predicted transmembrane domainsDDB0232431 CDS2797226 1476 + 0.278455
DDB_G0348940 DDB_G0348940 DDB0232429 CDS7403620 1473 + 0.220638
DDB_G0349043 DDB_G0349043 DDB0232432 CDS1336627 1767 - 0.271647
DDB_G0349375 DDB_G0349375 DDB0232429 CDS5604371 612 + 0.267974
DG1091 DDB_G0289175 DDB0232432 CDS2479410 5478 - 0.220701
abcD1 DDB_G0279917 half transporter consisting of one ABC domain and one transmembrane domainDDB0232430 CDS2772102 2205 - 0.247166
abcD2 DDB_G0293194 half transporter consisting of one ABC domain and one transmembrane domainDDB0232433 CDS2712310 2226 + 0.32929
abcD3 DDB_G0279919 half transporter consisting of one ABC domain and one transmembrane domainDDB0232430 CDS2769281 2253 - 0.246338
abcE1 DDB_G0290483 DDB0232432 CDS4209815 1812 - 0.34989
abcF1 DDB_G0285997 DDB0232431 CDS3922084 2127 - 0.381758
abcF2 DDB_G0284047 DDB0232431 CDS1542455 1782 - 0.335578
abcF3 DDB_G0275637 DDB0232429 CDS6056870 1959 - 0.325166
abcF4 DDB_G0267436 DDB0232428 CDS1263019 3429 + 0.31846
abhd DDB_G0289723 DDB0232432 CDS3165541 1188 - 0.289562
abkA DDB_G0288749 atypical protein serinethreonine kinase contains ABC1 kinase (protein kinase-like) domain yeast ABC1 essential for the electron transfer in the BC(1) complex E.coli homolog required for ubiquinone biosynthesisDDB0232432 CDS1916080 1698 - 0.246761
abkB DDB_G0281799 atypical protein serinethreonine kinase contains ABC1 kinase (protein kinase-like) domain yeast ABC1 essential for the electron transfer in the BC(1) complex E.coli homolog required for ubiquinone biosynthesisDDB0232430 CDS4693676 2007 - 0.255107
abkC DDB_G0267774 atypical protein serinethreonine kinase contains ABC1 kinase (protein kinase-like) domain yeast ABC1 essential for the electron transfer in the BC(1) complex E.coli homolog required for ubiquinone biosynthesisDDB0232428 CDS825289 2070 - 0.246377
abkD DDB_G0284897 atypical protein serinethreonine kinase contains ABC1 kinase (protein kinase-like) domain yeast ABC1 essential for the electron transfer in the BC(1) complex E.coli homolog required for ubiquinone biosynthesisDDB0232431 CDS2611033 2088 - 0.273946
acmsd DDB_G0286525 catalyzes the reaction: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate 2-aminomuconate semialdehyde CO2DDB0232431 CDS4592587 1080 + 0.340741
aco DDB_G0277497 bNomenclature conflict:b Do not confuse this gene with acoA the acyl-CoA oxidase or aco1 and aco2 the aconitasesDDB0232429 CDS8019782 1107 + 0.29991
adcB DDB_G0274395 DDB0232429 CDS4691677 1854 - 0.288565
agtA DDB_G0283005 likely catalyzes the alpha addition of galactose to Fuc-Gal-GlcNAc-HyPro143-Skp1 (FpaAFpaB)DDB0232431 CDS143819 1947 - 0.214689
aif DDB_G0288247 involved in caspase-independent mitochondrial cell death similar to H. sapiens AIFM1 the mitochondrial Apoptosis-Inducing Factor 1DDB0232432 CDS1306170 1599 - 0.317699
aip1 DDB_G0278733 conserved protein containing WD40 repeats involved in actin-dependent processes such as endocytosis cytokinesis and motility interacts genetically with nhe1 and suppresses nhe1- mutant phenotypesDDB0232430 CDS1283399 1794 + 0.377926
alg9 DDB_G0279349 CAZy family GT22 catalyzes N-linked mannosylationDDB0232430 CDS1972184 1950 + 0.232308
alrA DDB_G0293850 involved in regulation of aggregate size member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232433 CDS3404974 894 + 0.325503
alrB DDB_G0285053 member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232431 CDS2618768 936 - 0.318376
alrC DDB_G0268058 member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232428 CDS1371493 966 - 0.258799
alrD DDB_G0285027 member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232431 CDS2833891 873 - 0.266896
alrE DDB_G0285025 member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232431 CDS2832495 870 - 0.301149
alrF DDB_G0285023 member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232431 CDS2831142 918 - 0.238562
alr_ps DDB_G0268562 putative pseudogene similar to aldo-keto reductases alrA-FDDB0232428 CDS1373976 462 - 0.248918
anapc3 DDB_G0288223 component of the anaphase-promoting complexcyclosome (APCC) a cell cycle-regulated ubiquitin ligase that controls progression through the cell cycleDDB0232432 CDS1273822 2913 - 0.278064
anapc6 DDB_G0286233 putative ortholog of cdc16 a conserved protein containing several TPRs (tetratrico peptide repeats)DDB0232431 CDS4222260 2598 - 0.234411
anapc7 DDB_G0292470 component of the anaphase-promoting complexcyclosome (APCC) a cell cycle-regulated ubiquitin ligase that controls progression through the cell cycleDDB0232433 CDS1686299 1743 + 0.243259
anapc8 DDB_G0272775 DDB0232429 CDS2162746 1779 - 0.323215
ankrd39 DDB_G0287345 DDB0232432 CDS159445 525 - 0.266667
aprA DDB_G0281663 secreted protein that exists in a 150 kDa complex repressor of cell proliferationDDB0232430 CDS4787137 1485 + 0.334007
arcA DDB_G0277825 component of the Dictyostelium Arp2Arp3 complexDDB0232430 CDS304397 1110 - 0.396396
arfA DDB_G0289173 DDB0232432 CDS2516577 549 + 0.35337
arfrp1 DDB_G0283631 DDB0232431 CDS888563 651 + 0.271889
arkA DDB_G0289555 suppressor of spalten (spnA) mutant member of the TKL (tyrosine kinase-like) group and ARK (ankyrin repeat-containing kinase) familyDDB0232432 CDS2941850 4383 + 0.300707
arl1 DDB_G0288163 DDB0232432 CDS1170444 552 - 0.304348
arl2 DDB_G0281307 DDB0232430 CDS4073757 555 + 0.261261
arl5 DDB_G0271942 DDB0232429 CDS1019381 552 - 0.293478
arl8 DDB_G0283525 DDB0232431 CDS729167 558 + 0.284946
arrA DDB_G0282457 DDB0232430 CDS5783278 594 - 0.210438
arrB DDB_G0274445 DDB0232429 CDS4578208 540 - 0.244444
arrC DDB_G0271792 DDB0232429 CDS729816 603 + 0.26534
arrD DDB_G0289069 DDB0232432 CDS2306273 651 + 0.265745
arrE DDB_G0280479 DDB0232430 CDS3427999 594 - 0.287879
arrF DDB_G0289435 DDB0232432 CDS2746763 573 + 0.273997
arrH DDB_G0288015 bCommunity annotations: b The arrH arrJ and arrK genes and no others of the arrX group are strongly (6 to 30-fold) overexpressed in a Dictyostelium strain in which the retinoblastoma-like gene rblA has been disrupted. Most of the genes overexpressed in this strain are associated with cell cycle progression and this suggests that the main role of the corresponding proteins is in S-phase or mitosis. Human Arf1 has been reported to be essential for Golgi complex fragmentation during mitosis (Tang et al JBC 283 6085-94 (2008) Xiang et al JBC 282 21829-37 (2007). It thus seems possible that ArrH ArrJ and ArrK are involved in this process in Dicty. Harry MacWilliams September 2009brbr We have found very similar results including human C. elegans and D. melanogaster sequences in the set of proteins used for the tree. See Weeks G Gaudet P and Insall RH. (2005) The small GTPase superfamily. in Dictyostelium Genomics. Horizon Bioscience. Pascale Gaudet October 2009br DDB0232432 CDS977719 570 + 0.282456
arrI_ps DDB_G0280687 putative pseudogene ADP-ribosylation factor family proteinDDB0232430 CDS3629662 234 + 0.286325
arrJ DDB_G0280621 DDB0232430 CDS3577717 567 + 0.282187
arrK DDB_G0280633 DDB0232430 CDS3586248 567 + 0.280423
arrL DDB_G0278057 DDB0232430 CDS206243 588 + 0.267007
ascc3 DDB_G0290389 ortholog of human ASCC3 part of the TRIP4 complex that enhances activation of NF-kappa-B SRF and AP1DDB0232432 CDS4020336 6588 - 0.307377
ascc3l DDB_G0270042 putative RNA helicase involved in the second step of RNA splicing ortholog of human ASCC3L1 and yeast BRR2DDB0232428 CDS4082408 6714 - 0.320077
atg1 DDB_G0292390 Dictyostelium homolog of yeast atg1 belongs to the ULK (Unc-51-like kinase) family of kinases required for macroautophagyDDB0232433 CDS1694801 2007 + 0.255605
aurK DDB_G0279343 putative protein serinethreonine kinase Aur family associates with the mitotic spindle and plays a key role in mitosis the single Dictyostelium aurora kinase has properties of both aurora A and B kinases in other organismsDDB0232430 CDS1959552 1155 - 0.30303
bub2 DDB_G0268794 putative ortholog of S. cerevisiae BUB2 a mitotic checkpoint proteinDDB0232428 CDS2123318 1101 + 0.269755
bub3 DDB_G0292134 ortholog of BUB3 a mitotic checkpoint protein in human a kinetochore protein that interacts with BUB1DDB0232433 CDS1247461 996 - 0.346386
cak1-1 DDB_G0273059 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS2688821 1281 + 0.320062
cak1-2 DDB_G0273737 protein serinethreonine kinase CK1 family similar to human CK1 and yeast YCK may play a role in DNA repair there is a second copy of this gene DDB0232429 CDS3341355 1281 - 0.320062
calA DDB_G0279407 calcium-dependent regulatory protein involved in cytokinesis regulated by cytosolic Ca2 fluxes allowing differential binding to target CaM binding proteins (CaMBPs) binds several proteins among them nuclear NumA and Cdk5DDB0232430 CDS2244074 459 - 0.35512
calB DDB_G0269104 DDB0232428 CDS2981116 450 + 0.275556
casK DDB_G0276885 CK2 family protein kinase a ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232429 CDS7370887 1014 + 0.310651
cbpL DDB_G0288785 putative Ca2-binding protein with 4 putative EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232432 CDS1964055 576 + 0.258681
cbpM DDB_G0286371 putative Ca2-binding protein with 4 putative EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232431 CDS4370399 552 - 0.277174
cdc20 DDB_G0285601 ortholog of CDC20 a cell-cycle regulated activator of anaphase-promoting complexcyclosome (APCC) which is required for metaphaseanaphase transition directs ubiquitination of mitotic cyclinsDDB0232431 CDS3433247 1500 + 0.346
cdc40 DDB_G0289501 conserved splicing factor S. cerevisiae cdc40 is important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progressionDDB0232432 CDS2860682 1788 + 0.319351
cdc7 DDB_G0292152 similar to S. cerevisiae cell division control protein 7 (CDC7) a serinethreonine kinase required for mitosis and meiosisDDB0232433 CDS1294776 3186 + 0.23666
cdh1 DDB_G0287259 ortholog of FZR1CDH1 that regulates the ubiquitin ligase activity of the anaphase promoting complexcyclosome (APCC) which directs ubiquitination of cyclins resulting in mitotic exit related to cdc20 DDB0232432 CDS54882 2265 - 0.284768
cdk1 DDB_G0272813 similar to CDK1 and CDK2 cell cycle CAK (CDK-activating kinase) kinases predicted to activate SG2 cyclins cyclin A B and DDDB0232429 CDS2216835 891 + 0.331089
cdk10 DDB_G0268480 putative cell division cycle 2 (CDC2)-like protein kinase has similarity to PITSLRE proteins and other cyclin-dependent kinase 2 kinasesDDB0232428 CDS294048 1101 - 0.256131
cdk11 DDB_G0283279 very similar to human CDL1 (PITSLRE serinethreonine-protein kinase CDC2L1) which appears to play multiple roles in cell cycle progression cytokinesis and apoptosis predicted to interact with DDB0232431 CDS446640 1077 - 0.338904
cdk5 DDB_G0288677 CMGC group protein kinase highly similar to mammalian cdk5 localizes to the nucleus and shuttles to the cytoplasm during late mitosis binds calmodulin PsaADDB0232432 CDS1885785 879 + 0.302617
cdk7 DDB_G0285417 putative ortholog of CDK7 and CTK1 which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit predicted to be activated by DDB0232431 CDS3627427 1083 + 0.307479
cdk8 DDB_G0267442 controls RNA polymerase II activity by phosphorylating the carboxy terminal domain (CTD) of the largest subunit predicted to interact with DDB0232428 CDS1582311 1143 - 0.314961
cdk9-1 DDB_G0273207 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS2708039 2085 + 0.282974
cdk9-2 DDB_G0273721 similar to the cell division cycle 2-related protein kinase 7 (CRK7) and other cell division cycle 2-like protein kinases there is a second copy of this gene DDB0232429 CDS3321422 2085 - 0.282974
celA DDB_G0271134 CAZy family GH9 catalyzes the hydrolysis of glucosidic linkagesDDB0232429 CDS58680 2118 - 0.36119
cenA DDB_G0288427 similar to human Centrin 2 EF-hand protein localizes to the centromer from which it dissociates during mitosisDDB0232432 CDS1525659 456 + 0.245614
cenB DDB_G0279151 centrin required for nuclear and centrosome stability localizes to the nucleus in interphase but not during mitosis and is involved in the centrosome cycleDDB0232430 CDS1697579 453 - 0.258278
chid1 DDB_G0290417 DDB0232432 CDS4060970 1158 - 0.244387
ciao1 DDB_G0269728 ortholog of the conserved CIA1 (S. cerevisiae) or CIAO1 (Mammals) which in yeast is essential for assembly of cytosolic and nuclear iron-sulfur proteins contains 7 WD40 repeatsDDB0232428 CDS3427650 1002 + 0.284431
clkA DDB_G0281179 similar to cyclin-like kinases (CLK) putative dual specifity kinaseDDB0232430 CDS4167312 2799 + 0.215077
cln3 DDB_G0291157 ortholog of Cln3 responsible for Batten's disease a juvenile neurological disorderDDB0232432 CDS5060161 1266 - 0.313586
cnbA DDB_G0267446 regulatory subunit of the Casup2supcalmodulin-dependent serinethreonine protein phosphatase contains an EF-hand calcium binding motifDDB0232428 CDS816934 1041 - 0.26513
cnbB DDB_G0285999 contains 3 EF-hands similar to calcineurin B (cnbA) the regulatory subunit of the Ca2calmodulin-dependent serinethreonine protein phosphataseDDB0232431 CDS3918232 552 + 0.269928
cnrF DDB_G0276119 DDB0232429 CDS6259472 2961 + 0.280986
cnrM DDB_G0288307 DDB0232432 CDS1376942 4920 - 0.293089
comB DDB_G0281825 DDB0232430 CDS5112758 6324 - 0.278937
comD DDB_G0283345 similar to drug resistance transporters contains 14 transmembrane domainsDDB0232431 CDS539820 3528 + 0.291667
copA DDB_G0267982 contains five WD40 repeats alpha subunit of the coatomer complex essential for the secretory pathwayDDB0232428 CDS1232234 3666 + 0.331969
copB2 DDB_G0278285 contains six WD40 repeats beta prime subunit of the coatomer complex essential for the secretory pathwayDDB0232430 CDS618891 3018 - 0.333996
copE DDB_G0267950 DDB0232428 CDS1172814 903 + 0.272425
corA DDB_G0267382 actin binding protein regulating actin nucleation involved in cytokinesis and cell motilityDDB0232428 CDS943374 1338 - 0.400598
corB DDB_G0269388 ortholog of human coronin-7 (CORO7) long protein corresponding to two coronin equivalents regulates F-actin depolymerization and is thus involved in substrate adhesion phagocytosis and cell motilityDDB0232428 CDS2678066 2889 + 0.32918
cpras1 DDB_G0277381 DDB0232429 CDS7946446 2529 - 0.316726
cpras2 DDB_G0293376 contains a circularly permuted GTPase domain with the conserved motifs G1-G2 lying downstream of the G3-G4-G5 motifs large protein of unknown function whose domain composition is not conserved a closely related ortholog is found in D. purpureum DDB0232433 CDS2805934 11802 - 0.295543
cpsf4 DDB_G0270148 ortholog of the human CPSF4 and yeast YTH1 the 30 kDa subunit of the cleavage and polyadenylation specificity factor (CPSF) complex required for 3' processing of mRNAs human CPSF4 binds RNA polymers with a preference for poly(U)DDB0232428 CDS4311820 1119 + 0.324397
csn5 DDB_G0284597 subunit of the COP9 signalosome (CSN) a complex of the ubiquitin-proteasome pathway composed of eight subunits (CSN1-8) DDB0232431 CDS2205667 999 - 0.304304
cstf1 DDB_G0278769 component of the CSTF complex which in mammalian is required for polyadenylation and 3'-end cleavage of pre-mRNAsDDB0232430 CDS1141749 1521 + 0.302433
cstf2 DDB_G0280529 component of the CSTF complex which in mammalian is required for polyadenylation and 3'-end cleavage of pre-mRNAsDDB0232430 CDS3461453 1626 + 0.305043
ctbsA DDB_G0274233 very similar to H. sapiens di-N-acetylchitobiase (CBTS) a hydrolase involved in the degradation of asparagine-linked glycoproteins contains a putative N-terminal signal sequenceDDB0232429 CDS4699494 1158 + 0.310881
ctbsB DDB_G0276795 similar to H. sapiens di-N-acetylchitobiase (CBTS) a hydrolase involved in the degradation of asparagine-linked glycoproteins contains a putative N-terminal signal sequenceDDB0232429 CDS7316822 1122 + 0.294118
ctr9 DDB_G0277841 component of the conserved Paf1 complex a multifunctional complex involved in histone methylation and plays a role in RNA elongation and processing REMI mutant forms aberrant fruiting bodies see DDB0232430 CDS746082 3321 + 0.308341
dcp2 DDB_G0283315 ortholog of the conserved mRNA-decapping enzyme 2 necessary for the degradation of mRNAsDDB0232431 CDS515744 1863 + 0.31723
dcp2_ps DDB_G0283809 putative pseudogene similar to DDB0232431 CDS1130346 258 - 0.325581
dduA DDB_G0282559 downregulated in the uninfected DDB0232430 CDS5934889 1296 - 0.278549
dgkA DDB_G0277223 dgkA corresponds to a previously reported myosin II heavy chain kinase designated myosin heavy chain-protein kinase C (MHC-PKC) recent research shows the protein does not contain a protein kinase domain but a diacylglycerol kinase domainDDB0232429 CDS7741603 2664 + 0.28003
dhkG DDB_G0284045 DDB0232431 CDS1509861 10299 - 0.239441
dicA DDB_G0280849 DDB0232430 CDS3856978 1965 - 0.337405
dmtA DDB_G0289329 DDB0232432 CDS2694067 1092 - 0.271978
drg1 DDB_G0289317 ortholog of human DRG1 which may be involved in cell proliferation differentiation and death highly conserved in eukaryotes belongs to the GTP1OBG familyDDB0232432 CDS2634493 1113 - 0.337826
drg2 DDB_G0279451 ortholog of human DRG2 which may be involved in cell proliferation differentiation and death highly conserved in eukaryotes belongs to the GTP1OBG familyDDB0232430 CDS2066556 1095 - 0.305023
drkA DDB_G0289791 DDB0232432 CDS3144874 1929 + 0.276827
drkB DDB_G0289709 DDB0232432 CDS3147575 2073 + 0.2904
drkC DDB_G0281899 tyrosine kinase member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily involved in phagocytosis and late phagosomelysosome fusion enriched in S cells in slugsDDB0232430 CDS5088116 2250 - 0.305778
drkD DDB_G0281557 member of the TKL (tyrosine kinase-like) group and the DRK (Dictyostelium receptor-like kinase) subfamily contains a leucine-rich repeat (LRR) regionDDB0232430 CDS4777368 3867 + 0.334885
dst1 DDB_G0274593 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS3862026 2214 + 0.289521
dst2 DDB_G0267730 putative protein serinethreonine kinase the kinase domain is similar to mitogen-activated protein kinases and other STE20-like kinases stress-responsive kinaseDDB0232428 CDS719427 3429 + 0.33275
dst3 DDB_G0291267 putative protein serinethreonine kinase the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS35064 1689 - 0.351095
dst4 DDB_G0288071 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232432 CDS1048762 1458 - 0.325789
dupA DDB_G0277071 contains both a kinase domain and a phosphatase domain similar to MAP kinase phosphatase in plants and dual-specificty phosphatase 19 in mammals regulates the MAP Kinase response to Legionella pneumophila infection in DictyosteliumDDB0232429 CDS7439874 7365 - 0.295995
dymA DDB_G0277849 DDB0232430 CDS252381 2562 - 0.330211
dymB DDB_G0277851 DDB0232430 CDS1081009 2763 - 0.279045
dynE DDB_G0278579 DDB0232430 CDS1102831 597 + 0.269682
dyrk1 DDB_G0277485 DDB0232429 CDS7981156 2511 + 0.249303
dyrk2 DDB_G0293750 DDB0232433 CDS3272270 2748 + 0.306405
eIF2a DDB_G0284267 EIF2A ortholog the eukaryotic initiation factor 2A that binds Met-tRNADDB0232431 CDS1799493 1827 - 0.363437
egeA DDB_G0272002 DDB0232429 CDS1164190 765 - 0.300654
egeB DDB_G0269164 highly similar to EgeA required for aggregationDDB0232428 CDS4173872 1278 + 0.309859
eif3B DDB_G0283597 EIF3B ortholog the eukaryotic initiation factor eta subunit In human binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA is composed of at least 12 different subunitsDDB0232431 CDS847464 2013 + 0.350224
eif3I DDB_G0285683 EIF3I ortholog the eukaryotic initiation factor beta subunit In human binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA is composed of at least 12 different subunitsDDB0232431 CDS3586013 996 - 0.348394
elmoD DDB_G0280943 DDB0232430 CDS3852474 3804 + 0.253943
elof1 DDB_G0287203 ortholog of the conserved elongation factor 1 a transcription elongation factor that contains a conserved zinc finger domain implicated in chromatin structure maintenance in actively transcribed regions in S. cerevisiaeDDB0232431 CDS5404659 243 - 0.366255
elp2 DDB_G0275651 similar to S. cerevisiae ELP2 subunit of the RNA polymerase II elongator complexDDB0232429 CDS5847867 2706 - 0.318182
eral1 DDB_G0288609 DDB0232432 CDS1740020 1197 - 0.3066
ercc8 DDB_G0276481 ortholog of S. cerevisiae RAD26 and H. sapiens ERCC8 (CSA) involved in Cockayne syndromeDDB0232429 CDS6778627 1542 + 0.284695
eriA DDB_G0283113 similar to C. elegans eri-1 RNA exonuclease that acts as a negative regulator of RNA interference (RNAi) contains one exonuclease domainbrbr bCommunity annotation:b EriA codes for a multifunctional RNA exonuclease which has been identified with negative regulation of RNAi and in processing the 5.8s ribosomal RNA. The gene is nearly 8-fold overexpressed in a Dicty strain in which the retinoblastoma-like gene rblA is disrupted. Other genes overexpressed in this strain include virtually all those with unique or major functions in S-phase or mitosis. Neither RNAi nor ribosomal processing obviously fits into this class. However it has recently been shown in mammalian cells that eriA under the pseudonym 3'hExo stably associates with histone pre-mRNAs and participates in a complex that determines the site of their cleavage (see Yang et al Mol Cell Biol 29 4045-4056 (2009). Another protein in this complex is the histone stem-loop binding protein DDB_G0277383 which is threefold upregulated in tDDB0232431 CDS263707 663 + 0.273002
erkA DDB_G0286353 DDB0232431 CDS4355028 1590 + 0.303774
erkB DDB_G0283903 DDB0232431 CDS1385123 1110 - 0.323423
esd DDB_G0283037 very similar to human ESD and to S. cerevisiae S-formylglutathione hydrolase (YJL068C) which seems to be involved in formaldehyde detoxificationDDB0232431 CDS192516 858 + 0.264569
exoc5 DDB_G0287881 subunit of the exocyst complex which targets secretory vesicles to active sites of exocytosisDDB0232432 CDS652393 2937 - 0.290092
fbxA DDB_G0276887 F-box and WD40 domains containing protein part of a complex that targets proteins for ubiquination has the same domain composition as DDB0232429 CDS7333559 3744 + 0.311165
fcf1 DDB_G0267606 DDB0232428 CDS408722 585 + 0.261538
fdxr DDB_G0287353 catlyzes the reaction: reduced ferredoxin NADP oxidized ferredoxin NADPH HDDB0232432 CDS169845 1548 - 0.26292
fhit DDB_G0274257 ortholog of human FHIT which is a possible tumor suppressor for specific tissues numerous tumor types are associated with aberrant forms of human FHIT proteinDDB0232429 CDS4124527 450 - 0.311111
fhkA DDB_G0293656 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsbrbr bCommunity annotation:b The five fhk-X genes differ substantially in their response to the disruption of the retinoblastoma-like gene rblA. FhkA is substantially and highly signficantly upregulated in the ko strain while none of the other genes show major changes. Consistent with its regulation the fhkA promoter contains a putative E2F-type binding site (TTTGCGCCTTTT). Virtually all genes associated with replication fork progression are upregulated in the rblA disruptant these include cdc45 all mcm genes all gins genes all rfc genes four polA subunits three polD subunits two putatitive polE subunits PCNA the single-strand binding protein rfa1 the flap endonuclease repG as well as DNA ligase-1 and topoisomerase-2. All these genes show overexpression factors ranging from 4 to 15DDB0232433 CDS3219230 1782 - 0.231201
fhkB DDB_G0280599 CAMK group RAD53 family protein kinase the protein kinase domain is similar to those of mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3548058 3429 - 0.26305
fhkC DDB_G0281567 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 and yeast RAD53 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS4871788 1788 + 0.291387
fhkD DDB_G0285963 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232431 CDS3876403 2250 - 0.286667
fhkE DDB_G0280321 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsDDB0232430 CDS3257414 2139 + 0.257597
flpA DDB_G0286549 DDB0232431 CDS4784977 2148 + 0.268622
fnkA DDB_G0275561 protein kinase STE groupDDB0232429 CDS5624593 2382 + 0.283375
fnkB DDB_G0267934 DDB0232428 CDS1147906 1593 - 0.251726
fnkE DDB_G0275879 protein kinase domain similar to those of the mitogen-activated protein kinases which belong to the STE20 family contains two protein kinase domains one of which is predicted to be inactive contains several FNIP repeatsDDB0232429 CDS5838829 3966 + 0.2824
fnkF_ps DDB_G0275183 putative pseudogene STEFNIP protein kinase familyDDB0232429 CDS5290527 2628 - 0.270548
fray1 DDB_G0278863 kinase domain similar to OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232430 CDS1298188 1725 - 0.338551
fray2 DDB_G0276577 the kinase domain is similar to mammalian stress-induced STK and OSR1 (oxidative stress responsive 1) kinases and other STE20-like kinasesbrbr bCommunity annotation:b Fray1 and Fray2 represent the FRAY-subfamily of Ste20-like kinases in D. discoideum (see DDB0232429 CDS6994954 3087 - 0.339164
fslB DDB_G0270730 similar to the G-protein coupled receptors contains 7 putative transmembrane domains and a potential signal sequenceDDB0232428 CDS4235323 1929 - 0.258683
fuk DDB_G0269678 catalyzes the reaction: ATP L-fucose ADP beta-L-fucose 1-phosphateDDB0232428 CDS3301231 4215 - 0.288493
gacX DDB_G0288205 DDB0232432 CDS1235608 1692 + 0.309693
gbpC DDB_G0291079 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases belongs to the LRRK family of protein kinases contains LRR Roc COR RasGEF protein kinase DEP cyclic nucleotide-binding and GRAM domains involved in cGMP-mediated chemotaxis catalyzes GDP to GTP exchange on its own Roc domain translocates from cytoplasm to cell cortex after cAMP stimulation GRAM domain binds directly to plasma membraneDDB0232432 CDS4959991 7896 + 0.333967
gdap2 DDB_G0284349 ortholog of the human GDAP2 protein contains an Appr-1-p processing domain and a C-terminal cellular retinaldehyde-bindingtriple function domainDDB0232431 CDS1866926 1707 - 0.246632
gdt2 DDB_G0270666 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3713353 4914 - 0.252747
gdt3_ps DDB_G0285891 putative pseudogene member of the TKL (tyrosine kinase-like) group and the GDT family belongs to the MLK protein kinase familyDDB0232431 CDS3781232 5880 - 0.234014
gdt4 DDB_G0270550 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS2926042 4863 + 0.265474
gdt6 DDB_G0270544 member of the TKL (tyrosine kinase-like) group and the GDT family unlikely to function as a kinase as it does not contain a catalytic aspartate putative transmembrane proteinDDB0232428 CDS2913781 4359 + 0.274145
gdt8 DDB_G0270668 member of the TKL (tyrosine kinase-like) group and the GDT family putative transmembrane proteinDDB0232428 CDS3723386 3981 - 0.283848
gdt9 DDB_G0278879 DDB0232430 CDS1327589 4734 + 0.274398
gefX DDB_G0269298 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains RasGEF nucleotide exchange factor domainDDB0232428 CDS2476607 2883 - 0.312522
gemA DDB_G0267830 simlar to M. musculus mitochondrial Rho1 and S. cerevisiae GEM1 a conserved tail-anchored outer mitochondrial membrane GTPase contains two GTP-binding domains two EF hand domains and a C-terminal transmembrane domainDDB0232428 CDS929880 1977 - 0.265048
gemin5 DDB_G0288425 ortholog of Gemin 5 a component of Cajal bodies (CBs) and Gems nuclear organelles responsible for spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesisDDB0232432 CDS1517710 3831 + 0.257113
gerE DDB_G0286551 contains numerous TETP repeats expressed specifically in sporesDDB0232431 CDS4754201 1374 - 0.306405
glkA DDB_G0270218 putative protein serinethreonine kinase GSK family member of the CMGC kinase group similar to Drosophila shaggy and other glycogen synthase kinasesDDB0232428 CDS4429657 1422 + 0.23699
glnA3 DDB_G0279591 catalyzes the reaction ATP L-glutamate ammonia ADP phosphate L-glutamineDDB0232430 CDS2109355 2208 - 0.352355
gloB1 DDB_G0285717 catalyzes the reaction S-lactoyl-glutathione H2O reduced glutathione D-lactateDDB0232431 CDS3631211 807 - 0.275093
gloB2 DDB_G0291482 catalyzes the reaction S-lactoyl-glutathione H2O reduced glutathione D-lactateDDB0232433 CDS411372 879 + 0.335609
gna1 DDB_G0279475 gna bGblucosamibNbe-6-phosphate bAbcetyltransferaseDDB0232430 CDS2113626 474 - 0.242616
gnb1l DDB_G0289181 ortholog of the mammalian GNB1L contains several WD-40 repeatsDDB0232432 CDS2444140 1080 + 0.234259
gnl1 DDB_G0285371 DDB0232431 CDS3179167 2541 - 0.283747
gnl3 DDB_G0287147 similar to the conserved guanine nucleotide-binding protein-like 3 also called nucleostemin in mammals a protein in the nucleolus of most stem cells and many tumor cells involved in cell-cycle progressionDDB0232431 CDS5379967 1848 - 0.318182
gpbA DDB_G0277143 DDB0232429 CDS7812708 1044 - 0.3659
gpbB DDB_G0275045 DDB0232429 CDS5266629 990 + 0.419192
gpn1 DDB_G0293220 DDB0232433 CDS2684279 1191 + 0.309824
gpn2 DDB_G0281787 DDB0232430 CDS4982225 948 + 0.256329
gpn3 DDB_G0285197 DDB0232431 CDS2952647 858 + 0.29021
gppA DDB_G0267398 DDB0232428 CDS1607815 1635 - 0.285015
grlA DDB_G0271684 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signature plays a role in sporulationDDB0232429 CDS779738 2397 - 0.278264
grlB DDB_G0271686 DDB0232429 CDS776318 2268 - 0.283069
grlC DDB_G0282461 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232430 CDS5789478 2403 + 0.27965
grlD DDB_G0286895 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232431 CDS5037852 2376 + 0.280724
grlF DDB_G0282175 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232430 CDS5487367 2313 + 0.272806
grlG DDB_G0272244 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232429 CDS1741474 2319 - 0.292799
grlH DDB_G0282459 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232430 CDS5785479 2295 + 0.300218
grlJ DDB_G0272150 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232429 CDS1600728 2352 + 0.278061
grlK DDB_G0269386 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232428 CDS2668447 2115 - 0.327187
grlL DDB_G0281211 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232430 CDS4210774 2127 + 0.316408
grlM DDB_G0286643 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232431 CDS4778203 2250 + 0.317333
grlO DDB_G0271688 metabotropic glutamate receptors are coupled to G-proteins and stimulate the inositol phosphateCa2 intracellular signaling pathway distinctive '7TM' signatureDDB0232429 CDS773062 2460 - 0.239837
grwd1 DDB_G0291566 ortholog of the mammalian GRWD1 contains several WD-40 repeatsDDB0232433 CDS556339 1449 - 0.354727
gskA DDB_G0272110 protein serinethreonine kinase GSK family member of the CMGC kinase group essential for cell specification activated by CAR3 through ZAK1 (prespore-) and inhibited by CAR4 (prestalk-) signallingDDB0232429 CDS1334436 1404 - 0.324786
gtf3C3 DDB_G0278321 DDB0232430 CDS689224 2994 + 0.289579
gtpA DDB_G0275441 DDB0232429 CDS5822886 1350 - 0.347407
gtpbp1 DDB_G0292538 ortholog of the mammalian GTPBP1 and very similar to GTPBP2 contains a translation elongation factor EFTuEF1A domain 2 and C-terminal domainDDB0232433 CDS1635942 2034 + 0.357915
gtpbp3 DDB_G0270228 ortholog of the mammalian GTPBP3 and S. cerevisiae MSS1 GTPases responsible for the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAsDDB0232428 CDS4442110 1539 + 0.250162
gtpbp5 DDB_G0277801 similar to human GTPBP5 GTP1OBG family protein involved in the ribosome maturation processDDB0232429 CDS8429520 1887 - 0.254902
guaD DDB_G0277743 catalyzes the reaction guanine Hsub2subO xanthine NHsub3subDDB0232429 CDS8417392 1353 + 0.311899
gxcA DDB_G0277987 Rac guanyl-nucleotide exchange factor involved in chemotaxis and development there are two transcripts for this gene that seem to be differentially expressed during development with the shorter isoform expressed in vegetative cells and the longer isoform during developmentDDB0232430 CDS114291 6117 - 0.297695
hddc2 DDB_G0290795 conserved protein HD domains occur in a superfamily of enzymes with a predicted or known phosphohydrolase activityDDB0232432 CDS4613721 573 - 0.279232
hira DDB_G0276423 ortholog of yeast HIR1 a transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genesDDB0232429 CDS6881531 3345 - 0.30852
hpd DDB_G0277511 catalyzes the reaction 4-hydroxyphenylpyruvate Osub2sub homogentisate COsub2subDDB0232429 CDS8032217 2214 + 0.342367
hpdl-1 DDB_G0273429 catalyzes the reaction 4-hydroxyphenylpyruvate Osub2sub homogentisate COsub2sub there is a second copy of this gene DDB0232429 CDS2988290 1485 + 0.227609
hpdl-2 DDB_G0273513 catalyzes the reaction 4-hydroxyphenylpyruvate Osub2sub homogentisate COsub2sub there is a second copy of this gene DDB0232429 CDS3041831 1485 - 0.227609
iksA DDB_G0283109 similar to fungal kinases contains an IQ calmodulin-binding regionDDB0232431 CDS257953 2940 + 0.272449
iliQ DDB_G0292926 contains a large ankyrin repeat region induced by Legionella pneumophila infectionDDB0232433 CDS2280235 2490 + 0.214458
ireA DDB_G0267650 ortholog of the yeast IRE1 serinethreonine kinaseendoribonuclease a transmembrane protein involved in the unfolded protein response contains a ribonuclease 2-5A domain and 3 pyrrolo-quinoline quinone (PQQ) domainsDDB0232428 CDS495110 2955 + 0.237902
irlA DDB_G0272987 DDB0232429 CDS2020830 4296 + 0.26513
irlB-1 DDB_G0273333 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS2539802 4347 - 0.216931
irlB-2 DDB_G0273857 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy there is a second copy of this gene DDB0232429 CDS3487559 4347 + 0.216931
irlC DDB_G0270894 the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophy contains a SWIM Zn-finger domainDDB0232428 CDS3195968 4335 + 0.231834
irlD DDB_G0269632 DDB0232428 CDS3190841 4518 + 0.261399
irlE DDB_G0288803 putative protein serinethreonine kinase the kinase domain is similar to yeast IRE1 kinase required for inositol phototrophyDDB0232432 CDS1985593 4053 + 0.237602
kinX DDB_G0283391 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232431 CDS749416 3285 + 0.312329
kinY DDB_G0289661 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family similar to LIM kinases which regulate actin dynamicsDDB0232432 CDS3255902 1740 + 0.251149
krsA DDB_G0284181 putative protein serinethreonine kinase belongs to the protein kinase MST subfamily similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase involved in signal transduction and hyperosmotic responseDDB0232431 CDS1697612 1386 - 0.313853
krsB DDB_G0267978 putative protein serinethreonine kinase N-terminus similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinase C-terminal half belongs to the peptidase C2 family contains 4 calpain III domains and has similarity to calpain-like cysteine proteaseDDB0232428 CDS1220851 3318 + 0.331826
ksrA-1 DDB_G0272883 catalyzes the reduction of sphinganine to 3-dehydrosphinganine in glycosphingolipid metabolism there is a second copy of this gene DDB0232429 CDS2361855 1005 - 0.311443
ksrA-2 DDB_G0274015 catalyzes the reduction of sphinganine to 3-dehydrosphinganine in glycosphingolipid metabolism there is a second copy of this gene DDB0232429 CDS3668724 1005 + 0.311443
kxcA DDB_G0289859 member of the TKL (tyrosine kinase-like) group and the LISK (LIM domain and testis-specific kinase) family contains calmodulin-binding RhoGEF and pleckstrin homology (PH) domainsDDB0232432 CDS3309104 3936 + 0.256352
kxcB DDB_G0293124 kinase domain similar to those of stress-induced STK kinases contains a DH (Dbl homology) domain followed by a PH (pleckstrin homology) domain found in proteins shown to encode a GEF activity specific for Rho family membersDDB0232433 CDS2557594 3378 - 0.301066
l2hgdh DDB_G0267656 ortholog of the H. sapiens L2HGDH which when defective causes L-2-hydroxyglutaric aciduria-a rare autosomal recessive disorderDDB0232428 CDS518710 1341 + 0.282625
ldhA DDB_G0281101 DDB0232430 CDS4061672 1023 - 0.314761
lip1 DDB_G0268966 similar to the human lipase family catalyzes the reaction: Triacylglycerol Hsub2subO diacylglycerol a carboxylateDDB0232428 CDS2042126 1245 + 0.306827
lip5 DDB_G0277723 similar to the human lipase family catalyzes the reaction: Triacylglycerol Hsub2subO diacylglycerol a carboxylateDDB0232429 CDS8375987 1809 - 0.317302
lis1 DDB_G0288375 dynein regulator associated with centrosomes and microtubules functionally interacts with dcx in cAMP signallingDDB0232432 CDS1452516 1260 + 0.35
lkb1 DDB_G0279629 CAMK group CAMKL family kinase protein kinase involved in regulating both development and the stress responseDDB0232430 CDS2335074 1761 - 0.294719
lst8 DDB_G0292592 component of the TORC2 (Tor complex 2) with Tor Rip3 and PiaA that plays a role in regulation of adenylate cyclase (ACA) and protein kinase B (PKB) activation during aggregationDDB0232433 CDS1819608 915 - 0.338798
lvsA DDB_G0269150 DDB0232428 CDS3119127 10860 - 0.304236
lvsB DDB_G0271504 DDB0232429 CDS668886 12357 + 0.254916
lvsC DDB_G0280971 DDB0232430 CDS4286715 7476 + 0.290931
lvsE DDB_G0282925 DDB0232431 CDS90982 6579 + 0.286518
lvsF DDB_G0284333 similar to mammalian FAN human LYST and mouse Beige proteinsDDB0232431 CDS1946519 3465 - 0.278788
lvsG DDB_G0268088 protein with a beigeBEACH domain a weak protein kinase domain and N-terminal WD40 repeats does not contain the consensus sequences required for kinase functionDDB0232428 CDS1432947 6540 - 0.272018
mak16l DDB_G0269642 ortholog of S. cerevisiae MAK16 and mammalian RBM13 inyeast an essential nuclear protein constituent of 66S pre-ribosomal particlesDDB0232428 CDS3206739 930 + 0.307527
mdn1 DDB_G0295765 Dictyostelium ortholog of the conserved midasin a large protein containing an AAA ATPase domain and a C-terminal VWFA domain S. cerevisiae MDN1 is a rRNA processing ATPase.DDB0232429 CDS5627352 17703 - 0.282438
mecr DDB_G0278095 ortholog of the mammalian MECR and S. cerevisiae ETR1 a mitochondrial 2-enoyl thioester reductase that belongs to the zinc-containing alcohol dehydrogenase familyDDB0232430 CDS262493 1053 - 0.358025
med31 DDB_G0285221 ortholog of the mediator of RNA polymerase II transcription subunit 31 the mediator complex functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machineryDDB0232431 CDS2996613 531 - 0.265537
mekA DDB_G0269152 STE SerThr protein kinase family mitogen-activated protein kinase kinase involved in chemotaxis and early development phosphorylates the MAP kinase Erk1 (erkA) is sumoyalated by sumo and ubiquinated by mip1DDB0232428 CDS4015409 1983 - 0.252143
memo1 DDB_G0284869 ortholog of the H. sapiens MEMO1 a mediator of ErbB2-driven cell motilityDDB0232431 CDS2629450 873 - 0.293242
mettl1 DDB_G0276491 ortholog of the conserved methyltransferase-like 1 (METTL1) which in H. sapiens forms a complex with WDR4 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNADDB0232429 CDS6855520 837 + 0.309438
mfeA DDB_G0291247 DDB0232433 CDS383676 1326 - 0.390649
mfsd1 DDB_G0289201 ortholog of the human MSFD1 also knon as SMAP-4 (Smooth Muscle cell-Associated Protein 4) contains 10 putative transmembrane domains and an additional potential signal peptideDDB0232432 CDS2461603 1521 - 0.336621
mgp2 DDB_G0270024 DDB0232428 CDS4042887 2634 - 0.31549
mhkA DDB_G0291231 myosin II heavy chain kinase is an atypical protein serinethreonine kinase in the Alpha kinase group phosphorylates the myosin II heavy chain and drives myosin II disassemblyDDB0232433 CDS65139 3441 + 0.334496
mhkB DDB_G0289115 myosin heavy chain kinase an atypical protein serinethreonine kinase in the Alpha kinase group participates in the regulation of myosin II assembly into the cytoskeletonDDB0232432 CDS2375954 2199 + 0.289677
mhkC DDB_G0290687 myosin heavy chain kinase an atypical protein serinethreonine kinase in the Alpha kinase group drives the disassembly of myosin II filaments for efficient cytokinesis REMI mutant forms aberrant fruiting bodies see DDB0232432 CDS4426907 2343 - 0.349979
mhkD DDB_G0282489 belongs to the Atypical Alpha protein kinases highly similar to Dictyostelium mhkA contains N-terminal predicted coiled-coil domain contains C-terminal G-protein beta WD-40 repeatsDDB0232430 CDS5835955 2826 - 0.279193
mkcA DDB_G0285427 similar to MAP cascade kinases belonging to the PAK sub-family of the STE20 serinethreonine kinases partial suppressor of tagB mutationDDB0232431 CDS3440715 2583 - 0.275648
mkcB DDB_G0290723 similar to Dictyostelium mkcA and other mitogen-activated protein kinases (Ste20PAK family) REMI mutant forms aberrant fruiting bodies see DDB0232432 CDS4499748 2145 + 0.332867
mkcC DDB_G0287853 kinase domain very similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232432 CDS826726 2676 + 0.342302
mkcD DDB_G0277413 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232429 CDS7960057 1959 + 0.291986
mkcE DDB_G0281649 kinase domain similar to those of Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family)DDB0232430 CDS4757942 2148 + 0.271881
mkcF DDB_G0270102 similar to Dictyostelium mkcA and mkcB and other mitogen-activated protein kinases (Ste20PAK family) contains one SH3 (src Homology-3) domainDDB0232428 CDS4222376 2034 - 0.319076
mkkA DDB_G0283265 developmentally regulated MEKKDDB0232431 CDS530684 3804 + 0.287066
mlcC DDB_G0289563 light chain that binds to the neck region of myoC contains two calcium-binding EF-hand motifs but does not bind calciumDDB0232432 CDS2954406 225 - 0.311111
mlcD DDB_G0277917 DDB0232430 CDS607477 444 + 0.304054
mlcE DDB_G0277859 component of actin-based molecular motor myosin II (conventional myosin) componentDDB0232430 CDS76885 453 + 0.364238
mlcR DDB_G0276077 component of actin-based molecular motor myosin II (conventional myosin) componentDDB0232429 CDS6426413 486 + 0.31893
mlkA DDB_G0279925 CAMK1 family protein kinase phosphorylates the myosin II regulatory light chain at S13 is not regulated by Ca2calmodulinDDB0232430 CDS2752719 888 - 0.317568
mnd1 DDB_G0291750 DDB0232433 CDS686426 666 - 0.252252
morg1 DDB_G0289711 ortholog of MORG1 a molecular scaffold protein that acts as a module in the assembly of a multicomponent scaffold for the ERK (extracellular signal-regulated kinase) pathway contains 7 WD40 repeatsDDB0232432 CDS3150155 978 - 0.260736
mpdu1 DDB_G0295677 contains at least three transmembrane domains ortholog of mannose-P-dolichol utilization defect 1 protein MPDU1DDB0232428 CDS3914310 708 + 0.286723
mppA1 DDB_G0274809 part of a complex that removes the transit peptide from the precursor form of proteins imported from the cytoplasm across the mitochondrial inner membrane consists of an alpha and a beta (DDB0232429 CDS3949604 1965 + 0.279389
mppA2 DDB_G0290997 the mitochondrial processing peptidase removes the transit peptide from the precursor form of proteins imported from the cytoplasm across the mitochondrial inner membrane consists of an alpha and a beta (DDB0232432 CDS4869039 1338 - 0.35725
mppB DDB_G0288777 removes the transit peptide from the precursor form of proteins imported from the cytoplasm across the mitochondrial inner membrane consists of an alpha (DDB0232432 CDS1942737 1410 - 0.358156
mps1 DDB_G0280995 putative protein threoninetyrosine kinase similar to yeast and zebrafish mps1 (monopolar spindle) kinase a threoninetyrosine kinaseDDB0232430 CDS3923506 2952 + 0.289295
mrd1 DDB_G0284663 ortholog of yeast MRD1 and mammalian RBM19 yeast MRD1 binds to the 35S pre-rRNA and the U3 snoRNA and is involved in pre-rRNA processing contains 5 RRM domainsDDB0232431 CDS2315842 2688 - 0.278646
mrkA DDB_G0292304 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains 1 kinase-associated (KA1) domain and 1 UBA domainDDB0232433 CDS1433748 3183 - 0.286836
mrkB DDB_G0285643 CAMKL family protein kinase similar to SNF1 kinases MARK kinases and AMPK kinasesDDB0232431 CDS3523048 2148 - 0.284916
mrkC DDB_G0281895 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains C-terminal kinase associated domain 1DDB0232430 CDS5083659 2322 + 0.295866
mtpn DDB_G0268038 Ortholog of metazoan myotrophin (MTPN) which might be involved in cerebellar morphogenesis and cardiac hypertrophy contains 2 ankyrin repeatsDDB0232428 CDS1344276 363 + 0.30854
naa20 DDB_G0276345 ortholog of the conserved catalytic subunit of the NatB N-terminal acetyltransferase (NAA20) which in yeast catalyzes the transfer of an acetyl group to the N-terminal residue of a protein that contains a Met-Glu Met-Asp Met-Asn or Met-Met N-terminusDDB0232429 CDS6679320 522 + 0.293103
naa50 DDB_G0295721 highly conserved protein ortholog of human NAA50 and yeast Mak3DDB0232430 CDS183263 510 - 0.258824
nat10 DDB_G0268868 highly conserved protein ortholog of human NAT10 and yeast KRE33 predicted to localize to the nucleolusDDB0232428 CDS2281503 3174 - 0.290485
nat9 DDB_G0272710 DDB0232429 CDS1909663 639 - 0.256651
natA DDB_G0275449 DDB0232429 CDS5856743 612 - 0.276144
ncbp2 DDB_G0287197 ortholog of mammalian NCPB2 and yeast CBP2 small subunit of the heterodimeric cap binding complex involved in mediating U snRNA export from the nucleusDDB0232431 CDS5395993 705 + 0.299291
ncfA DDB_G0288773 homolog of the essential mammalian neutrophil cytosolic factor p67 that functions as an NADPH oxidase activator contains N-terminal TPR repeats and a C-terminal WW domainDDB0232432 CDS2003648 1815 - 0.32011
ncsA DDB_G0275931 contains four EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232429 CDS6088223 561 - 0.279857
ndrA DDB_G0278457 member of the AGC kinases NDR group localizes to centrosomes and to the spindle during prometaphase and is involved in phagocytosisDDB0232430 CDS907158 1593 + 0.344633
ndrB DDB_G0288753 member of the AGC kinase group similar to NDR protein kinases including yeast morphogenesis proteins ORB6 and CBK1DDB0232432 CDS1909293 1629 - 0.324125
ndrC DDB_G0284839 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinases DDB0232431 CDS2493584 3939 + 0.307692
ndrD DDB_G0289543 member of the AGC kinase group NDR family related to mammalian LATS1 and LATS2 (LArge Tumor Suppressor homolog) kinasesDDB0232432 CDS2920470 6339 + 0.255088
ndufaf5 DDB_G0287769 conserved mitochondrial complex I (CI) assembly factor which when mutated in human leads to mitochondrial disease in Dictyostelium mutations in the ndufaf5 gene cause defects in growth and development and autophagy is increased.DDB0232432 CDS675763 1311 - 0.254767
nek2 DDB_G0270814 protein serinethreonine kinase homologous to human Nek2 kinase involved in formation of microtubule-organizing centers (MTOCs)DDB0232428 CDS4847143 1257 - 0.258552
nek3 DDB_G0275241 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosis not a human Nek3 homologDDB0232429 CDS4983790 3372 - 0.269276
nek4 DDB_G0289277 similar to vertebrate Nek kinases which are involved in regulation of mitosis most similar to Nek4DDB0232432 CDS2561379 1494 - 0.222222
nit1-1 DDB_G0273457 similar to mammalian NIT1 there is a second copy of this gene DDB0232429 CDS2982881 876 - 0.289954
nit1-2 DDB_G0273519 similar to mammalian NIT1 there is a second copy of this gene DDB0232429 CDS3048030 876 + 0.289954
nit2 DDB_G0287939 DDB0232432 CDS872348 987 - 0.274569
nle1 DDB_G0295761 DDB0232428 CDS2884549 1524 - 0.330052
nog1 DDB_G0285465 very similar to NOG1GTPBP4 GTPases which in S. cerevisiae associates with free 60S ribosomal subunits in the nucleolus and is involved in their biogenesisDDB0232431 CDS3263032 2025 - 0.342222
nol9 DDB_G0277945 ortholog of H. sapiens NOL9 similar to S. cerevisiae GRC3 believed to be involved in rRNA processingDDB0232430 CDS44863 2052 + 0.20614
npcA DDB_G0269158 one of two orthologs of NPC1 (with DDB0232428 CDS4862383 4029 + 0.336808
npcB DDB_G0276657 one of two orthologs of NPC1 (with DDB0232429 CDS7081017 4194 - 0.284454
nup43 DDB_G0277955 component of the nuclear pore complex contains four WD40 repeatsDDB0232430 CDS60115 1254 - 0.22807
nup62 DDB_G0274587 ortholog of the 62 kDa nucleoporin an essential component of the nuclear pore complexDDB0232429 CDS3866512 2130 + 0.378404
omt1 DDB_G0271590 DDB0232429 CDS696177 756 + 0.244709
omt11 DDB_G0293886 similar to plant and bacterial O-methyltransferases expressed in pstO cells during culminationDDB0232433 CDS3424368 996 + 0.247992
omt12 DDB_G0293888 highly similar to plant and bacterial O-methyltransferases expressed in pstA cellsDDB0232433 CDS3426309 1110 + 0.243243
omt3 DDB_G0274197 DDB0232429 CDS4793181 1314 - 0.267884
omt4 DDB_G0275013 DDB0232429 CDS5190004 1017 - 0.26057
omt5 DDB_G0275499 DDB0232429 CDS6014515 693 + 0.307359
omt6 DDB_G0275501 DDB0232429 CDS6015883 696 + 0.304598
omt7 DDB_G0282591 DDB0232430 CDS5980059 1020 - 0.221569
omt9 DDB_G0289823 DDB0232432 CDS3290073 1074 - 0.286778
pARTg DDB_G0271766 DDB0232429 CDS860066 4857 - 0.224212
pXi DDB_G0289119 CAMK group protein serinethreonine kinaseDDB0232432 CDS2420542 2076 - 0.25289
pabpc1A DDB_G0293558 similar to mammalian PABPC1 involved in cytoplasmic regulatory processes of mRNA metabolism binding the poly(A) tail of mRNADDB0232433 CDS3041877 1698 + 0.415783
pabpc1B DDB_G0290745 similar to mammalian PABPC1 involved in cytoplasmic regulatory processes of mRNA metabolism binding the poly(A) tail of mRNA contains an additional N-terminal H-rich domainDDB0232432 CDS4494408 2445 + 0.325153
pabpn1 DDB_G0277371 similar to human PABPN1 (PAB2) which is involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail defects in PABPN1 may be the cause of an autosomal dominant oculopharyngeal muscular dystrophyDDB0232429 CDS7899822 669 - 0.327354
pakA DDB_G0269166 STE20PAKA protein kinase involved in the regulation of the cytoskeleton during chemotaxis and required for cytokinesis contains PAK-boxP21-Rho-binding (CRIB) domain found in the WASP C-terminalDDB0232428 CDS3436536 3594 + 0.33222
pakB DDB_G0276459 protein serinethreonine kinase that phosphorylates myoD (myosin ID) and myoK (myosin IK) heavy chains similar to p21-activated kinase belongs to the STE20 family PAKA subfamily of protein kinasesDDB0232429 CDS6847900 2559 - 0.339195
pakC DDB_G0267450 STE20PAK protein kinase required for normal chemotaxis contains PAK-boxP21-Rho-binding (CRIB) domain and pleckstrin homology (PH) domainDDB0232428 CDS229145 1434 - 0.33682
pakD DDB_G0269696 similar to Dictyostelium pakA and other mitogen-activated protein kinases (Ste20PAK family) putative p21-activated kinase contains a calponin-like actin-binding domain a p21-Rho-binding domain and a PKC conserved region 1 (C1) regulates the actin cytoskeleton response during chemotaxis to cAMPDDB0232428 CDS3345400 5037 + 0.25273
pakE DDB_G0293932 putative protein serinethreonine kinase belongs to the PAKL subfamily of protein kinases the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS3512665 2781 + 0.270766
pakF DDB_G0274409 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232429 CDS4648326 3531 - 0.282073
pakG DDB_G0282891 putative protein serinethreonine kinase belongs to the protein kinase PAKL subfamily the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232430 CDS6346144 3540 + 0.284181
pakH-1 DDB_G0273121 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamily stress-responsive kinase there is a second copy of this gene DDB0232429 CDS2532742 1542 + 0.282101
pakH-2 DDB_G0273865 putative protein serinethreonine kinase similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases belongs to the PAKL subfamilystress-responsive kinase there is a second copy of this gene DDB0232429 CDS3497296 1542 - 0.282101
pats1 DDB_G0269250 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 and protein kinase domainsDDB0232428 CDS2657392 9555 - 0.289901
pdkA DDB_G0281471 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232430 CDS4550105 2061 - 0.273654
pdkB DDB_G0284489 member of the AGC kinase group similar to mammalian PDK (phosphoinositide-dependent protein kinase) known to phosphorylate AktPKBDDB0232431 CDS2038480 2727 + 0.260726
pelo DDB_G0280447 ortholog of the conserved D. melanogaster protein pelota which is required for spindle formation and nuclear envelope breakdown during spermatogenesis and is proposed to act in protein translation.DDB0232430 CDS3368362 1326 - 0.295626
pex7 DDB_G0279801 ortholog of peroxin 7 binds the peroxisome targeting signal type 2 (PTS2) contains 6 WD40 repeats mutations in human homolog cause a variety of peroxisomal disordersDDB0232430 CDS2554628 951 + 0.31756
pfp1 DDB_G0276405 putative cysteine protease member of the DJ-1ThiJPfpI family which includes human PARK7 associated with Parkinson's diseaseDDB0232429 CDS6818286 585 - 0.317949
phg2 DDB_G0283699 serinethreonine kinase regulating cell substrate adhesion phagocytosis motility and actin organization member of the TKL (tyrosine kinase-like) group belongs to the ARK (ankyrin repeat-containing kinase) family although it does not contain ankyrin repeatsDDB0232431 CDS995559 4164 - 0.304275
phgA DDB_G0269130 conserved protein involved in contractile vacuole discharge upon osmotic stressbr bNomenclature conflict: b Do not confuse this gene with phg1a encoding the putative phagocytic receptor 1a or with the phgA locus (DDB0232428 CDS3817626 1317 - 0.347001
pigN DDB_G0279313 highly conserved protein involved in GPI anchor biosynthesis ortholog of yeast MCD4DDB0232430 CDS1921668 3099 + 0.308809
pigO DDB_G0278687 putative transferase involved in GPI biosynthesis functions with PigF to transfer ethanolamine phosphate to the third mannose of GPI (glycosylphosphatidylinositol)DDB0232430 CDS887014 3363 + 0.223015
pitrm1 DDB_G0271506 DDB0232429 CDS455398 3201 - 0.282099
pkaC DDB_G0283907 AGC group PKA family protein kinase protein serinethreonine kinase regulates spore cell differentiationDDB0232431 CDS1394958 1947 + 0.333847
pkaD DDB_G0277145 DDB0232429 CDS7643321 2145 - 0.253613
pkbA DDB_G0268620 AGC group AKT family protein serinethreonine kinase similar to other metazoan AktPKB including an N-terminal PH domain homologous kinase and C-terminal regulatory domains and phosphorylation sites required for AktPKB activationDDB0232428 CDS1977388 1335 + 0.357303
pkgA DDB_G0276157 serinethreonine protein kinase of the MAST (Microtubule Associated SerineThreonine kinase) familyDDB0232429 CDS6275918 4104 - 0.287037
pkgB DDB_G0290157 AGC group protein serinethreonine kinase cAMP-activated protein kinase involved in morphogenesis during multicellular developmentDDB0232432 CDS3717777 1440 - 0.324306
pkgC DDB_G0286125 serinethreonine protein kinase of the AGC group similar to mammalian ribosomal protein S6 kinaseDDB0232431 CDS4067973 2733 - 0.312843
pkgD DDB_G0284029 AGC group protein serinethreonine kinase similar to cAMP-activated protein kinase catalytic subunitsDDB0232431 CDS1459718 2979 - 0.28231
pkgE_ps DDB_G0280981 putative pseudogene similar to AGC protein kinases of the AKT familyDDB0232430 CDS3912677 1095 + 0.343379
pkiA DDB_G0289391 DDB0232432 CDS2783089 384 + 0.351562
pksB DDB_G0282357 ortholog of E. coli ydfG and S. cerevisiae TMA29 that have NADP-dependent L-serine dehydrogenase activity also acts on other amino acids such as D-threonine and L-allo-threonine homotetramer DDB0232430 CDS6131868 783 + 0.303959
plaA DDB_G0278525 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232430 CDS1019968 1161 - 0.289406
plk DDB_G0274503 putative protein serinethreonine kinase similar to yeast CDC5 Drosophila polo and mammalian PLK which play a role in mitosis and localize to the centrosomesDDB0232429 CDS4379150 2937 - 0.280899
plrg1 DDB_G0279507 DDB0232430 CDS2174875 1551 + 0.317215
pmmA DDB_G0279289 catalyzes the reaction alpha-D-mannose 1-phosphate D-mannose 6-phosphateDDB0232430 CDS1893937 750 - 0.262667
pmmB DDB_G0272781 catalyzes the reaction alpha-D-mannose 1-phosphate D-mannose 6-phosphateDDB0232429 CDS2170341 750 - 0.268
pno1 DDB_G0287557 conserved protein in S. cerevisiae a nucleolar protein required for pre-18S rRNA processingDDB0232432 CDS417964 720 + 0.290278
ppme1 DDB_G0281651 similar to H. sapiens PPME1 which demethylates proteins that have been reversibly carboxymethylatedDDB0232430 CDS4760769 966 + 0.272257
prkag DDB_G0272542 non-catalytic subunit of the AMP-activated protein kinase (AMPK) complex contains two CBS domainsDDB0232429 CDS1788557 1734 - 0.277393
prmt1 DDB_G0291556 DDB0232433 CDS504463 1026 - 0.287524
prmt2 DDB_G0289445 DDB0232432 CDS2803733 1539 - 0.275504
prosc DDB_G0278713 highly similar to mammalian PROSC a homolog of a bacterial gene co-transcribed with proline synthetaseDDB0232430 CDS1087624 768 - 0.24349
prp19 DDB_G0276803 ortholog of the Prp19 protein in mammals a nuclear matrix protein protein that plays a role in DNA double-strand break repair in S. cerevisiae and in S. pombe a RNA splicing factor and a ubiquitin-protein ligase contains 6 WD-40 repeats and an N-terminal U-box motifDDB0232429 CDS7360384 1545 - 0.337864
prpD DDB_G0288681 DDB0232432 CDS1873609 1479 + 0.354293
prpf4 DDB_G0287635 ortholog of the prp4 splicing factor component of the U4U6-U5 snRNP complex contains 7 WD repeats and a splicing factor motifDDB0232432 CDS533367 1803 - 0.297837
prpf4B DDB_G0279703 protein serinethreonine kinase DYRK family member of the CMGC kinase group similar to mammalian pre-mRNA processing factor PRP4 kinase and DYRK kinasesDDB0232430 CDS2466144 2436 + 0.296388
prpf6 DDB_G0272374 component of the U5 sRNP complex may act in the tri-snRNP complex as a bridging factor between U5 and U4U6 snRNPsDDB0232429 CDS1378065 3045 + 0.324138
psmD10 DDB_G0289189 DDB0232432 CDS2453090 699 - 0.304721
psmD14 DDB_G0272566 DDB0232429 CDS1896679 921 + 0.313789
ptcA DDB_G0293882 DDB0232433 CDS3419922 1518 + 0.216733
ptcE DDB_G0268718 DDB0232428 CDS1991527 2241 - 0.285141
ptcI DDB_G0275823 DDB0232429 CDS5546562 3492 - 0.269759
pter DDB_G0293394 DDB0232433 CDS2831683 1113 - 0.277628
pwp1 DDB_G0275073 DDB0232429 CDS5128411 1710 + 0.334503
pwp2 DDB_G0284621 DDB0232431 CDS2240813 2769 - 0.298664
pyd1 DDB_G0267966 ortholog of S. cerevisiae URA1 and human DPYD defects in DPYD cause dihydropyrimidine dehydrogenase deficiency catalyzes the reaction 56-dihydrouracil NADP uracil NADPH HDDB0232428 CDS1202711 3030 + 0.367327
pyd3 DDB_G0274123 DDB0232429 CDS4571492 1176 + 0.333333
pyk3 DDB_G0289001 member of the TKL (tyrosine kinase-like) group and the DPYK (Dictyostelium protein tyrosine kinase) family of protein kinases contains two kinase domains one of which is predicted to be inactive the C-terminal kinase domain has tyrosine kinase activitybr bCommunity annotation:b Pyk3 appears to be involved in differentiation pathway choice as the KO shows reduced pstO differentiation and compensatory expansion of the prespore region. Pyk3 has been proposed to act in a pathway involving ptpC and statC effectively potentiating the action of DIF-1. One of the factors that influences pathway choice is cell cycle position classic experiments show that cold-synchronized cells which enter development shortly after warming prefer the stalk pathway. This is due to an increased DIF sensitivity. New results (Strasser Tsang and MacWilliams in preparation) now show that the pyk3 transcript is upregulated roughly fivefold after cold synchronization at a time when cells show strong stalk preference (pDDB0232432 CDS2269413 4017 - 0.283047
pyroxd1 DDB_G0289727 DDB0232432 CDS3170582 1641 + 0.233394
qdpr DDB_G0272684 ortholog of QDPR which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin (a 5678-tetrahydropteridine NAD(P) a 67-dihydropteridine NAD(P)H H) the last step of tetrahydrobiopterin (BH4) recycling in higher eukaryotes an essential cofactorDDB0232429 CDS1985270 696 - 0.329023
qkgA-1 DDB_G0273259 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS2831844 4662 + 0.27885
qkgA-2 DDB_G0273635 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domains there is a second copy of this gene DDB0232429 CDS3195191 4662 - 0.27885
rab11A DDB_G0269238 DDB0232428 CDS4269122 645 - 0.344186
rab11B DDB_G0287211 DDB0232432 CDS41773 663 + 0.235294
rab11C DDB_G0277101 DDB0232429 CDS7509311 675 - 0.317037
rab14 DDB_G0281337 DDB0232430 CDS4383385 621 - 0.339775
rab18 DDB_G0289827 DDB0232432 CDS3292859 609 - 0.287356
rab1A DDB_G0283757 DDB0232431 CDS1241175 609 - 0.326765
rab1B DDB_G0277867 DDB0232430 CDS743092 621 - 0.330113
rab1C DDB_G0269174 DDB0232428 CDS2911005 606 - 0.310231
rab1D DDB_G0284985 DDB0232431 CDS2756032 615 - 0.304065
rab1E DDB_G0275969 DDB0232429 CDS6179943 651 + 0.274962
rab21 DDB_G0286553 DDB0232431 CDS4804109 639 + 0.309859
rab24 DDB_G0268402 DDB0232428 CDS1157427 609 - 0.325123
rab2A DDB_G0292268 DDB0232433 CDS1422661 624 + 0.310897
rab2B DDB_G0272138 DDB0232429 CDS1483407 609 + 0.297209
rab32A DDB_G0283603 DDB0232431 CDS965063 660 - 0.309091
rab32B DDB_G0269416 DDB0232428 CDS2727197 783 + 0.265645
rab32C DDB_G0275675 DDB0232429 CDS5696031 675 + 0.302222
rab32D DDB_G0285051 DDB0232431 CDS2597422 687 + 0.263464
rab4 DDB_G0292406 DDB0232433 CDS1558648 618 + 0.302589
rab5A DDB_G0271984 DDB0232429 CDS1113320 606 + 0.328383
rab5B DDB_G0282847 similar to rab5 but has a long amino extension and is missing two conserved cysteine residues at the carboxyl terminusDDB0232430 CDS6292039 645 + 0.311628
rab6 DDB_G0268068 DDB0232428 CDS1398472 627 + 0.287081
rab7A DDB_G0269236 rab family small GTPase involved in vesicle fusion during endocytosis there is another rab7 homolog rab7BDDB0232428 CDS2627248 612 + 0.348039
rab7B DDB_G0287553 there is another rab7 homolog rab7ADDB0232432 CDS408133 594 - 0.294613
rab8A DDB_G0280043 regulates contractile vacuole discharging in response to osmotic stress regulated by DDB0232430 CDS3266503 627 + 0.317384
rab8B DDB_G0276399 DDB0232429 CDS6878753 612 - 0.328431
rabA DDB_G0291233 DDB0232433 CDS312209 606 - 0.268977
rabC DDB_G0271736 DDB0232429 CDS718547 591 + 0.291032
rabF1-1 DDB_G0272905 there is a second copy of this gene DDB0232429 CDS2459564 573 - 0.277487
rabF1-2 DDB_G0273935 there is a second copy of this gene DDB0232429 CDS3571468 585 + 0.273504
rabG1 DDB_G0291738 DDB0232433 CDS677353 591 + 0.323181
rabG2 DDB_G0290783 DDB0232432 CDS4595466 483 + 0.335404
rabH DDB_G0275955 DDB0232429 CDS6208676 597 - 0.211055
rabJ DDB_G0277441 DDB0232429 CDS8110957 771 + 0.273671
rabK1 DDB_G0290833 DDB0232432 CDS4609179 642 - 0.239875
rabL DDB_G0290779 DDB0232432 CDS4606115 615 - 0.297561
rabM DDB_G0290829 DDB0232432 CDS4605000 609 - 0.284072
rabN1 DDB_G0290789 DDB0232432 CDS4608094 651 - 0.254992
rabN2 DDB_G0290793 DDB0232432 CDS4612672 555 - 0.27027
rabO DDB_G0290407 DDB0232432 CDS4047054 657 + 0.232877
rabP DDB_G0290875 DDB0232432 CDS4703255 699 + 0.250358
rabQ DDB_G0268760 DDB0232428 CDS2054001 615 + 0.282927
rabS DDB_G0282537 DDB0232430 CDS5897353 666 - 0.234234
rabT1 DDB_G0268910 DDB0232428 CDS2365532 669 + 0.22571
rabT2 DDB_G0269262 DDB0232428 CDS2416810 657 + 0.235921
rabU DDB_G0291293 DDB0232433 CDS69908 585 + 0.268376
rabV DDB_G0282899 DDB0232430 CDS6281058 702 + 0.176638
rabW DDB_G0276295 DDB0232429 CDS6558113 657 + 0.226788
rabY DDB_G0282203 DDB0232430 CDS5519409 711 - 0.255977
rabZ DDB_G0286169 DDB0232431 CDS4062977 690 - 0.298551
rac1A DDB_G0277869 DDB0232430 CDS441220 585 - 0.358974
rac1B DDB_G0268622 DDB0232428 CDS2364212 585 - 0.317949
rac1C DDB_G0282365 DDB0232430 CDS6045140 582 - 0.324742
racA DDB_G0286555 RhoBTB subfamily protein which have a unique domain architecture composed of a N-terminal GTPase domain two bric a brac domains (BTB and a conserved C-terminal domain there are orthoolgs in several eukaryotes including mammals but are absent from fungi and plants in Dictyostelium appears to be involved in the regulation of the actin cytoskeletonDDB0232431 CDS4692759 1797 - 0.327212
racB DDB_G0279605 DDB0232430 CDS2370154 588 - 0.323129
racC DDB_G0293526 DDB0232433 CDS3000314 579 + 0.322971
racD DDB_G0291976 DDB0232433 CDS1210911 765 + 0.32549
racE DDB_G0280975 interacts with gxcT rgaA and darA acts together with fttB (14-3-3) to regulate the cortical cytoskeleton and cleavage furrow progression during cytokinesisDDB0232430 CDS4354163 672 - 0.360119
racF1 DDB_G0269176 DDB0232428 CDS3007465 582 + 0.271478
racF2 DDB_G0276967 DDB0232429 CDS7215630 582 - 0.274914
racG DDB_G0269178 DDB0232428 CDS3735334 606 - 0.250825
racH DDB_G0269240 DDB0232428 CDS3360340 603 + 0.325041
racI DDB_G0277897 DDB0232430 CDS93233 618 - 0.273463
racJ DDB_G0292560 DDB0232433 CDS1884330 618 + 0.263754
racL DDB_G0292816 DDB0232433 CDS2181555 591 + 0.279188
racM DDB_G0289103 DDB0232432 CDS2368291 570 - 0.27193
racN DDB_G0278009 DDB0232430 CDS154173 660 + 0.259091
racO DDB_G0277791 DDB0232429 CDS8401462 831 + 0.202166
racP DDB_G0285453 DDB0232431 CDS3245052 1131 + 0.312113
racQ DDB_G0278011 DDB0232430 CDS155490 558 + 0.256272
rae1 DDB_G0283835 DDB0232431 CDS1191439 1029 + 0.308066
ragA DDB_G0288701 ortholog of S. cerevisiae GTR1 and H. sapiens RagA and RagB a cytoplasmic GTP binding protein DDB0232432 CDS1844809 906 + 0.296909
ranA DDB_G0291235 DDB0232433 CDS78789 639 + 0.363067
ranB DDB_G0274943 DDB0232429 CDS4583590 2265 - 0.316998
rapA DDB_G0291237 DDB0232433 CDS98914 561 + 0.354724
rapB DDB_G0272857 DDB0232429 CDS2094380 618 - 0.305825
rapC DDB_G0270340 DDB0232428 CDS4670322 837 + 0.296296
raptor DDB_G0270398 putative Raptor protein ortholog a component of the TORC1 complex in yeasts with Lst8 and Tor does not co-immunoprecipitate with the TORC2 complex DDB0232428 CDS4758927 4530 - 0.330905
rasB DDB_G0292998 nuclear Ras that may have a role in cell division andor nuclear division expressed throughout growth and developmentDDB0232433 CDS2415988 594 - 0.3367
rasC DDB_G0281385 Ras protein required for aggregation activated by rasGEF GefA enriched in prestalk cellsbr bCommunity annotation:b Gene expression is greatly perturbed in vegetative rasC-rasG- double null mutants and in early development a subset of important signalling genes are not induced adequately. Notable among these early genes are acaA dagA erkA erkB gpaB and csbA. The discoidin I genes are also underexpresed. The expression of most of these genes (not the discoidins) is rescued when carA is overexpressed in the double null line. Most remarkably the overall profile of gene expression changes in vegetative double null mutants compared to the parent strain is highly similar to that of wild-type cells six hours after infection with Legionella pneumophila compared to uninfected cells (in terms of gene expression changes correlation coefficient 0.61) (Li et al 2009) making this strain phenocopy the Legionella-resistant dupA mutant to some extent (correlation coefficient 0.49). Of 55 genes overeDDB0232430 CDS4519070 570 + 0.333333
rasD DDB_G0292996 DDB0232433 CDS2530991 564 - 0.294326
rasG DDB_G0293434 maximally expressed during growth activated by rasGEF GefRbr bCommunity annotation:b Gene expression is greatly perturbed in vegetative rasC-rasG- double null mutants and in early development a subset of important signalling genes are not induced adequately. Notable among these early genes are acaA dagA erkA erkB gpaB and csbA. The discoidin I genes are also underexpresed. The expression of most of these genes (not the discoidins) is rescued when carA is overexpressed in the double null line. Most remarkably the overall profile of gene expression changes in vegetative double null mutants compared to the parent strain is highly similar to that of wild-type cells six hours after infection with Legionella pneumophila compared to uninfected cells (correlation coefficient 0.61) (Li et al 2009) making this strain partially phenocopy the Legionella-resistant dupA mutant (in terms of gene expression changes correlation coefficient 0.49). Of 55 genes overexpressed at least 4-fold in the vegetDDB0232433 CDS2877682 570 - 0.368421
rasS DDB_G0283537 DDB0232431 CDS849934 585 - 0.305983
rasU DDB_G0270138 DDB0232428 CDS4299011 642 + 0.253894
rasV DDB_G0270736 DDB0232428 CDS4279831 690 - 0.234783
rasW DDB_G0270122 DDB0232428 CDS4277085 651 - 0.282642
rasX DDB_G0270124 DDB0232428 CDS4281896 642 - 0.267913
rasY DDB_G0270126 DDB0232428 CDS4283626 651 - 0.282642
rasZ DDB_G0270140 DDB0232428 CDS4300316 645 + 0.272868
rbbD DDB_G0282529 similar to H. sapiens Retinoblastoma binding proteins RBBP4 and RBBP7 and S. cerevisiae HAT2 a subunit of the HAT1HAT2 histone acetyltransferase complexDDB0232430 CDS5888997 1272 - 0.331761
rbbE DDB_G0285847 DDB0232431 CDS3858078 1578 + 0.292142
rbm8A DDB_G0286007 conserved protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance the human ortholog has been shown to interact with DDB0232431 CDS3939784 564 - 0.281915
rckA DDB_G0278737 member of the TKL (tyrosine kinase-like) group contains an RGS (Regulator of G protein Signaling) domainDDB0232430 CDS1218919 3378 + 0.261693
rheb DDB_G0277041 DDB0232429 CDS7321470 558 + 0.28853
rliA DDB_G0272783 twelve transmembrane domain protein that may act as a transporter repressed after Legionella pneumophila infectionDDB0232429 CDS2172067 1416 + 0.267655
rmd5 DDB_G0274829 ortholog of the conserved RMD5 which in yeast has has an E3-like ubiquitin ligase activityDDB0232429 CDS4057449 1335 - 0.262921
rnf113 DDB_G0267870 DDB0232428 CDS995736 1068 + 0.251873
rnf160 DDB_G0274875 DDB0232429 CDS4311743 5595 - 0.235746
roco11 DDB_G0268636 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232428 CDS2199646 4464 + 0.267473
roco4 DDB_G0288251 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR and protein kinase domainsDDB0232432 CDS1284583 5181 + 0.332947
roco5 DDB_G0294533 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains RhoGEF PH LRR Roc COR and protein kinase domainsDDB0232432 CDS1439427 8403 - 0.309413
roco6 DDB_G0279417 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains LRR Roc COR WD40 PH and protein kinase domainsDDB0232430 CDS2094570 6444 + 0.293451
roco7 DDB_G0267472 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains Roc COR WD40 and protein kinase domains related to LRR-containing kinases but does not contain an LRR domainDDB0232428 CDS628403 7848 - 0.293833
roco8 DDB_G0286127 member of the TKL (tyrosine kinase-like) group and the ROCO family of protein kinases contains DEP LRR Roc COR and protein kinase domainsDDB0232431 CDS4112361 5604 - 0.267131
roco9 DDB_G0288183 member of the TKL (tyrosine kinase-like) group and ROCO family of protein kinases contains RhoGAP LRR Roc Cor and protein kinase domainsDDB0232432 CDS1219231 10098 - 0.264706
rsc11-1 DDB_G0272791 conserved protein of unknown function there is a second copy of this gene DDB0232429 CDS2268088 1731 + 0.306759
rsc11-2 DDB_G0295699 conserved protein of unknown function there is a second copy of this gene DDB0232429 CDS3761741 1731 - 0.306759
rsmA DDB_G0283547 DDB0232431 CDS800136 660 + 0.260606
rsmB DDB_G0281253 DDB0232430 CDS4295825 783 + 0.219668
rsmC DDB_G0278449 DDB0232430 CDS896854 723 + 0.236515
rsmD DDB_G0292318 DDB0232433 CDS1471614 684 + 0.19152
rsmE-1 DDB_G0273099 there is a second copy of this gene DDB0232429 CDS2580465 663 + 0.205128
rsmE-2 DDB_G0273825 there is a second copy of this gene DDB0232429 CDS3450554 663 - 0.205128
rsmF DDB_G0278389 DDB0232430 CDS814663 627 + 0.239234
rsmG DDB_G0278717 DDB0232430 CDS501817 609 - 0.192118
rsmH DDB_G0278403 DDB0232430 CDS825274 819 + 0.229548
rsmK DDB_G0278217 DDB0232430 CDS491519 588 + 0.19898
rsmM DDB_G0292300 DDB0232433 CDS1426160 645 + 0.308527
samkA DDB_G0269876 DDB0232428 CDS3775693 1923 + 0.228289
samkB DDB_G0284859 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232431 CDS2549067 1782 + 0.251403
samkB_ps1 DDB_G0270988 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232428 CDS3791042 1593 - 0.264909
samkC DDB_G0270678 putative protein kinase containing a SAM (sterile alpha motif) homology domain a putative protein interaction moduleDDB0232428 CDS3778203 2628 + 0.251903
samkD DDB_G0270680 similar to SNF1-like kinases unlikely to function as a kinase as it lacks the catalytic aspartateDDB0232428 CDS3781297 1662 + 0.197954
samkE_ps1 DDB_G0283165 putative pseudogene SAMK (SAM domain-containing kinase) familyDDB0232431 CDS352482 1272 - 0.26022
sarA DDB_G0272296 similar to budding yeast Sar1 a 21 kDa GTP- binding protein involved in vesicular transport between the endoplasmic reticulum and the GolgiDDB0232429 CDS1644732 567 - 0.33157
sarB DDB_G0278477 weakly similar to budding yeast Sar1 a 21 kDa GTP- binding protein involved in vesicular transport between the endoplasmic reticulum and the GolgiDDB0232430 CDS934441 585 - 0.268376
sdrA DDB_G0290659 DDB0232432 CDS4286973 873 + 0.290951
sec13 DDB_G0292052 DDB0232433 CDS1099513 906 + 0.34106
sec31 DDB_G0270992 DDB0232428 CDS3837509 4068 + 0.346853
sec7 DDB_G0272486 belongs to the Sec7 superfamily involved in phagocytosis and cell motilityDDB0232429 CDS1791640 2796 - 0.299714
secG DDB_G0287459 Arf-guanyl-nucleotide exchange factor of the cytohesin family involved in chemotaxis to cAMP during development and substrate adhesionDDB0232432 CDS318028 2961 - 0.372847
sepA DDB_G0276465 plays a role in the regulation of cleavage furrow formation similar to S. pombe cdc7DDB0232429 CDS6942806 3504 + 0.32363
set1 DDB_G0289257 DDB0232432 CDS2551579 4461 + 0.297467
sf3b4 DDB_G0267714 DDB0232428 CDS676187 1080 - 0.333333
sgkA DDB_G0272522 homolog of human Sphk1 phosphorylates sphinganine to sphinganine 1-phosphateDDB0232429 CDS1846158 1875 + 0.3088
sgkB DDB_G0284545 homolog of human Sphk2 phosphorylates sphinganine to sphinganine 1-phosphateDDB0232431 CDS2087340 2283 + 0.251862
sgkC DDB_G0272350 DDB0232429 CDS1700447 2178 + 0.344812
sgkD DDB_G0289343 DDB0232432 CDS2664172 2052 + 0.203704
sgtA DDB_G0280345 DDB0232430 CDS3286144 1005 - 0.311443
shkA DDB_G0283267 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domain negative regulator of phosphoinositol signalingDDB0232431 CDS438511 1584 + 0.318182
shkB DDB_G0288617 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS1745652 1962 - 0.331295
shkC DDB_G0278409 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS836437 1521 - 0.332676
shkD DDB_G0281343 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232430 CDS4376038 2235 + 0.314541
shkE DDB_G0290451 member of the TKL (tyrosine kinase-like) group and the SHK (SH2-domain containing kinase) subfamily contains a C-terminal SH2 (Src homology 2) domainDDB0232432 CDS4058161 2133 + 0.284107
sigI DDB_G0275177 DDB0232429 CDS5054068 915 - 0.27541
sky1 DDB_G0275627 similar to SRPKs (Serinearginine-Rich Protein specific Kinases) serinethreonine kinases that specifically phosphoryate arginine-serine rich domains found in the SR family of splicing factorsDDB0232429 CDS5951942 1971 - 0.318113
slc35b2 DDB_G0269602 belongs to the drugmetabolite transporter (DMT) superfamily similar to D. melanogaster sll human SLC35B2 contains 8 predicted transmembrane domainsDDB0232428 CDS3110201 1080 - 0.297222
smu1 DDB_G0278353 DDB0232430 CDS737677 1593 - 0.266164
snfA DDB_G0277905 CAMKL family protein kinase catalytic subunit of the AMP-activated protein kinase (AMPK) complex similar to SNF1 kinases and AMPK experiments in Dictyostelium show that AMPK signaling plays an important role in mitochondrial disease.DDB0232430 CDS589784 2184 + 0.250458
snpA DDB_G0285111 DDB0232431 CDS2863727 876 - 0.3379
spg1 DDB_G0291269 DDB0232433 CDS37774 612 + 0.338235
spkA-1 DDB_G0273445 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS2969377 1917 - 0.310381
spkA-2 DDB_G0273531 member of the TKL (tyrosine kinase-like) group and the ARK (ankyrin repeat-containing kinase) family kinase activity stimulated by hyperosmolarity and heat shock there is a second copy of this gene DDB0232429 CDS3060166 1917 + 0.310381
splA DDB_G0283385 dual-specificity protein kinase involved in spore coat formation and morphogenesis member of the TKL (tyrosine kinase-like) group and the CZAK (C-terminal domain of ZakA) familyDDB0232431 CDS623097 7233 + 0.323655
splB DDB_G0285321 member of the TKL (tyrosine kinase-like) group activates the transcriptional regulator STATcDDB0232431 CDS3131349 3468 + 0.27797
sqrdl DDB_G0292250 ortholog of the conserved sulfide quinone reductase-like protein in S. pombe this oxidoreductase is involved in mitochondrial sulfide oxidationDDB0232433 CDS1300465 1359 - 0.341428
sr DDB_G0290009 catalyzes the reaction 78-dihydrobiopterin NADPsupsup sepiapterin NADPH Hsupsup the final step in L-erythro-tetrahydrobiopterin (BH4) biosynthesis a cofactor for aromatic amino acid oxidationbr DDB0232432 CDS3552302 804 + 0.238806
srp72 DDB_G0291412 component of the signal recognition particle (SRP) which ensures correct targeting of nascent secretory proteins to the endoplasmic reticulumDDB0232433 CDS275731 2019 - 0.270926
srpRB DDB_G0278543 DDB0232430 CDS1043259 873 + 0.269187
sti1 DDB_G0292404 DDB0232433 CDS1556012 1695 - 0.362242
strap DDB_G0286457 ortholog of the serine-threonine kinase receptor-associated protein STRAP an inhibitor of TGF-beta signaling contains 7 WD40 repeatsDDB0232431 CDS4462466 882 - 0.349206
strn DDB_G0288327 homolog of mammalians striatins calmodulin-binding proteins expressed in the central nervous system and Drosophila Cka involved in the Jun kinase pathwayDDB0232432 CDS1395012 2484 + 0.288647
stt3 DDB_G0285159 CAZy family GT66 subunit of the oligosaccharyltransferase complex which catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER lumen ortholog of S. cerevisiae OST1 contains 13 transmembrane domainsDDB0232431 CDS2899851 2145 + 0.359441
sugt1 DDB_G0269292 ortholog of S. cerevisiae SGT1 and mammalian SUGT1 associated with the SCF (Skp1pCdc53pF box protein) ubiquitin ligase complexDDB0232428 CDS2470067 1164 + 0.293814
sunB DDB_G0285925 SUN-like protein with a centrally located domain contains a predicted N-terminal signal sequenceDDB0232431 CDS3835569 3837 + 0.250195
suox DDB_G0278893 catalyzes the reaction sulfite Osub2sub Hsub2subO sulfate Hsub2subOsub2subbr ortholog of H. sapiens SUOX of which defects cause isolated sulfite oxidase deficiency (ISOD) characterized by neurological abnormalities requires molybdopterin cofactorDDB0232430 CDS1346298 1197 - 0.324144
suvA DDB_G0269554 the D. melanogaster ortholog su(var)3-9 has a central role in heterochromatin-induced gene silencingDDB0232428 CDS2983180 4605 + 0.283388
svkA DDB_G0286359 very similar to mammalian ST25 kinase (SOK1) and other STE20-like kinases stress-responsive kinase phosphorylates severin essential for cell separation during cytokinesisDDB0232431 CDS4476218 1437 + 0.343076
symA DDB_G0292814 DDB0232433 CDS2158906 1371 - 0.33698
taf5 DDB_G0287337 subunit of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modificationDDB0232432 CDS150447 2847 + 0.316473
tbck DDB_G0267760 similar to TBCK in human fly and worm TBC domain-containing proteins in yeast are GTPase activator proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232428 CDS792299 3102 + 0.275306
thoc6 DDB_G0287653 ortholog of THOC6 which exists in the THO complex required for transcriptional elongationDDB0232432 CDS441079 1440 + 0.271528
tipD DDB_G0275323 ortholog of the mammalian ATG16l1 which is involved in autophagy defects in human cause inflammatory bowel disease type 10 in D. discoideum involved in early development and tip formationDDB0232429 CDS5406103 1839 + 0.334965
tkrA DDB_G0292104 catalyzes the reaction D-gluconate NADPsupsup 2-dehydro-D-gluconate NADPH HsupsupDDB0232433 CDS1190069 1005 + 0.300498
tmem115 DDB_G0278061 DDB0232430 CDS209901 867 - 0.262976
tmem20 DDB_G0292606 putative drugmetabolite transporter containing 10 predicted transmembrane domainsDDB0232433 CDS1830985 2097 + 0.311874
tra1 DDB_G0281947 atypical protein kinase belongs to the PIKK family of protein kinases similar to transformationtranscription domain-associated protein (TRRAP)DDB0232430 CDS5137846 13749 + 0.291294
tra2 DDB_G0278349 similar to the conserved Tra2 proteins (including human TRA2A TRA2B and SFRS10) that have splicing regulatory function involved in sex-determination in DrosophilaDDB0232430 CDS731119 981 + 0.415902
trfA DDB_G0269194 DDB0232428 CDS3020703 4173 - 0.309609
trmt5 DDB_G0279739 ortholog of the mammalian TRMT5 and the S. cerevisiae TRM5 tRNAmethyltransferase that methylates guanosine-37 in various tRNAsDDB0232430 CDS2486411 1383 - 0.253796
tssc1 DDB_G0274279 DDB0232429 CDS4037996 1203 + 0.267664
tsuA DDB_G0267962 putative protein serinethreonine kinase similar to mammalian STK36 and fly fused kinase (fu) a ST kinase involved in the hedgehog signal transduction pathway belongs to the ULK (Unc-51-like kinase) family of kinasesDDB0232428 CDS1191800 6744 + 0.248517
ttc27 DDB_G0293372 DDB0232433 CDS2801637 2562 - 0.296253
ttc4 DDB_G0286253 DDB0232431 CDS4254280 1194 - 0.278057
tupA DDB_G0282189 DDB0232430 CDS5574241 1740 + 0.331034
u2af2 DDB_G0286395 large subunit of the U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) which is a splicing factor that forms a heterodimer with DDB0232431 CDS4405482 2016 + 0.361607
utp13 DDB_G0276283 component of the small subunit (SSU) processome containing the U3 snoRNA involved in processing of pre-18S rRNA highly similar to H. sapiens transducin beta-like 3 (TBL3)DDB0232429 CDS6600384 2709 + 0.277593
utp15 DDB_G0283581 DDB0232431 CDS863530 1590 - 0.3
utp6 DDB_G0279601 DDB0232430 CDS2214566 1830 + 0.227322
vilA DDB_G0288557 DDB0232432 CDS1709022 5115 - 0.324536
vps15 DDB_G0282627 putative protein serinethreonine kinase similar to human PIK3R4 and yeast VPS15 which regulate the phosphatidylinositol 3 kinase VPS34 (hVps34) yeast VPS15VPS34 complex known to be involved in vacuolar protein sortingDDB0232430 CDS6019111 5901 + 0.306219
vps29 DDB_G0288787 ortholog of VPS29 a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transportDDB0232432 CDS1965193 552 - 0.311594
vps5 DDB_G0272989 putative ortholog of mammalian sorting nexin and S. cerevisiae VPS5 a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transportDDB0232429 CDS2025586 1638 - 0.339438
vps8 DDB_G0291606 putative ortholog of VPS8 involved in vacuolar protein localizationDDB0232433 CDS397697 5256 + 0.296233
wdr12 DDB_G0279903 DDB0232430 CDS2678219 1392 + 0.30819
wdr18 DDB_G0288659 DDB0232432 CDS1790292 1683 + 0.273321
wdr23 DDB_G0291832 DDB0232433 CDS834929 1986 - 0.291541
wdr24 DDB_G0287817 DDB0232432 CDS760582 3072 - 0.277995
wdr3 DDB_G0282623 DDB0232430 CDS6010118 2829 + 0.308236
wdr36 DDB_G0277019 putative U3 snoRNP protein ortholog of H. sapiens WDR36 and S. cerevisiae UTP21 WDR36 has been implicated in open angle glaucoma 1 type G (GLC1G)DDB0232429 CDS7238641 3081 + 0.278156
wdr4 DDB_G0281061 similar to H. sapiens WDR4 which is required for 7-methylguanosine modification of tRNA and forms a complex with METTL1DDB0232430 CDS3999282 1404 - 0.254274
wdr45l DDB_G0282581 ortholog of the conserved WDR45 like protein that is up-regulated in a variety of human cancers contains 3 WD-40 repeatsDDB0232430 CDS5969861 1053 + 0.304843
wdr46 DDB_G0280489 DDB0232430 CDS3437042 1869 + 0.308186
wdr5 DDB_G0287273 highly similar to WDR5 protein involved in histone H3 K4 methylationDDB0232432 CDS72820 1008 + 0.298611
wdr53 DDB_G0293608 DDB0232433 CDS3130386 1107 + 0.226739
wdr57 DDB_G0271788 ortholog of human WDR57 which binds PRP8 contains 7 WD40 repeatsDDB0232429 CDS716526 1068 + 0.32397
wdr61 DDB_G0282793 DDB0232430 CDS6064156 900 + 0.306667
wdr68 DDB_G0275925 DDB0232429 CDS6064231 978 + 0.312883
wdr7 DDB_G0272771 putative ortholog of H. sapiens WDR7 also known as TGF-beta resistance-associated protein (TRAG) and rabconnectin-3 betaDDB0232429 CDS2154360 4029 - 0.327128
wdr89 DDB_G0283635 DDB0232431 CDS891645 1080 + 0.285185
wdr91 DDB_G0268084 DDB0232428 CDS1428913 2301 - 0.263798
xab2 DDB_G0277977 DDB0232430 CDS88368 2553 + 0.278104
yakA DDB_G0283605 belongs to the CMGC group of protein kinases putative protein serinethreonine kinaseDDB0232431 CDS868454 4377 + 0.303404
zak2 DDB_G0276187 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL group highly similar to zakA and has overlapping function with zakA shown to be a tyrosine kinase and regulator of GSK3 also regulates pattern formation during development via dstC (STATc) signalingDDB0232429 CDS6396810 1908 - 0.253145
zakA DDB_G0276025 contains two kinase domains N-terminal kinase domain related to STE group C-terminal domain similar to TKL groupDDB0232429 CDS6393550 2346 - 0.239983
zfand DDB_G0270362 DDB0232428 CDS4713592 498 + 0.289157
zpr1 DDB_G0269438 ortholog of ZPR1 a eukaryotic zinc finger protein DDB0232428 CDS2767401 1434 - 0.288703