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2024-05-19 17:20:34

Gene list

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COG category: Coenzyme transport and metabolism
Organism: Dictyostelium discoideum AX4, AX4

Number of genes found: 119

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0267546 DDB_G0267546 DDB0232428 CDS311255 1014 + 0.301775
DDB_G0267734 DDB_G0267734 contains a SAM (and some other nucleotide) binding motif similar to bacterial and eukaryotic methyltransferasesDDB0232428 CDS730241 873 + 0.358534
DDB_G0268496 DDB_G0268496 DDB0232428 CDS554652 1434 - 0.357043
DDB_G0268742 DDB_G0268742 DDB0232428 CDS2030028 1182 - 0.212352
DDB_G0269330 DDB_G0269330 DDB0232428 CDS2552986 876 + 0.211187
DDB_G0269376 DDB_G0269376 DDB0232428 CDS2642577 852 - 0.269953
DDB_G0269446 DDB_G0269446 DDB0232428 CDS2789495 1077 - 0.221913
DDB_G0270158 DDB_G0270158 DDB0232428 CDS4337917 588 + 0.238095
DDB_G0270172 DDB_G0270172 DDB0232428 CDS4366498 552 - 0.226449
DDB_G0270580 DDB_G0270580 DDB0232428 CDS3152348 930 + 0.211828
DDB_G0275359 DDB_G0275359 DDB0232429 CDS5424566 1389 - 0.397408
DDB_G0275417 DDB_G0275417 DDB0232429 CDS5450465 1092 + 0.192308
DDB_G0277047 DDB_G0277047 DDB0232429 CDS7348550 3483 + 0.250072
DDB_G0277621_ps DDB_G0277621 putative pseudogene fragment similar to D. discoideum genes DDB0232429 CDS8227373 270 - 0.307407
DDB_G0278107 DDB_G0278107 catalyzes the reaction pyridoxamine 5'-phosphate Hsub2subO Osub2sub pyridoxal 5'-phosphate NHsub3sub Hsub2subOsub2subDDB0232430 CDS283161 684 + 0.30117
DDB_G0278249 DDB_G0278249 DDB0232430 CDS554945 750 + 0.225333
DDB_G0278823 DDB_G0278823 similar to human FDPS (farnesyl pyrophosphate synthetase) which is a key enzyme in isoprenoid biosynthesis may have both dimethylallyltranstransferase and geranyltranstransferase activitiesDDB0232430 CDS1243679 1071 - 0.267974
DDB_G0278993 DDB_G0278993 DDB0232430 CDS1489337 573 + 0.239092
DDB_G0280189 DDB_G0280189 DDB0232430 CDS3081325 1293 + 0.276875
DDB_G0280291 DDB_G0280291 bifunctional enzyme that catalyzes the reactions methylene-tetrahydrofolate NADP NADPH methenyl-Hsub4subF and NADPH methenyl-Hsub4subF methylene-tetrahydrofolate NADPDDB0232430 CDS3212417 1323 + 0.254724
DDB_G0280411 DDB_G0280411 belongs to the anaerobic coproporphyrinogen-III oxidase family similar to human RSAD1DDB0232430 CDS3317501 1341 + 0.260254
DDB_G0281053 DDB_G0281053 conserved hypothetical Dictyostelium protein similar to bacterial ubiquinonemenaquinone biosynthesis methyltransferase ubiEDDB0232430 CDS3982008 864 + 0.278935
DDB_G0281055 DDB_G0281055 conserved hypothetical Dictyostelium protein similar to bacterial ubiquinonemenaquinone biosynthesis methyltransferase ubiEDDB0232430 CDS3983103 864 + 0.260417
DDB_G0282611 DDB_G0282611 catalyzes the reactoin CTP (R)-4'-phosphopantothenate L-cysteine CMP diphosphate N-[(R)-4'-phosphopantothenoyl]-L-cysteineDDB0232430 CDS6001079 1170 + 0.260684
DDB_G0282955 DDB_G0282955 DDB0232431 CDS49492 903 + 0.221484
DDB_G0283121 DDB_G0283121 bifunctional enzyme that catalyzes the reactions methylene-tetrahydrofolate NADP NADPH methenyl-Hsub4subF and NADPH methenyl-Hsub4subF methylene-tetrahydrofolate NADPDDB0232431 CDS275079 879 + 0.285552
DDB_G0283975 DDB_G0283975 DDB0232431 CDS1408395 834 + 0.317746
DDB_G0284401 DDB_G0284401 conserved hypothetical Dictyostelium protein similar to bacterial ubiquinonemenaquinone biosynthesis methyltransferase ubiEDDB0232431 CDS1952708 879 - 0.287827
DDB_G0285525 DDB_G0285525 phosphorylates dephospho-CoA to CoA in other organisms this activity is part of a bifunctional enzyme that also has pantetheine-phosphate adenylyltransferase activity in Dictyostelium the latter activity is encoded by DDB0232431 CDS3344366 624 - 0.245192
DDB_G0285927 DDB_G0285927 similar to mammalian AASDHPPT that transfers the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptorsDDB0232431 CDS3839546 891 - 0.216611
DDB_G0285983 DDB_G0285983 DDB0232431 CDS3904475 633 - 0.339652
DDB_G0286363 DDB_G0286363 DDB0232431 CDS4359667 1233 + 0.301703
DDB_G0286413 DDB_G0286413 DDB0232431 CDS4443400 903 + 0.299003
DDB_G0286637 DDB_G0286637 bifunctional enzyme catalyzes the reactions 510-methylenetetrahydrofolate 3-methyl-2-oxobutanoate tetrahydrofolate 2-dehydropantoate and (R)-pantoate NADP 2-dehydropantoate NADPH HDDB0232431 CDS4765267 2502 - 0.289369
DDB_G0286755 DDB_G0286755 catalyzes the reaction NADPH 78-dihydrofolate NADP tetrahydrofolate in folate biosynthesis and formylTHF biosynthesisDDB0232431 CDS4931449 615 - 0.260163
DDB_G0287107 DDB_G0287107 DDB0232431 CDS5223614 1176 - 0.261054
DDB_G0287201 DDB_G0287201 DDB0232431 CDS5401496 1863 - 0.243156
DDB_G0287509 DDB_G0287509 similar to bacterial 14-dihydroxy-2-naphthoate octaprenyltransferase which catalyzes the reaction 14-dihydroxy-2-naphthoate polyprenylpyrophosphate demethylmenaquinone-8 pyrophosphate COsub2sub and similar to mammalian transitional epithelia response protein of unknown functionDDB0232432 CDS341417 993 - 0.266868
DDB_G0287695 DDB_G0287695 DDB0232432 CDS566252 2037 + 0.26215
DDB_G0288757 DDB_G0288757 catalyzes the reaction ATP nicotinamide ribonucleotide diphosphate NADDDB0232432 CDS1926304 579 - 0.229706
DDB_G0289999 DDB_G0289999 DDB0232432 CDS3529568 879 - 0.25711
DDB_G0290001 DDB_G0290001 DDB0232432 CDS3530853 855 - 0.260819
DDB_G0290401 DDB_G0290401 phosphorylates (R)-pantothenate to (R)-4'-phosphopantothenateDDB0232432 CDS4038671 2058 + 0.270651
DDB_G0290557 DDB_G0290557 DDB0232432 CDS4269452 2061 + 0.280932
DDB_G0290641 DDB_G0290641 DDB0232432 CDS4179788 17406 + 0.258704
DDB_G0290721 DDB_G0290721 similar to bacterial aminotransferase class-III proteins which are pyridoxal-phosphate-dependent enzymesDDB0232432 CDS4489219 1485 - 0.346128
DDB_G0291071 DDB_G0291071 DDB0232432 CDS4948671 1275 - 0.278431
DDB_G0291410 DDB_G0291410 DDB0232433 CDS274574 858 + 0.30303
DDB_G0291426 DDB_G0291426 DDB0232433 CDS292100 870 - 0.297701
DDB_G0291654 DDB_G0291654 DDB0232433 CDS138933 867 - 0.294118
DDB_G0292448 DDB_G0292448 DDB0232433 CDS1659633 1044 - 0.234674
DDB_G0295777 DDB_G0295777 DDB0232432 CDS428287 927 - 0.186624
DDB_G0305538 DDB_G0305538 very similar to neighboring genes that belong to a large D. discoideum protein family of unknown function many clustered on chr 2DDB0232429 CDS8239430 4189 + 0.226307
atg7 DDB_G0271096 DDB0232429 CDS20345 2124 - 0.285782
bcaA DDB_G0285509 catalyzes the reaction 2-keto-3-methyl-valerate L-glutamate L-iso-leucine DDB0232431 CDS3329709 1137 + 0.35708
coq1 DDB_G0280293 adds prenyl units to all-trans-polyprenyl diphosphate similar to S. cerevisiae COQ1 which catalyzes the first step in ubiquinone (coenzyme Q) biosynthesisDDB0232430 CDS3214568 1371 + 0.278629
coq2 DDB_G0281241 catalyzes the reaction solanesyl diphosphate 4-hydroxybenzoate diphosphate nonaprenyl-4-hydroxybenzoate in ubiquinone biosynthesisDDB0232430 CDS4263598 1392 + 0.239224
coq3 DDB_G0279037 similar to S. cevevisiae and R. norvegicus coq3 which catalyze two O-methylation steps in ubiquinone biosynthesisDDB0232430 CDS1539737 966 - 0.233954
coq4 DDB_G0292620 similar to S. cerevisiae COQ4 a protein of unknown function required for ubiquinone biosynthesisDDB0232433 CDS1849018 861 + 0.269454
coq5 DDB_G0280237 S-adenosyl-L-methionine (SAM)-dependent methyltransferase methylates quinones: in E. coli: demethylmenaquinone and 2-octaprenyl-6-methoxy-14-benzoquinone and in S. cerevisiae: 2-hexaprenyl-6-methoxy-14-benzoquinone the substrates of this enzyme in Dictyostelium are not known.DDB0232430 CDS3148507 945 + 0.286772
coq6 DDB_G0291440 similar to S. cerevisiae COQ6 a putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesisDDB0232433 CDS308878 1488 + 0.252016
coq7 DDB_G0280475 ortholog of the conserved COQ7 a protein which in S. cerevisiae is required for ubiquinone (coenzyme Q) biosynthesisDDB0232430 CDS3414983 654 - 0.313456
cotA DDB_G0276941 DDB0232429 CDS7449284 1803 + 0.415973
cyb5r1 DDB_G0285399 catalyzes the reaction NADH 2 ferricytochrome b5 NAD() H() 2 ferrocytochrome involved in desaturation and elongation of fatty acids cholesterol biosynthesis and drug metabolism DDB0232431 CDS3151723 861 + 0.341463
fol1 DDB_G0278283 multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase domainsDDB0232430 CDS616133 1974 - 0.267477
folC DDB_G0292632 catalyzes the reaction L-glutamate H4PteGlu(n) ATP H4PteGlu(n1) phosphate ADP responsible for the addition of a polyglutamate tail to folate and folate derivativesDDB0232433 CDS1872495 1881 + 0.279638
fps DDB_G0278735 target for bisphosphonate drugs catalyzes the reaction geranyl diphosphate isopentenyl diphosphate diphosphate transtrans-farnesyl diphosphateDDB0232430 CDS1245549 1149 - 0.317668
gchA DDB_G0288481 catalyzes the reaction GTP 2 Hsub2subO formate 2-amino-4-hydroxy-6-(erythro-123-trihydroxypropyl)-dihydropteridine triphosphate the first step in the biosynthesis of tetrahydropteridines which have been shown to regulate G-protein coupled signalling the gchA gene is expressed and the enzyme is active during the onset of Dictyostelium developmentDDB0232432 CDS1602765 699 - 0.314735
ggps1 DDB_G0293588 ortholog of the mammalian geranylgeranyl diphosphate synthase 1 includes the enzymes dimethylallyltransferase (EC 2.5.1.1) geranyltranstransferase (EC 2.5.1.10) and farnesyltranstransferase (EC 2.5.1.29)DDB0232433 CDS3093908 912 - 0.25
gphn DDB_G0287261 conserved microtubule-associated protein involved in membrane protein-cytoskeleton interactions implicated in molybdenum cofactor biosynthesisDDB0232432 CDS61689 2157 - 0.298563
hacl1 DDB_G0292402 putative 2-hydroxyacyl-CoA lyase which cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehydeDDB0232433 CDS1553647 1743 - 0.324154
hacl1_ps DDB_G0292762 putative pseudogene 2-hydroxyacyl-CoA lyase (hacl) family proteinDDB0232433 CDS2051654 138 + 0.355072
hemA DDB_G0280763 catalyzes the reaction succinyl-CoA glycine 5-aminolevulinate CoA COsub2subDDB0232430 CDS3708667 1965 - 0.332316
hemB DDB_G0269444 catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen the second step in heme biosynthesisDDB0232428 CDS2788108 1002 + 0.329341
hemC DDB_G0284697 DDB0232431 CDS2361299 978 + 0.294479
hemD DDB_G0285009 catalyzes the reaction hydroxymethylbilane uroporphyrinogen III Hsub2subO in heme biosynthesisDDB0232431 CDS2803238 1152 - 0.171875
hemE DDB_G0292294 catalyzes the reaction uroporphyrinogen III coproporphyrinogen 4 COsub2sub in heme biosynthesisDDB0232433 CDS1412890 1095 - 0.340639
hemF DDB_G0288893 catalyzes the reaction coproporphyrinogen-III Osub2sub 2 H protoporphyrinogen-IX 2 COsub2sub 2 Hsub2subODDB0232432 CDS2090427 999 + 0.336336
hemG DDB_G0292040 DDB0232433 CDS1063213 1599 + 0.238274
hemH DDB_G0288891 catalyzes the reaction protoporphyrin Fesup2sup protoheme 2 Hsupsup in heme biosynthesisDDB0232432 CDS2088484 1272 - 0.29717
hlcs1 DDB_G0288791 functions in post-translational modification of various carboxylases by attachment of biotin similar to human HLCS which when defect causes a neonatal form of multiple carboxylase deficiency Dictytostelium contains three similar enzymes DDB0232432 CDS1968883 1128 + 0.289894
hlcs2 DDB_G0288789 functions in post-translational modification of various carboxylases by attachment of biotin similar to human HLCS which when defect causes a neonatal form of multiple carboxylase deficiency Dictytostelium contains three similar enzymes DDB0232432 CDS1967179 1128 + 0.289894
hlcs3 DDB_G0289035 functions in post-translational modification of various carboxylases by attachment of biotin similar to human HLCS which when defect causes a neonatal form of multiple carboxylase deficiency Dictytostelium contains three similar enzymes DDB0232432 CDS2283370 1215 + 0.288889
iliM DDB_G0292328 similar to bacterial aromatic-ring hydroxylases and fungal monooxygenases induced by Legionella pneumophila infectionDDB0232433 CDS1489407 1272 - 0.259434
ilvB DDB_G0278053 catalyzes the reaction: 2 pyruvate 2-acetolactate COsub2subDDB0232430 CDS198473 1935 - 0.331783
kmo DDB_G0283173 catalyzes the reaction L-kynurenine NADPH H Osub2sub 3-hydroxy-L-kynurenine NADP Hsub2subO during nicotinic acid biosynthesisDDB0232431 CDS359274 1383 - 0.31598
ldhA DDB_G0281101 DDB0232430 CDS4061672 1023 - 0.314761
metK DDB_G0291179 catalyzes the reaction ATP L-methionine Hsub2subO phosphate pyrophosphate S-adenosyl-L-methionineDDB0232432 CDS5102281 1155 - 0.406926
mocs1 DDB_G0285137 DDB0232431 CDS2905081 1893 + 0.24617
mocs2l DDB_G0271864 DDB0232429 CDS980070 477 + 0.251572
mocs2s DDB_G0285133 DDB0232431 CDS2902514 261 - 0.275862
mocs3 DDB_G0267980 DDB0232428 CDS1230144 1278 - 0.289515
nadsyn1 DDB_G0285877 catalyzes the reaction ATP deamido-NAD L-glutamine Hsub2subO AMP diphosphate NAD L-glutamateDDB0232431 CDS3760460 2142 + 0.351074
nae1 DDB_G0287965 conserved regulatory subunit of the dimeric UBA3-NEA1 E1 enzyme which activates NEDD8 necessary for cell cycle progression through the S-M checkpointDDB0232432 CDS887341 1563 + 0.287268
naprt DDB_G0268472 catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) which elevates cellular NAD levels and prevent oxidative stressDDB0232428 CDS1010098 1770 - 0.337853
noxA DDB_G0289653 homolog of the mammalian flavocytochrome b large subunit gp91phox essential for spore formationDDB0232432 CDS3117432 1554 - 0.310811
panC DDB_G0288935 catalyzes the reaction ATP (R)-pantoate beta-alanine AMP diphosphate (R)-pantothenateDDB0232432 CDS2148704 903 + 0.27021
pcbd DDB_G0282831 catalyzes the dehydration of 4a-hydroxytetrahydrobiopterins might function in both as transcriptional coactivator and as pterin dehydratase similar to H. sapiens PCBD1 and PCBD2DDB0232430 CDS6273125 300 + 0.29
pdx1 DDB_G0288299 DDB0232432 CDS1363519 918 + 0.37037
pdx2 DDB_G0288305 member of the SNO glutamine amidotransferase family predicted to be involved in the pyridoxine (vitamin B6) biosynthetic pathway catalyzes the deamidation of glutamine as part of the synthesis of pyridoxal 5'-phosphate the resulting ammonia molecule is channeled to pdxSDDB0232432 CDS1361910 747 - 0.238286
ppcdc DDB_G0278413 decarboxylates N-[(R)-4'-phosphopantothenoyl]-L-cysteine to pantotheine 4'-phosphateDDB0232430 CDS851201 594 - 0.249158
ptsA DDB_G0279095 catalyzes the reaction 6-(L-erythro-12-dihydroxypropyl 3-triphosphate)-78-dihydropterin 6-(12-dioxopropyl)-5678-tetrahydropterin triphosphateDDB0232430 CDS1624152 408 + 0.254902
pykA DDB_G0268628 phosphorylates pyridoxal to pyridoxal 5'-phosphate member of the TKL (tyrosine kinase-like) group of protein kinases belongs to the MLK protein kinase familyDDB0232428 CDS2219371 909 + 0.254125
qprt DDB_G0272462 catalyzes the reaction nicotinate D-ribonucleotide diphosphate COsub2sub pyridine-23-dicarboxylate 5-phospho-alpha-D-ribose 1-diphosphateDDB0232429 CDS1703083 903 - 0.317829
rfk DDB_G0305357 DDB0232429 CDS5767351 489 - 0.286299
sae1 DDB_G0279641 conserved protein forms a heterodimer with sae2 (uba2) acts as a E1 ligase for sumoDDB0232430 CDS2354365 993 + 0.254783
sahA DDB_G0267418 highly similar to mammalian SAHH (catalyzes the hydrolysis of S-adenosyl-L-homocysteine into adenosine and homocysteine) localizes to actin rods found in sporesDDB0232428 CDS1662307 1296 + 0.415895
sahA_ps DDB_G0278037 putative pseudogene similar to S-adenosyl-L-homocysteine hydrolase sahADDB0232430 CDS184302 1518 + 0.242424
serA DDB_G0281071 catalyzes the reaction 3-phosphoglycerate NAD 3-phospho-hydroxypyruvate NADHDDB0232430 CDS4007757 1224 + 0.330882
serC DDB_G0269950 catalyzes the reaction 3-phospho-hydroxypyruvate L-glutamate 2-oxoglutarate 3-phospho-serineDDB0232428 CDS3920593 1125 + 0.266667
sptA DDB_G0268056 similar to S. cerevisiae LCB1 dimerizes with SptB to catalyze the conversion of palmitoyl-CoA L-serine into CoA 3-dehydro-D-sphinganine COsub2subDDB0232428 CDS1366267 1440 - 0.277083
sptB DDB_G0291283 similar to S. cerevisiae LCB2 dimerizes with SptA to catalyze the conversion of palmitoyl-CoA L-serine into CoA 3-dehydro-D-sphinganine COsub2subDDB0232433 CDS51803 1473 + 0.35981
sqle DDB_G0293584 catalyzes the reaction squalene AH2 O2 (S)-squalene-23-epoxide A H2O catalyzes the first oxygenation step in sterol biosynthesisDDB0232433 CDS3076225 1509 + 0.307488
thfA DDB_G0277725 catalyzes the reaction 510-methylenetetrahydrofolate NADsupsup 510-methenyl-tetrahydrofolate NADH Hsupsup enriched in prespore cellsDDB0232429 CDS8379878 942 - 0.316348
tkrA DDB_G0292104 catalyzes the reaction D-gluconate NADPsupsup 2-dehydro-D-gluconate NADPH HsupsupDDB0232433 CDS1190069 1005 + 0.300498
uae1 DDB_G0270272 DDB0232428 CDS4544769 3054 + 0.341519
uba2 DDB_G0286919 conserved protein forms a heterodimer with sae1 acts as a E1 ligase for sumoDDB0232431 CDS5077667 1986 - 0.302618
uba5 DDB_G0293306 DDB0232433 CDS2741328 1146 + 0.287086
ube1c DDB_G0283891 conserved catalytic subunit of the dimeric UBE1C-APPBP1 E1 enzyme which activates NEDD8 necessary for cell cycle progression through the S-M checkpointDDB0232431 CDS1193106 1329 - 0.311512