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2024-05-19 15:51:48

Gene list

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COG category: Cell cycle control, mitosis and meiosis
Organism: Dictyostelium discoideum AX4, AX4

Number of genes found: 243

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DD8-14 DDB_G0289467 DDB0232432 CDS2821081 1992 - 0.317269
DDB_G0267220 DDB_G0267220 DDB0232428 CDS37303 231 - 0.21645
DDB_G0267586 DDB_G0267586 DDB0232428 CDS375348 1389 + 0.267099
DDB_G0267852 DDB_G0267852 the Maf protein is a putative inhibitor of septum formation found in eukaryotes bacteria and archaeaDDB0232428 CDS968117 651 - 0.262673
DDB_G0267918 DDB_G0267918 DDB0232428 CDS1118591 2514 + 0.222355
DDB_G0268246 DDB_G0268246 DDB0232428 CDS1764265 2478 + 0.166263
DDB_G0268498 DDB_G0268498 DDB0232428 CDS573341 2457 - 0.334961
DDB_G0269700 DDB_G0269700 DDB0232428 CDS3352107 2622 + 0.249809
DDB_G0269926 DDB_G0269926 DDB0232428 CDS3880004 2175 - 0.306207
DDB_G0269934 DDB_G0269934 DDB0232428 CDS3897216 6135 + 0.351263
DDB_G0270090 DDB_G0270090 DDB0232428 CDS4198052 774 + 0.22093
DDB_G0270092 DDB_G0270092 DDB0232428 CDS4199147 771 + 0.223087
DDB_G0270246 DDB_G0270246 DDB0232428 CDS4514326 1725 - 0.225507
DDB_G0270864 DDB_G0270864 DDB0232428 CDS2744495 2892 - 0.357538
DDB_G0270902 DDB_G0270902 DDB0232428 CDS3239824 3621 + 0.257387
DDB_G0271250 DDB_G0271250 DDB0232429 CDS214985 1278 + 0.234742
DDB_G0271334 DDB_G0271334 contains a dilute domain found at the carboxyl terminus of non-muscle myosin VDDB0232429 CDS87969 4518 + 0.279991
DDB_G0271816 DDB_G0271816 DDB0232429 CDS825354 3726 + 0.318304
DDB_G0272558 DDB_G0272558 DDB0232429 CDS1851656 3241 + 0.294971
DDB_G0272576 DDB_G0272576 there is a second copy of this gene DDB0232429 CDS2466189 543 - 0.276243
DDB_G0272997 DDB_G0272997 DDB0232429 CDS2081848 3345 - 0.23707
DDB_G0273041 DDB_G0273041 there is a second copy of this gene DDB0232429 CDS2381533 1344 - 0.299851
DDB_G0273205 DDB_G0273205 contains an EF hand but shows little similarity to other proteins there is a second copy of this gene DDB0232429 CDS2704086 3033 + 0.279261
DDB_G0273723 DDB_G0273723 contains an EF hand but shows little similarity to other proteins there is a second copy of this gene DDB0232429 CDS3324668 3033 - 0.279261
DDB_G0273927 DDB_G0273927 there is a second copy of this gene DDB0232429 CDS3564872 543 + 0.276243
DDB_G0273997 DDB_G0273997 there is a second copy of this gene DDB0232429 CDS3648910 1344 + 0.299851
DDB_G0274259 DDB_G0274259 DDB0232429 CDS4126091 3507 + 0.260907
DDB_G0274323 DDB_G0274323 DDB0232429 CDS3956333 840 - 0.242857
DDB_G0274695 DDB_G0274695 ortholog of human CD2 binding proteinproline-serine-threonine phosphatase-interacting protein 1DDB0232429 CDS4207853 1170 + 0.289744
DDB_G0274781 DDB_G0274781 contains three EF hands similar to mammalian neuron specific calcium-binding protein hippocalcin belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232429 CDS3825256 678 + 0.29646
DDB_G0274785 DDB_G0274785 similar to the H. sapiens TATA element modulatory factor (TMF1) which binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein TBPDDB0232429 CDS3826769 3255 + 0.2553
DDB_G0274789 DDB_G0274789 DDB0232429 CDS3841237 6309 + 0.277223
DDB_G0274893 DDB_G0274893 DDB0232429 CDS4359088 2748 - 0.270742
DDB_G0275331 DDB_G0275331 DDB0232429 CDS5365929 3147 + 0.280902
DDB_G0275401 DDB_G0275401 DDB0232429 CDS5385395 5256 + 0.272831
DDB_G0275505 DDB_G0275505 DDB0232429 CDS6018482 3393 + 0.325965
DDB_G0275783 DDB_G0275783 contains a predicted signal anchor contains 3 coiled coil domainsDDB0232429 CDS5653320 1734 + 0.252018
DDB_G0275795 DDB_G0275795 DDB0232429 CDS5596338 2427 - 0.301607
DDB_G0275935 DDB_G0275935 DDB0232429 CDS6095467 807 - 0.2057
DDB_G0276029 DDB_G0276029 putative ortholog of H. sapiens CNOT1 and S. cerevisiae CDC39 REMI mutant forms aberrant fruiting bodies (see DDB0232429 CDS6435703 7581 - 0.303654
DDB_G0276361 DDB_G0276361 DDB0232429 CDS6745195 2370 + 0.332489
DDB_G0276553 DDB_G0276553 DDB0232429 CDS6875533 2703 + 0.260451
DDB_G0276567 DDB_G0276567 homolog of S. cerevisiae CDC50 (cell division control protein 50) which is required for polarized cell growth contains two putative transmembrane domainsDDB0232429 CDS6951075 939 - 0.292865
DDB_G0276695 DDB_G0276695 DDB0232429 CDS7141543 1941 + 0.301391
DDB_G0276719 DDB_G0276719 DDB0232429 CDS7123870 2268 + 0.22619
DDB_G0277077 DDB_G0277077 contains a UvrBUvrC domain however does not share similarity with UvrB or UvrCDDB0232429 CDS7466122 2190 + 0.252968
DDB_G0277185 DDB_G0277185 DDB0232429 CDS7699060 6855 + 0.307513
DDB_G0277197 DDB_G0277197 DDB0232429 CDS7732529 678 + 0.205015
DDB_G0277429 DDB_G0277429 DDB0232429 CDS8039644 2550 - 0.296863
DDB_G0277537 DDB_G0277537 subunit of PI4K responsible for the phosphorylation of phosphatidylinositol (PI) to PI4P (ATP 1-phosphatidyl-1D-myo-inositol ADP 1-phosphatidyl-1D-myo-inositol 4-phosphate) the first committed step in the generation of phosphatidylinositol 45-bisphosphate (PIP2) a precursor of the second messenger inositol 145-trisphosphate (InsP3)DDB0232429 CDS7989159 7383 + 0.301233
DDB_G0277675 DDB_G0277675 DDB0232429 CDS8331577 2112 - 0.288826
DDB_G0277807 DDB_G0277807 DDB0232429 CDS8439922 1833 + 0.19749
DDB_G0278073 DDB_G0278073 DDB0232430 CDS229027 3633 - 0.24305
DDB_G0278125 DDB_G0278125 DDB0232430 CDS327348 2496 - 0.333333
DDB_G0278255 DDB_G0278255 DDB0232430 CDS568794 1545 - 0.260841
DDB_G0278351 DDB_G0278351 DDB0232430 CDS734436 2991 + 0.265129
DDB_G0278547 DDB_G0278547 DDB0232430 CDS1050062 2214 - 0.268744
DDB_G0279253 DDB_G0279253 DDB0232430 CDS1838283 1539 - 0.238467
DDB_G0279435 DDB_G0279435 DDB0232430 CDS2045716 1461 - 0.299795
DDB_G0279449 DDB_G0279449 DDB0232430 CDS2062975 3303 + 0.350288
DDB_G0279655 DDB_G0279655 similar to Dictyostelium and H. sapiens ppp2r4 (PTPA) the phosphatase 2A regulatory subunit B'DDB0232430 CDS2376263 1407 - 0.257996
DDB_G0279693 DDB_G0279693 contains 1 importin N-terminal domain homolog of human IPO11 (importin-11) and S. cerevisiae KAP120 (importin beta-like protein) both of which function in nuclear protein import as a nuclear transport receptorDDB0232430 CDS2453262 3078 - 0.294997
DDB_G0279745 DDB_G0279745 DDB0232430 CDS2496825 1233 - 0.25223
DDB_G0279863 DDB_G0279863 DDB0232430 CDS2641846 3852 - 0.314901
DDB_G0280249 DDB_G0280249 member of the MAP65ASE1 family of microtubule associated proteins the putative yeast orthologs is an anaphase spindle elongation protein brbr bCommunity annotation:b The provisional identification of this gene as Ase1 is supported by its threefold overexpression in a Dicty strain lacking the Dicty retinoblastoma-like gene rblA (Doquang et al in preparation). Most genes whose products are involved in cell cycle progression are overexpressed in this strain. br Ase1 is a microtubule associated protein resident in the midbody of the mitotic spindle it is phosphorylated by cdk1 during mitotic entry dephosphorylated by the mitotic-exit specific phosphatase cdc14 and degraded by the anaphase promoting complex (see Khmelinskii and Schiebel Cell Cycle 7 283-6 (2008). In budding yeast ase1 is required for spindle elongation and stabilization. br Harry MacWilliams April 2009 DDB0232430 CDS3162671 2316 - 0.262522
DDB_G0280921 DDB_G0280921 contains a PX (phox) domain which is found in various proteins involved in intracellular signalingDDB0232430 CDS3881788 3150 + 0.32381
DDB_G0281485 DDB_G0281485 DDB0232430 CDS4599041 4422 + 0.246721
DDB_G0281767 DDB_G0281767 DDB0232430 CDS4930354 2652 + 0.255656
DDB_G0281937 DDB_G0281937 DDB0232430 CDS5037215 594 + 0.304714
DDB_G0282101 DDB_G0282101 DDB0232430 CDS5369694 3006 + 0.276114
DDB_G0282471 DDB_G0282471 DDB0232430 CDS5811380 4041 + 0.303885
DDB_G0282633 DDB_G0282633 DDB0232430 CDS6031309 2760 + 0.285507
DDB_G0283369 DDB_G0283369 DDB0232431 CDS587429 6252 - 0.274152
DDB_G0283441 DDB_G0283441 DDB0232431 CDS702819 2916 + 0.284636
DDB_G0283545 DDB_G0283545 DDB0232431 CDS794803 2850 + 0.309474
DDB_G0283681 DDB_G0283681 similar to STAG (stromal antigen) proteins which are subunits of a protein complex required for sister chromatid cohesion in eukaryotesDDB0232431 CDS973798 4020 - 0.302488
DDB_G0283827 DDB_G0283827 DDB0232431 CDS1180565 2718 + 0.307947
DDB_G0283939 DDB_G0283939 DDB0232431 CDS1338263 3156 + 0.290875
DDB_G0284037 DDB_G0284037 weakly similar to 26S proteasome regulatory subunit RPN11 (MPR1 protein) REMI mutant forms aberrant fruiting bodies (see DDB0232431 CDS1593040 2148 + 0.288175
DDB_G0284145 DDB_G0284145 DDB0232431 CDS1523365 1317 - 0.2612
DDB_G0284281 DDB_G0284281 DDB0232431 CDS1827185 2940 - 0.25102
DDB_G0285121 DDB_G0285121 DDB0232431 CDS2881701 297 + 0.228956
DDB_G0285261 DDB_G0285261 DDB0232431 CDS3027528 1266 + 0.239336
DDB_G0285265 DDB_G0285265 contains one EF hand similar to calmodulinDDB0232431 CDS3032493 420 - 0.292857
DDB_G0285305_RTE DDB_G0285305 ORF2 protein encoding endonuclease and reverse transcriptase of tRNA-specific non-long terminal repeat retrotransposon TRE3-A refer to GenBank AF134169 for full-length consensus elementDDB0232431 CDS3073434 2127 + 0.368594
DDB_G0285329 DDB_G0285329 C-terminal half very similar to nucleotide binding protein 1 belongs to the highly conserved MrpNBP35 ATP-binding protein familyDDB0232431 CDS3094412 1497 - 0.311289
DDB_G0285813 DDB_G0285813 belongs to the DUF812 family homolog of human CCDC22 (coiled-coil domain-containing protein 22) contains at least two coiled-coil domainsDDB0232431 CDS3688403 1914 + 0.293103
DDB_G0285851 DDB_G0285851 DDB0232431 CDS3717914 708 + 0.305085
DDB_G0286479 DDB_G0286479 DDB0232431 CDS4506469 3504 - 0.257991
DDB_G0286543 DDB_G0286543 contains a RUN domain which is predicted to play a role in Ras-like GTPase signaling pathwaysDDB0232431 CDS4611232 4086 + 0.26603
DDB_G0287103 DDB_G0287103 similar to timeless which in Drosophila forms a complex at replication forks that plays a role in the DNA damage response and is phosphorylated by cyclin-dependent kinases brbr bCommunity annotation: bDDB G0287103 is induced 11-fold in a DDB0232431 CDS5268402 3981 + 0.262999
DDB_G0287289 DDB_G0287289 DDB0232432 CDS86247 4419 + 0.283548
DDB_G0287325 DDB_G0287325 similar to mammalian EPS15 a clathrin adaptor that binds to the AP2 alpha subunit in mammalian cellsDDB0232432 CDS137312 3591 + 0.310498
DDB_G0287709 DDB_G0287709 DDB0232432 CDS584610 2652 - 0.245098
DDB_G0288013 DDB_G0288013 DDB0232432 CDS975395 756 - 0.244709
DDB_G0288125 DDB_G0288125 DDB0232432 CDS1099194 795 - 0.262893
DDB_G0288539 DDB_G0288539 DDB0232432 CDS1648133 798 - 0.177945
DDB_G0289077 DDB_G0289077 DDB0232432 CDS2326670 3246 - 0.254775
DDB_G0289183 DDB_G0289183 DDB0232432 CDS2445521 2337 - 0.307231
DDB_G0289185 DDB_G0289185 DDB0232432 CDS2448283 3081 + 0.212918
DDB_G0289761 DDB_G0289761 DDB0232432 CDS3227434 5901 - 0.239451
DDB_G0289921 DDB_G0289921 DDB0232432 CDS3426110 3708 + 0.263484
DDB_G0290231 DDB_G0290231 DDB0232432 CDS3832338 1356 - 0.233038
DDB_G0290305 DDB_G0290305 DDB0232432 CDS3936242 1716 + 0.287296
DDB_G0290503 DDB_G0290503 DDB0232432 CDS4159418 4479 - 0.20384
DDB_G0290619 DDB_G0290619 DDB0232432 CDS4380155 2163 - 0.283403
DDB_G0290973 DDB_G0290973 similar to Polysphondylium pallidum protein contains at least two predicted coiled-coil domainsDDB0232432 CDS4816558 5334 - 0.250469
DDB_G0291558 DDB_G0291558 DDB0232433 CDS503745 420 - 0.202381
DDB_G0292520 DDB_G0292520 DDB0232433 CDS1591188 747 + 0.322624
DDB_G0292586 DDB_G0292586 DDB0232433 CDS1803595 1368 + 0.29386
DDB_G0292742 DDB_G0292742 contains a dilute domain found at the carboxyl terminus of non-muscle myosin VDDB0232433 CDS2074742 2640 + 0.267803
DDB_G0293216 DDB_G0293216 DDB0232433 CDS2689035 3537 - 0.240317
DDB_G0293342_RTE DDB_G0293342 ORF2 protein encoding endonuclease and reverse transcriptase of tRNA-specific non-long terminal repeat retrotransposon TRE3-A refer to GenBank AF134169 for full-length consensus elementDDB0232433 CDS2768512 684 - 0.342105
DDB_G0293548 DDB_G0293548 DDB0232433 CDS3018651 1998 - 0.23974
DDB_G0293620 DDB_G0293620 DDB0232433 CDS3157149 1728 - 0.234375
DDB_G0293628 DDB_G0293628 DDB0232433 CDS3167249 4926 + 0.252944
DDB_G0293756 DDB_G0293756 DDB0232433 CDS3283369 3300 - 0.23
DDB_G0293990 DDB_G0293990 DDB0232433 CDS3578831 966 - 0.219462
DDB_G0295671 DDB_G0295671 DDB0232431 CDS4703129 1083 - 0.237304
DDB_G0295713 DDB_G0295713 DDB0232430 CDS4417290 2115 - 0.249645
DDB_G0346831 DDB_G0346831 DDB0232428 CDS4895305 2262 + 0.229443
DG1113 DDB_G0280959 DDB0232430 CDS4213401 3474 - 0.250144
agnD DDB_G0281955 DDB0232430 CDS5166543 3888 + 0.35571
alxA DDB_G0275451 similar to mammalian Alix which interacts with ALG-2 (apoptosis-linked gene 2) contains 1 BRO1 (Bro1-rhophilin) domain 3 coiled-coil regions 1 proline-rich region and a conserved recognition sequence for Src-type tyrosine kinasesDDB0232429 CDS5948745 2385 - 0.30021
anapc10 DDB_G0268992 component of the anaphase-promoting complexcyclosome (APCC) a cell cycle-regulated ubiquitin ligase that controls progression through the cell cycleDDB0232428 CDS2080758 567 + 0.257496
anapc11 DDB_G0286909 component of the anaphase-promoting complexcyclosome (APCC) a cell cycle-regulated ubiquitin ligase that controls progression through the cell cycleDDB0232431 CDS5059870 264 - 0.348485
ascc2 DDB_G0280455 ortholog of human ASCC2 part of the TRIP4 complex that enhances activation of NF-kappa-B SRF and AP1DDB0232430 CDS3375530 2826 + 0.284501
atr1 DDB_G0291380 atypical PIKK family protein kinase similar to protein kinase ATR which modulates cell cycle progression and DNA repair in other organisms ATR phosphorylates Rad17 histone H2AX p53 and Nbs1DDB0232433 CDS214264 9474 - 0.259552
bloc1s6 DDB_G0290921 ortholog of human BLOC1S6 a component of the BLOC-1 complex mutations in human BLOC1S6 have been linked to Hermansky-Pudlak syndrome 9 DDB0232432 CDS4755734 624 - 0.213141
bre1 DDB_G0274241 very similar in the C-terminal RING Zn finger domain belongs to the BRE1 familyDDB0232429 CDS4227111 3243 - 0.258094
bud31 DDB_G0270360 a very conserved protein known as G10 protein or BUD31 which in human is suggested to be a nuclear transcription factor and in S. pombe and S. cerevisiae has been shown to be a splicing factorDDB0232428 CDS4710295 666 - 0.27027
bzpG DDB_G0282749 DDB0232430 CDS6241172 1119 - 0.247542
calA DDB_G0279407 calcium-dependent regulatory protein involved in cytokinesis regulated by cytosolic Ca2 fluxes allowing differential binding to target CaM binding proteins (CaMBPs) binds several proteins among them nuclear NumA and Cdk5DDB0232430 CDS2244074 459 - 0.35512
calB DDB_G0269104 DDB0232428 CDS2981116 450 + 0.275556
cbpL DDB_G0288785 putative Ca2-binding protein with 4 putative EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232432 CDS1964055 576 + 0.258681
cbpM DDB_G0286371 putative Ca2-binding protein with 4 putative EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232431 CDS4370399 552 - 0.277174
cdc25 DDB_G0283617 similar to mammalian dual specificity protein phosphatases cdc25B and cdc25C involved in the G2M transition through dephosphorylation of cdc2 at Tyr15 and Thr14DDB0232431 CDS1053164 3162 - 0.256799
cdc5l DDB_G0279311 contains two Myb DNA-binding domains ortholog of human CDC5L and yeast CEF1 may play a role in transcriptional activation and in mRNA splicingDDB0232430 CDS1918418 2403 - 0.28506
cenA DDB_G0288427 similar to human Centrin 2 EF-hand protein localizes to the centromer from which it dissociates during mitosisDDB0232432 CDS1525659 456 + 0.245614
cenB DDB_G0279151 centrin required for nuclear and centrosome stability localizes to the nucleus in interphase but not during mitosis and is involved in the centrosome cycleDDB0232430 CDS1697579 453 - 0.258278
cepC DDB_G0290509 DDB0232432 CDS4173965 1413 - 0.219391
cepE DDB_G0275495 DDB0232429 CDS6003763 2400 - 0.307083
cepG DDB_G0278809 DDB0232430 CDS1225451 3894 + 0.248074
cnbA DDB_G0267446 regulatory subunit of the Casup2supcalmodulin-dependent serinethreonine protein phosphatase contains an EF-hand calcium binding motifDDB0232428 CDS816934 1041 - 0.26513
cnbB DDB_G0285999 contains 3 EF-hands similar to calcineurin B (cnbA) the regulatory subunit of the Ca2calmodulin-dependent serinethreonine protein phosphataseDDB0232431 CDS3918232 552 + 0.269928
cnrP DDB_G0279327 ortholog of importin 9 a nuclear transport receptor that is thought to mediate docking of the importinsubstrate complex to the nuclear pore complex identified as a suppressor of smlA null mutant cnr16DDB0232430 CDS1941566 3333 - 0.311131
cog7 DDB_G0286705 highly similar to COG7 component of the conserved oligomeric Golgi complex which is composed of eight different subunits Defects in human COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) DDB0232431 CDS4871672 2991 - 0.252424
csnk2b DDB_G0284601 ortholog of the CK2 beta chain the regulatory subunit of the ubiquitious serinethreonine protein kinase in eukaryotic cells that phosphorylates many protein substrates in addition to caseinDDB0232431 CDS2209637 807 - 0.281289
ctu1 DDB_G0282921 ortholog of S. pombe ctu1 (cytosolic thiouridylase subunit 1) with ctu2 required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAsDDB0232431 CDS190346 1083 - 0.272391
ctu2 DDB_G0268714 ortholog of S. pombe ctu2 (cytosolic thiouridylase subunit 2) with ctu1 required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAsDDB0232428 CDS1986771 1572 - 0.246819
cycA DDB_G0279085 weakly similar to cyclin A predicted to interact with the cyclin-dependent kinase CDK12 (DDB0232430 CDS1598641 1767 + 0.254669
cycB DDB_G0275493 similar to metazoan cyclin B predicted to interact with the cyclin-dependent kinase CDK12 (DDB0232429 CDS6000211 1311 - 0.363844
cycC DDB_G0274139 similar to metazoan cyclin C predicted to interact with cyclin-dependent kinase DDB0232429 CDS4921649 768 + 0.247396
cycD DDB_G0277439 similar to metazoan and plant type-cyclins of the cell cycle group (G1 subgroup) highest similarity to algal cyclin D predicted to interact with the cyclin-dependent kinase CDK12 (DDB0232429 CDS8066558 2085 + 0.242686
cycH DDB_G0268668 similar to metazoan cyclin H predicted to interact with cyclin-dependent kinase DDB0232428 CDS1891354 861 - 0.190476
cycK DDB_G0286617 similar to metazoan cyclin K predicted to interact with the cyclin-dependent kinase DDB0232431 CDS4722525 1218 - 0.297209
cycL DDB_G0285553 similar to metazoan and higher plants cyclin Lania-6 predicted to interact with DDB0232431 CDS3372094 822 - 0.284672
dnapkcs DDB_G0281167 atypical PIKK family protein kinase similar to human DNA-PKcs required for the repair of DNA double-strand breaks belongs to the PIKK family of protein kinasesDDB0232430 CDS4132807 12900 + 0.265504
dotA DDB_G0271626 H3K79 methyltransferase in Dictyostelium involved in development and DNA repair similar to S. cerevisiae DOT1 which functions in gene silencing at telomeres and DNA repair and is cell cycle regulated Dictyostelium Dot1 however is not cell cycle dependentDDB0232429 CDS563064 5538 + 0.267786
dynA DDB_G0280435 DDB0232430 CDS3347902 4620 - 0.303896
eb1 DDB_G0283607 DDB0232431 CDS912876 1521 + 0.326759
eif3A DDB_G0272078 EIF3A ortholog the eukaryotic initiation factor theta subunit In human binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA is composed of at least 12 different subunitsDDB0232429 CDS1223494 3093 + 0.38086
espl1 DDB_G0290325 caspase-like protease also called separin (ESP1) which plays a central role in sister chromosome segregation in yeastbrbr bCommunity annotation:b espl1 is highly similar to separase (aka separin) a widely-conserved peptidase which cleaves the rad21ssc1 non-SMC subunit of cohesin rings remaining at the centromere at metaphase allowing the sister chromatids to separate. Consistent with this homology espl1 is overexpressed fourfold (p6e-14) in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted. Most genes with roles in S-phase or mitosis are overexpressed in this strain and most of the overexpressed genes have identifiable cell cycle functions. espl1 also shows the developmental time course most typical of cell cycle genes.br The separase inhibitor securin conserved between yeast and humans which is broken down at the metaphaseanaphase junction under control of the spindle checkpoint is not recognizable in Dicty. Securin is also unrecognizable plants however whleDDB0232432 CDS3958340 7284 - 0.240527
forA DDB_G0279607 DDB0232430 CDS2388583 3657 + 0.346185
forG DDB_G0277175 DDB0232429 CDS7682673 3225 - 0.310698
frpA DDB_G0292068 contains two N-terminal calponin homology (CH) domains which is similar to fimbrins and a long unrelated C-terminal tailDDB0232433 CDS1144263 3291 - 0.267396
fszA DDB_G0277721 DDB0232429 CDS8463906 1554 + 0.310811
fszB DDB_G0269224 DDB0232428 CDS4529920 1101 + 0.266122
gacGG DDB_G0280093 DDB0232430 CDS2923710 3612 - 0.295958
gacI DDB_G0275185 DDB0232429 CDS5262569 2400 - 0.281667
gacN DDB_G0279315 DDB0232430 CDS1925209 1836 - 0.259804
gacR DDB_G0278755 DDB0232430 CDS1120346 2352 - 0.306122
gapA DDB_G0269140 DDB0232428 CDS3059126 2583 - 0.297716
gefC DDB_G0282381 DDB0232430 CDS6243320 4374 - 0.299268
gflC DDB_G0270880 contains a plant homeodomain (PHD) finger motif no other sequence similarity exists outside this small domainDDB0232428 CDS2933712 5163 - 0.270385
gnrA DDB_G0291125 DDB0232432 CDS5022395 3264 - 0.324449
gxcC DDB_G0284845 plays a role in the regulation of development contains N-terminal armadillo repeats a RhoGEF domain and a C-terminal pleckstrin homology (PH) domainDDB0232431 CDS2552011 3648 + 0.347039
gxcJJ DDB_G0275679 DDB0232429 CDS5709701 3522 - 0.293583
gxcQ DDB_G0284501 DDB0232431 CDS2058245 3513 + 0.320239
hipA DDB_G0285703 clathrin-associated protein involved in spore coat formation and regulated by epsin contains an Epsin N-terminal homology domain (ENTH) and a C-terminal ILWEQ domain that has been shown to bind to F-actinDDB0232431 CDS3610989 2883 + 0.367673
hook DDB_G0288691 similar to C. elegans ZYG-12 and mammalian HOOK proteins which mediates the attachment between the centrosome and the nucleusDDB0232432 CDS1822874 2205 + 0.275737
hop2 DDB_G0280989 DDB0232430 CDS3917295 732 - 0.260929
iqgC DDB_G0288977 contains a rasGAP domain similar to mammalian IQGAP proteins but lacking the calponin domain and the IQ-calmodulin binding regionDDB0232432 CDS2198403 2454 + 0.347596
lmnB DDB_G0289429 similar to mammalian lamin B1 localizes to the inner membrane of the nuclear envelope involved in chromatin and centrosome organization and stabilizationDDB0232432 CDS2787284 2151 + 0.317062
mad1 DDB_G0287755 conserved component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate localized to centromeres during mitosisDDB0232432 CDS658379 2460 - 0.208537
mgp1 DDB_G0290233 DDB0232432 CDS3834823 2763 + 0.287007
mlcC DDB_G0289563 light chain that binds to the neck region of myoC contains two calcium-binding EF-hand motifs but does not bind calciumDDB0232432 CDS2954406 225 - 0.311111
mlcD DDB_G0277917 DDB0232430 CDS607477 444 + 0.304054
mlcE DDB_G0277859 component of actin-based molecular motor myosin II (conventional myosin) componentDDB0232430 CDS76885 453 + 0.364238
mlcR DDB_G0276077 component of actin-based molecular motor myosin II (conventional myosin) componentDDB0232429 CDS6426413 486 + 0.31893
mnat1 DDB_G0289079 DDB0232432 CDS2330339 978 + 0.293456
mnd1 DDB_G0291750 DDB0232433 CDS686426 666 - 0.252252
mybA DDB_G0293900 DDB0232433 CDS3493719 3693 - 0.25589
mybAA DDB_G0268368 DDB0232428 CDS1003245 2916 + 0.284979
mybQ DDB_G0289319 DDB0232432 CDS2641022 2730 - 0.334066
ncapD2 DDB_G0293984 component of the condensin I complex required for conversion of interphase chromatin into mitotic condensed chromosomesDDB0232433 CDS3563765 4212 - 0.243115
ncapGa DDB_G0281419 putative component of the condensin I complex required for conversion of interphase chromatin into mitotic condensed chromosomes There is another putative NCAPG gene in D. discoideum (DDB0232430 CDS4452796 4611 - 0.227933
ncapH DDB_G0292066 component of the condensin I complex required for conversion of interphase chromatin into mitotic condensed chromosomesDDB0232433 CDS1141212 2637 + 0.264316
ncsA DDB_G0275931 contains four EF-hands belongs to the frequenins a family of myristoyl-switch calcium-binding proteinsDDB0232429 CDS6088223 561 - 0.279857
ndc80 DDB_G0284003 ortholog of NDC80 (also known as HEC1 and TID3) a subunit of the kinetochore complex involved in microtubule binding and the spindle assembly checkpoint brbr bCommunity annotation: bndc80 is overexpressed 16-fold in a Dictyostelium DDB0232431 CDS1379527 2568 + 0.257399
ndm DDB_G0272368 contains a coiled coil C-terminal BAR-like domainDDB0232429 CDS1340572 5346 - 0.245417
nubp1 DDB_G0277437 ortholog of the human nucleotide binding protein NUBP1 belongs to the highly conserved MrpNBP35 ATP-binding protein familyDDB0232429 CDS8068928 948 - 0.336498
nubp2 DDB_G0277157 ortholog of the human nucleotide binding protein NUBP2 belongs to the highly conserved MrpNBP35 ATP-binding protein family contains a Zinc finger C4-type domainDDB0232429 CDS7917419 798 + 0.289474
nubpl DDB_G0291193 conserved protein belongs to the MrpNBP35 ATP-binding protein familyDDB0232432 CDS5087724 972 - 0.304527
nudE DDB_G0272326 DDB0232429 CDS1288191 1197 - 0.265664
nuf2 DDB_G0279553 ortholog of NUF2 a component of the evolutionarily conserved kinetochore-associated Ndc80 complex (in S. pombe composed of: Ndc80-Nuf2-Spc24-Spc25)DDB0232430 CDS2245750 1410 - 0.289362
nup54 DDB_G0270320 similar to mammalian Nup54 component of the nuclear pore complexDDB0232428 CDS4639723 1323 - 0.312925
pikA DDB_G0278727 DDB0232430 CDS1154369 4716 + 0.261026
pikB DDB_G0283081 DDB0232431 CDS247398 5574 - 0.311805
pikC DDB_G0275011 DDB0232429 CDS5211773 5094 + 0.270907
pikD DDB_G0288485 subunit of PI4K responsible for the phosphorylation of phosphatidylinositol (PI) to PI4P (ATP 1-phosphatidyl-1D-myo-inositol ADP 1-phosphatidyl-1D-myo-inositol 4-phosphate) the first committed step in the generation of phosphatidylinositol 45-bisphosphate (PIP2) a precursor of the second messenger inositol 145-trisphosphate (InsP3)DDB0232432 CDS1616073 3543 + 0.269828
pikE DDB_G0289601 ortholog of yeast VPS34 a phosphatidylinositol 3-kinaseDDB0232432 CDS3005109 2451 - 0.299878
pikF DDB_G0268548 putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring has the capacity to bind and be activated by the GTP-bound small GTPase rasDDB0232428 CDS1099622 4149 + 0.291396
pikG DDB_G0282625 putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring has the capacity to bind and be activated by the GTP-bound small GTPase rasDDB0232430 CDS6013022 5016 - 0.234649
pikH DDB_G0291093 putative PI3k putative PI3K that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring unlike other PI3Ks does not contain a ras binding domain but a PH domain and does not localize to the cell cortex upon chemotactic stimulationDDB0232432 CDS4980832 5463 - 0.242541
ppp2r4 DDB_G0270036 ortholog of the human PPP2R4 (PTPA) that stimulates the phosphotyrosyl phosphatase activity of PP2A in the presence of ATP and Mg(2) in vitroDDB0232428 CDS4068160 978 + 0.287321
rbx1 DDB_G0287629 DDB0232432 CDS496993 315 + 0.342857
rgaA DDB_G0287585 DDB0232432 CDS498740 2469 + 0.357635
rio1 DDB_G0280431 atypical RIO family protein kinase yeast serinethreonine kinase RIO1 plays a role in cell cycle progressionDDB0232430 CDS3344181 1725 - 0.302609
rngB DDB_G0268860 DDB0232428 CDS2266964 2832 + 0.278249
scdA DDB_G0283375 DDB0232431 CDS574408 2586 + 0.287703
sec20 DDB_G0267646 DDB0232428 CDS490625 732 + 0.210383
smc1 DDB_G0291752 functions in chromosome dynamics heterodimerizes with smc3DDB0232433 CDS688164 4122 + 0.312712
smc2 DDB_G0284499 functions in chromosome dynamics heterodimerizes with smc4DDB0232431 CDS2051268 3555 - 0.320394
smc3 DDB_G0276101 functions in chromosome dynamics heterodimerizes with smc1DDB0232429 CDS6321257 4314 - 0.309458
smc4 DDB_G0286403 functions in chromosome dynamics heterodimerizes with smc2DDB0232431 CDS4414331 4248 - 0.318974
smc5 DDB_G0290919 functions in chromosome dynamics heterodimerizes with smc6DDB0232432 CDS4745027 3396 - 0.328033
smc6 DDB_G0288993 functions in chromosome dynamics heterodimerizes with smc5DDB0232432 CDS2211609 3558 - 0.324902
smg1 DDB_G0275845 atypical PIKK family protein kinase similar to the PI-3-kinase-related kinase SMG1 which functions in nonsense-mediated mRNA decay belongs to the PIKK family of protein kinasesDDB0232429 CDS5665840 7035 + 0.267235
syf2 DDB_G0284573 D. discoideum SYF2 homolog SYF2 proteins are involved in cell cycle progression and pre-mRNA splicingDDB0232431 CDS2172315 882 + 0.250567
syn10 DDB_G0284385 similar to syntaxin a subfamily of the SNARE family (Soluble NSF Attachment Protein REceptor) involved in vesicle fusionDDB0232431 CDS1923544 774 - 0.31137
syn5 DDB_G0277565 similar to syntaxin 5 a subfamily of the SNARE family (Soluble NSF Attachment Protein REceptor) involved in vesicle fusionDDB0232429 CDS8154194 909 - 0.265127
tacc DDB_G0275391 promotes microtubule growth localizes to the centromer and has been shown to physically interact with DDB0232429 CDS5495060 4437 - 0.320036
tbcB DDB_G0277983 DDB0232430 CDS98599 813 - 0.276753
thoc2 DDB_G0291063 ortholog of human THOC2 and yeast RLR1 which exist in the THO complex required for transcriptional elongationDDB0232432 CDS4908746 6333 + 0.291963
tirA DDB_G0289237 DDB0232432 CDS2526970 4011 - 0.222638
tor DDB_G0281569 atypical PIKK family FRAP subfamily protein kinase ortholog of tor a protein kinase that plays a central role in response to nutrients stress and intracellular energy state called mTOR in mammals in dTOR in Drosophila DDB0232430 CDS4934791 7143 - 0.347893
vps52A DDB_G0293772 putative ortholog of S. cerevisiae VPS52 component of the GARP (Golgi-associated retrograde protein) complexDDB0232433 CDS3307775 2517 + 0.222487
vps52B DDB_G0293496 similar to S. cerevisiae VPS52 component of the GARP (Golgi-associated retrograde protein) complexDDB0232433 CDS2961150 2631 - 0.247815
xpo2 DDB_G0291838 bCommunity annotation:b DDB_G0291838 is highly similar to cse1 of budding yeast and CAS of metazoans. In yeast this protein has been shown to be essential for the re-export of importin alpha (see Schroeder et al Mol Gen Genet 261 788-795 (1999). CSE stands for DDB0232433 CDS815672 2856 - 0.308473
xrn1 DDB_G0276137 DDB0232429 CDS6232603 5250 - 0.333333
xrn2 DDB_G0269922 DDB0232428 CDS3871046 3573 - 0.285195
zipA DDB_G0286985 DDB0232431 CDS5171363 3075 - 0.294959