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2024-06-02 13:07:24

Gene list

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COG category: General function prediction only
Genomic element: DDB0232433

Number of genes found: 146

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Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0291336 DDB_G0291336 DDB0232433 CDS134282 834 - 0.2494
DDB_G0291338 DDB_G0291338 DDB0232433 CDS135540 657 + 0.219178
DDB_G0291350 DDB_G0291350 putative protein serinethreonine kinase similar to mammalian MPSK (myristoylated and palmitoylated serinethreonine kinase) a kinase involved in transcriptional regulation and protein phosphorylation may be an intermediary in the TGF-beta signaling pathwayDDB0232433 CDS162730 1110 - 0.245045
DDB_G0291402 DDB_G0291402 DDB0232433 CDS257921 447 - 0.306488
DDB_G0291444 DDB_G0291444 DDB0232433 CDS320738 1344 + 0.287946
DDB_G0291468 DDB_G0291468 DDB0232433 CDS378403 1608 + 0.264303
DDB_G0291472 DDB_G0291472 DDB0232433 CDS381635 1221 - 0.290745
DDB_G0291476 DDB_G0291476 DDB0232433 CDS396540 726 + 0.316804
DDB_G0291486 DDB_G0291486 similar to CUGBP proteins and Bruno-like proteins human CUGBP1 regulates splicing and translation of various RNAs contains 3 RRM domainsDDB0232433 CDS413873 1470 + 0.348299
DDB_G0291538 DDB_G0291538 similar to bacterial acetyltransferases homolog of E. coli maa (maltose O-acetyltransferase) contains a predicted peroxisomal targeting signalDDB0232433 CDS533329 546 + 0.322344
DDB_G0291578 DDB_G0291578 member of a small Dictyostelium gene family missing the carboxyl half compared to related proteinsDDB0232433 CDS571007 486 + 0.195473
DDB_G0291664 DDB_G0291664 highly similar to DDB0232433 CDS338918 2880 + 0.291319
DDB_G0291674 DDB_G0291674 similar to bacterial short-chain dehydrogenasereductase family proteins and human RDH8 (retinol dehydrogenase 8)DDB0232433 CDS431044 951 - 0.281809
DDB_G0291676 DDB_G0291676 similar to bacterial short-chain dehydrogenasereductase family proteinsDDB0232433 CDS432569 903 - 0.282392
DDB_G0291716 DDB_G0291716 DDB0232433 CDS726193 2322 - 0.251938
DDB_G0291720 DDB_G0291720 DDB0232433 CDS721305 1278 - 0.311424
DDB_G0291722 DDB_G0291722 DDB0232433 CDS719367 1344 - 0.233631
DDB_G0291726 DDB_G0291726 DDB0232433 CDS716979 690 - 0.356522
DDB_G0291758 DDB_G0291758 DDB0232433 CDS697440 1194 + 0.273869
DDB_G0291796 DDB_G0291796 DDB0232433 CDS757607 2541 + 0.284534
DDB_G0291824 DDB_G0291824 DDB0232433 CDS827281 1878 - 0.300319
DDB_G0291842 DDB_G0291842 putative protein tyrosine kinase similar to S. pombe WEE1 inhibitor of mitosis through phosphorylation of cdc2DDB0232433 CDS822502 1059 - 0.351275
DDB_G0291886_ps DDB_G0291886 similar to DDB0232433 CDS881755 2151 + 0.248257
DDB_G0291888 DDB_G0291888 DDB0232433 CDS886219 1416 + 0.214689
DDB_G0291896 DDB_G0291896 weakly similar to mammalian NASP (Nuclear Autoantigenic Sperm Protein) a histone chaperone required for DNA replication normal cell cycle progression and cell proliferationbrbr bCommunity annotation:b DDB G0291896 is similar (first blast hit both ways) to the N1N2 protein of Xenopus in humans known as NASP (nuclear autoantigenic sperm protein) a histone chaperone found in all dividing cells and implicated in chromatin assembly (see Wang et al NAR 36 5763-5772 (2008). NASP is required for cell cycle progression and is upregulated in a variety of cancers (see Alekseev et al Reproductive Biology and Endocrinology 7 45 2009).br DDB_G0291896 is overexpressed threefold (p2e-72) in a Dicty strain in which the retinoblastoma-like protein rblA has been disrupted. Most genes with functions in cell cycle progression are overexpressed in this strain and most overexpressed genes have identifiable cell cycle functions (Doquang et al. in preparation) these include other genes involved in chromatin asDDB0232433 CDS904350 1503 + 0.314039
DDB_G0291918 DDB_G0291918 putative protein serinethreonine kinase CAMK group kinase domain is similar to those of mammalian death-associated protein kinases (DAPK)DDB0232433 CDS943654 2010 + 0.287065
DDB_G0291926 DDB_G0291926 weakly similar ro S. cerevisiae Arc1 a protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasmDDB0232433 CDS959253 1092 - 0.282967
DDB_G0292006 DDB_G0292006 DDB0232433 CDS1004992 966 + 0.247412
DDB_G0292056 DDB_G0292056 DDB0232433 CDS1115547 5472 + 0.272844
DDB_G0292110 DDB_G0292110 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activityDDB0232433 CDS1201167 1053 + 0.253561
DDB_G0292116 DDB_G0292116 belongs to the short-chain dehydrogenasesreductases family similar to human HSDL2 (Hydroxysteroid dehydrogenase-like protein 2)DDB0232433 CDS1219275 849 - 0.328622
DDB_G0292298 DDB_G0292298 DDB0232433 CDS1424473 501 - 0.307385
DDB_G0292312 DDB_G0292312 DDB0232433 CDS1454104 1593 - 0.287508
DDB_G0292332 DDB_G0292332 DDB0232433 CDS1500852 561 + 0.210339
DDB_G0292350 DDB_G0292350 DDB0232433 CDS1496951 3675 + 0.270204
DDB_G0292354 DDB_G0292354 putative protein serinethreonine kinase TTBK family similar to casein kinase similar to mammalian tau-tubulin kinase (TTBK) which phosphorylates the microtubule-associated protein tau implicated in Alzheimer's diseaseDDB0232433 CDS1420214 1488 + 0.30578
DDB_G0292410 DDB_G0292410 similar to H. sapiens zinc finger CCCH-type containing 15 and M. musculus immediate early response erythropoietin 4DDB0232433 CDS1561008 1122 - 0.336898
DDB_G0292424 DDB_G0292424 DDB0232433 CDS1593747 1017 + 0.285152
DDB_G0292430 DDB_G0292430 DDB0232433 CDS1609068 1323 - 0.249433
DDB_G0292432 DDB_G0292432 DDB0232433 CDS1610862 1815 - 0.293113
DDB_G0292494 DDB_G0292494 similar to human TTC39A and TTC39B matches PFAM outer membrane protein IML2 mitochondrialtetratricopeptide repeat protein 39DDB0232433 CDS1739944 2388 - 0.220268
DDB_G0292528 DDB_G0292528 DDB0232433 CDS1616689 897 - 0.331104
DDB_G0292530 DDB_G0292530 DDB0232433 CDS1625548 2967 + 0.276373
DDB_G0292550 DDB_G0292550 DDB0232433 CDS1642791 4194 - 0.223891
DDB_G0292570 DDB_G0292570 DDB0232433 CDS1784981 522 - 0.254789
DDB_G0292574 DDB_G0292574 DDB0232433 CDS1791327 870 + 0.270115
DDB_G0292602 DDB_G0292602 DDB0232433 CDS1827272 879 - 0.31058
DDB_G0292624 DDB_G0292624 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232433 CDS1864394 942 + 0.298301
DDB_G0292698 DDB_G0292698 DDB0232433 CDS1997307 921 - 0.365907
DDB_G0292700 DDB_G0292700 DDB0232433 CDS1999329 894 - 0.241611
DDB_G0292714 DDB_G0292714 DDB0232433 CDS1780390 4446 + 0.234818
DDB_G0292746 DDB_G0292746 member of the patatin family of glycoproteins which are storage proteins but also possess lipase activity also contains a PH domain involved in intracellular signalingDDB0232433 CDS2069434 2898 + 0.327467
DDB_G0292774 DDB_G0292774 DDB0232433 CDS2013605 1098 + 0.270492
DDB_G0292834 DDB_G0292834 DDB0232433 CDS2130562 1710 - 0.29883
DDB_G0292852 DDB_G0292852 ortholog of human LACE1 an AFG1-like ATPase and similar to yeast AFG1 family of proteins contains a P-loop motif and are predicted to be ATPasesDDB0232433 CDS2099022 1584 + 0.279672
DDB_G0292960 DDB_G0292960 DDB0232433 CDS2129207 1173 + 0.225916
DDB_G0293032 DDB_G0293032 DDB0232433 CDS2351624 4698 - 0.270115
DDB_G0293034 DDB_G0293034 DDB0232433 CDS2371825 942 - 0.33121
DDB_G0293062 DDB_G0293062 conserved in plants and bacteria predicted to have a structural domain found in several acyl-CoA acyltransferase enzymesDDB0232433 CDS2415200 246 + 0.313008
DDB_G0293070 DDB_G0293070 putative ortholog of H. sapiens TEP1 a component of the telomerase ribonucleoprotein complex involved in replication of chromosome terminiDDB0232433 CDS2426564 7293 - 0.319896
DDB_G0293072 DDB_G0293072 DDB0232433 CDS2434758 1701 - 0.258083
DDB_G0293170 DDB_G0293170 DDB0232433 CDS2392178 3165 + 0.222749
DDB_G0293174 DDB_G0293174 DDB0232433 CDS2473465 3810 + 0.246194
DDB_G0293184 DDB_G0293184 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesis contains RhoGAP domain found in the Rho family of small G proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS2540484 3561 + 0.281382
DDB_G0293234 DDB_G0293234 ortholog of the conserved non-catalytic N-acetyltransferase that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein that contains a Met-Glu Met-Asp Met-Asn or Met-Met N-terminus ortholog of S. cerevisiae MDM20 the N-terminal acetyltransferase B (NatB) complex subunitDDB0232433 CDS2661843 2814 - 0.27221
DDB_G0293276 DDB_G0293276 member of the AGC kinase group similar to kinase domains of AktPKB and MAST (microtubule-associated serinethreonine kinase) family membersDDB0232433 CDS2701490 1551 - 0.246937
DDB_G0293292 DDB_G0293292 putative protein serinethreonine kinase N-terminal kinase domain similar to vertebrate Nek kinases which are involved in regulation of mitosis C-terminal kinase domain weakly similar to ULK (Unc-51-like kinase)DDB0232433 CDS2647324 4116 + 0.234208
DDB_G0293392 DDB_G0293392 conserved protein mammalian orthologs are predicted Zn-dependent hydrolases of the beta-lactamase foldDDB0232433 CDS2830538 1110 + 0.282883
DDB_G0293412 DDB_G0293412 DDB0232433 CDS2844115 2010 + 0.30199
DDB_G0293460 DDB_G0293460 DDB0232433 CDS2919081 1275 + 0.287843
DDB_G0293514 DDB_G0293514 DDB0232433 CDS2984590 492 + 0.292683
DDB_G0293562 DDB_G0293562 DDB0232433 CDS3048907 1584 + 0.289141
DDB_G0293592 DDB_G0293592 DDB0232433 CDS3100713 483 + 0.277433
DDB_G0293594 DDB_G0293594 DDB0232433 CDS3101875 492 + 0.264228
DDB_G0293604 DDB_G0293604 DDB0232433 CDS3126896 897 - 0.248606
DDB_G0293658 DDB_G0293658 DDB0232433 CDS3221806 1245 - 0.258635
DDB_G0293668 DDB_G0293668 DDB0232433 CDS3238981 909 + 0.20242
DDB_G0293670 DDB_G0293670 DDB0232433 CDS3241196 792 + 0.224747
DDB_G0293714 DDB_G0293714 DDB0232433 CDS3102749 504 + 0.281746
DDB_G0293718 DDB_G0293718 DDB0232433 CDS3104858 483 + 0.318841
DDB_G0293862 DDB_G0293862 DDB0232433 CDS3396260 750 - 0.309333
DDB_G0293864 DDB_G0293864 DDB0232433 CDS3398572 1527 + 0.251473
DDB_G0293868 DDB_G0293868 DDB0232433 CDS3402442 1638 - 0.230159
DDB_G0293930 DDB_G0293930 similar to human ZDHHC16 (zinc finger DHHC domain-containing protein 16) contains 4 putative transmembrane domainsDDB0232433 CDS3510935 960 - 0.258333
DDB_G0293956 DDB_G0293956 DDB0232433 CDS3572844 354 - 0.30226
DDB_G0293958 DDB_G0293958 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232433 CDS3460612 4779 + 0.208203
DDB_G0293976 DDB_G0293976 DDB0232433 CDS3485736 1347 - 0.200445
DDB_G0294629 DDB_G0294629 DDB0232433 CDS1603469 1785 - 0.285154
DDB_G0295691 DDB_G0295691 shares a region of similarity with proteins of unknown functions contains eight predicted transmembrane domainsDDB0232433 CDS883760 1164 + 0.256873
DDB_G0295793 DDB_G0295793 DDB0232433 CDS2856788 1974 + 0.340426
abcD2 DDB_G0293194 half transporter consisting of one ABC domain and one transmembrane domainDDB0232433 CDS2712310 2226 + 0.32929
alrA DDB_G0293850 involved in regulation of aggregate size member of aldo-keto reductase family which reduces CO to C-OH in aldehydes and ketonesDDB0232433 CDS3404974 894 + 0.325503
anapc7 DDB_G0292470 component of the anaphase-promoting complexcyclosome (APCC) a cell cycle-regulated ubiquitin ligase that controls progression through the cell cycleDDB0232433 CDS1686299 1743 + 0.243259
atg1 DDB_G0292390 Dictyostelium homolog of yeast atg1 belongs to the ULK (Unc-51-like kinase) family of kinases required for macroautophagyDDB0232433 CDS1694801 2007 + 0.255605
bub3 DDB_G0292134 ortholog of BUB3 a mitotic checkpoint protein in human a kinetochore protein that interacts with BUB1DDB0232433 CDS1247461 996 - 0.346386
cdc7 DDB_G0292152 similar to S. cerevisiae cell division control protein 7 (CDC7) a serinethreonine kinase required for mitosis and meiosisDDB0232433 CDS1294776 3186 + 0.23666
cpras2 DDB_G0293376 contains a circularly permuted GTPase domain with the conserved motifs G1-G2 lying downstream of the G3-G4-G5 motifs large protein of unknown function whose domain composition is not conserved a closely related ortholog is found in D. purpureum DDB0232433 CDS2805934 11802 - 0.295543
dst3 DDB_G0291267 putative protein serinethreonine kinase the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS35064 1689 - 0.351095
dyrk2 DDB_G0293750 DDB0232433 CDS3272270 2748 + 0.306405
fhkA DDB_G0293656 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsbrbr bCommunity annotation:b The five fhk-X genes differ substantially in their response to the disruption of the retinoblastoma-like gene rblA. FhkA is substantially and highly signficantly upregulated in the ko strain while none of the other genes show major changes. Consistent with its regulation the fhkA promoter contains a putative E2F-type binding site (TTTGCGCCTTTT). Virtually all genes associated with replication fork progression are upregulated in the rblA disruptant these include cdc45 all mcm genes all gins genes all rfc genes four polA subunits three polD subunits two putatitive polE subunits PCNA the single-strand binding protein rfa1 the flap endonuclease repG as well as DNA ligase-1 and topoisomerase-2. All these genes show overexpression factors ranging from 4 to 15DDB0232433 CDS3219230 1782 - 0.231201
gloB2 DDB_G0291482 catalyzes the reaction S-lactoyl-glutathione H2O reduced glutathione D-lactateDDB0232433 CDS411372 879 + 0.335609
gpn1 DDB_G0293220 DDB0232433 CDS2684279 1191 + 0.309824
grwd1 DDB_G0291566 ortholog of the mammalian GRWD1 contains several WD-40 repeatsDDB0232433 CDS556339 1449 - 0.354727
gtpbp1 DDB_G0292538 ortholog of the mammalian GTPBP1 and very similar to GTPBP2 contains a translation elongation factor EFTuEF1A domain 2 and C-terminal domainDDB0232433 CDS1635942 2034 + 0.357915
iliQ DDB_G0292926 contains a large ankyrin repeat region induced by Legionella pneumophila infectionDDB0232433 CDS2280235 2490 + 0.214458
kxcB DDB_G0293124 kinase domain similar to those of stress-induced STK kinases contains a DH (Dbl homology) domain followed by a PH (pleckstrin homology) domain found in proteins shown to encode a GEF activity specific for Rho family membersDDB0232433 CDS2557594 3378 - 0.301066
lst8 DDB_G0292592 component of the TORC2 (Tor complex 2) with Tor Rip3 and PiaA that plays a role in regulation of adenylate cyclase (ACA) and protein kinase B (PKB) activation during aggregationDDB0232433 CDS1819608 915 - 0.338798
mfeA DDB_G0291247 DDB0232433 CDS383676 1326 - 0.390649
mhkA DDB_G0291231 myosin II heavy chain kinase is an atypical protein serinethreonine kinase in the Alpha kinase group phosphorylates the myosin II heavy chain and drives myosin II disassemblyDDB0232433 CDS65139 3441 + 0.334496
mnd1 DDB_G0291750 DDB0232433 CDS686426 666 - 0.252252
mrkA DDB_G0292304 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains 1 kinase-associated (KA1) domain and 1 UBA domainDDB0232433 CDS1433748 3183 - 0.286836
omt11 DDB_G0293886 similar to plant and bacterial O-methyltransferases expressed in pstO cells during culminationDDB0232433 CDS3424368 996 + 0.247992
omt12 DDB_G0293888 highly similar to plant and bacterial O-methyltransferases expressed in pstA cellsDDB0232433 CDS3426309 1110 + 0.243243
pabpc1A DDB_G0293558 similar to mammalian PABPC1 involved in cytoplasmic regulatory processes of mRNA metabolism binding the poly(A) tail of mRNADDB0232433 CDS3041877 1698 + 0.415783
pakE DDB_G0293932 putative protein serinethreonine kinase belongs to the PAKL subfamily of protein kinases the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS3512665 2781 + 0.270766
prmt1 DDB_G0291556 DDB0232433 CDS504463 1026 - 0.287524
ptcA DDB_G0293882 DDB0232433 CDS3419922 1518 + 0.216733
pter DDB_G0293394 DDB0232433 CDS2831683 1113 - 0.277628
rab2A DDB_G0292268 DDB0232433 CDS1422661 624 + 0.310897
rab4 DDB_G0292406 DDB0232433 CDS1558648 618 + 0.302589
rabA DDB_G0291233 DDB0232433 CDS312209 606 - 0.268977
rabG1 DDB_G0291738 DDB0232433 CDS677353 591 + 0.323181
rabU DDB_G0291293 DDB0232433 CDS69908 585 + 0.268376
racC DDB_G0293526 DDB0232433 CDS3000314 579 + 0.322971
racD DDB_G0291976 DDB0232433 CDS1210911 765 + 0.32549
racJ DDB_G0292560 DDB0232433 CDS1884330 618 + 0.263754
racL DDB_G0292816 DDB0232433 CDS2181555 591 + 0.279188
ranA DDB_G0291235 DDB0232433 CDS78789 639 + 0.363067
rapA DDB_G0291237 DDB0232433 CDS98914 561 + 0.354724
rasB DDB_G0292998 nuclear Ras that may have a role in cell division andor nuclear division expressed throughout growth and developmentDDB0232433 CDS2415988 594 - 0.3367
rasD DDB_G0292996 DDB0232433 CDS2530991 564 - 0.294326
rasG DDB_G0293434 maximally expressed during growth activated by rasGEF GefRbr bCommunity annotation:b Gene expression is greatly perturbed in vegetative rasC-rasG- double null mutants and in early development a subset of important signalling genes are not induced adequately. Notable among these early genes are acaA dagA erkA erkB gpaB and csbA. The discoidin I genes are also underexpresed. The expression of most of these genes (not the discoidins) is rescued when carA is overexpressed in the double null line. Most remarkably the overall profile of gene expression changes in vegetative double null mutants compared to the parent strain is highly similar to that of wild-type cells six hours after infection with Legionella pneumophila compared to uninfected cells (correlation coefficient 0.61) (Li et al 2009) making this strain partially phenocopy the Legionella-resistant dupA mutant (in terms of gene expression changes correlation coefficient 0.49). Of 55 genes overexpressed at least 4-fold in the vegetDDB0232433 CDS2877682 570 - 0.368421
rsmD DDB_G0292318 DDB0232433 CDS1471614 684 + 0.19152
rsmM DDB_G0292300 DDB0232433 CDS1426160 645 + 0.308527
sec13 DDB_G0292052 DDB0232433 CDS1099513 906 + 0.34106
spg1 DDB_G0291269 DDB0232433 CDS37774 612 + 0.338235
sqrdl DDB_G0292250 ortholog of the conserved sulfide quinone reductase-like protein in S. pombe this oxidoreductase is involved in mitochondrial sulfide oxidationDDB0232433 CDS1300465 1359 - 0.341428
srp72 DDB_G0291412 component of the signal recognition particle (SRP) which ensures correct targeting of nascent secretory proteins to the endoplasmic reticulumDDB0232433 CDS275731 2019 - 0.270926
sti1 DDB_G0292404 DDB0232433 CDS1556012 1695 - 0.362242
symA DDB_G0292814 DDB0232433 CDS2158906 1371 - 0.33698
tkrA DDB_G0292104 catalyzes the reaction D-gluconate NADPsupsup 2-dehydro-D-gluconate NADPH HsupsupDDB0232433 CDS1190069 1005 + 0.300498
tmem20 DDB_G0292606 putative drugmetabolite transporter containing 10 predicted transmembrane domainsDDB0232433 CDS1830985 2097 + 0.311874
ttc27 DDB_G0293372 DDB0232433 CDS2801637 2562 - 0.296253
vps8 DDB_G0291606 putative ortholog of VPS8 involved in vacuolar protein localizationDDB0232433 CDS397697 5256 + 0.296233
wdr23 DDB_G0291832 DDB0232433 CDS834929 1986 - 0.291541
wdr53 DDB_G0293608 DDB0232433 CDS3130386 1107 + 0.226739