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2024-06-02 14:24:28

Gene list

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COG category: Replication, recombination and repair
Genomic element: DDB0232433

Number of genes found: 61

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Show UniProt / TrEMBL protein name View in Fasta format (DNA) View in Fasta format (Protein)  

 
Dictyostelium discoideum AX4, AX4
NameLocus tagProduct / DescriptionGenomic elementTypeBeginLengthStrandGC-content
DDB_G0291350 DDB_G0291350 putative protein serinethreonine kinase similar to mammalian MPSK (myristoylated and palmitoylated serinethreonine kinase) a kinase involved in transcriptional regulation and protein phosphorylation may be an intermediary in the TGF-beta signaling pathwayDDB0232433 CDS162730 1110 - 0.245045
DDB_G0291464 DDB_G0291464 DDB0232433 CDS369674 3414 - 0.289104
DDB_G0291534 DDB_G0291534 DDB0232433 CDS487852 1113 + 0.261456
DDB_G0291664 DDB_G0291664 highly similar to DDB0232433 CDS338918 2880 + 0.291319
DDB_G0291842 DDB_G0291842 putative protein tyrosine kinase similar to S. pombe WEE1 inhibitor of mitosis through phosphorylation of cdc2DDB0232433 CDS822502 1059 - 0.351275
DDB_G0291872 DDB_G0291872 DDB0232433 CDS855161 2688 + 0.273438
DDB_G0291918 DDB_G0291918 putative protein serinethreonine kinase CAMK group kinase domain is similar to those of mammalian death-associated protein kinases (DAPK)DDB0232433 CDS943654 2010 + 0.287065
DDB_G0292010 DDB_G0292010 DDB0232433 CDS1014321 2334 + 0.288346
DDB_G0292108 DDB_G0292108 DDB0232433 CDS1192584 2490 - 0.278715
DDB_G0292350 DDB_G0292350 DDB0232433 CDS1496951 3675 + 0.270204
DDB_G0292354 DDB_G0292354 putative protein serinethreonine kinase TTBK family similar to casein kinase similar to mammalian tau-tubulin kinase (TTBK) which phosphorylates the microtubule-associated protein tau implicated in Alzheimer's diseaseDDB0232433 CDS1420214 1488 + 0.30578
DDB_G0292416 DDB_G0292416 DDB0232433 CDS1569201 2793 - 0.257787
DDB_G0292550 DDB_G0292550 DDB0232433 CDS1642791 4194 - 0.223891
DDB_G0292624 DDB_G0292624 protein serinethreonine kinase CAMK group CAMK1 family similar to the Dictyostelium myosin light chain kinase (mlkA) and mammalian CAM kinasesDDB0232433 CDS1864394 942 + 0.298301
DDB_G0292914 DDB_G0292914 DDB0232433 CDS2269065 723 + 0.262794
DDB_G0293064 DDB_G0293064 DDB0232433 CDS2418202 1722 - 0.334495
DDB_G0293120 DDB_G0293120 chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2546935 6618 - 0.294349
DDB_G0293184 DDB_G0293184 kinase domain similar to S. pombe cdc7 cell division control protein 7 which plays a role in cytokinesis contains RhoGAP domain found in the Rho family of small G proteins unlikely to function as a kinase as it does not contain a catalytic aspartateDDB0232433 CDS2540484 3561 + 0.281382
DDB_G0293212 DDB_G0293212 DDB0232433 CDS2696303 2541 + 0.275482
DDB_G0293276 DDB_G0293276 member of the AGC kinase group similar to kinase domains of AktPKB and MAST (microtubule-associated serinethreonine kinase) family membersDDB0232433 CDS2701490 1551 - 0.246937
DDB_G0293292 DDB_G0293292 putative protein serinethreonine kinase N-terminal kinase domain similar to vertebrate Nek kinases which are involved in regulation of mitosis C-terminal kinase domain weakly similar to ULK (Unc-51-like kinase)DDB0232433 CDS2647324 4116 + 0.234208
DDB_G0293380 DDB_G0293380 bCommunity annotation:b DDB G0293380 contains a conserved domain which is best matched by COG0116 N6 adenine-specific DNA methylase (E-value 5e-14). The similarity to PRK11783 rRNA methyltransferase is lower (9e-11). The blast matches list both putative RNA methylases and putative N6 adenine-specific DNA methylases. Thus although it does not now appear to be possible to assign DDB_G0293380 conclusively to either category the case for a DNA methylase currently looks a bit stronger.br DDB_G0293380 is overexpressed fivefold (p0.008) in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted. Most genes with functions necessary for cell cycle progression are overexpressed in this strain and most of the overexpressed genes have identifiable cell cycle functions. A tempting interpretation is that the product of DDB_G0293380 is involved in a DNA methylation pathway which is coupled with DNA replication. Harry MacWilliams December 2009br DDB0232433 CDS2824551 1686 + 0.242586
DDB_G0293582 DDB_G0293582 DDB0232433 CDS3074914 744 + 0.264785
DDB_G0293586 DDB_G0293586 contains one LisH domain contains 3 predicted coiled-coil domainsDDB0232433 CDS3081583 6045 - 0.305045
DDB_G0293958 DDB_G0293958 putative protein serinethreonine kinase similar to vertebrate Nek kinases which are involved in regulation of mitosisDDB0232433 CDS3460612 4779 + 0.208203
DDB_G0295683 DDB_G0295683 DDB0232433 CDS1769740 4770 + 0.291614
atg1 DDB_G0292390 Dictyostelium homolog of yeast atg1 belongs to the ULK (Unc-51-like kinase) family of kinases required for macroautophagyDDB0232433 CDS1694801 2007 + 0.255605
atr1 DDB_G0291380 atypical PIKK family protein kinase similar to protein kinase ATR which modulates cell cycle progression and DNA repair in other organisms ATR phosphorylates Rad17 histone H2AX p53 and Nbs1DDB0232433 CDS214264 9474 - 0.259552
blm DDB_G0292130 E. coli ATP-dependent DNA helicase RecQ is involved in genome maintenance this is the ortholog of the H. sapiens Bloom syndrome protein defects in BLM cause genetic instability including a high level of sister chromatid exchanges associated with a greatly increased predisposition to a wide range of cancersDDB0232433 CDS1240457 3780 + 0.286243
cdc7 DDB_G0292152 similar to S. cerevisiae cell division control protein 7 (CDC7) a serinethreonine kinase required for mitosis and meiosisDDB0232433 CDS1294776 3186 + 0.23666
cepK DDB_G0293544 localizes to the corona of the centrosome and to centromeres affects cell growth and chemotactic motility and is involved in the interaction with the nuclear envelopeDDB0232433 CDS2990987 6333 - 0.225959
chdC DDB_G0293012 CHD gene family protein containing a chromodomain a helicase domain and a DNA-binding domain chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2321154 9216 + 0.312174
commd1 DDB_G0292074 belongs to a family of conserved mammalian HCaRG (hypertension-related calcium-regulated gene) proteinsDDB0232433 CDS1155156 564 - 0.210993
ddx17 DDB_G0293168 conserved RNA helicase very similar to mammalian DDX17 (p72) and DDX5 (p68) and yeast DBP2DDB0232433 CDS2360817 2358 - 0.370229
ddx5 DDB_G0293036 DDB0232433 CDS2373448 2094 + 0.258835
ddx51 DDB_G0293740 DDB0232433 CDS3249527 1692 - 0.229905
ddx55 DDB_G0291588 ortholog of H. sapiens DDX55 and S. cerevisiae SBP4 (Suppressor of PAB1) SBP4 required for synthesis of 60S ribosomal subunitsDDB0232433 CDS577637 1992 - 0.270582
ddx6 DDB_G0291804 ortholog of H. sapiens DDX6 and S. cerevisiae DHH1 (DExDH-box Helicase)DDB0232433 CDS773358 1272 + 0.367925
dst3 DDB_G0291267 putative protein serinethreonine kinase the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS35064 1689 - 0.351095
dyrk2 DDB_G0293750 DDB0232433 CDS3272270 2748 + 0.306405
exo1 DDB_G0291570 highly similar to S. pombe exonuclease I a 5'-3' exonuclease involved in DNA repair recombination replication and telomere integrityDDB0232433 CDS561048 3141 + 0.266794
fhkA DDB_G0293656 CAMK group RAD53 family protein kinase similar to mammalian cell cycle checkpoint kinases chk2 contains a forkhead-associated (FHA) domain a phosphopeptide recognition domain found in many regulatory proteinsbrbr bCommunity annotation:b The five fhk-X genes differ substantially in their response to the disruption of the retinoblastoma-like gene rblA. FhkA is substantially and highly signficantly upregulated in the ko strain while none of the other genes show major changes. Consistent with its regulation the fhkA promoter contains a putative E2F-type binding site (TTTGCGCCTTTT). Virtually all genes associated with replication fork progression are upregulated in the rblA disruptant these include cdc45 all mcm genes all gins genes all rfc genes four polA subunits three polD subunits two putatitive polE subunits PCNA the single-strand binding protein rfa1 the flap endonuclease repG as well as DNA ligase-1 and topoisomerase-2. All these genes show overexpression factors ranging from 4 to 15DDB0232433 CDS3219230 1782 - 0.231201
gtf2h4 DDB_G0293228 ortholog of S. cerevisiae TFB2 subunit of TFIIH and nucleotide excision repair factor 3 complexes involved in transcription initiation required for nucleotide excision repairDDB0232433 CDS2676500 1452 - 0.303719
helA DDB_G0292992 DDB0232433 CDS2367392 3276 + 0.291209
ino80 DDB_G0292358 similar to S. cerevisiae INO80 an ATPase that forms a large complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS1406177 6390 + 0.308607
isw DDB_G0292948 similar to ISWI and mammalian SMARCA ATPases involved in nucleosome remodeling chromatin remodeling complex subunit R (CHR) protein SWI2SNF2 homologDDB0232433 CDS2254360 3666 + 0.336061
kxcB DDB_G0293124 kinase domain similar to those of stress-induced STK kinases contains a DH (Dbl homology) domain followed by a PH (pleckstrin homology) domain found in proteins shown to encode a GEF activity specific for Rho family membersDDB0232433 CDS2557594 3378 - 0.301066
lig4 DDB_G0292760 ATP-dependent DNA ligase contains the BRCT domain which is also found in BRCA1 forms a complex with XRCC4DDB0232433 CDS2052081 3267 + 0.270279
mcm5 DDB_G0292958 similar to MCM5 a component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexDDB0232433 CDS2121500 2274 - 0.329815
mre11 DDB_G0293546 similar to S. cerevisiae MRE11 involved in processing double-strand DNA breaks with Rad50 in other organisms Mre11 is part of a complex with Rad50 and Nbs1 no Nbs1 ortholog has been found in Dictyostelium DDB0232433 CDS3016431 2070 + 0.304348
mrkA DDB_G0292304 CAMKL family protein kinase similar to MARK kinases SNF1 kinases and AMPK kinases contains 1 kinase-associated (KA1) domain and 1 UBA domainDDB0232433 CDS1433748 3183 - 0.286836
ogg1 DDB_G0292618 similar to E. coli MutM and OGG1 a bifunctional DNA glycosylase that contains an activity that excises 8-oxoguanine and other derivatives of guanine from DNA and a beta-lyase activity that nicks DNA 3' of the lesionDDB0232433 CDS1847428 1320 - 0.258333
pakE DDB_G0293932 putative protein serinethreonine kinase belongs to the PAKL subfamily of protein kinases the kinase domain is similar to mammalian STK3 and STK4 (MST) kinases and other STE20-like kinases stress-responsive kinaseDDB0232433 CDS3512665 2781 + 0.270766
rad17 DDB_G0292504 similar to S. pombe and H. sapiens RAD17 and S. cerevisiae RAD24 component of Rad17-RFC complex which loads the 9-1-1 (Rad9-Rad1-Hus1) complex onto damaged DNADDB0232433 CDS1748396 3576 + 0.245526
rad50 DDB_G0292786 similar to S. cerevisiae RAD50 involved in processing double-strand DNA breaks with Mre11 in other organisms Rad50 is part of a complex with Mre11 and Nbs1 no Nbs1 ortholog has been found in Dictyostelium DDB0232433 CDS2029933 4056 + 0.272189
rfc2 DDB_G0291868 ortholog of H. sapiens RFC2 (40 kDa subunit) and S. cerevisiae RFC2DDB0232433 CDS850606 1017 + 0.328417
rfc3 DDB_G0293702 ortholog of H. sapiens RFC3 (38 kDa subunit) and S. cerevisiae RFC5DDB0232433 CDS3014705 1044 - 0.331418
rnaseh2A DDB_G0292584 catalytic subunit of RNase HII an endonuclease that specifically degrades the RNA of RNA:DNA hybrids defects in H. sapiens RNASEH2A cause Aicardi-Goutieres syndrome type 4 a genetically heterogeneous autosomal recessive encephalopathyDDB0232433 CDS1802425 870 - 0.287356
rrpB DDB_G0291249 one of the three D. discoideum RNA-directed RNA polymerases for which a distinct function has not yet been identifiedDDB0232433 CDS442657 7212 - 0.266916
vti1A DDB_G0292974 DDB0232433 CDS2202494 654 - 0.281346
xpc DDB_G0292296 DDB0232433 CDS1414792 2904 + 0.266529